1dy6 - Revision history

OCA at 08:09, 6 December 2023

OCA — Wed, 06 Dec 2023 08:09:06 GMT

←Older revision		Revision as of 08:09, 6 December 2023
Line 3:		Line 3:
	<StructureSection load='1dy6' size='340' side='right'caption='[[1dy6]], [[Resolution\|resolution]] 2.13Å' scene=''>		<StructureSection load='1dy6' size='340' side='right'caption='[[1dy6]], [[Resolution\|resolution]] 2.13Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dy6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_marcescens"_(bizio_1823)_trevisan_in_de_toni_and_trevisan_1889 "bacillus~~ marcescens~~" (bizio 1823) trevisan in de toni and trevisan 1889~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DY6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dy6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DY6 FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>~~[https://en.wikipedia.org/wiki/Beta~~-~~lactamase Beta-lactamase]~~, ~~with EC number~~ [~~https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.~~2.~~6 3.5.2.6] </span>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.13Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dy6 OCA], [https://pdbe.org/1dy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dy6 RCSB], [https://www.ebi.ac.uk/pdbsum/1dy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dy6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dy6 OCA], [https://pdbe.org/1dy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dy6 RCSB], [https://www.ebi.ac.uk/pdbsum/1dy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dy6 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q54488_SERMA Q54488_SERMA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Beta-lactamase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Billy, I]]	+	[[Category: Serratia marcescens]]
-	[[Category: Delettre, J]]	+	[[Category: Billy I]]
-	[[Category: Guillet, V]]	+	[[Category: Delettre J]]
-	[[Category: ~~Hermite, G L~~]]	+	[[Category: Guillet V]]
-	[[Category: ~~Jarlier, V~~]]	+	[[Category: Jarlier V]]
-	[[Category: Naas, T]]	+	[[Category: L'Hermite G]]
-	[[Category: Nordman, P]]	+	[[Category: Naas T]]
-	[[Category: Sougakoff, W]]	+	[[Category: Nordman P]]
-	~~[[Category: Antibiotic]]~~	+	[[Category: Sougakoff W]]
-	~~[[Category: Carbapenem]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Imipenem]]~~	+
-	~~[[Category: Lactamase~~]]	+

OCA at 07:03, 24 February 2021

OCA — Wed, 24 Feb 2021 07:03:51 GMT

←Older revision		Revision as of 07:03, 24 February 2021
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	<StructureSection load='1dy6' size='340' side='right'caption='[[1dy6]], [[Resolution\|resolution]] 2.13Å' scene=''>		<StructureSection load='1dy6' size='340' side='right'caption='[[1dy6]], [[Resolution\|resolution]] 2.13Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dy6]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_marcescens"_(bizio_1823)_trevisan_in_de_toni_and_trevisan_1889 "bacillus marcescens" (bizio 1823) trevisan in de toni and trevisan 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DY6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1DY6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dy6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_marcescens"_(bizio_1823)_trevisan_in_de_toni_and_trevisan_1889 "bacillus marcescens" (bizio 1823) trevisan in de toni and trevisan 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DY6 FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1dy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dy6 OCA], [~~http~~://pdbe.org/1dy6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1dy6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1dy6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1dy6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dy6 OCA], [https://pdbe.org/1dy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dy6 RCSB], [https://www.ebi.ac.uk/pdbsum/1dy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dy6 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 06:59, 23 May 2019

OCA — Thu, 23 May 2019 06:59:52 GMT

←Older revision		Revision as of 06:59, 23 May 2019
Line 1:		Line 1:

	==Structure of the imipenem-hydrolyzing beta-lactamase SME-1==		==Structure of the imipenem-hydrolyzing beta-lactamase SME-1==
-	<StructureSection load='1dy6' size='340' side='right' caption='[[1dy6]], [[Resolution\|resolution]] 2.13Å' scene=''>	+	<StructureSection load='1dy6' size='340' side='right'caption='[[1dy6]], [[Resolution\|resolution]] 2.13Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dy6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DY6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dy6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_marcescens"_(bizio_1823)_trevisan_in_de_toni_and_trevisan_1889 "bacillus marcescens" (bizio 1823) trevisan in de toni and trevisan 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DY6 FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dy6 OCA], [http://pdbe.org/1dy6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dy6 RCSB], [http://www.ebi.ac.uk/pdbsum/1dy6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dy6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dy6 OCA], [http://pdbe.org/1dy6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dy6 RCSB], [http://www.ebi.ac.uk/pdbsum/1dy6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dy6 ProSAT]</span></td></tr>
Line 11:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dy/1dy6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dy/1dy6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 26:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 1dy6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1dy6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 31:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
		+	[[Category: Large Structures]]
	[[Category: Billy, I]]		[[Category: Billy, I]]
	[[Category: Delettre, J]]		[[Category: Delettre, J]]

OCA at 06:53, 16 November 2017

OCA — Thu, 16 Nov 2017 06:53:49 GMT

←Older revision		Revision as of 06:53, 16 November 2017
Line 26:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 1dy6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1dy6" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Beta-lactamase\|Beta-lactamase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:07, 30 August 2017

OCA — Wed, 30 Aug 2017 04:07:23 GMT

←Older revision		Revision as of 04:07, 30 August 2017
Line 1:		Line 1:
-	==~~STRUCTURE OF THE IMIPENEM~~-~~HYDROLYZING BETA~~-~~LACTAMASE~~ SME-1==	+
		+	==Structure of the imipenem-hydrolyzing beta-lactamase SME-1==
	<StructureSection load='1dy6' size='340' side='right' caption='[[1dy6]], [[Resolution\|resolution]] 2.13Å' scene=''>		<StructureSection load='1dy6' size='340' side='right' caption='[[1dy6]], [[Resolution\|resolution]] 2.13Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dy6]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/"bacillus_marcescens"_(bizio_1823)_trevisan_in_de_toni_and_trevisan_1889 "bacillus marcescens" (bizio 1823) trevisan in de toni and trevisan 1889]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DY6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dy6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DY6 FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dy6 OCA], [http://pdbe.org/1dy6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dy6 RCSB], [http://www.ebi.ac.uk/pdbsum/1dy6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dy6 OCA], [http://pdbe.org/1dy6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dy6 RCSB], [http://www.ebi.ac.uk/pdbsum/1dy6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dy6 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dy6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:56, 11 September 2015

OCA — Fri, 11 Sep 2015 11:56:45 GMT

←Older revision		Revision as of 11:56, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1dy6' size='340' side='right' caption='[[1dy6]], [[Resolution\|resolution]] 2.13Å' scene=''>		<StructureSection load='1dy6' size='340' side='right' caption='[[1dy6]], [[Resolution\|resolution]] 2.13Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dy6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Serratia_marcescens Serratia~~ marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DY6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dy6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_marcescens"_(bizio_1823)_trevisan_in_de_toni_and_trevisan_1889 "bacillus marcescens" (bizio 1823) trevisan in de toni and trevisan 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DY6 FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dy6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dy6 RCSB], [http://www.ebi.ac.uk/pdbsum/1dy6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dy6 OCA], [http://pdbe.org/1dy6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dy6 RCSB], [http://www.ebi.ac.uk/pdbsum/1dy6 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1dy6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
-	[[Category: Serratia marcescens]]
	[[Category: Billy, I]]		[[Category: Billy, I]]
	[[Category: Delettre, J]]		[[Category: Delettre, J]]

OCA at 20:10, 22 December 2014

OCA — Mon, 22 Dec 2014 20:10:49 GMT

←Older revision		Revision as of 20:10, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1dy6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DY6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1dy6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DY6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dy6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dy6 RCSB], [http://www.ebi.ac.uk/pdbsum/1dy6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dy6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dy6 RCSB], [http://www.ebi.ac.uk/pdbsum/1dy6 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Serratia marcescens]]		[[Category: Serratia marcescens]]
-	[[Category: Billy, I.]]	+	[[Category: Billy, I]]
-	[[Category: Delettre, J.]]	+	[[Category: Delettre, J]]
-	[[Category: Guillet, V.]]	+	[[Category: Guillet, V]]
-	[[Category: Hermite, G L.]]	+	[[Category: Hermite, G L]]
-	[[Category: Jarlier, V.]]	+	[[Category: Jarlier, V]]
-	[[Category: Naas, T.]]	+	[[Category: Naas, T]]
-	[[Category: Nordman, P.]]	+	[[Category: Nordman, P]]
-	[[Category: Sougakoff, W.]]	+	[[Category: Sougakoff, W]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]
	[[Category: Carbapenem]]		[[Category: Carbapenem]]

OCA at 10:43, 10 September 2014

OCA — Wed, 10 Sep 2014 10:43:25 GMT

←Older revision		Revision as of 10:43, 10 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1dy6.~~png\|left~~\|200px]]	+	==STRUCTURE OF THE IMIPENEM-HYDROLYZING BETA-LACTAMASE SME-1==
		+	<StructureSection load='1dy6' size='340' side='right' caption='[[1dy6]], [[Resolution\|resolution]] 2.13Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1dy6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DY6 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dy6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dy6 RCSB], [http://www.ebi.ac.uk/pdbsum/1dy6 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dy/1dy6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure of the beta-lactamase SME-1 from Serratia marcescens, a class A enzyme characterized by its significant activity against imipenem, has been determined to 2.13 A resolution. The overall structure of SME-1 is similar to that of other class A beta-lactamases. In the active-site cavity, most of the residues found in SME-1 are conserved among class A beta-lactamases, except at positions 104, 105 and 237, where a tyrosine, a histidine and a serine are found, respectively, and at position 238, which is occupied by a cysteine forming a disulfide bridge with the other cysteine residue located at position 69. The crucial role played by this disulfide bridge in SME-1 was confirmed by site-directed mutagenesis of Cys69 to Ala, which resulted in a mutant unable to confer resistance to imipenem and all other beta-lactam antibiotics tested. Another striking structural feature found in SME-1 was the short distance separating the side chains of the active serine residue at position 70 and the strictly conserved glutamate at position 166, which is up to 1.4 A shorter in SME-1 compared with other class A beta-lactamases. Consequently, the SME-1 structure cannot accommodate the essential catalytic water molecule found between Ser70 and Glu166 in the other class A beta-lactamases described so far, suggesting that a significant conformational change may be necessary in SME-1 to properly position the hydrolytic water molecule involved in the hydrolysis of the acyl-enzyme intermediate.

-	~~{{STRUCTURE_1dy6\| PDB=1dy6 \| SCENE= }}~~	+	Structure of the imipenem-hydrolyzing class A beta-lactamase SME-1 from Serratia marcescens.,Sougakoff W, L'Hermite G, Pernot L, Naas T, Guillet V, Nordmann P, Jarlier V, Delettre J Acta Crystallogr D Biol Crystallogr. 2002 Feb;58(Pt 2):267-74. Epub 2002, Jan 24. PMID:11807251<ref>PMID:11807251</ref>

-	~~===STRUCTURE OF THE IMIPENEM-HYDROLYZING BETA-LACTAMASE SME-1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11807251}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1dy6]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Serratia_marcescens Serratia marcescens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1DY6 OCA].~~	+

	==See Also==		==See Also==
	*[[Beta-lactamase\|Beta-lactamase]]		*[[Beta-lactamase\|Beta-lactamase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011807251<~~/~~ref~~><~~ref group="xtra">PMID:008812987</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Serratia marcescens]]		[[Category: Serratia marcescens]]

OCA at 18:43, 20 October 2012

OCA — Sat, 20 Oct 2012 18:43:10 GMT

←Older revision		Revision as of 18:43, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1dy6]] is a 2 chain structure ~~of [[Beta-lactamase]]~~ with sequence from [http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DY6 OCA].	+	[[1dy6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DY6 OCA].

	==See Also==		==See Also==

OCA at 05:00, 27 July 2012

OCA — Fri, 27 Jul 2012 05:00:13 GMT

←Older revision		Revision as of 05:00, 27 July 2012
Line 1:		Line 1:
	[[Image:1dy6.png\|left\|200px]]		[[Image:1dy6.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1dy6", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1dy6\| PDB=1dy6 \| SCENE= }}		{{STRUCTURE_1dy6\| PDB=1dy6 \| SCENE= }}

	===STRUCTURE OF THE IMIPENEM-HYDROLYZING BETA-LACTAMASE SME-1===		===STRUCTURE OF THE IMIPENEM-HYDROLYZING BETA-LACTAMASE SME-1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11807251}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11807251 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11807251}}		{{ABSTRACT_PUBMED_11807251}}

	==About this Structure==		==About this Structure==
-	[[1dy6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DY6 OCA].	+	[[1dy6]] is a 2 chain structure of [[Beta-lactamase]] with sequence from [http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DY6 OCA].
		+
		+	==See Also==
		+	*[[Beta-lactamase\|Beta-lactamase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11807251~~</ref><ref group="xtra">PMID:~~8812987~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011807251</ref><ref group="xtra">PMID:008812987</ref><references group="xtra"/>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Serratia marcescens]]		[[Category: Serratia marcescens]]