1dlw - Revision history

OCA at 06:55, 7 February 2024

OCA — Wed, 07 Feb 2024 06:55:53 GMT

←Older revision		Revision as of 06:55, 7 February 2024
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	<StructureSection load='1dlw' size='340' side='right'caption='[[1dlw]], [[Resolution\|resolution]] 1.54Å' scene=''>		<StructureSection load='1dlw' size='340' side='right'caption='[[1dlw]], [[Resolution\|resolution]] 1.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dlw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Parca Parca~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DLW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dlw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Paramecium_caudatum Paramecium caudatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DLW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.54Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1dly\|1dly]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dlw OCA], [https://pdbe.org/1dlw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dlw RCSB], [https://www.ebi.ac.uk/pdbsum/1dlw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dlw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dlw OCA], [https://pdbe.org/1dlw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dlw RCSB], [https://www.ebi.ac.uk/pdbsum/1dlw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dlw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TRHBN_PARCA TRHBN_PARCA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dlw ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dlw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Small hemoproteins displaying amino acid sequences 20-40 residues shorter than (non-)vertebrate hemoglobins (Hbs) have recently been identified in several pathogenic and non-pathogenic unicellular organisms, and named 'truncated hemoglobins' (trHbs). They have been proposed to be involved not only in oxygen transport but also in other biological functions, such as protection against reactive nitrogen species, photosynthesis or to act as terminal oxidases. Crystal structures of trHbs from the ciliated protozoan Paramecium caudatum and the green unicellular alga Chlamydomonas eugametos show that the tertiary structure of both proteins is based on a 'two-over-two' alpha-helical sandwich, reflecting an unprecedented editing of the classical 'three-over-three' alpha-helical globin fold. Based on specific Gly-Gly motifs the tertiary structure accommodates the deletion of the N-terminal A-helix and replacement of the crucial heme-binding F-helix with an extended polypeptide loop. Additionally, concerted structural modifications allow burying of the heme group and define the distal site, which hosts a TyrB10, GlnE7 residue pair. A set of structural and amino acid sequence consensus rules for stabilizing the fold and the bound heme in the trHbs homology subfamily is deduced.
-
-	A novel two-over-two alpha-helical sandwich fold is characteristic of the truncated hemoglobin family.,Pesce A, Couture M, Dewilde S, Guertin M, Yamauchi K, Ascenzi P, Moens L, Bolognesi M EMBO J. 2000 Jun 1;19(11):2424-34. PMID:10835341<ref>PMID:10835341</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1dlw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]		*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Parca~~]]	+	[[Category: Paramecium caudatum]]
-	[[Category: Bolognesi, M]]	+	[[Category: Bolognesi M]]
-	[[Category: Couture, M]]	+	[[Category: Couture M]]
-	[[Category: Dewilde, S]]	+	[[Category: Dewilde S]]
-	[[Category: Guertin, M]]	+	[[Category: Guertin M]]
-	[[Category: Moens, L]]	+	[[Category: Moens L]]
-	[[Category: Pesce, A]]	+	[[Category: Pesce A]]
-	~~[[Category: Globin fold truncated hemoglobin non vertebrate hemoglobin]]~~	+
-	~~[[Category: Oxygen storage-transport complex~~]]	+

OCA at 09:28, 21 July 2021

OCA — Wed, 21 Jul 2021 09:28:34 GMT

←Older revision		Revision as of 09:28, 21 July 2021
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	<StructureSection load='1dlw' size='340' side='right'caption='[[1dlw]], [[Resolution\|resolution]] 1.54Å' scene=''>		<StructureSection load='1dlw' size='340' side='right'caption='[[1dlw]], [[Resolution\|resolution]] 1.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dlw]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Parca Parca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1DLW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dlw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Parca Parca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DLW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dly\|1dly]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1dly\|1dly]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1dlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dlw OCA], [~~http~~://pdbe.org/1dlw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1dlw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1dlw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1dlw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dlw OCA], [https://pdbe.org/1dlw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dlw RCSB], [https://www.ebi.ac.uk/pdbsum/1dlw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dlw ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:45, 16 October 2019

OCA — Wed, 16 Oct 2019 08:45:43 GMT

←Older revision		Revision as of 08:45, 16 October 2019
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	==X-RAY CRYSTAL STRUCTURE OF TRUNCATED HEMOGLOBIN FROM P.CAUDATUM.==		==X-RAY CRYSTAL STRUCTURE OF TRUNCATED HEMOGLOBIN FROM P.CAUDATUM.==
-	<StructureSection load='1dlw' size='340' side='right' caption='[[1dlw]], [[Resolution\|resolution]] 1.54Å' scene=''>	+	<StructureSection load='1dlw' size='340' side='right'caption='[[1dlw]], [[Resolution\|resolution]] 1.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1dlw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Parca Parca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DLW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1dlw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Parca Parca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DLW FirstGlance]. <br>
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Parca]]		[[Category: Parca]]
	[[Category: Bolognesi, M]]		[[Category: Bolognesi, M]]

OCA at 07:48, 13 December 2017

OCA — Wed, 13 Dec 2017 07:48:36 GMT

←Older revision		Revision as of 07:48, 13 December 2017
Line 1:		Line 1:
		+
	==X-RAY CRYSTAL STRUCTURE OF TRUNCATED HEMOGLOBIN FROM P.CAUDATUM.==		==X-RAY CRYSTAL STRUCTURE OF TRUNCATED HEMOGLOBIN FROM P.CAUDATUM.==
	<StructureSection load='1dlw' size='340' side='right' caption='[[1dlw]], [[Resolution\|resolution]] 1.54Å' scene=''>		<StructureSection load='1dlw' size='340' side='right' caption='[[1dlw]], [[Resolution\|resolution]] 1.54Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dly\|1dly]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dly\|1dly]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dlw OCA], [http://pdbe.org/1dlw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dlw RCSB], [http://www.ebi.ac.uk/pdbsum/1dlw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dlw OCA], [http://pdbe.org/1dlw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dlw RCSB], [http://www.ebi.ac.uk/pdbsum/1dlw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dlw ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/1dlw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/1dlw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 19:27, 8 February 2016

OCA — Mon, 08 Feb 2016 19:27:14 GMT

←Older revision		Revision as of 19:27, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dlw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:40, 10 September 2015

OCA — Thu, 10 Sep 2015 14:40:40 GMT

←Older revision		Revision as of 14:40, 10 September 2015
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	<StructureSection load='1dlw' size='340' side='right' caption='[[1dlw]], [[Resolution\|resolution]] 1.54Å' scene=''>		<StructureSection load='1dlw' size='340' side='right' caption='[[1dlw]], [[Resolution\|resolution]] 1.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dlw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Paramecium_caudatum Paramecium caudatum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DLW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dlw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Parca Parca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DLW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dly\|1dly]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dly\|1dly]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dlw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dlw RCSB], [http://www.ebi.ac.uk/pdbsum/1dlw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dlw OCA], [http://pdbe.org/1dlw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dlw RCSB], [http://www.ebi.ac.uk/pdbsum/1dlw PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1dlw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Paramecium caudatum~~]]	+	[[Category: Parca]]
	[[Category: Bolognesi, M]]		[[Category: Bolognesi, M]]
	[[Category: Couture, M]]		[[Category: Couture, M]]

OCA at 23:23, 22 December 2014

OCA — Mon, 22 Dec 2014 23:23:03 GMT

←Older revision		Revision as of 23:23, 22 December 2014
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Paramecium caudatum]]		[[Category: Paramecium caudatum]]
-	[[Category: Bolognesi, M.]]	+	[[Category: Bolognesi, M]]
-	[[Category: Couture, M.]]	+	[[Category: Couture, M]]
-	[[Category: Dewilde, S.]]	+	[[Category: Dewilde, S]]
-	[[Category: Guertin, M.]]	+	[[Category: Guertin, M]]
-	[[Category: Moens, L.]]	+	[[Category: Moens, L]]
-	[[Category: Pesce, A.]]	+	[[Category: Pesce, A]]
	[[Category: Globin fold truncated hemoglobin non vertebrate hemoglobin]]		[[Category: Globin fold truncated hemoglobin non vertebrate hemoglobin]]
	[[Category: Oxygen storage-transport complex]]		[[Category: Oxygen storage-transport complex]]

OCA at 05:47, 10 October 2014

OCA — Fri, 10 Oct 2014 05:47:27 GMT

←Older revision		Revision as of 05:47, 10 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1dlw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Paramecium_caudatum Paramecium caudatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DLW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1dlw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Paramecium_caudatum Paramecium caudatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DLW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dly\|1dly]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dly\|1dly]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dlw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dlw RCSB], [http://www.ebi.ac.uk/pdbsum/1dlw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dlw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dlw RCSB], [http://www.ebi.ac.uk/pdbsum/1dlw PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:31, 4 September 2014

OCA — Thu, 04 Sep 2014 06:31:27 GMT

←Older revision		Revision as of 06:31, 4 September 2014
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-	[[~~Image:~~1dlw.~~png~~\|~~left~~\|200px]]	+	==X-RAY CRYSTAL STRUCTURE OF TRUNCATED HEMOGLOBIN FROM P.CAUDATUM.==
		+	<StructureSection load='1dlw' size='340' side='right' caption='[[1dlw]], [[Resolution\|resolution]] 1.54Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1dlw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Paramecium_caudatum Paramecium caudatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DLW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dly\|1dly]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dlw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dlw RCSB], [http://www.ebi.ac.uk/pdbsum/1dlw PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/1dlw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Small hemoproteins displaying amino acid sequences 20-40 residues shorter than (non-)vertebrate hemoglobins (Hbs) have recently been identified in several pathogenic and non-pathogenic unicellular organisms, and named 'truncated hemoglobins' (trHbs). They have been proposed to be involved not only in oxygen transport but also in other biological functions, such as protection against reactive nitrogen species, photosynthesis or to act as terminal oxidases. Crystal structures of trHbs from the ciliated protozoan Paramecium caudatum and the green unicellular alga Chlamydomonas eugametos show that the tertiary structure of both proteins is based on a 'two-over-two' alpha-helical sandwich, reflecting an unprecedented editing of the classical 'three-over-three' alpha-helical globin fold. Based on specific Gly-Gly motifs the tertiary structure accommodates the deletion of the N-terminal A-helix and replacement of the crucial heme-binding F-helix with an extended polypeptide loop. Additionally, concerted structural modifications allow burying of the heme group and define the distal site, which hosts a TyrB10, GlnE7 residue pair. A set of structural and amino acid sequence consensus rules for stabilizing the fold and the bound heme in the trHbs homology subfamily is deduced.

-	~~{{STRUCTURE_1dlw\| PDB=1dlw \| SCENE= }}~~	+	A novel two-over-two alpha-helical sandwich fold is characteristic of the truncated hemoglobin family.,Pesce A, Couture M, Dewilde S, Guertin M, Yamauchi K, Ascenzi P, Moens L, Bolognesi M EMBO J. 2000 Jun 1;19(11):2424-34. PMID:10835341<ref>PMID:10835341</ref>

-	~~===X-RAY CRYSTAL STRUCTURE OF TRUNCATED HEMOGLOBIN FROM P.CAUDATUM.===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10835341}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1dlw]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Paramecium_caudatum Paramecium caudatum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1DLW OCA].~~	+

	==See Also==		==See Also==
-	*[[Hemoglobin\|Hemoglobin]]	+	*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:010835341<~~/~~ref~~><~~ref group="xtra">PMID:011178916</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Paramecium caudatum]]		[[Category: Paramecium caudatum]]
	[[Category: Bolognesi, M.]]		[[Category: Bolognesi, M.]]

OCA at 11:13, 20 October 2012

OCA — Sat, 20 Oct 2012 11:13:29 GMT

←Older revision		Revision as of 11:13, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1dlw]] is a 1 chain structure ~~of [[Hemoglobin]]~~ with sequence from [http://en.wikipedia.org/wiki/Paramecium_caudatum Paramecium caudatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLW OCA].	+	[[1dlw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Paramecium_caudatum Paramecium caudatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLW OCA].

	==See Also==		==See Also==