1e1m - Revision history

OCA at 08:10, 6 December 2023

OCA — Wed, 06 Dec 2023 08:10:17 GMT

←Older revision		Revision as of 08:10, 6 December 2023
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	<StructureSection load='1e1m' size='340' side='right'caption='[[1e1m]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='1e1m' size='340' side='right'caption='[[1e1m]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1e1m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E1M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1e1m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E1M FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FAD:FLAVIN~~-~~ADENINE+DINUCLEOTIDE'>FAD</scene>~~, ~~<scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1cjc\|1cjc]]~~, ~~[[1e1k\|1e1k]], [[1e1l\|1e1l]], [[1e1n\|1e1n]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e1m OCA], [https://pdbe.org/1e1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e1m RCSB], [https://www.ebi.ac.uk/pdbsum/1e1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e1m ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e1m OCA], [https://pdbe.org/1e1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e1m RCSB], [https://www.ebi.ac.uk/pdbsum/1e1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e1m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ADRO_BOVIN ADRO_BOVIN]] Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.	+	[https://www.uniprot.org/uniprot/ADRO_BOVIN ADRO_BOVIN] Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Schulz~~, G E~~]]	+	[[Category: Schulz GE]]
-	[[Category: Ziegler~~, G A]]~~	+	[[Category: Ziegler GA]]
-	~~[[Category: Electron transferase]]~~	+
-	~~[[Category: Flavoenzyme]]~~	+
-	~~[[Category: Nadph]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 05:44, 28 April 2021

OCA — Wed, 28 Apr 2021 05:44:57 GMT

←Older revision		Revision as of 05:44, 28 April 2021
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	<StructureSection load='1e1m' size='340' side='right'caption='[[1e1m]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='1e1m' size='340' side='right'caption='[[1e1m]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1e1m]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E1M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1E1M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1e1m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E1M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cjc\|1cjc]], [[1e1k\|1e1k]], [[1e1l\|1e1l]], [[1e1n\|1e1n]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cjc\|1cjc]], [[1e1k\|1e1k]], [[1e1l\|1e1l]], [[1e1n\|1e1n]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1e1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e1m OCA], [~~http~~://pdbe.org/1e1m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1e1m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1e1m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1e1m ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e1m OCA], [https://pdbe.org/1e1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e1m RCSB], [https://www.ebi.ac.uk/pdbsum/1e1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e1m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ADRO_BOVIN ADRO_BOVIN]] Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.	+	[[https://www.uniprot.org/uniprot/ADRO_BOVIN ADRO_BOVIN]] Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:34, 24 July 2019

OCA — Wed, 24 Jul 2019 06:34:37 GMT

←Older revision		Revision as of 06:34, 24 July 2019
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	==ADRENODOXIN REDUCTASE in complex with NADPH obtained by a soaking experiment==		==ADRENODOXIN REDUCTASE in complex with NADPH obtained by a soaking experiment==
-	<StructureSection load='1e1m' size='340' side='right' caption='[[1e1m]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='1e1m' size='340' side='right'caption='[[1e1m]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1e1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E1M FirstGlance]. <br>		<table><tr><td colspan='2'>[[1e1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E1M FirstGlance]. <br>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1e1m" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1e1m" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Adrenodoxin reductase 3D structures\|Adrenodoxin reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Bovin]]		[[Category: Bovin]]
		+	[[Category: Large Structures]]
	[[Category: Schulz, G E]]		[[Category: Schulz, G E]]
	[[Category: Ziegler, G A]]		[[Category: Ziegler, G A]]

OCA at 08:00, 13 December 2017

OCA — Wed, 13 Dec 2017 08:00:37 GMT

←Older revision		Revision as of 08:00, 13 December 2017
Line 1:		Line 1:
-	==ADRENODOXIN REDUCTASE ~~IN COMPLEX WITH~~ NADPH ~~OBTAINED BY A SOAKING EXPERIMENT~~==	+
		+	==ADRENODOXIN REDUCTASE in complex with NADPH obtained by a soaking experiment==
	<StructureSection load='1e1m' size='340' side='right' caption='[[1e1m]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='1e1m' size='340' side='right' caption='[[1e1m]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cjc\|1cjc]], [[1e1k\|1e1k]], [[1e1l\|1e1l]], [[1e1n\|1e1n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cjc\|1cjc]], [[1e1k\|1e1k]], [[1e1l\|1e1l]], [[1e1n\|1e1n]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e1m OCA], [http://pdbe.org/1e1m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e1m RCSB], [http://www.ebi.ac.uk/pdbsum/1e1m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e1m OCA], [http://pdbe.org/1e1m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e1m RCSB], [http://www.ebi.ac.uk/pdbsum/1e1m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1e1m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e1/1e1m_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e1/1e1m_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1e1m" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1e1m" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Adrenodoxin reductase\|Adrenodoxin reductase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:24, 10 February 2016

OCA — Wed, 10 Feb 2016 05:24:19 GMT

←Older revision		Revision as of 05:24, 10 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e1m ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Adrenodoxin reductase ~~3D structures~~\|Adrenodoxin reductase ~~3D structures~~]]	+	*[[Adrenodoxin reductase\|Adrenodoxin reductase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:47, 11 September 2015

OCA — Fri, 11 Sep 2015 05:47:59 GMT

←Older revision		Revision as of 05:47, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1e1m' size='340' side='right' caption='[[1e1m]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='1e1m' size='340' side='right' caption='[[1e1m]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1e1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E1M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1e1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E1M FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cjc\|1cjc]], [[1e1k\|1e1k]], [[1e1l\|1e1l]], [[1e1n\|1e1n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cjc\|1cjc]], [[1e1k\|1e1k]], [[1e1l\|1e1l]], [[1e1n\|1e1n]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e1m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e1m RCSB], [http://www.ebi.ac.uk/pdbsum/1e1m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e1m OCA], [http://pdbe.org/1e1m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e1m RCSB], [http://www.ebi.ac.uk/pdbsum/1e1m PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1e1m" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Adrenodoxin reductase\|Adrenodoxin reductase]]	+	*[[Adrenodoxin reductase 3D structures\|Adrenodoxin reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
	[[Category: Schulz, G E]]		[[Category: Schulz, G E]]
	[[Category: Ziegler, G A]]		[[Category: Ziegler, G A]]

OCA at 12:07, 25 December 2014

OCA — Thu, 25 Dec 2014 12:07:41 GMT

←Older revision		Revision as of 12:07, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e1m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e1m RCSB], [http://www.ebi.ac.uk/pdbsum/1e1m PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e1m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e1m RCSB], [http://www.ebi.ac.uk/pdbsum/1e1m PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ADRO_BOVIN ADRO_BOVIN]] Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 19:53, 22 December 2014

OCA — Mon, 22 Dec 2014 19:53:02 GMT

←Older revision		Revision as of 19:53, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1e1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E1M FirstGlance]. <br>		<table><tr><td colspan='2'>[[1e1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E1M FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cjc\|1cjc]], [[1e1k\|1e1k]], [[1e1l\|1e1l]], [[1e1n\|1e1n]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cjc\|1cjc]], [[1e1k\|1e1k]], [[1e1l\|1e1l]], [[1e1n\|1e1n]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e1m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e1m RCSB], [http://www.ebi.ac.uk/pdbsum/1e1m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e1m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e1m RCSB], [http://www.ebi.ac.uk/pdbsum/1e1m PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Schulz, G E.]]	+	[[Category: Schulz, G E]]
-	[[Category: Ziegler, G A.]]	+	[[Category: Ziegler, G A]]
	[[Category: Electron transferase]]		[[Category: Electron transferase]]
	[[Category: Flavoenzyme]]		[[Category: Flavoenzyme]]
	[[Category: Nadph]]		[[Category: Nadph]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 10:52, 10 September 2014

OCA — Wed, 10 Sep 2014 10:52:27 GMT

←Older revision		Revision as of 10:52, 10 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1e1m.~~png~~\|~~left~~\|200px]]	+	==ADRENODOXIN REDUCTASE IN COMPLEX WITH NADPH OBTAINED BY A SOAKING EXPERIMENT==
		+	<StructureSection load='1e1m' size='340' side='right' caption='[[1e1m]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1e1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E1M FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cjc\|1cjc]], [[1e1k\|1e1k]], [[1e1l\|1e1l]], [[1e1n\|1e1n]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e1m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e1m RCSB], [http://www.ebi.ac.uk/pdbsum/1e1m PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e1/1e1m_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Adrenodoxin reductase is a flavoenzyme that shuffles electrons for the biosynthesis of steroids. Its chain topology belongs to the glutathione reductase family of disulfide oxidoreductases, all of which bind FAD at equivalent positions. The three reported structures of adrenodoxin reductase were ligated with reduced and oxidized NADP and have now confirmed this equivalence also for the NADP-binding site. Remarkably, the conformations and relative positions of the prosthetic group FAD and the cofactor NADP have been conserved during protein evolution despite very substantial changes in the polypeptide. The ligated enzymes showed small changes in the domain positions. When compared with the structure of the NADP-free enzyme, these positions correspond to several states of the domain motion during NADP binding. On the basis of the observed structures, we suggest an enzymatic mechanism for the subdivision of the received two-electron package into the two single electrons transferred to the carrier protein adrenodoxin. The data banks contain 10 sequences that are closely related to bovine adrenodoxin reductase. Most of them code for gene products with unknown functions. Within this family, the crucial residues of adrenodoxin reductase are strictly conserved. Moreover, the putative docking site of the carrier is rather well conserved. Five of the family members were assigned names related to ferredoxin:NADP(+) reductase, presumably because adrenodoxin reductase was considered a member of this functionally similar family. Since this is not the case, the data bank entries should be corrected.

-	~~{{STRUCTURE_1e1m\| PDB=1e1m \| SCENE= }}~~	+	Crystal structures of adrenodoxin reductase in complex with NADP+ and NADPH suggesting a mechanism for the electron transfer of an enzyme family.,Ziegler GA, Schulz GE Biochemistry. 2000 Sep 12;39(36):10986-95. PMID:10998235<ref>PMID:10998235</ref>

-	~~===ADRENODOXIN REDUCTASE IN COMPLEX WITH NADPH OBTAINED BY A SOAKING EXPERIMENT===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10998235}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1e1m]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1E1M OCA].~~	+

	==See Also==		==See Also==
	*[[Adrenodoxin reductase\|Adrenodoxin reductase]]		*[[Adrenodoxin reductase\|Adrenodoxin reductase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:010998235<~~/~~ref~~><~~ref group="xtra">PMID:010369776</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Schulz, G E.]]		[[Category: Schulz, G E.]]

OCA at 16:28, 20 October 2012

OCA — Sat, 20 Oct 2012 16:28:53 GMT

←Older revision		Revision as of 16:28, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1e1m]] is a 1 chain structure ~~of [[Adrenodoxin reductase]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E1M OCA].	+	[[1e1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E1M OCA].

	==See Also==		==See Also==
Line 14:		Line 14:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:010998235</ref><ref group="xtra">PMID:010369776~~</ref><ref group="xtra">PMID:009989598~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010998235</ref><ref group="xtra">PMID:010369776</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Schulz, G E.]]		[[Category: Schulz, G E.]]