1dwy - Revision history

OCA at 09:55, 20 March 2024

OCA — Wed, 20 Mar 2024 09:55:05 GMT

←Older revision		Revision as of 09:55, 20 March 2024
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	==Bovine prion protein fragment 121-230==		==Bovine prion protein fragment 121-230==
-	<StructureSection load='1dwy' size='340' side='right'caption='[[1dwy~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='1dwy' size='340' side='right'caption='[[1dwy]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dwy]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DWY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1DWY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dwy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DWY FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[1dwz\|1dwz]], [[1dx0\|1dx0]], [[1dx1\|1dx1]], [[1ag2\|1ag2]], [[1b10\|1b10]], [[1qlx\|1qlx]], [[1qm0\|1qm0]], [[1qm1\|1qm1]], [[1qm2\|1qm2]], [[1qm3\|1qm3]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRNP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dwy OCA], [https://pdbe.org/1dwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dwy RCSB], [https://www.ebi.ac.uk/pdbsum/1dwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dwy ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1dwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dwy OCA], [~~http~~://pdbe.org/1dwy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1dwy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1dwy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1dwy ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/PRIO_BOVIN PRIO_BOVIN] Note=Variations in PRNP are responsible of transmissible bovine spongiform encephalopathies (BSE), a class of neurodegenerative diseases that affect various mammals. These diseases are caused by abnormally folded prion proteins. BSE can be subdivided into at least three groups: classical, H-type and L-type, with the latter 2 collectively referred to as atypical BSE. Susceptibility or resistance to a BSE disease can be influenced by at least 3 factors related to the host prion protein: protein expression levels, number of octapeptide repeats, and specific polymorphisms. In cattle, as in humans, BSEs can occur as infectious, spontaneous and genetic diseases.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PRIO_BOVIN PRIO_BOVIN] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 21:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dwy ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dwy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The NMR structures of the recombinant 217-residue polypeptide chain of the mature bovine prion protein, bPrP(23-230), and a C-terminal fragment, bPrP(121-230), include a globular domain extending from residue 125 to residue 227, a short flexible chain end of residues 228-230, and an N-terminal flexibly disordered "tail" comprising 108 residues for the intact protein and 4 residues for bPrP(121-230), respectively. The globular domain contains three alpha-helices comprising the residues 144-154, 173-194, and 200-226, and a short antiparallel beta-sheet comprising the residues 128-131 and 161-164. The best-defined parts of the globular domain are the central portions of the helices 2 and 3, which are linked by the only disulfide bond in bPrP. Significantly increased disorder and mobility is observed for helix 1, the loop 166-172 leading from the beta-strand 2 to helix 2, the end of helix 2 and the following loop, and the last turn of helix 3. Although there are characteristic local differences relative to the conformations of the murine and Syrian hamster prion proteins, the bPrP structure is essentially identical to that of the human prion protein. On the other hand, there are differences between bovine and human PrP in the surface distribution of electrostatic charges, which then appears to be the principal structural feature of the "healthy" PrP form that might affect the stringency of the species barrier for transmission of prion diseases between humans and cattle.
-
-	NMR structure of the bovine prion protein.,Lopez Garcia F, Zahn R, Riek R, Wuthrich K Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8334-9. PMID:10899999<ref>PMID:10899999</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1dwy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Prion 3D structures\|Prion 3D structures]]		*[[Prion 3D structures\|Prion 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Billeter, M]]	+	[[Category: Billeter M]]
-	[[Category: Lopez-Garcia, F]]	+	[[Category: Lopez-Garcia F]]
-	[[Category: Riek, R]]	+	[[Category: Riek R]]
-	[[Category: Wuthrich, K]]	+	[[Category: Wuthrich K]]
-	[[Category: Zahn, R]]	+	[[Category: Zahn R]]
-	~~[[Category: Brain]]~~	+
-	~~[[Category: Prion]]~~	+
-	~~[[Category: Prion protein~~]]	+

OCA at 10:21, 18 November 2020

OCA — Wed, 18 Nov 2020 10:21:35 GMT

←Older revision		Revision as of 10:21, 18 November 2020
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	==Bovine prion protein fragment 121-230==		==Bovine prion protein fragment 121-230==
-	<StructureSection load='1dwy' size='340' side='right' caption='[[1dwy]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='1dwy' size='340' side='right'caption='[[1dwy]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dwy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DWY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1DWY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dwy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DWY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1DWY FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dwz\|1dwz]], [[1dx0\|1dx0]], [[1dx1\|1dx1]], [[1ag2\|1ag2]], [[1b10\|1b10]], [[1qlx\|1qlx]], [[1qm0\|1qm0]], [[1qm1\|1qm1]], [[1qm2\|1qm2]], [[1qm3\|1qm3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dwz\|1dwz]], [[1dx0\|1dx0]], [[1dx1\|1dx1]], [[1ag2\|1ag2]], [[1b10\|1b10]], [[1qlx\|1qlx]], [[1qm0\|1qm0]], [[1qm1\|1qm1]], [[1qm2\|1qm2]], [[1qm3\|1qm3]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRNP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRNP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1dwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dwy OCA], [http://pdbe.org/1dwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dwy RCSB], [http://www.ebi.ac.uk/pdbsum/1dwy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dwy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1dwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dwy OCA], [http://pdbe.org/1dwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dwy RCSB], [http://www.ebi.ac.uk/pdbsum/1dwy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dwy ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</div>		</div>
	<div class="pdbe-citations 1dwy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1dwy" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Prion 3D structures\|Prion 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Bovin]]		[[Category: Bovin]]
		+	[[Category: Large Structures]]
	[[Category: Billeter, M]]		[[Category: Billeter, M]]
	[[Category: Lopez-Garcia, F]]		[[Category: Lopez-Garcia, F]]

OCA at 07:52, 13 December 2017

OCA — Wed, 13 Dec 2017 07:52:53 GMT

←Older revision		Revision as of 07:52, 13 December 2017
Line 1:		Line 1:
-	==~~BOVINE PRION PROTEIN FRAGMENT~~ 121-230==	+
		+	==Bovine prion protein fragment 121-230==
	<StructureSection load='1dwy' size='340' side='right' caption='[[1dwy]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1dwy' size='340' side='right' caption='[[1dwy]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dwz\|1dwz]], [[1dx0\|1dx0]], [[1dx1\|1dx1]], [[1ag2\|1ag2]], [[1b10\|1b10]], [[1qlx\|1qlx]], [[1qm0\|1qm0]], [[1qm1\|1qm1]], [[1qm2\|1qm2]], [[1qm3\|1qm3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dwz\|1dwz]], [[1dx0\|1dx0]], [[1dx1\|1dx1]], [[1ag2\|1ag2]], [[1b10\|1b10]], [[1qlx\|1qlx]], [[1qm0\|1qm0]], [[1qm1\|1qm1]], [[1qm2\|1qm2]], [[1qm3\|1qm3]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRNP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRNP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dwy OCA], [http://pdbe.org/1dwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dwy RCSB], [http://www.ebi.ac.uk/pdbsum/1dwy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dwy OCA], [http://pdbe.org/1dwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dwy RCSB], [http://www.ebi.ac.uk/pdbsum/1dwy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dwy ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/1dwy_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/1dwy_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 26:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1dwy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1dwy" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Prion\|Prion]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:20, 7 February 2016

OCA — Sun, 07 Feb 2016 23:20:38 GMT

←Older revision		Revision as of 23:20, 7 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dwy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:47, 10 September 2015

OCA — Thu, 10 Sep 2015 05:47:19 GMT

←Older revision		Revision as of 05:47, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1dwy' size='340' side='right' caption='[[1dwy]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1dwy' size='340' side='right' caption='[[1dwy]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dwy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DWY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dwy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DWY FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dwz\|1dwz]], [[1dx0\|1dx0]], [[1dx1\|1dx1]], [[1ag2\|1ag2]], [[1b10\|1b10]], [[1qlx\|1qlx]], [[1qm0\|1qm0]], [[1qm1\|1qm1]], [[1qm2\|1qm2]], [[1qm3\|1qm3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dwz\|1dwz]], [[1dx0\|1dx0]], [[1dx1\|1dx1]], [[1ag2\|1ag2]], [[1b10\|1b10]], [[1qlx\|1qlx]], [[1qm0\|1qm0]], [[1qm1\|1qm1]], [[1qm2\|1qm2]], [[1qm3\|1qm3]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRNP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 ~~Bos taurus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRNP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dwy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dwy RCSB], [http://www.ebi.ac.uk/pdbsum/1dwy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dwy OCA], [http://pdbe.org/1dwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dwy RCSB], [http://www.ebi.ac.uk/pdbsum/1dwy PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1dwy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
	[[Category: Billeter, M]]		[[Category: Billeter, M]]
	[[Category: Lopez-Garcia, F]]		[[Category: Lopez-Garcia, F]]

OCA at 20:35, 22 December 2014

OCA — Mon, 22 Dec 2014 20:35:08 GMT

←Older revision		Revision as of 20:35, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1dwy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DWY FirstGlance]. <br>		<table><tr><td colspan='2'>[[1dwy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DWY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dwz\|1dwz]], [[1dx0\|1dx0]], [[1dx1\|1dx1]], [[1ag2\|1ag2]], [[1b10\|1b10]], [[1qlx\|1qlx]], [[1qm0\|1qm0]], [[1qm1\|1qm1]], [[1qm2\|1qm2]], [[1qm3\|1qm3]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dwz\|1dwz]], [[1dx0\|1dx0]], [[1dx1\|1dx1]], [[1ag2\|1ag2]], [[1b10\|1b10]], [[1qlx\|1qlx]], [[1qm0\|1qm0]], [[1qm1\|1qm1]], [[1qm2\|1qm2]], [[1qm3\|1qm3]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRNP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRNP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dwy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dwy RCSB], [http://www.ebi.ac.uk/pdbsum/1dwy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dwy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dwy RCSB], [http://www.ebi.ac.uk/pdbsum/1dwy PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Billeter, M.]]	+	[[Category: Billeter, M]]
-	[[Category: Lopez-Garcia, F.]]	+	[[Category: Lopez-Garcia, F]]
-	[[Category: Riek, R.]]	+	[[Category: Riek, R]]
-	[[Category: Wuthrich, K.]]	+	[[Category: Wuthrich, K]]
-	[[Category: Zahn, R.]]	+	[[Category: Zahn, R]]
	[[Category: Brain]]		[[Category: Brain]]
	[[Category: Prion]]		[[Category: Prion]]
	[[Category: Prion protein]]		[[Category: Prion protein]]

OCA at 15:10, 29 September 2014

OCA — Mon, 29 Sep 2014 15:10:55 GMT

←Older revision		Revision as of 15:10, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1dwy~~\| ~~PDB~~=1dwy \| ~~SCENE~~= }}	+	==BOVINE PRION PROTEIN FRAGMENT 121-230==
-	===~~BOVINE PRION PROTEIN FRAGMENT 121~~-~~230~~===	+	<StructureSection load='1dwy' size='340' side='right' caption='[[1dwy]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_10899999}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1dwy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DWY FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dwz\|1dwz]], [[1dx0\|1dx0]], [[1dx1\|1dx1]], [[1ag2\|1ag2]], [[1b10\|1b10]], [[1qlx\|1qlx]], [[1qm0\|1qm0]], [[1qm1\|1qm1]], [[1qm2\|1qm2]], [[1qm3\|1qm3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRNP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dwy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dwy RCSB], [http://www.ebi.ac.uk/pdbsum/1dwy PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/1dwy_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The NMR structures of the recombinant 217-residue polypeptide chain of the mature bovine prion protein, bPrP(23-230), and a C-terminal fragment, bPrP(121-230), include a globular domain extending from residue 125 to residue 227, a short flexible chain end of residues 228-230, and an N-terminal flexibly disordered "tail" comprising 108 residues for the intact protein and 4 residues for bPrP(121-230), respectively. The globular domain contains three alpha-helices comprising the residues 144-154, 173-194, and 200-226, and a short antiparallel beta-sheet comprising the residues 128-131 and 161-164. The best-defined parts of the globular domain are the central portions of the helices 2 and 3, which are linked by the only disulfide bond in bPrP. Significantly increased disorder and mobility is observed for helix 1, the loop 166-172 leading from the beta-strand 2 to helix 2, the end of helix 2 and the following loop, and the last turn of helix 3. Although there are characteristic local differences relative to the conformations of the murine and Syrian hamster prion proteins, the bPrP structure is essentially identical to that of the human prion protein. On the other hand, there are differences between bovine and human PrP in the surface distribution of electrostatic charges, which then appears to be the principal structural feature of the "healthy" PrP form that might affect the stringency of the species barrier for transmission of prion diseases between humans and cattle.

-	~~==About this Structure==~~	+	NMR structure of the bovine prion protein.,Lopez Garcia F, Zahn R, Riek R, Wuthrich K Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8334-9. PMID:10899999<ref>PMID:10899999</ref>
-	~~[[1dwy]] is a 1 chain~~ structure ~~with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full experimental information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1DWY OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Prion\|Prion]]		*[[Prion\|Prion]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:010899999</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Billeter, M.]]		[[Category: Billeter, M.]]

OCA at 01:39, 25 March 2013

OCA — Mon, 25 Mar 2013 01:39:40 GMT

←Older revision		Revision as of 01:39, 25 March 2013
Line 1:		Line 1:
-	[[Image:1dwy.png\|left\|200px]]
-
	{{STRUCTURE_1dwy\| PDB=1dwy \| SCENE= }}		{{STRUCTURE_1dwy\| PDB=1dwy \| SCENE= }}
-
	===BOVINE PRION PROTEIN FRAGMENT 121-230===		===BOVINE PRION PROTEIN FRAGMENT 121-230===
-
	{{ABSTRACT_PUBMED_10899999}}		{{ABSTRACT_PUBMED_10899999}}

Line 14:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:010899999</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010899999</ref><references group="xtra"/><references/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Billeter, M.]]		[[Category: Billeter, M.]]

OCA at 08:08, 20 October 2012

OCA — Sat, 20 Oct 2012 08:08:41 GMT

←Older revision		Revision as of 08:08, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1dwy]] is a 1 chain structure ~~of [[Prion]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DWY OCA].	+	[[1dwy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DWY OCA].

	==See Also==		==See Also==

OCA: Protected "1dwy" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 18:35:40 GMT

Protected "1dwy" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:35, 25 July 2012