1emz - Revision history

OCA at 11:48, 22 November 2023

OCA — Wed, 22 Nov 2023 11:48:15 GMT

←Older revision		Revision as of 11:48, 22 November 2023
Line 1:		Line 1:

	==SOLUTION STRUCTURE OF FRAGMENT (350-370) OF THE TRANSMEMBRANE DOMAIN OF HEPATITIS C ENVELOPE GLYCOPROTEIN E1==		==SOLUTION STRUCTURE OF FRAGMENT (350-370) OF THE TRANSMEMBRANE DOMAIN OF HEPATITIS C ENVELOPE GLYCOPROTEIN E1==
-	<StructureSection load='1emz' size='340' side='right'caption='[[1emz~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='1emz' size='340' side='right'caption='[[1emz]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1emz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EMZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1emz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EMZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1emz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1emz OCA], [https://pdbe.org/1emz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1emz RCSB], [https://www.ebi.ac.uk/pdbsum/1emz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1emz ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1emz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1emz OCA], [https://pdbe.org/1emz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1emz RCSB], [https://www.ebi.ac.uk/pdbsum/1emz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1emz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9Q3N3_9HEPC Q9Q3N3_9HEPC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hepacivirus C]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barberot, B]]	+	[[Category: Barberot B]]
-	~~[[Category: Beeck, A Op De~~]]	+	[[Category: Cacan R]]
-	[[Category: Cacan, R]]	+	[[Category: Cocquerel L]]
-	[[Category: Cocquerel, L]]	+	[[Category: Dubuisson J]]
-	[[Category: Dubuisson, J]]	+	[[Category: Duvet S]]
-	[[Category: Duvet, S]]	+	[[Category: Le Maire M]]
-	[[Category: Maire, M Le]]	+	[[Category: Montserret R]]
-	[[Category: Montserret, R]]	+	[[Category: Op De Beeck A]]
-	[[Category: ~~Penin, F~~]]	+	[[Category: Penin F]]
-	[[Category: ~~Envelope protein e1]]~~	+
-	~~[[Category: Hepatitis c virus]]~~	+
-	~~[[Category: Transmembrane domain]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 07:13, 17 March 2021

OCA — Wed, 17 Mar 2021 07:13:24 GMT

←Older revision		Revision as of 07:13, 17 March 2021
Line 3:		Line 3:
	<StructureSection load='1emz' size='340' side='right'caption='[[1emz]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1emz' size='340' side='right'caption='[[1emz]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1emz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1EMZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1emz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EMZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1emz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1emz OCA], [~~http~~://pdbe.org/1emz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1emz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1emz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1emz ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1emz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1emz OCA], [https://pdbe.org/1emz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1emz RCSB], [https://www.ebi.ac.uk/pdbsum/1emz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1emz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:56, 12 June 2019

OCA — Wed, 12 Jun 2019 06:56:56 GMT

←Older revision		Revision as of 06:56, 12 June 2019
Line 1:		Line 1:

	==SOLUTION STRUCTURE OF FRAGMENT (350-370) OF THE TRANSMEMBRANE DOMAIN OF HEPATITIS C ENVELOPE GLYCOPROTEIN E1==		==SOLUTION STRUCTURE OF FRAGMENT (350-370) OF THE TRANSMEMBRANE DOMAIN OF HEPATITIS C ENVELOPE GLYCOPROTEIN E1==
-	<StructureSection load='1emz' size='340' side='right' caption='[[1emz]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='1emz' size='340' side='right'caption='[[1emz]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1emz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EMZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1emz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EMZ FirstGlance]. <br>
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Barberot, B]]		[[Category: Barberot, B]]
	[[Category: Beeck, A Op De]]		[[Category: Beeck, A Op De]]

OCA at 03:45, 6 September 2017

OCA — Wed, 06 Sep 2017 03:45:30 GMT

←Older revision		Revision as of 03:45, 6 September 2017
Line 1:		Line 1:
		+
	==SOLUTION STRUCTURE OF FRAGMENT (350-370) OF THE TRANSMEMBRANE DOMAIN OF HEPATITIS C ENVELOPE GLYCOPROTEIN E1==		==SOLUTION STRUCTURE OF FRAGMENT (350-370) OF THE TRANSMEMBRANE DOMAIN OF HEPATITIS C ENVELOPE GLYCOPROTEIN E1==
	<StructureSection load='1emz' size='340' side='right' caption='[[1emz]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1emz' size='340' side='right' caption='[[1emz]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1emz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EMZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1emz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EMZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1emz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1emz OCA], [http://pdbe.org/1emz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1emz RCSB], [http://www.ebi.ac.uk/pdbsum/1emz PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1emz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1emz OCA], [http://pdbe.org/1emz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1emz RCSB], [http://www.ebi.ac.uk/pdbsum/1emz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1emz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:41, 11 September 2015

OCA — Fri, 11 Sep 2015 17:41:49 GMT

←Older revision		Revision as of 17:41, 11 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1emz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EMZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1emz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EMZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1emz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1emz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1emz RCSB], [http://www.ebi.ac.uk/pdbsum/1emz PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1emz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1emz OCA], [http://pdbe.org/1emz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1emz RCSB], [http://www.ebi.ac.uk/pdbsum/1emz PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 13:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1emz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:23, 22 December 2014

OCA — Mon, 22 Dec 2014 06:23:37 GMT

←Older revision		Revision as of 06:23, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1emz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EMZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1emz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EMZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1emz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1emz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1emz RCSB], [http://www.ebi.ac.uk/pdbsum/1emz PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1emz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1emz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1emz RCSB], [http://www.ebi.ac.uk/pdbsum/1emz PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Barberot, B.]]	+	[[Category: Barberot, B]]
-	[[Category: Beeck, A Op De.]]	+	[[Category: Beeck, A Op De]]
-	[[Category: Cacan, R.]]	+	[[Category: Cacan, R]]
-	[[Category: Cocquerel, L.]]	+	[[Category: Cocquerel, L]]
-	[[Category: Dubuisson, J.]]	+	[[Category: Dubuisson, J]]
-	[[Category: Duvet, S.]]	+	[[Category: Duvet, S]]
-	[[Category: Maire, M Le.]]	+	[[Category: Maire, M Le]]
-	[[Category: Montserret, R.]]	+	[[Category: Montserret, R]]
-	[[Category: Penin, F.]]	+	[[Category: Penin, F]]
	[[Category: Envelope protein e1]]		[[Category: Envelope protein e1]]
	[[Category: Hepatitis c virus]]		[[Category: Hepatitis c virus]]
	[[Category: Transmembrane domain]]		[[Category: Transmembrane domain]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 05:25, 8 June 2014

OCA — Sun, 08 Jun 2014 05:25:15 GMT

←Older revision		Revision as of 05:25, 8 June 2014
Line 1:		Line 1:
-	[[~~Image~~:1emz.~~png\|left\|200px~~]]	+	==SOLUTION STRUCTURE OF FRAGMENT (350-370) OF THE TRANSMEMBRANE DOMAIN OF HEPATITIS C ENVELOPE GLYCOPROTEIN E1==
		+	<StructureSection load='1emz' size='340' side='right' caption='[[1emz]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1emz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EMZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1emz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1emz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1emz RCSB], [http://www.ebi.ac.uk/pdbsum/1emz PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Oligomerization of viral envelope proteins is essential to control virus assembly and fusion. The transmembrane domains (TMDs) of hepatitis C virus envelope glycoproteins E1 and E2 have been shown to play multiple functions during the biogenesis of E1E2 heterodimer. This makes them very unique among known transmembrane sequences. In this report, we used alanine scanning insertion mutagenesis in the TMDs of E1 and E2 to examine their role in the assembly of E1E2 heterodimer. Alanine insertion within the center of the TMDs of E1 or E2 or in the N-terminal part of the TMD of E1 dramatically reduced heterodimerization, demonstrating the essential role played by these domains in the assembly of hepatitis C virus envelope glycoproteins. To better understand the alanine scanning data obtained for the TMD of E1 which contains GXXXG motifs, we analyzed by circular dichroism and nuclear magnetic resonance the three-dimensional structure of the E1-(350-370) peptide encompassing the N-terminal sequence of the TMD of E1 involved in heterodimerization. Alanine scanning results and the three-dimensional molecular model we obtained provide the first framework for a molecular level understanding of the mechanism of hepatitis C virus envelope glycoprotein heterodimerization.

-	~~{{STRUCTURE_1emz\| PDB=1emz \| SCENE= }}~~	+	The transmembrane domains of hepatitis C virus envelope glycoproteins E1 and E2 play a major role in heterodimerization.,Op De Beeck A, Montserret R, Duvet S, Cocquerel L, Cacan R, Barberot B, Le Maire M, Penin F, Dubuisson J J Biol Chem. 2000 Oct 6;275(40):31428-37. PMID:10807921<ref>PMID:10807921</ref>

-	~~===SOLUTION STRUCTURE OF FRAGMENT (350-370) OF THE TRANSMEMBRANE DOMAIN OF HEPATITIS C ENVELOPE GLYCOPROTEIN E1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10807921}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1emz]] is~~ a ~~1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1EMZ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:010807921<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Barberot, B.]]		[[Category: Barberot, B.]]
	[[Category: Beeck, A Op De.]]		[[Category: Beeck, A Op De.]]

OCA: Protected "1emz" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 18:25:17 GMT

Protected "1emz" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:25, 14 August 2012

OCA at 18:25, 14 August 2012

OCA — Tue, 14 Aug 2012 18:25:14 GMT

←Older revision		Revision as of 18:25, 14 August 2012
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-	{{Seed}}
	[[Image:1emz.png\|left\|200px]]		[[Image:1emz.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1emz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1emz\| PDB=1emz \| SCENE= }}		{{STRUCTURE_1emz\| PDB=1emz \| SCENE= }}

	===SOLUTION STRUCTURE OF FRAGMENT (350-370) OF THE TRANSMEMBRANE DOMAIN OF HEPATITIS C ENVELOPE GLYCOPROTEIN E1===		===SOLUTION STRUCTURE OF FRAGMENT (350-370) OF THE TRANSMEMBRANE DOMAIN OF HEPATITIS C ENVELOPE GLYCOPROTEIN E1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10807921}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10807921 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_10807921}}		{{ABSTRACT_PUBMED_10807921}}

	==About this Structure==		==About this Structure==
-	~~1EMZ is a~~ [[~~Single protein~~]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMZ OCA].	+	[[1emz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMZ OCA].

	==Reference==		==Reference==
-	The transmembrane domains of hepatitis C virus envelope glycoproteins E1 and E2 play a major role in heterodimerization., Op De Beeck A, Montserret R, Duvet S, Cocquerel L, Cacan R, Barberot B, Le Maire M, Penin F, Dubuisson J, J Biol Chem. 2000 Oct 6;275(40):31428-37. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/10807921 10807921]~~	+	<ref group="xtra">PMID:010807921</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Barberot, B.]]		[[Category: Barberot, B.]]
	[[Category: Beeck, A Op De.]]		[[Category: Beeck, A Op De.]]
Line 36:		Line 23:
	[[Category: Envelope protein e1]]		[[Category: Envelope protein e1]]
	[[Category: Hepatitis c virus]]		[[Category: Hepatitis c virus]]
-	[[Category: Peptide]]
	[[Category: Transmembrane domain]]		[[Category: Transmembrane domain]]
-		+	[[Category: Viral protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Jul 1 01:00:38 2008''~~	+

OCA at 22:00, 30 June 2008

OCA — Mon, 30 Jun 2008 22:00:40 GMT

←Older revision		Revision as of 22:00, 30 June 2008
Line 1:		Line 1:
-	[[Image:1emz.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1emz.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1emz\| PDB=1emz \| SCENE= }}		{{STRUCTURE_1emz\| PDB=1emz \| SCENE= }}

-	~~'''~~SOLUTION STRUCTURE OF FRAGMENT (350-370) OF THE TRANSMEMBRANE DOMAIN OF HEPATITIS C ENVELOPE GLYCOPROTEIN E1~~'''~~	+	===SOLUTION STRUCTURE OF FRAGMENT (350-370) OF THE TRANSMEMBRANE DOMAIN OF HEPATITIS C ENVELOPE GLYCOPROTEIN E1===


-	~~==Overview==~~	+	<!--
-	~~Oligomerization of viral envelope proteins is essential to control virus assembly and fusion.~~ The transmembrane domains (TMDs) of hepatitis C virus envelope glycoproteins E1 and E2 have been shown to play multiple functions during the biogenesis of E1E2 heterodimer. This makes them very unique among known transmembrane sequences. In this ~~report~~, ~~we used alanine scanning insertion mutagenesis in~~ the ~~TMDs of E1 and E2~~ to ~~examine their role in~~ the ~~assembly of E1E2 heterodimer~~. ~~Alanine insertion within the center of the TMDs of E1 or E2 or in the N-terminal part of the TMD of E1 dramatically reduced heterodimerization~~, ~~demonstrating~~ the ~~essential role played by these domains in the assembly of hepatitis C virus envelope glycoproteins~~. ~~To better understand the alanine scanning data obtained for the TMD of E1 which contains GXXXG motifs, we analyzed by circular dichroism and nuclear magnetic resonance the three~~-~~dimensional structure of the E1~~-(350-370) peptide encompassing the N-terminal sequence of the TMD of E1 involved in heterodimerization. Alanine scanning results and the three-dimensional molecular model we obtained provide the first framework for a molecular level understanding of the mechanism of hepatitis C virus envelope glycoprotein heterodimerization.	+	The line below this paragraph, {{ABSTRACT_PUBMED_10807921}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 10807921 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_10807921}}

	==About this Structure==		==About this Structure==
-	1EMZ is a [[Single protein]] structure. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMZ OCA].	+	1EMZ is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMZ OCA].

	==Reference==		==Reference==
Line 34:		Line 38:
	[[Category: Peptide]]		[[Category: Peptide]]
	[[Category: Transmembrane domain]]		[[Category: Transmembrane domain]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 15~~:17:55 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:00:38 2008''