1f67 - Revision history

OCA at 11:08, 28 July 2021

OCA — Wed, 28 Jul 2021 11:08:56 GMT

←Older revision		Revision as of 11:08, 28 July 2021
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	<StructureSection load='1f67' size='340' side='right'caption='[[1f67]]' scene=''>		<StructureSection load='1f67' size='340' side='right'caption='[[1f67]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1F67 FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F67 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1f67 FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/1f67 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1f67 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f67 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1f67 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f67 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:54, 23 October 2019

OCA — Wed, 23 Oct 2019 08:54:20 GMT

←Older revision		Revision as of 08:54, 23 October 2019
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	==MOLECULAR MODELING OF HUMAN TYPE 10 17BETA-HYDROXYSTEROID DEHYDROGENASE==		==MOLECULAR MODELING OF HUMAN TYPE 10 17BETA-HYDROXYSTEROID DEHYDROGENASE==
-	<StructureSection load='1f67' size='340' side='right' caption='[[1f67]]' scene=''>	+	<StructureSection load='1f67' size='340' side='right'caption='[[1f67]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F67 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F67 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Jornvall, H]]		[[Category: Jornvall, H]]
	[[Category: Nordling, E]]		[[Category: Nordling, E]]
	[[Category: Oppermann, U C]]		[[Category: Oppermann, U C]]
	[[Category: Persson, B]]		[[Category: Persson, B]]

OCA at 09:20, 27 December 2017

OCA — Wed, 27 Dec 2017 09:20:13 GMT

←Older revision		Revision as of 09:20, 27 December 2017
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F67 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F67 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f67 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1f67 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f67 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1f67 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1f67 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:55, 11 February 2016

OCA — Thu, 11 Feb 2016 08:55:58 GMT

←Older revision		Revision as of 08:55, 11 February 2016
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		+	{{Theoretical_model}}
		+
	==MOLECULAR MODELING OF HUMAN TYPE 10 17BETA-HYDROXYSTEROID DEHYDROGENASE==		==MOLECULAR MODELING OF HUMAN TYPE 10 17BETA-HYDROXYSTEROID DEHYDROGENASE==
	<StructureSection load='1f67' size='340' side='right' caption='[[1f67]]' scene=''>		<StructureSection load='1f67' size='340' side='right' caption='[[1f67]]' scene=''>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Jornvall, H]]		[[Category: Jornvall, H]]
	[[Category: Nordling, E]]		[[Category: Nordling, E]]
	[[Category: Oppermann, U C]]		[[Category: Oppermann, U C]]
	[[Category: Persson, B]]		[[Category: Persson, B]]

OCA at 02:37, 11 September 2015

OCA — Fri, 11 Sep 2015 02:37:52 GMT

←Older revision		Revision as of 02:37, 11 September 2015
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1f67" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:20, 18 December 2014

OCA — Thu, 18 Dec 2014 12:20:03 GMT

←Older revision		Revision as of 12:20, 18 December 2014
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-	~~{{Theoretical_model}}~~	+	==MOLECULAR MODELING OF HUMAN TYPE 10 17BETA-HYDROXYSTEROID DEHYDROGENASE==
		+	<StructureSection load='1f67' size='340' side='right' caption='[[1f67]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F67 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f67 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1f67 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	17 beta-hydroxysteroid dehydrogenases catalyze the oxidoreduction of hydroxy/oxo groups at position C17 of steroid hormones, thereby constituting a prereceptor control mechanism of hormone action. At present, 11 different mammalian 17 beta-hydroxysteroid dehydrogenases have been identified, catalyzing the cell- and steroid-specific activation and inactivation of estrogens and androgens. The human type 10 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD-10) is a multifunctional mitochondrial enzyme that efficiently catalyzes the oxidative inactivation at C17 of androgens and estrogens. However, it also mediates oxidation of 3 alpha-hydroxy groups of androgens, thereby reactivating androgen metabolites. Finally, it is involved in beta-oxidation of fatty acids by catalyzing the L-hydroxyacyl CoA dehydrogenase reaction of the beta-oxidation cycle. These features and expression profiles suggest a critical role of 17 beta-HSD-10 in neurodegenerative and steroid-dependent cancer forms. Since no three-dimensional structure of 17 beta-HSD-10 is available, homology modelling was carried out to understand the molecular basis of these substrate specificities. The structure obtained displays the properties of a one-domain, alpha/beta fold enzyme of the SDR family. The active site is located within a large, hydrophobic cleft, which forms optimal contacts with the different steroid surfaces. The data provide explanations for the substrate specificities toward the various classes of sex steroid hormones. The model is suitable to explore substrate and inhibitor characteristics that may be used in the development of novel strategies in the treatment of degenerative or malignant diseases.

-	~~{{STRUCTURE_1f67\| PDB=1f67 \| SCENE= }}~~	+	Human type 10 17 beta-hydroxysteroid dehydrogenase: molecular modelling and substrate docking.,Nordling E, Oppermann UC, Jornvall H, Persson B J Mol Graph Model. 2001;19(6):514-20, 591-3. PMID:11552679<ref>PMID:11552679</ref>
-	~~===MOLECULAR MODELING OF HUMAN TYPE~~ 10 ~~17BETA~~-~~HYDROXYSTEROID DEHYDROGENASE===~~	+
-	~~{{ABSTRACT_PUBMED_11552679}}~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:011552679</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Jornvall, H]]		[[Category: Jornvall, H]]
	[[Category: Nordling, E]]		[[Category: Nordling, E]]
	[[Category: Oppermann, U C]]		[[Category: Oppermann, U C]]
	[[Category: Persson, B]]		[[Category: Persson, B]]

OCA at 19:54, 24 March 2013

OCA — Sun, 24 Mar 2013 19:54:50 GMT

←Older revision		Revision as of 19:54, 24 March 2013
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	{{Theoretical_model}}		{{Theoretical_model}}
-
-	[[Image:1f67.png\|left\|200px]]

	{{STRUCTURE_1f67\| PDB=1f67 \| SCENE= }}		{{STRUCTURE_1f67\| PDB=1f67 \| SCENE= }}
-
	===MOLECULAR MODELING OF HUMAN TYPE 10 17BETA-HYDROXYSTEROID DEHYDROGENASE===		===MOLECULAR MODELING OF HUMAN TYPE 10 17BETA-HYDROXYSTEROID DEHYDROGENASE===
-
	{{ABSTRACT_PUBMED_11552679}}		{{ABSTRACT_PUBMED_11552679}}

	==Reference==		==Reference==
-	<ref group="xtra">PMID:011552679</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011552679</ref><references group="xtra"/><references/>
	[[Category: Jornvall, H]]		[[Category: Jornvall, H]]
	[[Category: Nordling, E]]		[[Category: Nordling, E]]
	[[Category: Oppermann, U C]]		[[Category: Oppermann, U C]]
	[[Category: Persson, B]]		[[Category: Persson, B]]

OCA: Protected "1f67" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 09:47:10 GMT

Protected "1f67" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:47, 21 October 2012

OCA at 09:47, 21 October 2012

OCA — Sun, 21 Oct 2012 09:47:08 GMT

←Older revision		Revision as of 09:47, 21 October 2012
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	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:1f67.png\|left\|200px]]		[[Image:1f67.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1f67", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1f67\| PDB=1f67 \| SCENE= }}		{{STRUCTURE_1f67\| PDB=1f67 \| SCENE= }}

	===MOLECULAR MODELING OF HUMAN TYPE 10 17BETA-HYDROXYSTEROID DEHYDROGENASE===		===MOLECULAR MODELING OF HUMAN TYPE 10 17BETA-HYDROXYSTEROID DEHYDROGENASE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11552679}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11552679 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11552679}}		{{ABSTRACT_PUBMED_11552679}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F67 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11552679~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011552679</ref><references group="xtra"/>
	[[Category: Jornvall, H]]		[[Category: Jornvall, H]]
	[[Category: Nordling, E]]		[[Category: Nordling, E]]
	[[Category: Oppermann, U C]]		[[Category: Oppermann, U C]]
	[[Category: Persson, B]]		[[Category: Persson, B]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:58:07 2010''

OCA at 05:58, 8 April 2010

OCA — Thu, 08 Apr 2010 05:58:08 GMT

←Older revision		Revision as of 05:58, 8 April 2010
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-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:1f67.png\|left\|200px]]

-	The ~~entry 1F67~~ is ~~a Theoretical Model titled 'MOLECULAR MODELING OF HUMAN TYPE 10 17BETA-HYDROXYSTEROID DEHYDROGENASE'~~.	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_1f67", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_1f67\| PDB=1f67 \| SCENE= }}

-	~~[[Category:Theoretical Model]]~~	+	===MOLECULAR MODELING OF HUMAN TYPE 10 17BETA-HYDROXYSTEROID DEHYDROGENASE===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30 09~~:49:~~42 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_11552679}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 11552679 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_11552679}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F67 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:11552679</ref><references group="xtra"/>
		+	[[Category: Jornvall, H]]
		+	[[Category: Nordling, E]]
		+	[[Category: Oppermann, U C]]
		+	[[Category: Persson, B]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:58:07 2010''