1ddt - Revision history

OCA at 09:55, 19 April 2023

OCA — Wed, 19 Apr 2023 09:55:20 GMT

←Older revision		Revision as of 09:55, 19 April 2023
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	<StructureSection load='1ddt' size='340' side='right'caption='[[1ddt]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1ddt' size='340' side='right'caption='[[1ddt]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ddt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Corbe Corbe~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DDT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ddt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynephage_beta Corynephage beta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DDT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APU:ADENYLYL-3-5-PHOSPHO-URIDINE-3-MONOPHOSPHATE'>APU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APU:ADENYLYL-3-5-PHOSPHO-URIDINE-3-MONOPHOSPHATE'>APU</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ddt OCA], [https://pdbe.org/1ddt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ddt RCSB], [https://www.ebi.ac.uk/pdbsum/1ddt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ddt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ddt OCA], [https://pdbe.org/1ddt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ddt RCSB], [https://www.ebi.ac.uk/pdbsum/1ddt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ddt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DTX_CORBE DTX_CORBE]] Diphtheria toxin, produced by a phage infecting Corynebacterium diphtheriae, is a proenzyme that, after activation, catalyzes the covalent attachment of the ADP ribose moiety of NAD to eukaryotic elongation factor 2 (eEF-2). Fragment A is the catalytic portion responsible for enzymatic ADP-ribosylation of elongation factor 2, while fragment B is responsible for binding of toxin to cell receptors and entry of fragment A.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>	+	[https://www.uniprot.org/uniprot/DTX_CORBE DTX_CORBE] Diphtheria toxin, produced by a phage infecting Corynebacterium diphtheriae, is a proenzyme that, after activation, catalyzes the covalent attachment of the ADP ribose moiety of NAD to eukaryotic elongation factor 2 (eEF-2). Fragment A is the catalytic portion responsible for enzymatic ADP-ribosylation of elongation factor 2, while fragment B is responsible for binding of toxin to cell receptors and entry of fragment A.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Corbe~~]]	+	[[Category: Corynephage beta]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bennett~~, M J~~]]	+	[[Category: Bennett MJ]]
-	[[Category: Eisenberg, D]]	+	[[Category: Eisenberg D]]
-	~~[[Category: Toxin~~]]	+

OCA at 10:45, 14 July 2021

OCA — Wed, 14 Jul 2021 10:45:46 GMT

←Older revision		Revision as of 10:45, 14 July 2021
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	<StructureSection load='1ddt' size='340' side='right'caption='[[1ddt]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1ddt' size='340' side='right'caption='[[1ddt]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ddt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Corbe Corbe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1DDT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ddt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Corbe Corbe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DDT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APU:ADENYLYL-3-5-PHOSPHO-URIDINE-3-MONOPHOSPHATE'>APU</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APU:ADENYLYL-3-5-PHOSPHO-URIDINE-3-MONOPHOSPHATE'>APU</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ddt OCA], [~~http~~://pdbe.org/1ddt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ddt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ddt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ddt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ddt OCA], [https://pdbe.org/1ddt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ddt RCSB], [https://www.ebi.ac.uk/pdbsum/1ddt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ddt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DTX_CORBE DTX_CORBE]] Diphtheria toxin, produced by a phage infecting Corynebacterium diphtheriae, is a proenzyme that, after activation, catalyzes the covalent attachment of the ADP ribose moiety of NAD to eukaryotic elongation factor 2 (eEF-2). Fragment A is the catalytic portion responsible for enzymatic ADP-ribosylation of elongation factor 2, while fragment B is responsible for binding of toxin to cell receptors and entry of fragment A.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>	+	[[https://www.uniprot.org/uniprot/DTX_CORBE DTX_CORBE]] Diphtheria toxin, produced by a phage infecting Corynebacterium diphtheriae, is a proenzyme that, after activation, catalyzes the covalent attachment of the ADP ribose moiety of NAD to eukaryotic elongation factor 2 (eEF-2). Fragment A is the catalytic portion responsible for enzymatic ADP-ribosylation of elongation factor 2, while fragment B is responsible for binding of toxin to cell receptors and entry of fragment A.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:20, 10 October 2019

OCA — Thu, 10 Oct 2019 07:20:44 GMT

←Older revision		Revision as of 07:20, 10 October 2019
Line 1:		Line 1:

	==THE REFINED STRUCTURE OF DIMERIC DIPHTHERIA TOXIN AT 2.0 ANGSTROMS RESOLUTION==		==THE REFINED STRUCTURE OF DIMERIC DIPHTHERIA TOXIN AT 2.0 ANGSTROMS RESOLUTION==
-	<StructureSection load='1ddt' size='340' side='right' caption='[[1ddt]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1ddt' size='340' side='right'caption='[[1ddt]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ddt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Corbe Corbe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DDT FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ddt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Corbe Corbe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DDT FirstGlance]. <br>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 1ddt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1ddt" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Diphtheria toxin\|Diphtheria toxin]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Corbe]]		[[Category: Corbe]]
		+	[[Category: Large Structures]]
	[[Category: Bennett, M J]]		[[Category: Bennett, M J]]
	[[Category: Eisenberg, D]]		[[Category: Eisenberg, D]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 06:31, 29 November 2017

OCA — Wed, 29 Nov 2017 06:31:08 GMT

←Older revision		Revision as of 06:31, 29 November 2017
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	<StructureSection load='1ddt' size='340' side='right' caption='[[1ddt]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1ddt' size='340' side='right' caption='[[1ddt]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ddt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DDT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ddt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Corbe Corbe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DDT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APU:ADENYLYL-3-5-PHOSPHO-URIDINE-3-MONOPHOSPHATE'>APU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APU:ADENYLYL-3-5-PHOSPHO-URIDINE-3-MONOPHOSPHATE'>APU</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ddt OCA], [http://pdbe.org/1ddt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ddt RCSB], [http://www.ebi.ac.uk/pdbsum/1ddt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ddt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ddt OCA], [http://pdbe.org/1ddt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ddt RCSB], [http://www.ebi.ac.uk/pdbsum/1ddt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ddt ProSAT]</span></td></tr>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 1ddt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1ddt" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Diphtheria toxin\|Diphtheria toxin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Corbe]]
	[[Category: Bennett, M J]]		[[Category: Bennett, M J]]
	[[Category: Eisenberg, D]]		[[Category: Eisenberg, D]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 04:12, 30 August 2017

OCA — Wed, 30 Aug 2017 04:12:29 GMT

←Older revision		Revision as of 04:12, 30 August 2017
Line 1:		Line 1:
		+
	==THE REFINED STRUCTURE OF DIMERIC DIPHTHERIA TOXIN AT 2.0 ANGSTROMS RESOLUTION==		==THE REFINED STRUCTURE OF DIMERIC DIPHTHERIA TOXIN AT 2.0 ANGSTROMS RESOLUTION==
	<StructureSection load='1ddt' size='340' side='right' caption='[[1ddt]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1ddt' size='340' side='right' caption='[[1ddt]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ddt]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Corbe Corbe]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DDT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ddt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DDT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APU:ADENYLYL-3-5-PHOSPHO-URIDINE-3-MONOPHOSPHATE'>APU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APU:ADENYLYL-3-5-PHOSPHO-URIDINE-3-MONOPHOSPHATE'>APU</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ddt OCA], [http://pdbe.org/1ddt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ddt RCSB], [http://www.ebi.ac.uk/pdbsum/1ddt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ddt OCA], [http://pdbe.org/1ddt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ddt RCSB], [http://www.ebi.ac.uk/pdbsum/1ddt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ddt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Corbe]]
	[[Category: Bennett, M J]]		[[Category: Bennett, M J]]
	[[Category: Eisenberg, D]]		[[Category: Eisenberg, D]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 22:07, 10 September 2015

OCA — Thu, 10 Sep 2015 22:07:10 GMT

←Older revision		Revision as of 22:07, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1ddt' size='340' side='right' caption='[[1ddt]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1ddt' size='340' side='right' caption='[[1ddt]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ddt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Corynephage_beta Corynephage beta~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DDT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ddt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Corbe Corbe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DDT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APU:ADENYLYL-3-5-PHOSPHO-URIDINE-3-MONOPHOSPHATE'>APU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APU:ADENYLYL-3-5-PHOSPHO-URIDINE-3-MONOPHOSPHATE'>APU</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ddt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ddt RCSB], [http://www.ebi.ac.uk/pdbsum/1ddt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ddt OCA], [http://pdbe.org/1ddt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ddt RCSB], [http://www.ebi.ac.uk/pdbsum/1ddt PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ddt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Corynephage beta~~]]	+	[[Category: Corbe]]
	[[Category: Bennett, M J]]		[[Category: Bennett, M J]]
	[[Category: Eisenberg, D]]		[[Category: Eisenberg, D]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 06:43, 25 December 2014

OCA — Thu, 25 Dec 2014 06:43:35 GMT

←Older revision		Revision as of 06:43, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ddt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ddt RCSB], [http://www.ebi.ac.uk/pdbsum/1ddt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ddt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ddt RCSB], [http://www.ebi.ac.uk/pdbsum/1ddt PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DTX_CORBE DTX_CORBE]] Diphtheria toxin, produced by a phage infecting Corynebacterium diphtheriae, is a proenzyme that, after activation, catalyzes the covalent attachment of the ADP ribose moiety of NAD to eukaryotic elongation factor 2 (eEF-2). Fragment A is the catalytic portion responsible for enzymatic ADP-ribosylation of elongation factor 2, while fragment B is responsible for binding of toxin to cell receptors and entry of fragment A.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 00:40, 23 December 2014

OCA — Tue, 23 Dec 2014 00:40:42 GMT

←Older revision		Revision as of 00:40, 23 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ddt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Corynephage_beta Corynephage beta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DDT FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ddt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Corynephage_beta Corynephage beta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DDT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APU:ADENYLYL-3-5-PHOSPHO-URIDINE-3-MONOPHOSPHATE'>APU</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APU:ADENYLYL-3-5-PHOSPHO-URIDINE-3-MONOPHOSPHATE'>APU</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ddt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ddt RCSB], [http://www.ebi.ac.uk/pdbsum/1ddt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ddt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ddt RCSB], [http://www.ebi.ac.uk/pdbsum/1ddt PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Corynephage beta]]		[[Category: Corynephage beta]]
-	[[Category: Bennett, M J.]]	+	[[Category: Bennett, M J]]
-	[[Category: Eisenberg, D.]]	+	[[Category: Eisenberg, D]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 06:42, 4 September 2014

OCA — Thu, 04 Sep 2014 06:42:26 GMT

←Older revision		Revision as of 06:42, 4 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1ddt.~~png~~\|~~left\|200px~~]]	+	==THE REFINED STRUCTURE OF DIMERIC DIPHTHERIA TOXIN AT 2.0 ANGSTROMS RESOLUTION==
		+	<StructureSection load='1ddt' size='340' side='right' caption='[[1ddt]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ddt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Corynephage_beta Corynephage beta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DDT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APU:ADENYLYL-3-5-PHOSPHO-URIDINE-3-MONOPHOSPHATE'>APU</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ddt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ddt RCSB], [http://www.ebi.ac.uk/pdbsum/1ddt PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The refined structure of dimeric diphtheria toxin (DT) at 2.0 A resolution, based on 37,727 unique reflections (F > 1 sigma (F)), yields a final R factor of 19.5% with a model obeying standard geometry. The refined model consists of 523 amino acid residues, 1 molecule of the bound dinucleotide inhibitor adenylyl 3'-5' uridine 3' monophosphate (ApUp), and 405 well-ordered water molecules. The 2.0-A refined model reveals that the binding motif for ApUp includes residues in the catalytic and receptor-binding domains and is different from the Rossmann dinucleotide-binding fold. ApUp is bound in part by a long loop (residues 34-52) that crosses the active site. Several residues in the active site were previously identified as NAD-binding residues. Glu 148, previously identified as playing a catalytic role in ADP-ribosylation of elongation factor 2 by DT, is about 5 A from uracil in ApUp. The trigger for insertion of the transmembrane domain of DT into the endosomal membrane at low pH may involve 3 intradomain and 4 interdomain salt bridges that will be weakened at low pH by protonation of their acidic residues. The refined model also reveals that each molecule in dimeric DT has an "open" structure unlike most globular proteins, which we call an open monomer. Two open monomers interact by "domain swapping" to form a compact, globular dimeric DT structure. The possibility that the open monomer resembles a membrane insertion intermediate is discussed.

-	~~{{STRUCTURE_1ddt\| PDB=1ddt \| SCENE= }}~~	+	Refined structure of dimeric diphtheria toxin at 2.0 A resolution.,Bennett MJ, Choe S, Eisenberg D Protein Sci. 1994 Sep;3(9):1444-63. PMID:7833807<ref>PMID:7833807</ref>

-	~~===THE REFINED STRUCTURE OF DIMERIC DIPHTHERIA TOXIN AT 2~~.~~0 ANGSTROMS RESOLUTION===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_7833807}}~~	+	==See Also==
-		+	*[[Diphtheria toxin\|Diphtheria toxin]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1ddt~~]] ~~is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Corynephage_beta Corynephage beta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDT OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Corynephage beta]]		[[Category: Corynephage beta]]
	[[Category: Bennett, M J.]]		[[Category: Bennett, M J.]]
	[[Category: Eisenberg, D.]]		[[Category: Eisenberg, D.]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA: Protected "1ddt" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 20:45:38 GMT

Protected "1ddt" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:45, 21 October 2012