1f7s - Revision history

OCA at 07:11, 7 February 2024

OCA — Wed, 07 Feb 2024 07:11:48 GMT

←Older revision		Revision as of 07:11, 7 February 2024
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	<StructureSection load='1f7s' size='340' side='right'caption='[[1f7s]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1f7s' size='340' side='right'caption='[[1f7s]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1f7s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F7S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1f7s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F7S FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE~~-~~N-OXIDE'>LDA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1cof\|1cof]], [[1ahq\|1ahq]], [[1cnu\|1cnu]], [[1ak6\|1ak6]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f7s OCA], [https://pdbe.org/1f7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f7s RCSB], [https://www.ebi.ac.uk/pdbsum/1f7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f7s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f7s OCA], [https://pdbe.org/1f7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f7s RCSB], [https://www.ebi.ac.uk/pdbsum/1f7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f7s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ADF1_ARATH ADF1_ARATH]] Actin-depolymerizing protein. Stimulates F-actin depolymerization. Involved in plant development, cell organ expansion and flowering by controlling breakdown of thick actin cables.<ref>PMID:11402164</ref>	+	[https://www.uniprot.org/uniprot/ADF1_ARATH ADF1_ARATH] Actin-depolymerizing protein. Stimulates F-actin depolymerization. Involved in plant development, cell organ expansion and flowering by controlling breakdown of thick actin cables.<ref>PMID:11402164</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f7s ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f7s ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Actin-depolymerizing factor (ADF) and cofilin define a family of actin-binding proteins essential for the rapid turnover of filamentous actin in vivo. Here we present the 2.0 A crystal structure of Arabidopsis thaliana ADF1 (AtADF1), the first plant crystal structure from the ADF/cofilin (AC) family. Superposition of the four AC isoform structures permits an accurate sequence alignment that differs from previously reported data for the location of vertebrate-specific inserts and reveals a contiguous, vertebrate-specific surface opposite the putative actin-binding surface. Extending the structure-based sequence alignment to include 30 additional isoforms indicates three major groups: vertebrates, plants, and "other eukaryotes." Within these groups, several structurally conserved residues that are not conserved throughout the entire AC family have been identified. Residues that are highly conserved among all isoforms tend to cluster around the tryptophan at position 90 and a structurally conserved kink in alpha-helix 3. Analysis of surface character shows the presence of a hydrophobic patch and a highly conserved acidic cluster, both of which include several residues previously implicated in actin binding.
-
-	A comparative structural analysis of the ADF/cofilin family.,Bowman GD, Nodelman IM, Hong Y, Chua NH, Lindberg U, Schutt CE Proteins. 2000 Nov 15;41(3):374-84. PMID:11025548<ref>PMID:11025548</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1f7s" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bowman~~, G D~~]]	+	[[Category: Bowman GD]]
-	[[Category: Chua~~, N H~~]]	+	[[Category: Chua NH]]
-	[[Category: Lindberg, U]]	+	[[Category: Lindberg U]]
-	[[Category: Nodelman~~, I M~~]]	+	[[Category: Nodelman IM]]
-	[[Category: Schutt~~, C E]]~~	+	[[Category: Schutt CE]]
-	~~[[Category: Kink in alpha-helix 3]]~~	+
-	~~[[Category: Plant protein~~]]	+

OCA at 07:20, 17 March 2021

OCA — Wed, 17 Mar 2021 07:20:27 GMT

←Older revision		Revision as of 07:20, 17 March 2021
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	<StructureSection load='1f7s' size='340' side='right'caption='[[1f7s]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1f7s' size='340' side='right'caption='[[1f7s]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1f7s]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F7S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1F7S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1f7s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F7S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cof\|1cof]], [[1ahq\|1ahq]], [[1cnu\|1cnu]], [[1ak6\|1ak6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cof\|1cof]], [[1ahq\|1ahq]], [[1cnu\|1cnu]], [[1ak6\|1ak6]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1f7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f7s OCA], [~~http~~://pdbe.org/1f7s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1f7s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1f7s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1f7s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f7s OCA], [https://pdbe.org/1f7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f7s RCSB], [https://www.ebi.ac.uk/pdbsum/1f7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f7s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ADF1_ARATH ADF1_ARATH]] Actin-depolymerizing protein. Stimulates F-actin depolymerization. Involved in plant development, cell organ expansion and flowering by controlling breakdown of thick actin cables.<ref>PMID:11402164</ref>	+	[[https://www.uniprot.org/uniprot/ADF1_ARATH ADF1_ARATH]] Actin-depolymerizing protein. Stimulates F-actin depolymerization. Involved in plant development, cell organ expansion and flowering by controlling breakdown of thick actin cables.<ref>PMID:11402164</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:37, 12 June 2019

OCA — Wed, 12 Jun 2019 06:37:27 GMT

←Older revision		Revision as of 06:37, 12 June 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF ADF1 FROM ARABIDOPSIS THALIANA==		==CRYSTAL STRUCTURE OF ADF1 FROM ARABIDOPSIS THALIANA==
-	<StructureSection load='1f7s' size='340' side='right' caption='[[1f7s]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1f7s' size='340' side='right'caption='[[1f7s]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1f7s]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F7S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1f7s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F7S FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cof\|1cof]], [[1ahq\|1ahq]], [[1cnu\|1cnu]], [[1ak6\|1ak6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cof\|1cof]], [[1ahq\|1ahq]], [[1cnu\|1cnu]], [[1ak6\|1ak6]]</td></tr>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f7/1f7s_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f7/1f7s_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arath]]
		+	[[Category: Large Structures]]
	[[Category: Bowman, G D]]		[[Category: Bowman, G D]]
	[[Category: Chua, N H]]		[[Category: Chua, N H]]

OCA at 03:50, 6 September 2017

OCA — Wed, 06 Sep 2017 03:50:38 GMT

←Older revision		Revision as of 03:50, 6 September 2017
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF ADF1 FROM ARABIDOPSIS THALIANA==		==CRYSTAL STRUCTURE OF ADF1 FROM ARABIDOPSIS THALIANA==
	<StructureSection load='1f7s' size='340' side='right' caption='[[1f7s]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1f7s' size='340' side='right' caption='[[1f7s]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1f7s]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Arath Arath]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F7S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1f7s]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F7S FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cof\|1cof]], [[1ahq\|1ahq]], [[1cnu\|1cnu]], [[1ak6\|1ak6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cof\|1cof]], [[1ahq\|1ahq]], [[1cnu\|1cnu]], [[1ak6\|1ak6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f7s OCA], [http://pdbe.org/1f7s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1f7s RCSB], [http://www.ebi.ac.uk/pdbsum/1f7s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f7s OCA], [http://pdbe.org/1f7s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1f7s RCSB], [http://www.ebi.ac.uk/pdbsum/1f7s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1f7s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f7s ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Arath]]
	[[Category: Bowman, G D]]		[[Category: Bowman, G D]]
	[[Category: Chua, N H]]		[[Category: Chua, N H]]

OCA at 01:20, 12 September 2015

OCA — Sat, 12 Sep 2015 01:20:21 GMT

←Older revision		Revision as of 01:20, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1f7s' size='340' side='right' caption='[[1f7s]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1f7s' size='340' side='right' caption='[[1f7s]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1f7s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arabidopsis_thaliana Arabidopsis thaliana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F7S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1f7s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F7S FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cof\|1cof]], [[1ahq\|1ahq]], [[1cnu\|1cnu]], [[1ak6\|1ak6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cof\|1cof]], [[1ahq\|1ahq]], [[1cnu\|1cnu]], [[1ak6\|1ak6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1f7s RCSB], [http://www.ebi.ac.uk/pdbsum/1f7s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f7s OCA], [http://pdbe.org/1f7s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1f7s RCSB], [http://www.ebi.ac.uk/pdbsum/1f7s PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1f7s" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arabidopsis thaliana~~]]	+	[[Category: Arath]]
	[[Category: Bowman, G D]]		[[Category: Bowman, G D]]
	[[Category: Chua, N H]]		[[Category: Chua, N H]]

OCA at 21:55, 25 December 2014

OCA — Thu, 25 Dec 2014 21:55:30 GMT

←Older revision		Revision as of 21:55, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1f7s RCSB], [http://www.ebi.ac.uk/pdbsum/1f7s PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1f7s RCSB], [http://www.ebi.ac.uk/pdbsum/1f7s PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ADF1_ARATH ADF1_ARATH]] Actin-depolymerizing protein. Stimulates F-actin depolymerization. Involved in plant development, cell organ expansion and flowering by controlling breakdown of thick actin cables.<ref>PMID:11402164</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 23:27, 22 December 2014

OCA — Mon, 22 Dec 2014 23:27:10 GMT

←Older revision		Revision as of 23:27, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1f7s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F7S FirstGlance]. <br>		<table><tr><td colspan='2'>[[1f7s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F7S FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cof\|1cof]], [[1ahq\|1ahq]], [[1cnu\|1cnu]], [[1ak6\|1ak6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cof\|1cof]], [[1ahq\|1ahq]], [[1cnu\|1cnu]], [[1ak6\|1ak6]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1f7s RCSB], [http://www.ebi.ac.uk/pdbsum/1f7s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1f7s RCSB], [http://www.ebi.ac.uk/pdbsum/1f7s PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
-	[[Category: Bowman, G D.]]	+	[[Category: Bowman, G D]]
-	[[Category: Chua, N H.]]	+	[[Category: Chua, N H]]
-	[[Category: Lindberg, U.]]	+	[[Category: Lindberg, U]]
-	[[Category: Nodelman, I M.]]	+	[[Category: Nodelman, I M]]
-	[[Category: Schutt, C E.]]	+	[[Category: Schutt, C E]]
	[[Category: Kink in alpha-helix 3]]		[[Category: Kink in alpha-helix 3]]
	[[Category: Plant protein]]		[[Category: Plant protein]]

OCA at 13:09, 28 September 2014

OCA — Sun, 28 Sep 2014 13:09:21 GMT

←Older revision		Revision as of 13:09, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1f7s.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF ADF1 FROM ARABIDOPSIS THALIANA==
		+	<StructureSection load='1f7s' size='340' side='right' caption='[[1f7s]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1f7s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F7S FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cof\|1cof]], [[1ahq\|1ahq]], [[1cnu\|1cnu]], [[1ak6\|1ak6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1f7s RCSB], [http://www.ebi.ac.uk/pdbsum/1f7s PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f7/1f7s_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Actin-depolymerizing factor (ADF) and cofilin define a family of actin-binding proteins essential for the rapid turnover of filamentous actin in vivo. Here we present the 2.0 A crystal structure of Arabidopsis thaliana ADF1 (AtADF1), the first plant crystal structure from the ADF/cofilin (AC) family. Superposition of the four AC isoform structures permits an accurate sequence alignment that differs from previously reported data for the location of vertebrate-specific inserts and reveals a contiguous, vertebrate-specific surface opposite the putative actin-binding surface. Extending the structure-based sequence alignment to include 30 additional isoforms indicates three major groups: vertebrates, plants, and "other eukaryotes." Within these groups, several structurally conserved residues that are not conserved throughout the entire AC family have been identified. Residues that are highly conserved among all isoforms tend to cluster around the tryptophan at position 90 and a structurally conserved kink in alpha-helix 3. Analysis of surface character shows the presence of a hydrophobic patch and a highly conserved acidic cluster, both of which include several residues previously implicated in actin binding.

-	~~{{STRUCTURE_1f7s\| PDB=1f7s \| SCENE= }}~~	+	A comparative structural analysis of the ADF/cofilin family.,Bowman GD, Nodelman IM, Hong Y, Chua NH, Lindberg U, Schutt CE Proteins. 2000 Nov 15;41(3):374-84. PMID:11025548<ref>PMID:11025548</ref>

-	~~===CRYSTAL STRUCTURE OF ADF1 FROM ARABIDOPSIS THALIANA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~==About this Structure==~~	+	<references/>
-	~~[[1f7s]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1F7S OCA].~~	+	__TOC__
-		+	</StructureSection>
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011025548<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Bowman, G D.]]		[[Category: Bowman, G D.]]

OCA: Protected "1f7s" [edit=sysop:move=sysop]

OCA — Wed, 14 Nov 2012 07:30:28 GMT

Protected "1f7s" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:30, 14 November 2012

OCA at 07:30, 14 November 2012

OCA — Wed, 14 Nov 2012 07:30:25 GMT

←Older revision		Revision as of 07:30, 14 November 2012
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-	{{Seed}}
	[[Image:1f7s.png\|left\|200px]]		[[Image:1f7s.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1f7s", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1f7s\| PDB=1f7s \| SCENE= }}		{{STRUCTURE_1f7s\| PDB=1f7s \| SCENE= }}

	===CRYSTAL STRUCTURE OF ADF1 FROM ARABIDOPSIS THALIANA===		===CRYSTAL STRUCTURE OF ADF1 FROM ARABIDOPSIS THALIANA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11025548}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11025548 is the PubMed ID number.
-	-->
-	{{ABSTRACT_PUBMED_11025548}}

	==About this Structure==		==About this Structure==
-	~~1F7S~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F7S OCA].	+	[[1f7s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F7S OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11025548~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011025548</ref><references group="xtra"/>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Bowman, G D.]]		[[Category: Bowman, G D.]]
Line 31:		Line 18:
	[[Category: Schutt, C E.]]		[[Category: Schutt, C E.]]
	[[Category: Kink in alpha-helix 3]]		[[Category: Kink in alpha-helix 3]]
-		+	[[Category: Plant protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 09:04:04 2009''~~	+