1fen - Revision history

OCA at 07:13, 7 February 2024

OCA — Wed, 07 Feb 2024 07:13:52 GMT

←Older revision		Revision as of 07:13, 7 February 2024
Line 3:		Line 3:
	<StructureSection load='1fen' size='340' side='right'caption='[[1fen]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1fen' size='340' side='right'caption='[[1fen]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1fen]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FEN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1fen]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FEN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZE:ALL-TRANS+AXEROPHTHENE'>AZE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZE:ALL-TRANS+AXEROPHTHENE'>AZE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fen OCA], [https://pdbe.org/1fen PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fen RCSB], [https://www.ebi.ac.uk/pdbsum/1fen PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fen ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fen OCA], [https://pdbe.org/1fen PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fen RCSB], [https://www.ebi.ac.uk/pdbsum/1fen PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fen ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RET4_BOVIN RET4_BOVIN]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.	+	[https://www.uniprot.org/uniprot/RET4_BOVIN RET4_BOVIN] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fen ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fen ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The three-dimensional structures of complexes between bovine plasma retinol-binding protein (RBP) and three retinol analogs with different end groups (fenretinide, all-trans retinoic acid, and axerophthene) have been determined to 1.8-1.9-A resolution. Their models are very similar to that of the bovine retinol.RBP complex: the root mean square deviations between equivalent alpha-carbons in the two proteins range from 0.17 to 0.24 A. The retinoid molecules fit in the beta-barrel cavity assuming the same conformation of the vitamin, and the substitutions have no consequences on the overall protein structure. While confirming that an intact hydroxyl end group is not an absolute requirement for a correct retinoid binding to RBP, this study has shown the occurrence of conformational changes, although limited, in the rather flexible loop region at the entrance of the beta-barrel upon fenretinide and retinoic acid binding. These changes are suitable for accommodating the end groups of the above retinoids. Instead, no such changes have been revealed in RBP complexed with axerophthene, a retinol analog bearing a hydrogen atom in place of the hydroxyl end group. The protein conformational changes in the above loop region, the steric hindrance of bulky end groups of bound retinoids, and the lack of the retinol hydroxyl group appear to be responsible for the possible reduced affinity of retinoids for RBP relative to retinol and, at the same time, for the abolished or reduced affinity of retinoid.RBP complexes for transthyretin relative to retinol-RBP.
-
-	Crystallographic studies on complexes between retinoids and plasma retinol-binding protein.,Zanotti G, Marcello M, Malpeli G, Folli C, Sartori G, Berni R J Biol Chem. 1994 Nov 25;269(47):29613-20. PMID:7961949<ref>PMID:7961949</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1fen" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Retinol-binding protein 3D structures\|Retinol-binding protein 3D structures]]		*[[Retinol-binding protein 3D structures\|Retinol-binding protein 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Berni, R]]	+	[[Category: Berni R]]
-	[[Category: Malpeli, G]]	+	[[Category: Malpeli G]]
-	[[Category: Marcello, M]]	+	[[Category: Marcello M]]
-	[[Category: Sartori, G]]	+	[[Category: Sartori G]]
-	[[Category: Zanotti, G]]	+	[[Category: Zanotti G]]
-	~~[[Category: Transport protein~~]]	+

OCA at 09:49, 21 July 2021

OCA — Wed, 21 Jul 2021 09:49:55 GMT

←Older revision		Revision as of 09:49, 21 July 2021
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	<StructureSection load='1fen' size='340' side='right'caption='[[1fen]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1fen' size='340' side='right'caption='[[1fen]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1fen]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FEN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1FEN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1fen]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FEN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZE:ALL-TRANS+AXEROPHTHENE'>AZE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZE:ALL-TRANS+AXEROPHTHENE'>AZE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1fen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fen OCA], [~~http~~://pdbe.org/1fen PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1fen RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1fen PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1fen ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fen OCA], [https://pdbe.org/1fen PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fen RCSB], [https://www.ebi.ac.uk/pdbsum/1fen PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fen ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RET4_BOVIN RET4_BOVIN]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.	+	[[https://www.uniprot.org/uniprot/RET4_BOVIN RET4_BOVIN]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Retinol-binding protein\|Retinol-binding protein]]	+	*[[Retinol-binding protein 3D structures\|Retinol-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:51, 16 October 2019

OCA — Wed, 16 Oct 2019 08:51:33 GMT

←Older revision		Revision as of 08:51, 16 October 2019
Line 1:		Line 1:

	==CRYSTALLOGRAPHIC STUDIES ON COMPLEXES BETWEEN RETINOIDS AND PLASMA RETINOL-BINDING PROTEIN==		==CRYSTALLOGRAPHIC STUDIES ON COMPLEXES BETWEEN RETINOIDS AND PLASMA RETINOL-BINDING PROTEIN==
-	<StructureSection load='1fen' size='340' side='right' caption='[[1fen]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='1fen' size='340' side='right'caption='[[1fen]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1fen]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FEN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1fen]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FEN FirstGlance]. <br>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1fen" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1fen" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Retinol-binding protein\|Retinol-binding protein]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Bovin]]		[[Category: Bovin]]
		+	[[Category: Large Structures]]
	[[Category: Berni, R]]		[[Category: Berni, R]]
	[[Category: Malpeli, G]]		[[Category: Malpeli, G]]

OCA at 09:22, 27 December 2017

OCA — Wed, 27 Dec 2017 09:22:09 GMT

←Older revision		Revision as of 09:22, 27 December 2017
Line 1:		Line 1:
		+
	==CRYSTALLOGRAPHIC STUDIES ON COMPLEXES BETWEEN RETINOIDS AND PLASMA RETINOL-BINDING PROTEIN==		==CRYSTALLOGRAPHIC STUDIES ON COMPLEXES BETWEEN RETINOIDS AND PLASMA RETINOL-BINDING PROTEIN==
	<StructureSection load='1fen' size='340' side='right' caption='[[1fen]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1fen' size='340' side='right' caption='[[1fen]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1fen]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FEN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1fen]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FEN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZE:ALL-TRANS+AXEROPHTHENE'>AZE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZE:ALL-TRANS+AXEROPHTHENE'>AZE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fen OCA], [http://pdbe.org/1fen PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fen RCSB], [http://www.ebi.ac.uk/pdbsum/1fen PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fen OCA], [http://pdbe.org/1fen PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fen RCSB], [http://www.ebi.ac.uk/pdbsum/1fen PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1fen ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fe/1fen_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fe/1fen_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1fen" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1fen" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Retinol-binding protein\|Retinol-binding protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:17, 8 February 2016

OCA — Mon, 08 Feb 2016 14:17:12 GMT

←Older revision		Revision as of 14:17, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fen ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:23, 10 September 2015

OCA — Thu, 10 Sep 2015 12:23:13 GMT

←Older revision		Revision as of 12:23, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1fen' size='340' side='right' caption='[[1fen]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1fen' size='340' side='right' caption='[[1fen]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1fen]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FEN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1fen]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FEN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZE:ALL-TRANS+AXEROPHTHENE'>AZE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZE:ALL-TRANS+AXEROPHTHENE'>AZE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fen OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fen RCSB], [http://www.ebi.ac.uk/pdbsum/1fen PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fen OCA], [http://pdbe.org/1fen PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fen RCSB], [http://www.ebi.ac.uk/pdbsum/1fen PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1fen" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
	[[Category: Berni, R]]		[[Category: Berni, R]]
	[[Category: Malpeli, G]]		[[Category: Malpeli, G]]

OCA at 23:56, 24 December 2014

OCA — Wed, 24 Dec 2014 23:56:14 GMT

←Older revision		Revision as of 23:56, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fen OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fen RCSB], [http://www.ebi.ac.uk/pdbsum/1fen PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fen OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fen RCSB], [http://www.ebi.ac.uk/pdbsum/1fen PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RET4_BOVIN RET4_BOVIN]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 20:59, 22 December 2014

OCA — Mon, 22 Dec 2014 20:59:24 GMT

←Older revision		Revision as of 20:59, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1fen]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FEN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1fen]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FEN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZE:ALL-TRANS+AXEROPHTHENE'>AZE</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZE:ALL-TRANS+AXEROPHTHENE'>AZE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fen OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fen RCSB], [http://www.ebi.ac.uk/pdbsum/1fen PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fen OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fen RCSB], [http://www.ebi.ac.uk/pdbsum/1fen PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Berni, R.]]	+	[[Category: Berni, R]]
-	[[Category: Malpeli, G.]]	+	[[Category: Malpeli, G]]
-	[[Category: Marcello, M.]]	+	[[Category: Marcello, M]]
-	[[Category: Sartori, G.]]	+	[[Category: Sartori, G]]
-	[[Category: Zanotti, G.]]	+	[[Category: Zanotti, G]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 10:50, 28 September 2014

OCA — Sun, 28 Sep 2014 10:50:11 GMT

←Older revision		Revision as of 10:50, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1fen.~~png\|left~~\|200px]]	+	==CRYSTALLOGRAPHIC STUDIES ON COMPLEXES BETWEEN RETINOIDS AND PLASMA RETINOL-BINDING PROTEIN==
		+	<StructureSection load='1fen' size='340' side='right' caption='[[1fen]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1fen]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FEN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZE:ALL-TRANS+AXEROPHTHENE'>AZE</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fen OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fen RCSB], [http://www.ebi.ac.uk/pdbsum/1fen PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fe/1fen_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The three-dimensional structures of complexes between bovine plasma retinol-binding protein (RBP) and three retinol analogs with different end groups (fenretinide, all-trans retinoic acid, and axerophthene) have been determined to 1.8-1.9-A resolution. Their models are very similar to that of the bovine retinol.RBP complex: the root mean square deviations between equivalent alpha-carbons in the two proteins range from 0.17 to 0.24 A. The retinoid molecules fit in the beta-barrel cavity assuming the same conformation of the vitamin, and the substitutions have no consequences on the overall protein structure. While confirming that an intact hydroxyl end group is not an absolute requirement for a correct retinoid binding to RBP, this study has shown the occurrence of conformational changes, although limited, in the rather flexible loop region at the entrance of the beta-barrel upon fenretinide and retinoic acid binding. These changes are suitable for accommodating the end groups of the above retinoids. Instead, no such changes have been revealed in RBP complexed with axerophthene, a retinol analog bearing a hydrogen atom in place of the hydroxyl end group. The protein conformational changes in the above loop region, the steric hindrance of bulky end groups of bound retinoids, and the lack of the retinol hydroxyl group appear to be responsible for the possible reduced affinity of retinoids for RBP relative to retinol and, at the same time, for the abolished or reduced affinity of retinoid.RBP complexes for transthyretin relative to retinol-RBP.

-	~~{{STRUCTURE_1fen\| PDB=1fen \| SCENE= }}~~	+	Crystallographic studies on complexes between retinoids and plasma retinol-binding protein.,Zanotti G, Marcello M, Malpeli G, Folli C, Sartori G, Berni R J Biol Chem. 1994 Nov 25;269(47):29613-20. PMID:7961949<ref>PMID:7961949</ref>

-	~~===CRYSTALLOGRAPHIC STUDIES ON COMPLEXES BETWEEN RETINOIDS AND PLASMA RETINOL-BINDING PROTEIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-		+	==See Also==
-	==~~About this Structure~~==	+	*[[Retinol-binding protein\|Retinol-binding protein]]
-	[[~~1fen~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FEN OCA].	+	== References ==
-		+	<references/>
-	==~~Reference~~==	+	__TOC__
-	<~~ref group="xtra">PMID:007961949<~~/~~ref~~><~~references group="xtra"~~/>	+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Berni, R.]]		[[Category: Berni, R.]]

OCA: Protected "1fen" [edit=sysop:move=sysop]

OCA — Wed, 14 Nov 2012 07:27:38 GMT

Protected "1fen" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:27, 14 November 2012