1f89 - Revision history

OCA at 07:11, 7 February 2024

OCA — Wed, 07 Feb 2024 07:11:55 GMT

←Older revision		Revision as of 07:11, 7 February 2024
Line 1:		Line 1:

	==Crystal structure of Saccharomyces cerevisiae Nit3, a member of branch 10 of the nitrilase superfamily==		==Crystal structure of Saccharomyces cerevisiae Nit3, a member of branch 10 of the nitrilase superfamily==
-	<StructureSection load='1f89' size='340' side='right'caption='[[1f89]]' scene=''>	+	<StructureSection load='1f89' size='340' side='right'caption='[[1f89]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F89 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1f89]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F89 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f89 OCA], [https://pdbe.org/1f89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f89 RCSB], [https://www.ebi.ac.uk/pdbsum/1f89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f89 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1f89 TOPSAN]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f89 OCA], [https://pdbe.org/1f89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f89 RCSB], [https://www.ebi.ac.uk/pdbsum/1f89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f89 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1f89 TOPSAN]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NIT3_YEAST NIT3_YEAST]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Saccharomyces cerevisiae]]
	[[Category: Burley SK]]		[[Category: Burley SK]]
	[[Category: Eswaramoorthy S]]		[[Category: Eswaramoorthy S]]

OCA at 09:47, 21 July 2021

OCA — Wed, 21 Jul 2021 09:47:33 GMT

←Older revision		Revision as of 09:47, 21 July 2021
Line 1:		Line 1:

	==Crystal structure of Saccharomyces cerevisiae Nit3, a member of branch 10 of the nitrilase superfamily==		==Crystal structure of Saccharomyces cerevisiae Nit3, a member of branch 10 of the nitrilase superfamily==
-	<StructureSection load='1f89' size='340' side='right'caption='[[1f89]]~~, [[Resolution\|resolution]] 2.40Å~~' scene=''>	+	<StructureSection load='1f89' size='340' side='right'caption='[[1f89]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>~~[[1f89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824].~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F89 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1F89 FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F89 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1f89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f89 OCA], [~~http~~://pdbe.org/1f89 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1f89 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1f89 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1f89 ProSAT], [~~http~~://www.topsan.org/Proteins/NYSGXRC/1f89 TOPSAN]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f89 OCA], [https://pdbe.org/1f89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f89 RCSB], [https://www.ebi.ac.uk/pdbsum/1f89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f89 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1f89 TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f89 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f89 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The crystal structure of a yeast hypothetical protein with sequence similarity to CN hydrolases has been determined to 2.4 A resolution by the multiwavelength anomalous dispersion (MAD) method. The protein folds as a four-layer alphabetabetaalpha sandwich and exists as a dimer in the crystal and in solution. It was selected in a structural genomics project as representative of CN hydrolases at a time when no structures had been determined for members of this family. Structures for two other members of the family have since been reported and the three proteins have similar topology and dimerization modes, which are distinct from those of other alphabetabetaalpha proteins whose structures are known. The dimers form an unusual eight-layer alphabetabetaalpha:alphabetabetaalpha structure. Although the precise enzymatic reactions catalyzed by the yeast protein are not known, considerable information about the active site may be deduced from conserved sequence motifs, comparative biochemical information, and comparison with known structures of hydrolase active sites. As with serine hydrolases, the active-site nucleophile (cysteine in this case) is positioned on a nucleophile elbow.
-
-	Crystal structure of a putative CN hydrolase from yeast.,Kumaran D, Eswaramoorthy S, Gerchman SE, Kycia H, Studier FW, Swaminathan S Proteins. 2003 Aug 1;52(2):283-91. PMID:12833551<ref>PMID:12833551</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1f89" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Burley~~, S K~~]]	+	[[Category: Burley SK]]
-	[[Category: Eswaramoorthy, S]]	+	[[Category: Eswaramoorthy S]]
-	[[Category: Kumaran, D]]	+	[[Category: Kumaran D]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Studier FW]]
-	[[Category: Studier~~, F W~~]]	+	[[Category: Swaminathan S]]
-	[[Category: Swaminathan, S]]	+
-	~~[[Category: Dimer]]~~	+
-	~~[[Category: Four layer sandwich]]~~	+
-	~~[[Category: Nitrilase]]~~	+
-	~~[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Unknown function~~]]	+

OCA at 11:49, 16 October 2019

OCA — Wed, 16 Oct 2019 11:49:00 GMT

←Older revision		Revision as of 11:49, 16 October 2019
Line 1:		Line 1:

	==Crystal structure of Saccharomyces cerevisiae Nit3, a member of branch 10 of the nitrilase superfamily==		==Crystal structure of Saccharomyces cerevisiae Nit3, a member of branch 10 of the nitrilase superfamily==
-	<StructureSection load='1f89' size='340' side='right' caption='[[1f89]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='1f89' size='340' side='right'caption='[[1f89]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1f89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F89 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1f89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F89 FirstGlance]. <br>
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Burley, S K]]		[[Category: Burley, S K]]
	[[Category: Eswaramoorthy, S]]		[[Category: Eswaramoorthy, S]]

OCA at 09:19, 27 December 2017

OCA — Wed, 27 Dec 2017 09:19:46 GMT

←Older revision		Revision as of 09:19, 27 December 2017
Line 1:		Line 1:
		+
	==Crystal structure of Saccharomyces cerevisiae Nit3, a member of branch 10 of the nitrilase superfamily==		==Crystal structure of Saccharomyces cerevisiae Nit3, a member of branch 10 of the nitrilase superfamily==
	<StructureSection load='1f89' size='340' side='right' caption='[[1f89]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1f89' size='340' side='right' caption='[[1f89]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1f89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F89 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1f89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F89 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f89 OCA], [http://pdbe.org/1f89 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1f89 RCSB], [http://www.ebi.ac.uk/pdbsum/1f89 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1f89 TOPSAN]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f89 OCA], [http://pdbe.org/1f89 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1f89 RCSB], [http://www.ebi.ac.uk/pdbsum/1f89 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1f89 ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/1f89 TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 9:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/1f89_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/1f89_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:11, 9 February 2016

OCA — Tue, 09 Feb 2016 17:11:49 GMT

←Older revision		Revision as of 17:11, 9 February 2016
Line 13:		Line 13:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f89 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:22, 11 September 2015

OCA — Fri, 11 Sep 2015 00:22:51 GMT

←Older revision		Revision as of 00:22, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1f89' size='340' side='right' caption='[[1f89]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1f89' size='340' side='right' caption='[[1f89]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1f89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F89 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1f89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F89 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f89 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1f89 RCSB], [http://www.ebi.ac.uk/pdbsum/1f89 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1f89 TOPSAN]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f89 OCA], [http://pdbe.org/1f89 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1f89 RCSB], [http://www.ebi.ac.uk/pdbsum/1f89 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1f89 TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 23:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1f89" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Burley, S K]]		[[Category: Burley, S K]]
	[[Category: Eswaramoorthy, S]]		[[Category: Eswaramoorthy, S]]

OCA at 12:45, 6 November 2014

OCA — Thu, 06 Nov 2014 12:45:30 GMT

←Older revision		Revision as of 12:45, 6 November 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1f89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F89 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1f89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F89 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f89 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1f89 RCSB], [http://www.ebi.ac.uk/pdbsum/1f89 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1f89 TOPSAN]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f89 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1f89 RCSB], [http://www.ebi.ac.uk/pdbsum/1f89 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1f89 TOPSAN]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Burley, S K.]]	+	[[Category: Burley, S K]]
-	[[Category: Eswaramoorthy, S.]]	+	[[Category: Eswaramoorthy, S]]
-	[[Category: Kumaran, D.]]	+	[[Category: Kumaran, D]]
-	[[Category: ~~NYSGXRC, New York SGX Research Center for~~ Structural ~~Genomics.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Studier, F W.]]	+	[[Category: Studier, F W]]
-	[[Category: Swaminathan, S.]]	+	[[Category: Swaminathan, S]]
	[[Category: Dimer]]		[[Category: Dimer]]
	[[Category: Four layer sandwich]]		[[Category: Four layer sandwich]]
-	[[Category: New york sgx research center for structural genomic]]
	[[Category: Nitrilase]]		[[Category: Nitrilase]]
-	[[Category: ~~Nysgxrc~~]]	+	[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
-	[[Category: Protein structure initiative]]	+	[[Category: PSI, Protein structure initiative]]
-	~~[[Category: Psi]]~~	+
-	~~[[Category: Structural genomic~~]]	+
	[[Category: Unknown function]]		[[Category: Unknown function]]

OCA at 10:21, 28 September 2014

OCA — Sun, 28 Sep 2014 10:21:38 GMT

←Older revision		Revision as of 10:21, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1f89.~~png\|left~~\|200px]]	+	==Crystal structure of Saccharomyces cerevisiae Nit3, a member of branch 10 of the nitrilase superfamily==
		+	<StructureSection load='1f89' size='340' side='right' caption='[[1f89]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1f89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F89 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f89 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1f89 RCSB], [http://www.ebi.ac.uk/pdbsum/1f89 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1f89 TOPSAN]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/1f89_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of a yeast hypothetical protein with sequence similarity to CN hydrolases has been determined to 2.4 A resolution by the multiwavelength anomalous dispersion (MAD) method. The protein folds as a four-layer alphabetabetaalpha sandwich and exists as a dimer in the crystal and in solution. It was selected in a structural genomics project as representative of CN hydrolases at a time when no structures had been determined for members of this family. Structures for two other members of the family have since been reported and the three proteins have similar topology and dimerization modes, which are distinct from those of other alphabetabetaalpha proteins whose structures are known. The dimers form an unusual eight-layer alphabetabetaalpha:alphabetabetaalpha structure. Although the precise enzymatic reactions catalyzed by the yeast protein are not known, considerable information about the active site may be deduced from conserved sequence motifs, comparative biochemical information, and comparison with known structures of hydrolase active sites. As with serine hydrolases, the active-site nucleophile (cysteine in this case) is positioned on a nucleophile elbow.

-	~~{{STRUCTURE_1f89\| PDB=1f89 \| SCENE= }}~~	+	Crystal structure of a putative CN hydrolase from yeast.,Kumaran D, Eswaramoorthy S, Gerchman SE, Kycia H, Studier FW, Swaminathan S Proteins. 2003 Aug 1;52(2):283-91. PMID:12833551<ref>PMID:12833551</ref>

-	~~===Crystal structure of Saccharomyces cerevisiae Nit3~~, a ~~member of branch 10~~ of the ~~nitrilase superfamily===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~==About this Structure==~~	+	<references/>
-	~~[[1f89]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1F89 OCA].~~	+	__TOC__
-		+	</StructureSection>
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012833551<~~/~~ref~~><~~ref group="xtra">PMID:015390259</ref><references group="xtra"~~/>	+
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Burley, S K.]]		[[Category: Burley, S K.]]

OCA: Protected "1f89" [edit=sysop:move=sysop]

OCA — Wed, 14 Nov 2012 07:24:25 GMT

Protected "1f89" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:24, 14 November 2012

OCA at 07:24, 14 November 2012

OCA — Wed, 14 Nov 2012 07:24:20 GMT

←Older revision		Revision as of 07:24, 14 November 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1f89.png\|left\|200px]]		[[Image:1f89.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1f89", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1f89\| PDB=1f89 \| SCENE= }}		{{STRUCTURE_1f89\| PDB=1f89 \| SCENE= }}

	===Crystal structure of Saccharomyces cerevisiae Nit3, a member of branch 10 of the nitrilase superfamily===		===Crystal structure of Saccharomyces cerevisiae Nit3, a member of branch 10 of the nitrilase superfamily===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12833551}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12833551 is the PubMed ID number.
-	-->
-	{{ABSTRACT_PUBMED_12833551}}

	==About this Structure==		==About this Structure==
-	~~1F89~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F89 OCA].	+	[[1f89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F89 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12833551~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012833551</ref><ref group="xtra">PMID:015390259</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Burley, S K.]]		[[Category: Burley, S K.]]
	[[Category: Eswaramoorthy, S.]]		[[Category: Eswaramoorthy, S.]]
	[[Category: Kumaran, D.]]		[[Category: Kumaran, D.]]
-	[[Category: NYSGXRC, New York ~~Structural GenomiX~~ Research ~~Consortium~~.]]	+	[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
	[[Category: Studier, F W.]]		[[Category: Studier, F W.]]
	[[Category: Swaminathan, S.]]		[[Category: Swaminathan, S.]]
	[[Category: Dimer]]		[[Category: Dimer]]
	[[Category: Four layer sandwich]]		[[Category: Four layer sandwich]]
-	[[Category: New york ~~structural genomix~~ research ~~consortium~~]]	+	[[Category: New york sgx research center for structural genomic]]
	[[Category: Nitrilase]]		[[Category: Nitrilase]]
	[[Category: Nysgxrc]]		[[Category: Nysgxrc]]
Line 39:		Line 26:
	[[Category: Psi]]		[[Category: Psi]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
-		+	[[Category: Unknown function]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 11:25:33 2009''~~	+