1e2y - Revision history

OCA at 09:57, 20 March 2024

OCA — Wed, 20 Mar 2024 09:57:52 GMT

←Older revision		Revision as of 09:57, 20 March 2024
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	<StructureSection load='1e2y' size='340' side='right'caption='[[1e2y]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='1e2y' size='340' side='right'caption='[[1e2y]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1e2y]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Crifa Crifa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E2Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1e2y]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Crithidia_fasciculata Crithidia fasciculata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E2Y FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~MSE~~:~~SELENOMETHIONINE~~'>~~MSE~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">CF-TRYP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5656 CRIFA])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e2y OCA], [https://pdbe.org/1e2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e2y RCSB], [https://www.ebi.ac.uk/pdbsum/1e2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e2y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e2y OCA], [https://pdbe.org/1e2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e2y RCSB], [https://www.ebi.ac.uk/pdbsum/1e2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e2y ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9TZX2_CRIFA Q9TZX2_CRIFA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e2y ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e2y ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Tryparedoxin peroxidase (TryP) is a recently discovered 2Cys-peroxiredoxin involved in defence against oxidative stress in parasitic trypanosomatids. The crystal structure of recombinant Crithidia fasciculata TryP, in the reduced state, has been determined using multi-wavelength anomalous dispersion methods applied to a selenomethionyl derivative. The model comprises a decamer with 52 symmetry, ten chloride ions with 23 water molecules and has been refined, using data to 3.2 A resolution (1 A=0.1 nm), to an R-factor and R(free) of 27.3 and 28.6 %, respectively. Secondary structure topology places TryP along with tryparedoxin and glutathione peroxidase in a distinct subgroup of the thioredoxin super-family. The molecular details at the active site support ideas about the enzyme mechanism and comparisons with an oxidised 2Cys-peroxiredoxin reveal structural alterations induced by the change in oxidation state. These include a difference in quaternary structure from dimer (oxidised form) to decamer (reduced form). The 2Cys-peroxiredoxin assembly may prevent indiscriminate oligomerisation, localise ten peroxidase active sites and contribute to both the specificity of reduction by the redox partner tryparedoxin and attraction of peroxides into the active site.
-
-	The structure of reduced tryparedoxin peroxidase reveals a decamer and insight into reactivity of 2Cys-peroxiredoxins.,Alphey MS, Bond CS, Tetaud E, Fairlamb AH, Hunter WN J Mol Biol. 2000 Jul 21;300(4):903-16. PMID:10891277<ref>PMID:10891277</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1e2y" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Crifa~~]]	+	[[Category: Crithidia fasciculata]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Alphey~~, M S~~]]	+	[[Category: Alphey MS]]
-	[[Category: Bond~~, C S~~]]	+	[[Category: Bond CS]]
-	[[Category: Hunter~~, W N]]~~	+	[[Category: Hunter WN]]
-	~~[[Category: 2-cys peroxiredoxin]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 10:23, 17 February 2021

OCA — Wed, 17 Feb 2021 10:23:34 GMT

←Older revision		Revision as of 10:23, 17 February 2021
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	<StructureSection load='1e2y' size='340' side='right'caption='[[1e2y]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='1e2y' size='340' side='right'caption='[[1e2y]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1e2y]] is a 10 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Crifa Crifa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E2Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1E2Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1e2y]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Crifa Crifa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E2Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CF-TRYP ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5656 CRIFA])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CF-TRYP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5656 CRIFA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1e2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e2y OCA], [~~http~~://pdbe.org/1e2y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1e2y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1e2y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1e2y ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e2y OCA], [https://pdbe.org/1e2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e2y RCSB], [https://www.ebi.ac.uk/pdbsum/1e2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e2y ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:30, 10 May 2019

OCA — Fri, 10 May 2019 11:30:25 GMT

←Older revision		Revision as of 11:30, 10 May 2019
Line 1:		Line 1:

	==Tryparedoxin peroxidase from Crithidia fasciculata==		==Tryparedoxin peroxidase from Crithidia fasciculata==
-	<StructureSection load='1e2y' size='340' side='right' caption='[[1e2y]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='1e2y' size='340' side='right'caption='[[1e2y]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1e2y]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Crifa Crifa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E2Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[1e2y]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Crifa Crifa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E2Y FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Crifa]]		[[Category: Crifa]]
		+	[[Category: Large Structures]]
	[[Category: Alphey, M S]]		[[Category: Alphey, M S]]
	[[Category: Bond, C S]]		[[Category: Bond, C S]]

OCA at 08:03, 13 December 2017

OCA — Wed, 13 Dec 2017 08:03:25 GMT

←Older revision		Revision as of 08:03, 13 December 2017
Line 1:		Line 1:
-	==~~TRYPAREDOXIN PEROXIDASE FROM CRITHIDIA FASCICULATA~~==	+
		+	==Tryparedoxin peroxidase from Crithidia fasciculata==
	<StructureSection load='1e2y' size='340' side='right' caption='[[1e2y]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='1e2y' size='340' side='right' caption='[[1e2y]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CF-TRYP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5656 CRIFA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CF-TRYP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5656 CRIFA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e2y OCA], [http://pdbe.org/1e2y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e2y RCSB], [http://www.ebi.ac.uk/pdbsum/1e2y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e2y OCA], [http://pdbe.org/1e2y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e2y RCSB], [http://www.ebi.ac.uk/pdbsum/1e2y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1e2y ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/1e2y_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/1e2y_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:18, 9 February 2016

OCA — Tue, 09 Feb 2016 21:18:54 GMT

←Older revision		Revision as of 21:18, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e2y ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:07, 11 September 2015

OCA — Fri, 11 Sep 2015 02:07:51 GMT

←Older revision		Revision as of 02:07, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1e2y' size='340' side='right' caption='[[1e2y]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='1e2y' size='340' side='right' caption='[[1e2y]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1e2y]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Crithidia_fasciculata Crithidia fasciculata~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E2Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1e2y]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Crifa Crifa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E2Y FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CF-TRYP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5656 ~~Crithidia fasciculata~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CF-TRYP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5656 CRIFA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e2y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e2y RCSB], [http://www.ebi.ac.uk/pdbsum/1e2y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e2y OCA], [http://pdbe.org/1e2y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e2y RCSB], [http://www.ebi.ac.uk/pdbsum/1e2y PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1e2y" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Crithidia fasciculata~~]]	+	[[Category: Crifa]]
	[[Category: Alphey, M S]]		[[Category: Alphey, M S]]
	[[Category: Bond, C S]]		[[Category: Bond, C S]]

OCA at 22:27, 22 December 2014

OCA — Mon, 22 Dec 2014 22:27:17 GMT

←Older revision		Revision as of 22:27, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1e2y]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Crithidia_fasciculata Crithidia fasciculata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E2Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[1e2y]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Crithidia_fasciculata Crithidia fasciculata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E2Y FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CF-TRYP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5656 Crithidia fasciculata])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CF-TRYP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5656 Crithidia fasciculata])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e2y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e2y RCSB], [http://www.ebi.ac.uk/pdbsum/1e2y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e2y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e2y RCSB], [http://www.ebi.ac.uk/pdbsum/1e2y PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Crithidia fasciculata]]		[[Category: Crithidia fasciculata]]
-	[[Category: Alphey, M S.]]	+	[[Category: Alphey, M S]]
-	[[Category: Bond, C S.]]	+	[[Category: Bond, C S]]
-	[[Category: Hunter, W N.]]	+	[[Category: Hunter, W N]]
	[[Category: 2-cys peroxiredoxin]]		[[Category: 2-cys peroxiredoxin]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 10:33, 3 October 2014

OCA — Fri, 03 Oct 2014 10:33:53 GMT

←Older revision		Revision as of 10:33, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1e2y~~\| ~~PDB~~=1e2y \| ~~SCENE~~= }}	+	==TRYPAREDOXIN PEROXIDASE FROM CRITHIDIA FASCICULATA==
-	===~~TRYPAREDOXIN PEROXIDASE FROM CRITHIDIA FASCICULATA~~===	+	<StructureSection load='1e2y' size='340' side='right' caption='[[1e2y]], [[Resolution\|resolution]] 3.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_10891277}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1e2y]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Crithidia_fasciculata Crithidia fasciculata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E2Y FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CF-TRYP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5656 Crithidia fasciculata])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e2y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e2y RCSB], [http://www.ebi.ac.uk/pdbsum/1e2y PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/1e2y_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tryparedoxin peroxidase (TryP) is a recently discovered 2Cys-peroxiredoxin involved in defence against oxidative stress in parasitic trypanosomatids. The crystal structure of recombinant Crithidia fasciculata TryP, in the reduced state, has been determined using multi-wavelength anomalous dispersion methods applied to a selenomethionyl derivative. The model comprises a decamer with 52 symmetry, ten chloride ions with 23 water molecules and has been refined, using data to 3.2 A resolution (1 A=0.1 nm), to an R-factor and R(free) of 27.3 and 28.6 %, respectively. Secondary structure topology places TryP along with tryparedoxin and glutathione peroxidase in a distinct subgroup of the thioredoxin super-family. The molecular details at the active site support ideas about the enzyme mechanism and comparisons with an oxidised 2Cys-peroxiredoxin reveal structural alterations induced by the change in oxidation state. These include a difference in quaternary structure from dimer (oxidised form) to decamer (reduced form). The 2Cys-peroxiredoxin assembly may prevent indiscriminate oligomerisation, localise ten peroxidase active sites and contribute to both the specificity of reduction by the redox partner tryparedoxin and attraction of peroxides into the active site.

-	~~==About this Structure==~~	+	The structure of reduced tryparedoxin peroxidase reveals a decamer and insight into reactivity of 2Cys-peroxiredoxins.,Alphey MS, Bond CS, Tetaud E, Fairlamb AH, Hunter WN J Mol Biol. 2000 Jul 21;300(4):903-16. PMID:10891277<ref>PMID:10891277</ref>
-	~~[[1e2y]] is~~ a ~~10 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Crithidia_fasciculata Crithidia fasciculata]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1E2Y OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:010891277</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Crithidia fasciculata]]		[[Category: Crithidia fasciculata]]
	[[Category: Alphey, M S.]]		[[Category: Alphey, M S.]]

OCA at 11:00, 16 April 2014

OCA — Wed, 16 Apr 2014 11:00:09 GMT

←Older revision		Revision as of 11:00, 16 April 2014
Line 1:		Line 1:
-	[[Image:1e2y.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1e2y", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1e2y\| PDB=1e2y \| SCENE= }}		{{STRUCTURE_1e2y\| PDB=1e2y \| SCENE= }}
-
	===TRYPAREDOXIN PEROXIDASE FROM CRITHIDIA FASCICULATA===		===TRYPAREDOXIN PEROXIDASE FROM CRITHIDIA FASCICULATA===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10891277}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10891277 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_10891277}}		{{ABSTRACT_PUBMED_10891277}}

Line 22:		Line 7:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:010891277</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010891277</ref><references group="xtra"/><references/>
	[[Category: Crithidia fasciculata]]		[[Category: Crithidia fasciculata]]
	[[Category: Alphey, M S.]]		[[Category: Alphey, M S.]]

OCA: Protected "1e2y" [edit=sysop:move=sysop]

OCA — Sat, 02 Jun 2012 09:51:53 GMT

Protected "1e2y" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:51, 2 June 2012