1dgl - Revision history

OCA at 05:56, 9 August 2023

OCA — Wed, 09 Aug 2023 05:56:58 GMT

←Older revision		Revision as of 05:56, 9 August 2023
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	<StructureSection load='1dgl' size='340' side='right'caption='[[1dgl]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1dgl' size='340' side='right'caption='[[1dgl]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dgl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Dioclea_grandiflora Dioclea grandiflora~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DGL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dgl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Macropsychanthus_grandiflorus Macropsychanthus grandiflorus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DGL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:~~MANGANESE+(II)+ION~~'>MN</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-MANNOSE'>~~MAN~~</scene>, <scene name='pdbligand=~~MMA~~:~~O1-METHYL-MANNOSE~~'>~~MMA~~</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgl OCA], [https://pdbe.org/1dgl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dgl RCSB], [https://www.ebi.ac.uk/pdbsum/1dgl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dgl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgl OCA], [https://pdbe.org/1dgl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dgl RCSB], [https://www.ebi.ac.uk/pdbsum/1dgl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dgl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LECA_DIOGR LECA_DIOGR]] D-mannose/D-glucose-binding lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 50 ug/ml.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref>	+	[https://www.uniprot.org/uniprot/LECA_DIOGR LECA_DIOGR] D-mannose/D-glucose-binding lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 50 ug/ml.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Dioclea grandiflora]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Brewer, C F~~]]	+	[[Category: Macropsychanthus grandiflorus]]
-	[[Category: ~~Rozwarski, D A~~]]	+	[[Category: Brewer CF]]
-	[[Category: ~~Sacchettini, J C~~]]	+	[[Category: Rozwarski DA]]
-	[[Category: ~~Swami, B M~~]]	+	[[Category: Sacchettini JC]]
-	[[Category: ~~Lectin]]~~	+	[[Category: Swami BM]]
-	~~[[Category: Saccharide binding]]~~	+
-	~~[[Category: Trimannoside~~]]	+

OCA at 09:26, 21 July 2021

OCA — Wed, 21 Jul 2021 09:26:42 GMT

←Older revision		Revision as of 09:26, 21 July 2021
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	<StructureSection load='1dgl' size='340' side='right'caption='[[1dgl]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1dgl' size='340' side='right'caption='[[1dgl]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dgl]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Dioclea_grandiflora Dioclea grandiflora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1DGL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dgl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dioclea_grandiflora Dioclea grandiflora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DGL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA-D-MANNOSE~~'>~~MAN~~</scene>, <scene name='pdbligand=~~MMA~~:O1-~~METHYL~~-MANNOSE'>~~MMA~~</scene>, <scene name='pdbligand=MN:~~MANGANESE+(II)+ION~~'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1dgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgl OCA], [~~http~~://pdbe.org/1dgl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1dgl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1dgl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1dgl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgl OCA], [https://pdbe.org/1dgl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dgl RCSB], [https://www.ebi.ac.uk/pdbsum/1dgl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dgl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LECA_DIOGR LECA_DIOGR]] D-mannose/D-glucose-binding lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 50 ug/ml.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref>	+	[[https://www.uniprot.org/uniprot/LECA_DIOGR LECA_DIOGR]] D-mannose/D-glucose-binding lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 50 ug/ml.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:22, 16 October 2019

OCA — Wed, 16 Oct 2019 10:22:25 GMT

←Older revision		Revision as of 10:22, 16 October 2019
Line 1:		Line 1:

	==LECTIN FROM DIOCLEA GRANDIFLORA COMPLEXED TO TRIMANNOSIDE==		==LECTIN FROM DIOCLEA GRANDIFLORA COMPLEXED TO TRIMANNOSIDE==
-	<StructureSection load='1dgl' size='340' side='right' caption='[[1dgl]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='1dgl' size='340' side='right'caption='[[1dgl]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1dgl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dioclea_grandiflora Dioclea grandiflora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DGL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1dgl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dioclea_grandiflora Dioclea grandiflora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DGL FirstGlance]. <br>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Dioclea grandiflora]]		[[Category: Dioclea grandiflora]]
		+	[[Category: Large Structures]]
	[[Category: Brewer, C F]]		[[Category: Brewer, C F]]
	[[Category: Rozwarski, D A]]		[[Category: Rozwarski, D A]]

OCA at 08:25, 6 December 2017

OCA — Wed, 06 Dec 2017 08:25:16 GMT

←Older revision		Revision as of 08:25, 6 December 2017
Line 1:		Line 1:
		+
	==LECTIN FROM DIOCLEA GRANDIFLORA COMPLEXED TO TRIMANNOSIDE==		==LECTIN FROM DIOCLEA GRANDIFLORA COMPLEXED TO TRIMANNOSIDE==
	<StructureSection load='1dgl' size='340' side='right' caption='[[1dgl]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1dgl' size='340' side='right' caption='[[1dgl]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dgl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Diogr Diogr~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DGL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dgl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dioclea_grandiflora Dioclea grandiflora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DGL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:~~MANGANESE+(II)+ION~~'>MN</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-MANNOSE'>~~MAN~~</scene>, <scene name='pdbligand=~~MMA~~:~~O1-METHYL-MANNOSE~~'>~~MMA~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgl OCA], [http://pdbe.org/1dgl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dgl RCSB], [http://www.ebi.ac.uk/pdbsum/1dgl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgl OCA], [http://pdbe.org/1dgl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dgl RCSB], [http://www.ebi.ac.uk/pdbsum/1dgl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dgl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dg/1dgl_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dg/1dgl_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Diogr~~]]	+	[[Category: Dioclea grandiflora]]
	[[Category: Brewer, C F]]		[[Category: Brewer, C F]]
	[[Category: Rozwarski, D A]]		[[Category: Rozwarski, D A]]

OCA at 16:30, 9 February 2016

OCA — Tue, 09 Feb 2016 16:30:55 GMT

←Older revision		Revision as of 16:30, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dgl ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:04, 11 September 2015

OCA — Fri, 11 Sep 2015 00:04:45 GMT

←Older revision		Revision as of 00:04, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1dgl' size='340' side='right' caption='[[1dgl]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1dgl' size='340' side='right' caption='[[1dgl]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dgl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Dioclea_grandiflora Dioclea grandiflora~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DGL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dgl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Diogr Diogr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DGL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dgl RCSB], [http://www.ebi.ac.uk/pdbsum/1dgl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgl OCA], [http://pdbe.org/1dgl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dgl RCSB], [http://www.ebi.ac.uk/pdbsum/1dgl PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1dgl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dioclea grandiflora~~]]	+	[[Category: Diogr]]
	[[Category: Brewer, C F]]		[[Category: Brewer, C F]]
	[[Category: Rozwarski, D A]]		[[Category: Rozwarski, D A]]

OCA at 08:05, 25 December 2014

OCA — Thu, 25 Dec 2014 08:05:06 GMT

←Older revision		Revision as of 08:05, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dgl RCSB], [http://www.ebi.ac.uk/pdbsum/1dgl PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dgl RCSB], [http://www.ebi.ac.uk/pdbsum/1dgl PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LECA_DIOGR LECA_DIOGR]] D-mannose/D-glucose-binding lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 50 ug/ml.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 20:13, 22 December 2014

OCA — Mon, 22 Dec 2014 20:13:20 GMT

←Older revision		Revision as of 20:13, 22 December 2014
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Dioclea grandiflora]]		[[Category: Dioclea grandiflora]]
-	[[Category: Brewer, C F.]]	+	[[Category: Brewer, C F]]
-	[[Category: Rozwarski, D A.]]	+	[[Category: Rozwarski, D A]]
-	[[Category: Sacchettini, J C.]]	+	[[Category: Sacchettini, J C]]
-	[[Category: Swami, B M.]]	+	[[Category: Swami, B M]]
	[[Category: Lectin]]		[[Category: Lectin]]
	[[Category: Saccharide binding]]		[[Category: Saccharide binding]]
	[[Category: Trimannoside]]		[[Category: Trimannoside]]

OCA at 05:53, 10 October 2014

OCA — Fri, 10 Oct 2014 05:53:33 GMT

←Older revision		Revision as of 05:53, 10 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1dgl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dioclea_grandiflora Dioclea grandiflora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DGL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1dgl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dioclea_grandiflora Dioclea grandiflora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DGL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dgl RCSB], [http://www.ebi.ac.uk/pdbsum/1dgl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dgl RCSB], [http://www.ebi.ac.uk/pdbsum/1dgl PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:37, 4 September 2014

OCA — Thu, 04 Sep 2014 06:37:08 GMT

←Older revision		Revision as of 06:37, 4 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1dgl.~~png\|left~~\|200px]]	+	==LECTIN FROM DIOCLEA GRANDIFLORA COMPLEXED TO TRIMANNOSIDE==
		+	<StructureSection load='1dgl' size='340' side='right' caption='[[1dgl]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1dgl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dioclea_grandiflora Dioclea grandiflora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DGL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dgl RCSB], [http://www.ebi.ac.uk/pdbsum/1dgl PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dg/1dgl_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The seed lectin from Dioclea grandiflora (DGL) has recently been shown to possess high affinity for 3, 6-di-O-(alpha-D-mannopyranosyl)-alpha-D-mannopyranose, the core trimannoside of asparagine-linked carbohydrates, but lower affinity for biantennary complex carbohydrates. In the previous paper, the thermodynamics of DGL binding to deoxy analogs of the core trimannoside and to a biantennary complex carbohydrate were determined by isothermal titration microcalorimetry. The data suggest that DGL recognizes specific hydroxyl groups of the trimannoside similar to that of the jack bean lectin concanavalin A (ConA) (Gupta, D. Dam, T. K., Oscarson, S., and Brewer, C. F. (1997) J. Biol. Chem. 272, 6388-6392). However, the thermodynamics of DGL binding to certain deoxy analogs and to the complex carbohydrate are different from that of ConA. In the present paper, the x-ray crystal structure of DGL complexed to the core trimannoside was determined to a resolution of 2.6 A. The overall structure of the DGL complex is similar to the structure of the ConA-trimannoside complex (Naismith, J. H., and Field, R. A. (1996) J. Biol. Chem. 271, 972-976). The location and conformation of the bound trimannoside as well as its hydrogen-bonding interactions in both complexes are nearly identical. However, differences exist in the location of two loops outside of the respective binding sites containing residues 114-125 and 222-227. The latter residues affect the location of a network of hydrogen-bonded water molecules that interact with the trisaccharide. Differences in the arrangement of ordered water molecules in the binding site and/or protein conformational differences outside of the binding site may account for the differences in the thermodynamics of binding of the two lectins to deoxy analogs of the trimannoside. Molecular modeling studies suggest how DGL discriminates against binding the biantennary complex carbohydrate relative to ConA.

-	~~{{STRUCTURE_1dgl\| PDB=1dgl \| SCENE= }}~~	+	Crystal structure of the lectin from Dioclea grandiflora complexed with core trimannoside of asparagine-linked carbohydrates.,Rozwarski DA, Swami BM, Brewer CF, Sacchettini JC J Biol Chem. 1998 Dec 4;273(49):32818-25. PMID:9830028<ref>PMID:9830028</ref>

-	~~===LECTIN FROM DIOCLEA GRANDIFLORA COMPLEXED TO TRIMANNOSIDE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9830028}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1dgl]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Dioclea_grandiflora Dioclea grandiflora]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1DGL OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:009830028<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Dioclea grandiflora]]		[[Category: Dioclea grandiflora]]
	[[Category: Brewer, C F.]]		[[Category: Brewer, C F.]]