1d1f - Revision history

OCA at 07:15, 10 May 2023

OCA — Wed, 10 May 2023 07:15:05 GMT

←Older revision		Revision as of 07:15, 10 May 2023
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	==SOLUTION STRUCTURE OF LACTAM-BRIDGED C-TERMINAL ANALOGUE-III OF NEUROPEPTIDE Y==		==SOLUTION STRUCTURE OF LACTAM-BRIDGED C-TERMINAL ANALOGUE-III OF NEUROPEPTIDE Y==
-	<StructureSection load='1d1f' size='340' side='right'caption='[[1d1f~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1d1f' size='340' side='right'caption='[[1d1f]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1d1f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D1F FirstGlance]. <br>		<table><tr><td colspan='2'>[[1d1f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D1F FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1d0w\|1d0w]], [[1d1e\|1d1e]]</div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d1f OCA], [https://pdbe.org/1d1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d1f RCSB], [https://www.ebi.ac.uk/pdbsum/1d1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d1f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d1f OCA], [https://pdbe.org/1d1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d1f RCSB], [https://www.ebi.ac.uk/pdbsum/1d1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d1f ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Norton~~, R S~~]]	+	[[Category: Norton RS]]
-	[[Category: Yao, S]]	+	[[Category: Yao S]]
-	~~[[Category: Helix]]~~	+
-	~~[[Category: Lactam-bridged]]~~	+
-	~~[[Category: Neuropeptide~~]]	+

OCA at 10:45, 4 August 2021

OCA — Wed, 04 Aug 2021 10:45:43 GMT

←Older revision		Revision as of 10:45, 4 August 2021
Line 3:		Line 3:
	<StructureSection load='1d1f' size='340' side='right'caption='[[1d1f]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1d1f' size='340' side='right'caption='[[1d1f]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1d1f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1D1F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1d1f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D1F FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0w\|1d0w]], [[1d1e\|1d1e]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1d0w\|1d0w]], [[1d1e\|1d1e]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1d1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d1f OCA], [~~http~~://pdbe.org/1d1f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1d1f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1d1f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1d1f ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d1f OCA], [https://pdbe.org/1d1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d1f RCSB], [https://www.ebi.ac.uk/pdbsum/1d1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d1f ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:25, 30 October 2019

OCA — Wed, 30 Oct 2019 10:25:07 GMT

←Older revision		Revision as of 10:25, 30 October 2019
Line 1:		Line 1:

	==SOLUTION STRUCTURE OF LACTAM-BRIDGED C-TERMINAL ANALOGUE-III OF NEUROPEPTIDE Y==		==SOLUTION STRUCTURE OF LACTAM-BRIDGED C-TERMINAL ANALOGUE-III OF NEUROPEPTIDE Y==
-	<StructureSection load='1d1f' size='340' side='right' caption='[[1d1f]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1d1f' size='340' side='right'caption='[[1d1f]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1d1f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D1F FirstGlance]. <br>		<table><tr><td colspan='2'>[[1d1f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D1F FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Norton, R S]]		[[Category: Norton, R S]]
	[[Category: Yao, S]]		[[Category: Yao, S]]

OCA at 11:13, 24 August 2017

OCA — Thu, 24 Aug 2017 11:13:47 GMT

←Older revision		Revision as of 11:13, 24 August 2017
Line 1:		Line 1:
		+
	==SOLUTION STRUCTURE OF LACTAM-BRIDGED C-TERMINAL ANALOGUE-III OF NEUROPEPTIDE Y==		==SOLUTION STRUCTURE OF LACTAM-BRIDGED C-TERMINAL ANALOGUE-III OF NEUROPEPTIDE Y==
	<StructureSection load='1d1f' size='340' side='right' caption='[[1d1f]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1d1f' size='340' side='right' caption='[[1d1f]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0w\|1d0w]], [[1d1e\|1d1e]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0w\|1d0w]], [[1d1e\|1d1e]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d1f OCA], [http://pdbe.org/1d1f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1d1f RCSB], [http://www.ebi.ac.uk/pdbsum/1d1f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d1f OCA], [http://pdbe.org/1d1f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1d1f RCSB], [http://www.ebi.ac.uk/pdbsum/1d1f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1d1f ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:48, 10 September 2015

OCA — Thu, 10 Sep 2015 08:48:51 GMT

←Older revision		Revision as of 08:48, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0w\|1d0w]], [[1d1e\|1d1e]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0w\|1d0w]], [[1d1e\|1d1e]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d1f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1d1f RCSB], [http://www.ebi.ac.uk/pdbsum/1d1f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d1f OCA], [http://pdbe.org/1d1f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1d1f RCSB], [http://www.ebi.ac.uk/pdbsum/1d1f PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1d1f" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:52, 22 December 2014

OCA — Mon, 22 Dec 2014 05:52:18 GMT

←Older revision		Revision as of 05:52, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1d1f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D1F FirstGlance]. <br>		<table><tr><td colspan='2'>[[1d1f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D1F FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0w\|1d0w]], [[1d1e\|1d1e]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0w\|1d0w]], [[1d1e\|1d1e]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d1f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1d1f RCSB], [http://www.ebi.ac.uk/pdbsum/1d1f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d1f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1d1f RCSB], [http://www.ebi.ac.uk/pdbsum/1d1f PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Norton, R S.]]	+	[[Category: Norton, R S]]
-	[[Category: Yao, S.]]	+	[[Category: Yao, S]]
	[[Category: Helix]]		[[Category: Helix]]
	[[Category: Lactam-bridged]]		[[Category: Lactam-bridged]]
	[[Category: Neuropeptide]]		[[Category: Neuropeptide]]

OCA: Protected "1d1f" [edit=sysop:move=sysop]

OCA — Sun, 08 Jun 2014 05:42:51 GMT

Protected "1d1f" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:42, 8 June 2014

OCA at 05:42, 8 June 2014

OCA — Sun, 08 Jun 2014 05:42:49 GMT

←Older revision		Revision as of 05:42, 8 June 2014
Line 1:		Line 1:
-	~~{{Seed}}~~	+	==SOLUTION STRUCTURE OF LACTAM-BRIDGED C-TERMINAL ANALOGUE-III OF NEUROPEPTIDE Y==
-	[[~~Image:~~1d1f.~~png~~\|~~left~~\|~~200px~~]]	+	<StructureSection load='1d1f' size='340' side='right' caption='[[1d1f]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1d1f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D1F FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0w\|1d0w]], [[1d1e\|1d1e]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d1f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1d1f RCSB], [http://www.ebi.ac.uk/pdbsum/1d1f PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The importance of helical structure in an analogue of NPY selective for the Y2 receptor, Ac[Leu28,31]NPY24-36, has been investigated by introducing a lactam bridge between positions 28 and 32. The resulting analogue, Ac-cyclo28/32[Ala24,Lys28,Leu31,Glu32]NPY24-36, is a potent Y2-selective agonist. Structural analysis by NMR shows that this analogue forms a helical structure in a 40% trifluoroethanol/water mixture, whereas in water only the region around the lactam bridge (Lys28-Glu32) adopts helical-like structure, with both N- and C-termini being poorly defined. The observation of well-defined helical structure in aqueous TFE contrasts with that reported for a similar analogue, Ac-cyclo28/32[Lys28,Glu32]NPY25-36 (Rist et al. FEBS Lett. 1996, 394, 169-173), which consisted of a hairpin-like structure that brought the N- and C-termini into proximity. We have therefore determined the structures of this analogue, as well as those of Ac-cyclo28/32[Ala24,Lys28,Leu31,Glu32]NPY24-36 and Ac-cyclo28/32[Ala24,Lys28,Glu32]NPY24-36, under identical solution conditions (30% TFE/H2O mixture at 308 K) and find essentially the same helical structure in all three peptides. These findings support the proposal that these Y2-selective analogues adopt a helical structure when bound to the Y2 receptor.

-	<!--	+	Stabilization of the helical structure of Y2-selective analogues of neuropeptide Y by lactam bridges.,Yao S, Smith-White MA, Potter EK, Norton RS J Med Chem. 2002 May 23;45(11):2310-8. PMID:12014969<ref>PMID:12014969</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_1d1f"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_1d1f\| PDB=1d1f \| SCENE= }}~~	+

-	~~===SOLUTION STRUCTURE OF LACTAM-BRIDGED C-TERMINAL ANALOGUE-III OF NEUROPEPTIDE Y===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_12014969}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 12014969 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_12014969}}~~	+
-		+
-	==~~About this Structure~~==	+
-	~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1D1F OCA].~~	+
-		+
-	~~==Reference==~~	+
-	~~Stabilization of the helical structure of Y2-selective analogues of neuropeptide Y by lactam bridges., Yao S, Smith-White MA, Potter EK, Norton RS, J Med Chem. 2002 May 23;45(11):2310-8. PMID:[http:~~/~~/www.ncbi.nlm.nih.gov/pubmed/12014969 12014969]~~	+
	[[Category: Norton, R S.]]		[[Category: Norton, R S.]]
	[[Category: Yao, S.]]		[[Category: Yao, S.]]
	[[Category: Helix]]		[[Category: Helix]]
	[[Category: Lactam-bridged]]		[[Category: Lactam-bridged]]
-		+	[[Category: Neuropeptide]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Jun 30 22:03:38 2008''~~	+

OCA at 19:03, 30 June 2008

OCA — Mon, 30 Jun 2008 19:03:46 GMT

←Older revision		Revision as of 19:03, 30 June 2008
Line 1:		Line 1:
-	[[Image:1d1f.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1d1f.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1d1f\| PDB=1d1f \| SCENE= }}		{{STRUCTURE_1d1f\| PDB=1d1f \| SCENE= }}

-	~~'''~~SOLUTION STRUCTURE OF LACTAM-BRIDGED C-TERMINAL ANALOGUE-III OF NEUROPEPTIDE Y~~'''~~	+	===SOLUTION STRUCTURE OF LACTAM-BRIDGED C-TERMINAL ANALOGUE-III OF NEUROPEPTIDE Y===


-	~~==Overview==~~	+	<!--
-	The ~~importance of helical structure in an analogue of NPY selective for the Y2 receptor~~, ~~Ac[Leu28~~,31]NPY24-36, has been investigated by introducing a lactam bridge between positions 28 and 32. The resulting analogue, Ac-cyclo28/32[Ala24,Lys28,Leu31,Glu32]NPY24-36, is a potent Y2-selective agonist. Structural analysis by NMR shows that this analogue forms a helical structure in a 40% trifluoroethanol/water mixture, whereas in water only the ~~region around~~ the ~~lactam bridge~~ (Lys28-Glu32) adopts helical-like structure, with both N- and C-termini being poorly defined. The observation of well-defined helical structure in aqueous TFE contrasts with that reported for a similar analogue, Ac-cyclo28/~~32[Lys28,Glu32]NPY25-36 (Rist et al~~. ~~FEBS Lett~~. ~~1996, 394, 169-173~~), ~~which consisted of a hairpin-like structure that brought~~ the ~~N- and C-termini into proximity~~. ~~We have therefore determined the structures of this analogue, as well as those of Ac~~-~~cyclo28/32[Ala24,Lys28,Leu31,Glu32]NPY24~~-36 and Ac-cyclo28/32[Ala24,Lys28,Glu32]NPY24-36, under identical solution conditions (30% TFE/H2O mixture at 308 K) and find essentially the same helical structure in all three peptides. These findings support the proposal that these Y2-selective analogues adopt a helical structure when bound to the Y2 receptor.	+	The line below this paragraph, {{ABSTRACT_PUBMED_12014969}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 12014969 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_12014969}}

	==About this Structure==		==About this Structure==
-	Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1F OCA].	+	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1F OCA].

	==Reference==		==Reference==
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	[[Category: Helix]]		[[Category: Helix]]
	[[Category: Lactam-bridged]]		[[Category: Lactam-bridged]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 13~~:20:26 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:03:38 2008''

OCA at 10:20, 2 May 2008

OCA — Fri, 02 May 2008 10:20:27 GMT

←Older revision		Revision as of 10:20, 2 May 2008
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	[[Image:1d1f.jpg\|left\|200px]]		[[Image:1d1f.jpg\|left\|200px]]

-	{{Structure	+	<!--
-	\|PDB~~= 1d1f \|SIZE=350\|CAPTION= <scene name='initialview01'>1d1f</scene>~~	+	The line below this paragraph, containing "STRUCTURE_1d1f", creates the "Structure Box" on the page.
-	~~\|SITE=~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	~~\|LIGAND= <~~scene ~~name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>~~, ~~<scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>~~	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	~~\|ACTIVITY=~~	+	or leave the SCENE parameter empty for the default display.
-	~~\|GENE=~~	+	-->
-	\|~~DOMAIN~~=	+	{{STRUCTURE_1d1f\| PDB=1d1f \| SCENE= }}
-	\|~~RELATEDENTRY~~=~~[[1d0w\|1D0W]], [[1d1e\|1D1E]]~~	+
-	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d1f OCA], [http://www.ebi.ac.uk/pdbsum/1d1f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d1f RCSB]</span>	+
-	}}	+

	'''SOLUTION STRUCTURE OF LACTAM-BRIDGED C-TERMINAL ANALOGUE-III OF NEUROPEPTIDE Y'''		'''SOLUTION STRUCTURE OF LACTAM-BRIDGED C-TERMINAL ANALOGUE-III OF NEUROPEPTIDE Y'''
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	==About this Structure==		==About this Structure==
-	~~1D1F is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ].~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1F OCA].	+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1F OCA].

	==Reference==		==Reference==
	Stabilization of the helical structure of Y2-selective analogues of neuropeptide Y by lactam bridges., Yao S, Smith-White MA, Potter EK, Norton RS, J Med Chem. 2002 May 23;45(11):2310-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12014969 12014969]		Stabilization of the helical structure of Y2-selective analogues of neuropeptide Y by lactam bridges., Yao S, Smith-White MA, Potter EK, Norton RS, J Med Chem. 2002 May 23;45(11):2310-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12014969 12014969]
-	[[Category: Protein complex]]
	[[Category: Norton, R S.]]		[[Category: Norton, R S.]]
	[[Category: Yao, S.]]		[[Category: Yao, S.]]
-	[[Category: ~~helix~~]]	+	[[Category: Helix]]
-	[[Category: ~~lactam~~-bridged]]	+	[[Category: Lactam-bridged]]
-		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:20:26 2008''
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Mar 30 19~~:32:41 2008''	+