1exs - Revision history

OCA at 10:07, 20 March 2024

OCA — Wed, 20 Mar 2024 10:07:49 GMT

←Older revision		Revision as of 10:07, 20 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1exs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EXS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1exs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EXS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.39Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1exs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1exs OCA], [https://pdbe.org/1exs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1exs RCSB], [https://www.ebi.ac.uk/pdbsum/1exs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1exs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1exs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1exs OCA], [https://pdbe.org/1exs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1exs RCSB], [https://www.ebi.ac.uk/pdbsum/1exs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1exs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LACB_PIG LACB_PIG]] Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule.	+	[https://www.uniprot.org/uniprot/LACB_PIG LACB_PIG] Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1exs ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1exs ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	beta-Lactoglobulin (BLG) is a lipocalin and is the major protein in the whey of the milk of cows and other ruminants, but not in all mammalian species. The biological function of BLG is not clear, but a potential role in carrying fatty acids through the digestive tract has been proposed. The capability of BLG to aggregate and form gels is often used to thicken foodstuffs. The structure of the porcine form is sufficiently different from other known BLG structures that SIRAS phases had to be measured in order to solve the crystal structure to 2.4 A resolution. The r.m.s. deviation of C(alpha) atoms is 2.8 A between porcine and bovine BLG. Nevertheless, the typical lipocalin fold is conserved. Compared with bovine BLG, the tilted alpha-helix alters the arrangement of surface residues of the porcine form, completely changing the dimerization behaviour. Through a unique pH-dependent domain-swapping mechanism involving the first ten residues, a novel dimer interface is formed at the N-terminus of porcine BLG. The existence of this novel dimer at low pH is supported by gel-filtration experiments. These results provide a rationale for the difference in physicochemical behaviour between bovine and porcine BLG and point the way towards engineering such dimerization motifs into other members of the lipocalin family.
-
-	A novel pH-dependent dimerization motif in beta-lactoglobulin from pig (Sus scrofa).,Hoedemaeker FJ, Visschers RW, Alting AC, de Kruif KG, Kuil ME, Abrahams JP Acta Crystallogr D Biol Crystallogr. 2002 Mar;58(Pt 3):480-6. Epub 2002, Feb 21. PMID:11856834<ref>PMID:11856834</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1exs" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Beta-lactoglobulin 3D structures\|Beta-lactoglobulin 3D structures]]		*[[Beta-lactoglobulin 3D structures\|Beta-lactoglobulin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
-	[[Category: Abrahams~~, J P~~]]	+	[[Category: Abrahams JP]]
-	[[Category: Hoedemaeker~~, F J]]~~	+	[[Category: Hoedemaeker FJ]]
-	~~[[Category: Lipid binding protein]]~~	+
-	~~[[Category: Lipid-binding protein]]~~	+
-	~~[[Category: Lipocalin fold~~]]	+

OCA at 09:43, 21 July 2021

OCA — Wed, 21 Jul 2021 09:43:29 GMT

←Older revision		Revision as of 09:43, 21 July 2021
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	<StructureSection load='1exs' size='340' side='right'caption='[[1exs]], [[Resolution\|resolution]] 2.39Å' scene=''>		<StructureSection load='1exs' size='340' side='right'caption='[[1exs]], [[Resolution\|resolution]] 2.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1exs]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1EXS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1exs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EXS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1exs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1exs OCA], [~~http~~://pdbe.org/1exs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1exs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1exs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1exs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1exs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1exs OCA], [https://pdbe.org/1exs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1exs RCSB], [https://www.ebi.ac.uk/pdbsum/1exs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1exs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LACB_PIG LACB_PIG]] Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule.	+	[[https://www.uniprot.org/uniprot/LACB_PIG LACB_PIG]] Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:51, 16 October 2019

OCA — Wed, 16 Oct 2019 08:51:10 GMT

←Older revision		Revision as of 08:51, 16 October 2019
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	==STRUCTURE OF PORCINE BETA-LACTOGLOBULIN==		==STRUCTURE OF PORCINE BETA-LACTOGLOBULIN==
-	<StructureSection load='1exs' size='340' side='right' caption='[[1exs]], [[Resolution\|resolution]] 2.39Å' scene=''>	+	<StructureSection load='1exs' size='340' side='right'caption='[[1exs]], [[Resolution\|resolution]] 2.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1exs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EXS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1exs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EXS FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 1exs" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1exs" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-lactoglobulin 3D structures\|Beta-lactoglobulin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
	[[Category: Abrahams, J P]]		[[Category: Abrahams, J P]]

OCA at 07:06, 20 December 2017

OCA — Wed, 20 Dec 2017 07:06:56 GMT

←Older revision		Revision as of 07:06, 20 December 2017
Line 1:		Line 1:
		+
	==STRUCTURE OF PORCINE BETA-LACTOGLOBULIN==		==STRUCTURE OF PORCINE BETA-LACTOGLOBULIN==
	<StructureSection load='1exs' size='340' side='right' caption='[[1exs]], [[Resolution\|resolution]] 2.39Å' scene=''>		<StructureSection load='1exs' size='340' side='right' caption='[[1exs]], [[Resolution\|resolution]] 2.39Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1exs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EXS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1exs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EXS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1exs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1exs OCA], [http://pdbe.org/1exs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1exs RCSB], [http://www.ebi.ac.uk/pdbsum/1exs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1exs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1exs OCA], [http://pdbe.org/1exs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1exs RCSB], [http://www.ebi.ac.uk/pdbsum/1exs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1exs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/1exs_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/1exs_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 1exs" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1exs" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Beta-lactoglobulin\|Beta-lactoglobulin]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Abrahams, J P]]		[[Category: Abrahams, J P]]
	[[Category: Hoedemaeker, F J]]		[[Category: Hoedemaeker, F J]]
		+	[[Category: Lipid binding protein]]
	[[Category: Lipid-binding protein]]		[[Category: Lipid-binding protein]]
	[[Category: Lipocalin fold]]		[[Category: Lipocalin fold]]

OCA at 00:31, 9 February 2016

OCA — Tue, 09 Feb 2016 00:31:26 GMT

←Older revision		Revision as of 00:31, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1exs ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:51, 10 September 2015

OCA — Thu, 10 Sep 2015 16:51:30 GMT

←Older revision		Revision as of 16:51, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1exs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EXS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1exs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EXS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1exs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1exs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1exs RCSB], [http://www.ebi.ac.uk/pdbsum/1exs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1exs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1exs OCA], [http://pdbe.org/1exs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1exs RCSB], [http://www.ebi.ac.uk/pdbsum/1exs PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1exs" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 03:13, 25 December 2014

OCA — Thu, 25 Dec 2014 03:13:19 GMT

←Older revision		Revision as of 03:13, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1exs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1exs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1exs RCSB], [http://www.ebi.ac.uk/pdbsum/1exs PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1exs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1exs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1exs RCSB], [http://www.ebi.ac.uk/pdbsum/1exs PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LACB_PIG LACB_PIG]] Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 19:13, 22 December 2014

OCA — Mon, 22 Dec 2014 19:13:59 GMT

←Older revision		Revision as of 19:13, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1exs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EXS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1exs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EXS FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1exs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1exs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1exs RCSB], [http://www.ebi.ac.uk/pdbsum/1exs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1exs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1exs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1exs RCSB], [http://www.ebi.ac.uk/pdbsum/1exs PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
-	[[Category: Abrahams, J P.]]	+	[[Category: Abrahams, J P]]
-	[[Category: Hoedemaeker, F J.]]	+	[[Category: Hoedemaeker, F J]]
	[[Category: Lipid-binding protein]]		[[Category: Lipid-binding protein]]
	[[Category: Lipocalin fold]]		[[Category: Lipocalin fold]]

OCA at 09:11, 28 September 2014

OCA — Sun, 28 Sep 2014 09:11:37 GMT

←Older revision		Revision as of 09:11, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1exs.~~png\|left~~\|200px]]	+	==STRUCTURE OF PORCINE BETA-LACTOGLOBULIN==
		+	<StructureSection load='1exs' size='340' side='right' caption='[[1exs]], [[Resolution\|resolution]] 2.39Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1exs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EXS FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1exs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1exs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1exs RCSB], [http://www.ebi.ac.uk/pdbsum/1exs PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/1exs_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	beta-Lactoglobulin (BLG) is a lipocalin and is the major protein in the whey of the milk of cows and other ruminants, but not in all mammalian species. The biological function of BLG is not clear, but a potential role in carrying fatty acids through the digestive tract has been proposed. The capability of BLG to aggregate and form gels is often used to thicken foodstuffs. The structure of the porcine form is sufficiently different from other known BLG structures that SIRAS phases had to be measured in order to solve the crystal structure to 2.4 A resolution. The r.m.s. deviation of C(alpha) atoms is 2.8 A between porcine and bovine BLG. Nevertheless, the typical lipocalin fold is conserved. Compared with bovine BLG, the tilted alpha-helix alters the arrangement of surface residues of the porcine form, completely changing the dimerization behaviour. Through a unique pH-dependent domain-swapping mechanism involving the first ten residues, a novel dimer interface is formed at the N-terminus of porcine BLG. The existence of this novel dimer at low pH is supported by gel-filtration experiments. These results provide a rationale for the difference in physicochemical behaviour between bovine and porcine BLG and point the way towards engineering such dimerization motifs into other members of the lipocalin family.

-	~~{{STRUCTURE_1exs\| PDB=1exs \| SCENE= }}~~	+	A novel pH-dependent dimerization motif in beta-lactoglobulin from pig (Sus scrofa).,Hoedemaeker FJ, Visschers RW, Alting AC, de Kruif KG, Kuil ME, Abrahams JP Acta Crystallogr D Biol Crystallogr. 2002 Mar;58(Pt 3):480-6. Epub 2002, Feb 21. PMID:11856834<ref>PMID:11856834</ref>

-	~~===STRUCTURE OF PORCINE BETA-LACTOGLOBULIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11856834}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1exs]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Sus_scrofa Sus scrofa]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1EXS OCA].~~	+

	==See Also==		==See Also==
	*[[Beta-lactoglobulin\|Beta-lactoglobulin]]		*[[Beta-lactoglobulin\|Beta-lactoglobulin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011856834<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
	[[Category: Abrahams, J P.]]		[[Category: Abrahams, J P.]]

OCA at 12:00, 20 October 2012

OCA — Sat, 20 Oct 2012 12:00:32 GMT

←Older revision		Revision as of 12:00, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1exs]] is a 1 chain structure ~~of [[Beta-lactoglobulin]]~~ with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXS OCA].	+	[[1exs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXS OCA].

	==See Also==		==See Also==