1e5m - Revision history

OCA at 11:53, 13 December 2023

OCA — Wed, 13 Dec 2023 11:53:14 GMT

←Older revision		Revision as of 11:53, 13 December 2023
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	<StructureSection load='1e5m' size='340' side='right'caption='[[1e5m]], [[Resolution\|resolution]] 1.54Å' scene=''>		<StructureSection load='1e5m' size='340' side='right'caption='[[1e5m]], [[Resolution\|resolution]] 1.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1e5m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Aphanocapsa_sp~~.~~_(strain_n-1) Aphanocapsa~~ sp. ~~(strain n-1)~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E5M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1e5m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechocystis_sp._PCC_6803 Synechocystis sp. PCC 6803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E5M FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>~~[https://en.wikipedia.org/wiki/Beta-ketoacyl~~-[~~acyl-carrier-protein]_synthase_I Beta-ketoacyl-~~[~~acyl-carrier-protein~~] ~~synthase I~~]~~, with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.~~1.~~41 2.3.1.41] </span>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.54Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e5m OCA], [https://pdbe.org/1e5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e5m RCSB], [https://www.ebi.ac.uk/pdbsum/1e5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e5m ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e5m OCA], [https://pdbe.org/1e5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e5m RCSB], [https://www.ebi.ac.uk/pdbsum/1e5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e5m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FABF_SYNY3 FABF_SYNY3]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates.	+	[https://www.uniprot.org/uniprot/FABF_SYNY3 FABF_SYNY3] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dehesh, K]]	+	[[Category: Synechocystis sp. PCC 6803]]
-	[[Category: Edwards, P]]	+	[[Category: Dehesh K]]
-	[[Category: Lindqvist, Y]]	+	[[Category: Edwards P]]
-	[[Category: Moche, M]]	+	[[Category: Lindqvist Y]]
-	~~[[Category: Biosynthetic role]]~~	+	[[Category: Moche M]]
-	~~[[Category: Carbon-carbon bond formation]]~~	+
-	~~[[Category: Condensing enzyme~~]]	+

OCA at 11:07, 28 July 2021

OCA — Wed, 28 Jul 2021 11:07:57 GMT

←Older revision		Revision as of 11:07, 28 July 2021
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	<StructureSection load='1e5m' size='340' side='right'caption='[[1e5m]], [[Resolution\|resolution]] 1.54Å' scene=''>		<StructureSection load='1e5m' size='340' side='right'caption='[[1e5m]], [[Resolution\|resolution]] 1.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1e5m]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Aphanocapsa_sp._(strain_n-1) Aphanocapsa sp. (strain n-1)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1E5M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1e5m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aphanocapsa_sp._(strain_n-1) Aphanocapsa sp. (strain n-1)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E5M FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_I Beta-ketoacyl-[acyl-carrier-protein] synthase I], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_I Beta-ketoacyl-[acyl-carrier-protein] synthase I], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1e5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e5m OCA], [~~http~~://pdbe.org/1e5m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1e5m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1e5m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1e5m ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e5m OCA], [https://pdbe.org/1e5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e5m RCSB], [https://www.ebi.ac.uk/pdbsum/1e5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e5m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FABF_SYNY3 FABF_SYNY3]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates.	+	[[https://www.uniprot.org/uniprot/FABF_SYNY3 FABF_SYNY3]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:15, 23 October 2019

OCA — Wed, 23 Oct 2019 09:15:04 GMT

←Older revision		Revision as of 09:15, 23 October 2019
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	==Beta ketoacyl acyl carrier protein synthase II (KASII) from Synechocystis sp.==		==Beta ketoacyl acyl carrier protein synthase II (KASII) from Synechocystis sp.==
-	<StructureSection load='1e5m' size='340' side='right' caption='[[1e5m]], [[Resolution\|resolution]] 1.54Å' scene=''>	+	<StructureSection load='1e5m' size='340' side='right'caption='[[1e5m]], [[Resolution\|resolution]] 1.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1e5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aphanocapsa_sp._(strain_n-1) Aphanocapsa sp. (strain n-1)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E5M FirstGlance]. <br>		<table><tr><td colspan='2'>[[1e5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aphanocapsa_sp._(strain_n-1) Aphanocapsa sp. (strain n-1)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E5M FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 1e5m" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1e5m" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Acyl carrier protein synthase 3D structures\|Acyl carrier protein synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Dehesh, K]]		[[Category: Dehesh, K]]
	[[Category: Edwards, P]]		[[Category: Edwards, P]]

OCA at 08:04, 13 December 2017

OCA — Wed, 13 Dec 2017 08:04:05 GMT

←Older revision		Revision as of 08:04, 13 December 2017
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-	==~~BETA KETOACYL ACYL CARRIER PROTEIN SYNTHASE~~ II (KASII) ~~FROM SYNECHOCYSTIS SP~~.==	+
		+	==Beta ketoacyl acyl carrier protein synthase II (KASII) from Synechocystis sp.==
	<StructureSection load='1e5m' size='340' side='right' caption='[[1e5m]], [[Resolution\|resolution]] 1.54Å' scene=''>		<StructureSection load='1e5m' size='340' side='right' caption='[[1e5m]], [[Resolution\|resolution]] 1.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1e5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aphanocapsa_sp._(strain_n-1) Aphanocapsa sp. (strain n-1)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E5M FirstGlance]. <br>		<table><tr><td colspan='2'>[[1e5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aphanocapsa_sp._(strain_n-1) Aphanocapsa sp. (strain n-1)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E5M FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_I Beta-ketoacyl-[acyl-carrier-protein] synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_I Beta-ketoacyl-[acyl-carrier-protein] synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e5m OCA], [http://pdbe.org/1e5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e5m RCSB], [http://www.ebi.ac.uk/pdbsum/1e5m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e5m OCA], [http://pdbe.org/1e5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e5m RCSB], [http://www.ebi.ac.uk/pdbsum/1e5m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1e5m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/1e5m_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/1e5m_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1e5m" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1e5m" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Acyl carrier protein synthase\|Acyl carrier protein synthase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 03:53, 10 February 2016

OCA — Wed, 10 Feb 2016 03:53:19 GMT

←Older revision		Revision as of 03:53, 10 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e5m ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:07, 11 September 2015

OCA — Fri, 11 Sep 2015 05:07:17 GMT

←Older revision		Revision as of 05:07, 11 September 2015
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	<StructureSection load='1e5m' size='340' side='right' caption='[[1e5m]], [[Resolution\|resolution]] 1.54Å' scene=''>		<StructureSection load='1e5m' size='340' side='right' caption='[[1e5m]], [[Resolution\|resolution]] 1.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1e5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Synechocystis_sp~~. ~~Synechocystis~~ sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E5M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1e5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aphanocapsa_sp._(strain_n-1) Aphanocapsa sp. (strain n-1)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E5M FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-~~protein_synthase_I~~ Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_I Beta-ketoacyl-[acyl-carrier-protein] synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e5m RCSB], [http://www.ebi.ac.uk/pdbsum/1e5m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e5m OCA], [http://pdbe.org/1e5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e5m RCSB], [http://www.ebi.ac.uk/pdbsum/1e5m PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1e5m" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]
-	[[Category: Synechocystis sp]]
	[[Category: Dehesh, K]]		[[Category: Dehesh, K]]
	[[Category: Edwards, P]]		[[Category: Edwards, P]]

OCA at 11:36, 25 December 2014

OCA — Thu, 25 Dec 2014 11:36:43 GMT

←Older revision		Revision as of 11:36, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e5m RCSB], [http://www.ebi.ac.uk/pdbsum/1e5m PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e5m RCSB], [http://www.ebi.ac.uk/pdbsum/1e5m PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FABF_SYNY3 FABF_SYNY3]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 19:04, 22 December 2014

OCA — Mon, 22 Dec 2014 19:04:05 GMT

←Older revision		Revision as of 19:04, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1e5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E5M FirstGlance]. <br>		<table><tr><td colspan='2'>[[1e5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E5M FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e5m RCSB], [http://www.ebi.ac.uk/pdbsum/1e5m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e5m RCSB], [http://www.ebi.ac.uk/pdbsum/1e5m PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]		[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]
-	[[Category: Synechocystis sp.]]	+	[[Category: Synechocystis sp]]
-	[[Category: Dehesh, K.]]	+	[[Category: Dehesh, K]]
-	[[Category: Edwards, P.]]	+	[[Category: Edwards, P]]
-	[[Category: Lindqvist, Y.]]	+	[[Category: Lindqvist, Y]]
-	[[Category: Moche, M.]]	+	[[Category: Moche, M]]
	[[Category: Biosynthetic role]]		[[Category: Biosynthetic role]]
	[[Category: Carbon-carbon bond formation]]		[[Category: Carbon-carbon bond formation]]
	[[Category: Condensing enzyme]]		[[Category: Condensing enzyme]]

OCA at 10:56, 10 September 2014

OCA — Wed, 10 Sep 2014 10:56:25 GMT

←Older revision		Revision as of 10:56, 10 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1e5m.~~png\|left~~\|200px]]	+	==BETA KETOACYL ACYL CARRIER PROTEIN SYNTHASE II (KASII) FROM SYNECHOCYSTIS SP.==
		+	<StructureSection load='1e5m' size='340' side='right' caption='[[1e5m]], [[Resolution\|resolution]] 1.54Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1e5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E5M FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e5m RCSB], [http://www.ebi.ac.uk/pdbsum/1e5m PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/1e5m_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Condensing enzymes, catalyzing the formation of carbon-carbon bonds in several biosynthetic pathways, have lately been recognized as potential drug targets against cancer and tuberculosis, as crucial for combinatorial biosynthesis of antibiotics and related compounds, and as determinants of plant oil composition. beta-Ketoacyl-ACP synthases (KAS) are the condensing enzymes present in the fatty acid biosynthesis pathway and are able to elongate an acyl chain bound to either co-enzyme A (CoA) or acyl carrier protein (ACP) with a two-carbon unit derived from malonyl-ACP. Several isoforms of KAS with different substrate specificity are present in most species. We have determined the crystal structure of KAS II from Synechocystis sp. PCC 6803 to 1.54 A resolution giving a detailed description of the active site geometry. In order to analyze the structure-function relationships in this class of enzymes in more detail, we have compared all presently known three-dimensional structures of condensing enzymes from different pathways. The comparison reveals that these enzymes can be divided into three structural and functional classes. This classification can be related to variations in the catalytic mechanism and the set of residues in the catalytic site, e.g. due to differences in the nature of the second substrate providing the two-carbon elongation unit. The variation in the acyl-carrier (ACP or CoA) specificity might also be connected to this classification and residues involved in ACP binding in structure class 2 can be suggested based on the comparison. Finally, the two subunits in the dimer contribute differently to formation of the substrate binding-pocket in the three structural classes.

-	~~{{STRUCTURE_1e5m\| PDB=1e5m \| SCENE= }}~~	+	The crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Synechocystis sp. at 1.54 A resolution and its relationship to other condensing enzymes.,Moche M, Dehesh K, Edwards P, Lindqvist Y J Mol Biol. 2001 Jan 19;305(3):491-503. PMID:11152607<ref>PMID:11152607</ref>

-	~~===BETA KETOACYL ACYL CARRIER PROTEIN SYNTHASE II (KASII) FROM SYNECHOCYSTIS SP.===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11152607}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1e5m]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Synechocystis_sp~~. ~~Synechocystis sp.]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1E5M OCA].~~	+

	==See Also==		==See Also==
	*[[Acyl carrier protein synthase\|Acyl carrier protein synthase]]		*[[Acyl carrier protein synthase\|Acyl carrier protein synthase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011152607<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]		[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]
	[[Category: Synechocystis sp.]]		[[Category: Synechocystis sp.]]

OCA at 16:14, 20 October 2012

OCA — Sat, 20 Oct 2012 16:14:21 GMT

←Older revision		Revision as of 16:14, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1e5m]] is a 1 chain structure ~~of [[Acyl carrier protein synthase]]~~ with sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5M OCA].	+	[[1e5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5M OCA].

	==See Also==		==See Also==