1dq0 - Revision history

OCA at 05:57, 9 August 2023

OCA — Wed, 09 Aug 2023 05:57:41 GMT

←Older revision		Revision as of 05:57, 9 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1dq0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DQ0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1dq0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DQ0 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1enr\|1enr]]~~, [[~~1dq1~~\|~~1dq1~~]]~~, [[1dq2\|1dq2]], [[1dq4\|1dq4]], [[1dq5\|1dq5]], [[1dq6\|1dq6]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dq0 OCA], [https://pdbe.org/1dq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dq0 RCSB], [https://www.ebi.ac.uk/pdbsum/1dq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dq0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dq0 OCA], [https://pdbe.org/1dq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dq0 RCSB], [https://www.ebi.ac.uk/pdbsum/1dq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dq0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CONA_CANBR CONA_CANBR]] Glucose/D-mannose specific lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from hamster and rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 20 ug/ml.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:8891754</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref>	+	[https://www.uniprot.org/uniprot/CONA_CANBR CONA_CANBR] Glucose/D-mannose specific lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from hamster and rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 20 ug/ml.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:8891754</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Canavalia ensiformis]]		[[Category: Canavalia ensiformis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bouckaert, J]]	+	[[Category: Bouckaert J]]
-	[[Category: Dewallef, Y]]	+	[[Category: Dewallef Y]]
-	[[Category: Loris, R]]	+	[[Category: Loris R]]
-	[[Category: Poortmans, F]]	+	[[Category: Poortmans F]]
-	[[Category: Wyns, L]]	+	[[Category: Wyns L]]
-	~~[[Category: Beta-sheet]]~~	+
-	~~[[Category: Demetallized concanavalin some]]~~	+
-	~~[[Category: Locked state]]~~	+
-	~~[[Category: Minor structural species]]~~	+
-	~~[[Category: Solution]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 09:49, 26 May 2021

OCA — Wed, 26 May 2021 09:49:27 GMT

←Older revision		Revision as of 09:49, 26 May 2021
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	<StructureSection load='1dq0' size='340' side='right'caption='[[1dq0]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1dq0' size='340' side='right'caption='[[1dq0]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dq0]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQ0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1DQ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dq0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DQ0 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1enr\|1enr]], [[1dq1\|1dq1]], [[1dq2\|1dq2]], [[1dq4\|1dq4]], [[1dq5\|1dq5]], [[1dq6\|1dq6]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1enr\|1enr]], [[1dq1\|1dq1]], [[1dq2\|1dq2]], [[1dq4\|1dq4]], [[1dq5\|1dq5]], [[1dq6\|1dq6]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1dq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dq0 OCA], [~~http~~://pdbe.org/1dq0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1dq0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1dq0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1dq0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dq0 OCA], [https://pdbe.org/1dq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dq0 RCSB], [https://www.ebi.ac.uk/pdbsum/1dq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dq0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CONA_CANBR CONA_CANBR]] Glucose/D-mannose specific lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from hamster and rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 20 ug/ml.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:8891754</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref>	+	[[https://www.uniprot.org/uniprot/CONA_CANBR CONA_CANBR]] Glucose/D-mannose specific lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from hamster and rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 20 ug/ml.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:8891754</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
	*[[Concanavalin 3D structures\|Concanavalin 3D structures]]		*[[Concanavalin 3D structures\|Concanavalin 3D structures]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:06, 21 August 2019

OCA — Wed, 21 Aug 2019 07:06:35 GMT

←Older revision		Revision as of 07:06, 21 August 2019
Line 1:		Line 1:

	==Locked, metal-free concanavalin A, a minor species in solution==		==Locked, metal-free concanavalin A, a minor species in solution==
-	<StructureSection load='1dq0' size='340' side='right' caption='[[1dq0]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='1dq0' size='340' side='right'caption='[[1dq0]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1dq0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DQ0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1dq0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DQ0 FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dq/1dq0_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dq/1dq0_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1dq0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1dq0" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Concanavalin 3D structures\|Concanavalin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Canavalia ensiformis]]		[[Category: Canavalia ensiformis]]
		+	[[Category: Large Structures]]
	[[Category: Bouckaert, J]]		[[Category: Bouckaert, J]]
	[[Category: Dewallef, Y]]		[[Category: Dewallef, Y]]

OCA at 09:09, 16 November 2017

OCA — Thu, 16 Nov 2017 09:09:52 GMT

←Older revision		Revision as of 09:09, 16 November 2017
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1dq0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1dq0" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Concanavalin A\|Concanavalin A]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:15, 3 August 2017

OCA — Thu, 03 Aug 2017 10:15:09 GMT

←Older revision		Revision as of 10:15, 3 August 2017
Line 1:		Line 1:
		+
	==Locked, metal-free concanavalin A, a minor species in solution==		==Locked, metal-free concanavalin A, a minor species in solution==
	<StructureSection load='1dq0' size='340' side='right' caption='[[1dq0]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1dq0' size='340' side='right' caption='[[1dq0]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1dq0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DQ0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1dq0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DQ0 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1enr\|1enr]], [[1dq1\|1dq1]], [[1dq2\|1dq2]], [[1dq4\|1dq4]], [[1dq5\|1dq5]], [[1dq6\|1dq6]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1enr\|1enr]], [[1dq1\|1dq1]], [[1dq2\|1dq2]], [[1dq4\|1dq4]], [[1dq5\|1dq5]], [[1dq6\|1dq6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dq0 OCA], [http://pdbe.org/1dq0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dq0 RCSB], [http://www.ebi.ac.uk/pdbsum/1dq0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dq0 OCA], [http://pdbe.org/1dq0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dq0 RCSB], [http://www.ebi.ac.uk/pdbsum/1dq0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dq0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~CONA_CANEN CONA_CANEN~~]] D-mannose specific lectin.	+	[[http://www.uniprot.org/uniprot/CONA_CANBR CONA_CANBR]] Glucose/D-mannose specific lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from hamster and rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 20 ug/ml.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:8891754</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 04:06, 7 February 2016

OCA — Sun, 07 Feb 2016 04:06:44 GMT

←Older revision		Revision as of 04:06, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dq0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:38, 9 September 2015

OCA — Wed, 09 Sep 2015 21:38:10 GMT

←Older revision		Revision as of 21:38, 9 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1dq0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DQ0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1dq0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DQ0 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1enr\|1enr]], [[1dq1\|1dq1]], [[1dq2\|1dq2]], [[1dq4\|1dq4]], [[1dq5\|1dq5]], [[1dq6\|1dq6]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1enr\|1enr]], [[1dq1\|1dq1]], [[1dq2\|1dq2]], [[1dq4\|1dq4]], [[1dq5\|1dq5]], [[1dq6\|1dq6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dq0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dq0 RCSB], [http://www.ebi.ac.uk/pdbsum/1dq0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dq0 OCA], [http://pdbe.org/1dq0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dq0 RCSB], [http://www.ebi.ac.uk/pdbsum/1dq0 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1dq0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Concanavalin A\|Concanavalin A]]		*[[Concanavalin A\|Concanavalin A]]
-	*[[Monoclonal Antibody\|Monoclonal Antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:43, 24 December 2014

OCA — Wed, 24 Dec 2014 07:43:33 GMT

←Older revision		Revision as of 07:43, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dq0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dq0 RCSB], [http://www.ebi.ac.uk/pdbsum/1dq0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dq0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dq0 RCSB], [http://www.ebi.ac.uk/pdbsum/1dq0 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CONA_CANEN CONA_CANEN]] D-mannose specific lectin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 19:13, 22 December 2014

OCA — Mon, 22 Dec 2014 19:13:39 GMT

←Older revision		Revision as of 19:13, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1dq0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DQ0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1dq0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DQ0 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1enr\|1enr]], [[1dq1\|1dq1]], [[1dq2\|1dq2]], [[1dq4\|1dq4]], [[1dq5\|1dq5]], [[1dq6\|1dq6]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1enr\|1enr]], [[1dq1\|1dq1]], [[1dq2\|1dq2]], [[1dq4\|1dq4]], [[1dq5\|1dq5]], [[1dq6\|1dq6]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dq0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dq0 RCSB], [http://www.ebi.ac.uk/pdbsum/1dq0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dq0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dq0 RCSB], [http://www.ebi.ac.uk/pdbsum/1dq0 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Canavalia ensiformis]]		[[Category: Canavalia ensiformis]]
-	[[Category: Bouckaert, J.]]	+	[[Category: Bouckaert, J]]
-	[[Category: Dewallef, Y.]]	+	[[Category: Dewallef, Y]]
-	[[Category: Loris, R.]]	+	[[Category: Loris, R]]
-	[[Category: Poortmans, F.]]	+	[[Category: Poortmans, F]]
-	[[Category: Wyns, L.]]	+	[[Category: Wyns, L]]
	[[Category: Beta-sheet]]		[[Category: Beta-sheet]]
	[[Category: Demetallized concanavalin some]]		[[Category: Demetallized concanavalin some]]

OCA at 10:39, 10 September 2014

OCA — Wed, 10 Sep 2014 10:39:06 GMT

←Older revision		Revision as of 10:39, 10 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1dq0.~~png~~\|~~left~~\|200px]]	+	==Locked, metal-free concanavalin A, a minor species in solution==
		+	<StructureSection load='1dq0' size='340' side='right' caption='[[1dq0]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1dq0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DQ0 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1enr\|1enr]], [[1dq1\|1dq1]], [[1dq2\|1dq2]], [[1dq4\|1dq4]], [[1dq5\|1dq5]], [[1dq6\|1dq6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dq0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dq0 RCSB], [http://www.ebi.ac.uk/pdbsum/1dq0 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dq/1dq0_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The reversible binding of manganese and calcium to concanavalin A determines the carbohydrate binding of the lectin by inducing large conformational changes. These changes are governed by the isomerization of a non-proline peptide bond, Ala-207-Asp-208, positioned in a beta-strand in between the calcium binding site S2 and the carbohydrate specificity-determining loop. The replacement of calcium by manganese allowed us to investigate the structures of the carbohydrate binding, locked state and the inactive, unlocked state of concanavalin A, both with and without metal ions bound. Crystals of unlocked metal-free concanavalin A convert to the locked form with the binding of two Mn(2+) ions. Removal of these ions from the crystals traps metal-free concanavalin A in its locked state, a minority species in solution. The ligation of a metal ion in S2 to unlocked concanavalin A causes bending of the beta-strand foregoing the S2 ligand residues Asp-10 and Tyr-12. This bending disrupts conventional beta-sheet hydrogen bonding and forces the Thr-11 side chain against the Ala-207-Asp-208 peptide bond. The steric strain exerted by Thr-11 is presumed to drive the trans-to-cis isomerization. Upon isomerization, Asp-208 flips into its carbohydrate binding position, and the conformation of the carbohydrate specificity determining loop changes dramatically.

-	~~{{STRUCTURE_1dq0\| PDB=1dq0 \| SCENE= }}~~	+	The structural features of concanavalin A governing non-proline peptide isomerization.,Bouckaert J, Dewallef Y, Poortmans F, Wyns L, Loris R J Biol Chem. 2000 Jun 30;275(26):19778-87. PMID:10748006<ref>PMID:10748006</ref>

-	~~===Locked, metal-free concanavalin A~~, a ~~minor species in solution===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10748006}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1dq0]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Canavalia_ensiformis Canavalia ensiformis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1DQ0 OCA].~~	+

	==See Also==		==See Also==
	*[[Concanavalin A\|Concanavalin A]]		*[[Concanavalin A\|Concanavalin A]]
-		+	*[[Monoclonal Antibody\|Monoclonal Antibody]]
-	==~~Reference~~==	+	== References ==
-	<~~ref group="xtra">PMID:010748006<~~/~~ref~~><~~references group="xtra"~~/>	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Canavalia ensiformis]]		[[Category: Canavalia ensiformis]]
	[[Category: Bouckaert, J.]]		[[Category: Bouckaert, J.]]