1f0f - Revision history

OCA at 11:49, 22 November 2023

OCA — Wed, 22 Nov 2023 11:49:03 GMT

←Older revision		Revision as of 11:49, 22 November 2023
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	==Cecropin A(1-8)-magainin 2(1-12) gig deletion modification in dodecylphosphocholine micelles==		==Cecropin A(1-8)-magainin 2(1-12) gig deletion modification in dodecylphosphocholine micelles==
-	<StructureSection load='1f0f' size='340' side='right'caption='[[1f0f~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1f0f' size='340' side='right'caption='[[1f0f]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1f0f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F0F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1f0f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hyalophora_cecropia Hyalophora cecropia]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F0F FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=NH2:AMINO+GROUP'>NH2</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1d9j\|1d9j]], [[1d9l\|1d9l]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]], [[1f0d\|1f0d]], [[1f0e\|1f0e]], [[1f0g\|1f0g]], [[1f0h\|1f0h]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f0f OCA], [https://pdbe.org/1f0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f0f RCSB], [https://www.ebi.ac.uk/pdbsum/1f0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f0f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f0f OCA], [https://pdbe.org/1f0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f0f RCSB], [https://www.ebi.ac.uk/pdbsum/1f0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f0f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CECA_HYACE CECA_HYACE]] Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.	+	[https://www.uniprot.org/uniprot/MAGA_XENLA MAGA_XENLA] Antimicrobial peptides that inhibit the growth of numerous species of bacteria and fungi and induce osmotic lysis of protozoa. Magainins are membrane lytic agents.[https://www.uniprot.org/uniprot/CECA_HYACE CECA_HYACE] Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hyalophora cecropia]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kim, Y]]	+	[[Category: Kim Y]]
-	[[Category: Lee, S]]	+	[[Category: Lee S]]
-	[[Category: Oh, D]]	+	[[Category: Oh D]]
-	[[Category: Shin~~, S Y]]~~	+	[[Category: Shin SY]]
-	~~[[Category: Antitumor protein]]~~	+
-	~~[[Category: Helix~~]]	+

OCA at 07:17, 17 March 2021

OCA — Wed, 17 Mar 2021 07:17:33 GMT

←Older revision		Revision as of 07:17, 17 March 2021
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	<StructureSection load='1f0f' size='340' side='right'caption='[[1f0f]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1f0f' size='340' side='right'caption='[[1f0f]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1f0f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1F0F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1f0f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F0F FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9j\|1d9j]], [[1d9l\|1d9l]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]], [[1f0d\|1f0d]], [[1f0e\|1f0e]], [[1f0g\|1f0g]], [[1f0h\|1f0h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1d9j\|1d9j]], [[1d9l\|1d9l]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]], [[1f0d\|1f0d]], [[1f0e\|1f0e]], [[1f0g\|1f0g]], [[1f0h\|1f0h]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1f0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f0f OCA], [~~http~~://pdbe.org/1f0f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1f0f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1f0f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1f0f ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f0f OCA], [https://pdbe.org/1f0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f0f RCSB], [https://www.ebi.ac.uk/pdbsum/1f0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f0f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CECA_HYACE CECA_HYACE]] Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.	+	[[https://www.uniprot.org/uniprot/CECA_HYACE CECA_HYACE]] Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:55, 12 June 2019

OCA — Wed, 12 Jun 2019 06:55:05 GMT

←Older revision		Revision as of 06:55, 12 June 2019
Line 1:		Line 1:

	==Cecropin A(1-8)-magainin 2(1-12) gig deletion modification in dodecylphosphocholine micelles==		==Cecropin A(1-8)-magainin 2(1-12) gig deletion modification in dodecylphosphocholine micelles==
-	<StructureSection load='1f0f' size='340' side='right' caption='[[1f0f]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1f0f' size='340' side='right'caption='[[1f0f]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1f0f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F0F FirstGlance]. <br>		<table><tr><td colspan='2'>[[1f0f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F0F FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Kim, Y]]		[[Category: Kim, Y]]
	[[Category: Lee, S]]		[[Category: Lee, S]]

OCA at 04:02, 6 September 2017

OCA — Wed, 06 Sep 2017 04:02:44 GMT

←Older revision		Revision as of 04:02, 6 September 2017
Line 1:		Line 1:
		+
	==Cecropin A(1-8)-magainin 2(1-12) gig deletion modification in dodecylphosphocholine micelles==		==Cecropin A(1-8)-magainin 2(1-12) gig deletion modification in dodecylphosphocholine micelles==
	<StructureSection load='1f0f' size='340' side='right' caption='[[1f0f]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1f0f' size='340' side='right' caption='[[1f0f]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9j\|1d9j]], [[1d9l\|1d9l]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]], [[1f0d\|1f0d]], [[1f0e\|1f0e]], [[1f0g\|1f0g]], [[1f0h\|1f0h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9j\|1d9j]], [[1d9l\|1d9l]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]], [[1f0d\|1f0d]], [[1f0e\|1f0e]], [[1f0g\|1f0g]], [[1f0h\|1f0h]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f0f OCA], [http://pdbe.org/1f0f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1f0f RCSB], [http://www.ebi.ac.uk/pdbsum/1f0f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f0f OCA], [http://pdbe.org/1f0f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1f0f RCSB], [http://www.ebi.ac.uk/pdbsum/1f0f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1f0f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 1f0f" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1f0f" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Magainin 2\|Magainin 2]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:45, 10 September 2015

OCA — Thu, 10 Sep 2015 01:45:41 GMT

←Older revision		Revision as of 01:45, 10 September 2015
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9j\|1d9j]], [[1d9l\|1d9l]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]], [[1f0d\|1f0d]], [[1f0e\|1f0e]], [[1f0g\|1f0g]], [[1f0h\|1f0h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9j\|1d9j]], [[1d9l\|1d9l]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]], [[1f0d\|1f0d]], [[1f0e\|1f0e]], [[1f0g\|1f0g]], [[1f0h\|1f0h]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f0f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1f0f RCSB], [http://www.ebi.ac.uk/pdbsum/1f0f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f0f OCA], [http://pdbe.org/1f0f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1f0f RCSB], [http://www.ebi.ac.uk/pdbsum/1f0f PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1f0f" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:19, 24 December 2014

OCA — Wed, 24 Dec 2014 15:19:02 GMT

←Older revision		Revision as of 15:19, 24 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f0f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1f0f RCSB], [http://www.ebi.ac.uk/pdbsum/1f0f PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f0f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1f0f RCSB], [http://www.ebi.ac.uk/pdbsum/1f0f PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CECA_HYACE CECA_HYACE]] Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 22:55, 22 December 2014

OCA — Mon, 22 Dec 2014 22:55:16 GMT

←Older revision		Revision as of 22:55, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1f0f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F0F FirstGlance]. <br>		<table><tr><td colspan='2'>[[1f0f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F0F FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9j\|1d9j]], [[1d9l\|1d9l]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]], [[1f0d\|1f0d]], [[1f0e\|1f0e]], [[1f0g\|1f0g]], [[1f0h\|1f0h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9j\|1d9j]], [[1d9l\|1d9l]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]], [[1f0d\|1f0d]], [[1f0e\|1f0e]], [[1f0g\|1f0g]], [[1f0h\|1f0h]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f0f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1f0f RCSB], [http://www.ebi.ac.uk/pdbsum/1f0f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f0f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1f0f RCSB], [http://www.ebi.ac.uk/pdbsum/1f0f PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Kim, Y.]]	+	[[Category: Kim, Y]]
-	[[Category: Lee, S.]]	+	[[Category: Lee, S]]
-	[[Category: Oh, D.]]	+	[[Category: Oh, D]]
-	[[Category: Shin, S Y.]]	+	[[Category: Shin, S Y]]
	[[Category: Antitumor protein]]		[[Category: Antitumor protein]]
	[[Category: Helix]]		[[Category: Helix]]

OCA at 12:41, 28 September 2014

OCA — Sun, 28 Sep 2014 12:41:04 GMT

←Older revision		Revision as of 12:41, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1f0f.~~png~~\|~~left~~\|~~200px~~]]	+	==Cecropin A(1-8)-magainin 2(1-12) gig deletion modification in dodecylphosphocholine micelles==
		+	<StructureSection load='1f0f' size='340' side='right' caption='[[1f0f]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1f0f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F0F FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9j\|1d9j]], [[1d9l\|1d9l]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]], [[1f0d\|1f0d]], [[1f0e\|1f0e]], [[1f0g\|1f0g]], [[1f0h\|1f0h]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f0f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1f0f RCSB], [http://www.ebi.ac.uk/pdbsum/1f0f PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A 20-residue hybrid peptide CA(1-8)-MA(1-12) (CA-MA), incorporating residues 1-8 of cecropin A (CA) and residues 1-12 of magainin 2 (MA), has potent antimicrobial activity without toxicity against human erythrocytes. To investigate the effects of the Gly-Ile-Gly hinge sequence of CA-MA on the antibacterial and antitumor activities, two analogues in which the Gly-Ile-Gly sequence of CA-MA is either deleted (P1) or substituted with Pro (P2) were synthesized. The role of the tryptophan residue at position 2 of CA-MA on its antibiotic activity was also investigated using two analogues, in which the Trp2 residue of CA-MA is replaced with either Ala (P3) or Leu (P4). The tertiary structures of CA-MA, P2, and P4 in DPC micelles, as determined by NMR spectroscopy, have a short amphiphilic helix in the N-terminus and about three turns of alpha-helix in the C-terminus, with the flexible hinge region between them. The P1 analogue has an alpha-helix from Leu4 to Ala14 without any hinge structure. P1 has significantly decreased lytic activities against bacterial and tumor cells and PC/PS vesicles (3:1, w/w), and reduced pore-forming activity on lipid bilayers, while P2 retained effective lytic activities and pore-forming activity. The N-terminal region of P3 has a flexible structure without any specific secondary structure. The P3 modification caused a drastic decrease in the antibiotic activities, whereas P4, with the hydrophobic Leu side chain at position 2, retained its activities. On the basis of the tertiary structures, antibiotic activities, vesicle-disrupting activities, and pore-forming activities, the structure-function relationships can be summarized as follows. The partial insertion of the Trp2 of CA-MA into the membrane, as well as the electrostatic interactions between the positively charged Lys residues at the N-terminus of the CA-MA and the anionic phospholipid headgroups, leads to the primary binding to the cell membrane. Then, the flexibility or bending potential induced by the Gly-Ile-Gly hinge sequence or the Pro residue in the central part of the peptides may allow the alpha-helix in the C-terminus to span the lipid bilayer. These structural features are crucial for the potent antibiotic activities of CA-MA.

-	~~{{STRUCTURE_1f0f\| PDB=1f0f \| SCENE= }}~~	+	Role of the hinge region and the tryptophan residue in the synthetic antimicrobial peptides, cecropin A(1-8)-magainin 2(1-12) and its analogues, on their antibiotic activities and structures.,Oh D, Shin SY, Lee S, Kang JH, Kim SD, Ryu PD, Hahm KS, Kim Y Biochemistry. 2000 Oct 3;39(39):11855-64. PMID:11009597<ref>PMID:11009597</ref>

-	~~===Cecropin A(1-8)-magainin 2(1-12) gig deletion modification in dodecylphosphocholine micelles===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11009597}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1f0f]] is~~ a ~~1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1F0F OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011009597<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Kim, Y.]]		[[Category: Kim, Y.]]
	[[Category: Lee, S.]]		[[Category: Lee, S.]]

OCA: Protected "1f0f" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 18:20:50 GMT

Protected "1f0f" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:20, 14 August 2012

OCA at 18:20, 14 August 2012

OCA — Tue, 14 Aug 2012 18:20:48 GMT

←Older revision		Revision as of 18:20, 14 August 2012
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-	{{Seed}}
	[[Image:1f0f.png\|left\|200px]]		[[Image:1f0f.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1f0f", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1f0f\| PDB=1f0f \| SCENE= }}		{{STRUCTURE_1f0f\| PDB=1f0f \| SCENE= }}

	===Cecropin A(1-8)-magainin 2(1-12) gig deletion modification in dodecylphosphocholine micelles===		===Cecropin A(1-8)-magainin 2(1-12) gig deletion modification in dodecylphosphocholine micelles===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11009597}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11009597 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11009597}}		{{ABSTRACT_PUBMED_11009597}}

	==About this Structure==		==About this Structure==
-	~~1F0F is a~~ [[~~Single protein~~]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0F OCA].	+	[[1f0f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0F OCA].

	==Reference==		==Reference==
-	Role of the hinge region and the tryptophan residue in the synthetic antimicrobial peptides, cecropin A(1-8)-magainin 2(1-12) and its analogues, on their antibiotic activities and structures., Oh D, Shin SY, Lee S, Kang JH, Kim SD, Ryu PD, Hahm KS, Kim Y, Biochemistry. 2000 Oct 3;39(39):11855-64. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/11009597 11009597]~~	+	<ref group="xtra">PMID:011009597</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Kim, Y.]]		[[Category: Kim, Y.]]
	[[Category: Lee, S.]]		[[Category: Lee, S.]]
	[[Category: Oh, D.]]		[[Category: Oh, D.]]
	[[Category: Shin, S Y.]]		[[Category: Shin, S Y.]]
		+	[[Category: Antitumor protein]]
	[[Category: Helix]]		[[Category: Helix]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:17:47 2008''