1eoe - Revision history

OCA at 07:05, 7 February 2024

OCA — Wed, 07 Feb 2024 07:05:29 GMT

←Older revision		Revision as of 07:05, 7 February 2024
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	<StructureSection load='1eoe' size='340' side='right'caption='[[1eoe]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1eoe' size='340' side='right'caption='[[1eoe]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1eoe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Aplca Aplca~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EOE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1eoe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EOE FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1eod\|1eod]]~~, [[~~1eof~~\|~~1eof~~]]~~, [[1t1d\|1t1d]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.704Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eoe OCA], [https://pdbe.org/1eoe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eoe RCSB], [https://www.ebi.ac.uk/pdbsum/1eoe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eoe ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eoe OCA], [https://pdbe.org/1eoe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eoe RCSB], [https://www.ebi.ac.uk/pdbsum/1eoe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eoe ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q16968_APLCA Q16968_APLCA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1eoe ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1eoe ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The T1 domain, a highly conserved cytoplasmic portion at the N-terminus of the voltage-dependent K+ channel (Kv) alpha-subunit, is responsible for driving and regulating the tetramerization of the alpha-subunits. Here we report the identification of a set of mutations in the T1 domain that alter the gating properties of the Kv channel. Two mutants produce a leftward shift in the activation curve and slow the channel closing rate while a third mutation produces a rightward shift in the activation curve and speeds the channel closing rate. We have determined the crystal structures of T1 domains containing these mutations. Both of the leftward shifting mutants produce similar conformational changes in the putative membrane facing surface of the T1 domain. These results suggest that the structure of the T1 domain in this region is tightly coupled to the channel's gating states.
-
-	Voltage dependent activation of potassium channels is coupled to T1 domain structure.,Cushman SJ, Nanao MH, Jahng AW, DeRubeis D, Choe S, Pfaffinger PJ Nat Struct Biol. 2000 May;7(5):403-7. PMID:10802739<ref>PMID:10802739</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1eoe" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Potassium channel 3D structures\|Potassium channel 3D structures]]		*[[Potassium channel 3D structures\|Potassium channel 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aplca~~]]	+	[[Category: Aplysia californica]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Choe, S]]	+	[[Category: Choe S]]
-	[[Category: Cushman~~, S J~~]]	+	[[Category: Cushman SJ]]
-	[[Category: DeRubeis, D]]	+	[[Category: DeRubeis D]]
-	[[Category: Jahng~~, A W~~]]	+	[[Category: Jahng AW]]
-	[[Category: Nanao~~, M H~~]]	+	[[Category: Nanao MH]]
-	[[Category: Pfaffinger~~, P J]]~~	+	[[Category: Pfaffinger PJ]]
-	~~[[Category: Aplysia kv1 1]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Potassium channel]]~~	+
-	~~[[Category: Proton transport~~]]	+

OCA at 06:32, 11 August 2021

OCA — Wed, 11 Aug 2021 06:32:21 GMT

←Older revision		Revision as of 06:32, 11 August 2021
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	<StructureSection load='1eoe' size='340' side='right'caption='[[1eoe]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1eoe' size='340' side='right'caption='[[1eoe]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1eoe]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EOE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1EOE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1eoe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EOE FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eod\|1eod]], [[1eof\|1eof]], [[1t1d\|1t1d]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1eod\|1eod]], [[1eof\|1eof]], [[1t1d\|1t1d]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1eoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eoe OCA], [~~http~~://pdbe.org/1eoe PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1eoe RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1eoe PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1eoe ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eoe OCA], [https://pdbe.org/1eoe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eoe RCSB], [https://www.ebi.ac.uk/pdbsum/1eoe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eoe ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 28:		Line 28:

	==See Also==		==See Also==
-	*[[Potassium ~~Channel~~\|Potassium ~~Channel~~]]	+	*[[Potassium channel 3D structures\|Potassium channel 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:16, 6 November 2019

OCA — Wed, 06 Nov 2019 09:16:45 GMT

←Older revision		Revision as of 09:16, 6 November 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF THE V135R MUTANT OF A SHAKER T1 DOMAIN==		==CRYSTAL STRUCTURE OF THE V135R MUTANT OF A SHAKER T1 DOMAIN==
-	<StructureSection load='1eoe' size='340' side='right' caption='[[1eoe]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='1eoe' size='340' side='right'caption='[[1eoe]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1eoe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EOE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EOE FirstGlance]. <br>		<table><tr><td colspan='2'>[[1eoe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EOE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EOE FirstGlance]. <br>
Line 26:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 1eoe" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1eoe" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Potassium Channel\|Potassium Channel]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Aplca]]		[[Category: Aplca]]
		+	[[Category: Large Structures]]
	[[Category: Choe, S]]		[[Category: Choe, S]]
	[[Category: Cushman, S J]]		[[Category: Cushman, S J]]

OCA at 07:18, 20 December 2017

OCA — Wed, 20 Dec 2017 07:18:06 GMT

←Older revision		Revision as of 07:18, 20 December 2017
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE V135R MUTANT OF A SHAKER T1 DOMAIN==		==CRYSTAL STRUCTURE OF THE V135R MUTANT OF A SHAKER T1 DOMAIN==
	<StructureSection load='1eoe' size='340' side='right' caption='[[1eoe]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1eoe' size='340' side='right' caption='[[1eoe]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1eoe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EOE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EOE FirstGlance]. <br>		<table><tr><td colspan='2'>[[1eoe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EOE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EOE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eod\|1eod]], [[1eof\|1eof]], [[1t1d\|1t1d]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eod\|1eod]], [[1eof\|1eof]], [[1t1d\|1t1d]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eoe OCA], [http://pdbe.org/1eoe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1eoe RCSB], [http://www.ebi.ac.uk/pdbsum/1eoe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eoe OCA], [http://pdbe.org/1eoe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1eoe RCSB], [http://www.ebi.ac.uk/pdbsum/1eoe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1eoe ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/1eoe_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/1eoe_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 25:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 1eoe" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1eoe" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Potassium Channel\|Potassium Channel]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:11, 8 February 2016

OCA — Mon, 08 Feb 2016 04:11:54 GMT

←Older revision		Revision as of 04:11, 8 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1eoe ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:44, 10 September 2015

OCA — Thu, 10 Sep 2015 07:44:09 GMT

←Older revision		Revision as of 07:44, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1eoe' size='340' side='right' caption='[[1eoe]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1eoe' size='340' side='right' caption='[[1eoe]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1eoe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aplysia_californica Aplysia californica~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EOE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EOE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1eoe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EOE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EOE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eod\|1eod]], [[1eof\|1eof]], [[1t1d\|1t1d]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eod\|1eod]], [[1eof\|1eof]], [[1t1d\|1t1d]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eoe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1eoe RCSB], [http://www.ebi.ac.uk/pdbsum/1eoe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eoe OCA], [http://pdbe.org/1eoe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1eoe RCSB], [http://www.ebi.ac.uk/pdbsum/1eoe PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1eoe" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aplysia californica~~]]	+	[[Category: Aplca]]
	[[Category: Choe, S]]		[[Category: Choe, S]]
	[[Category: Cushman, S J]]		[[Category: Cushman, S J]]

OCA at 22:49, 22 December 2014

OCA — Mon, 22 Dec 2014 22:49:50 GMT

←Older revision		Revision as of 22:49, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1eoe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EOE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EOE FirstGlance]. <br>		<table><tr><td colspan='2'>[[1eoe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EOE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EOE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eod\|1eod]], [[1eof\|1eof]], [[1t1d\|1t1d]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eod\|1eod]], [[1eof\|1eof]], [[1t1d\|1t1d]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eoe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1eoe RCSB], [http://www.ebi.ac.uk/pdbsum/1eoe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eoe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1eoe RCSB], [http://www.ebi.ac.uk/pdbsum/1eoe PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Aplysia californica]]		[[Category: Aplysia californica]]
-	[[Category: Choe, S.]]	+	[[Category: Choe, S]]
-	[[Category: Cushman, S J.]]	+	[[Category: Cushman, S J]]
-	[[Category: DeRubeis, D.]]	+	[[Category: DeRubeis, D]]
-	[[Category: Jahng, A W.]]	+	[[Category: Jahng, A W]]
-	[[Category: Nanao, M H.]]	+	[[Category: Nanao, M H]]
-	[[Category: Pfaffinger, P J.]]	+	[[Category: Pfaffinger, P J]]
	[[Category: Aplysia kv1 1]]		[[Category: Aplysia kv1 1]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Potassium channel]]		[[Category: Potassium channel]]
	[[Category: Proton transport]]		[[Category: Proton transport]]

OCA at 11:27, 24 September 2014

OCA — Wed, 24 Sep 2014 11:27:53 GMT

←Older revision		Revision as of 11:27, 24 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1eoe.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF THE V135R MUTANT OF A SHAKER T1 DOMAIN==
		+	<StructureSection load='1eoe' size='340' side='right' caption='[[1eoe]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1eoe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EOE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EOE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eod\|1eod]], [[1eof\|1eof]], [[1t1d\|1t1d]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eoe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1eoe RCSB], [http://www.ebi.ac.uk/pdbsum/1eoe PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/1eoe_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The T1 domain, a highly conserved cytoplasmic portion at the N-terminus of the voltage-dependent K+ channel (Kv) alpha-subunit, is responsible for driving and regulating the tetramerization of the alpha-subunits. Here we report the identification of a set of mutations in the T1 domain that alter the gating properties of the Kv channel. Two mutants produce a leftward shift in the activation curve and slow the channel closing rate while a third mutation produces a rightward shift in the activation curve and speeds the channel closing rate. We have determined the crystal structures of T1 domains containing these mutations. Both of the leftward shifting mutants produce similar conformational changes in the putative membrane facing surface of the T1 domain. These results suggest that the structure of the T1 domain in this region is tightly coupled to the channel's gating states.

-	~~{{STRUCTURE_1eoe\| PDB=1eoe \| SCENE= }}~~	+	Voltage dependent activation of potassium channels is coupled to T1 domain structure.,Cushman SJ, Nanao MH, Jahng AW, DeRubeis D, Choe S, Pfaffinger PJ Nat Struct Biol. 2000 May;7(5):403-7. PMID:10802739<ref>PMID:10802739</ref>

-	~~===CRYSTAL STRUCTURE OF THE V135R MUTANT OF A SHAKER T1 DOMAIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10802739}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1eoe]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Aplysia_californica Aplysia californica]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1EOE OCA].~~	+

	==See Also==		==See Also==
	*[[Potassium Channel\|Potassium Channel]]		*[[Potassium Channel\|Potassium Channel]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:010802739<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Aplysia californica]]		[[Category: Aplysia californica]]
	[[Category: Choe, S.]]		[[Category: Choe, S.]]

OCA at 08:52, 20 October 2012

OCA — Sat, 20 Oct 2012 08:52:26 GMT

←Older revision		Revision as of 08:52, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1eoe]] is a 1 chain structure ~~of [[Potassium Channel]]~~ with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EOE OCA].	+	[[1eoe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EOE OCA].

	==See Also==		==See Also==

OCA: Protected "1eoe" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 21:02:31 GMT

Protected "1eoe" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:02, 25 July 2012