1fg1 - Revision history

OCA at 11:09, 28 July 2021

OCA — Wed, 28 Jul 2021 11:09:05 GMT

←Older revision		Revision as of 11:09, 28 July 2021
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	<StructureSection load='1fg1' size='340' side='right'caption='[[1fg1]]' scene=''>		<StructureSection load='1fg1' size='340' side='right'caption='[[1fg1]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1FG1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FG1 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1fg1 FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/1fg1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1fg1 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fg1 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1fg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fg1 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:16, 23 October 2019

OCA — Wed, 23 Oct 2019 09:16:29 GMT

←Older revision		Revision as of 09:16, 23 October 2019
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	==MODEL OF A HYPOTHESIZED HAMMERHEAD RIBOZYME CONFORMATIONAL CHANGE==		==MODEL OF A HYPOTHESIZED HAMMERHEAD RIBOZYME CONFORMATIONAL CHANGE==
-	<StructureSection load='1fg1' size='340' side='right' caption='[[1fg1]]' scene=''>	+	<StructureSection load='1fg1' size='340' side='right'caption='[[1fg1]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FG1 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FG1 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Murray, J B]]		[[Category: Murray, J B]]
	[[Category: Scott, W G]]		[[Category: Scott, W G]]

OCA at 09:35, 27 December 2017

OCA — Wed, 27 Dec 2017 09:35:20 GMT

←Older revision		Revision as of 09:35, 27 December 2017
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FG1 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FG1 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fg1 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1fg1 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fg1 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1fg1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1fg1 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:56, 11 February 2016

OCA — Thu, 11 Feb 2016 08:56:30 GMT

←Older revision		Revision as of 08:56, 11 February 2016
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		+	{{Theoretical_model}}
		+
	==MODEL OF A HYPOTHESIZED HAMMERHEAD RIBOZYME CONFORMATIONAL CHANGE==		==MODEL OF A HYPOTHESIZED HAMMERHEAD RIBOZYME CONFORMATIONAL CHANGE==
	<StructureSection load='1fg1' size='340' side='right' caption='[[1fg1]]' scene=''>		<StructureSection load='1fg1' size='340' side='right' caption='[[1fg1]]' scene=''>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Murray, J B]]		[[Category: Murray, J B]]
	[[Category: Scott, W G]]		[[Category: Scott, W G]]

OCA at 20:33, 10 September 2015

OCA — Thu, 10 Sep 2015 20:33:34 GMT

←Older revision		Revision as of 20:33, 10 September 2015
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1fg1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:18, 22 December 2014

OCA — Mon, 22 Dec 2014 23:18:44 GMT

←Older revision		Revision as of 23:18, 22 December 2014
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FG1 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FG1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fg1 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1fg1 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fg1 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1fg1 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:01, 28 September 2014

OCA — Sun, 28 Sep 2014 13:01:00 GMT

←Older revision		Revision as of 13:01, 28 September 2014
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-	~~{{Theoretical_model}}~~	+	==MODEL OF A HYPOTHESIZED HAMMERHEAD RIBOZYME CONFORMATIONAL CHANGE==
		+	<StructureSection load='1fg1' size='340' side='right' caption='[[1fg1]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FG1 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fg1 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1fg1 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We have constructed a model structure that we believe represents the strongest possible physically and chemically reasonable representation of a hypothesized catalytically active hammerhead ribozyme structure in which a single divalent metal ion bridges the A9 and scissile phosphate groups. It has been proposed that such a structure arises from a conformational change in which the so-called ground-state structure (as observed by X-ray crystallography) rearranges in such a way that the pro-R oxygen atoms of both the A9 and scissile phosphate groups are directly coordinated by a single divalent metal ion in the transition-state of the hammerhead ribozyme cleavage reaction. We show that even the small subset of possible model structures that are consistent with these requirements, and that are stereochemically and sterically reasonable, are contradicted by experimental evidence. We also demonstrate that even a minimal subset of assumptions, i.e. that stems I and II are helical and that the two phosphate groups are coordinated by a divalent metal ion in the standard octahedral geometry, are sufficient to lead to this contradiction. We therefore conclude that such a mechanism of hammerhead ribozyme catalysis is untenable, at least in its present formulation.

-	~~[[Image~~:~~1fg1~~.~~png\|left\|200px]]~~	+	Does a single metal ion bridge the A-9 and scissile phosphate groups in the catalytically active hammerhead ribozyme structure?,Murray JB, Scott WG J Mol Biol. 2000 Feb 11;296(1):33-41. PMID:10656816<ref>PMID:10656816</ref>

-	~~{{STRUCTURE_1fg1\| PDB=1fg1 \| SCENE= }}~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	==~~=MODEL OF A HYPOTHESIZED HAMMERHEAD RIBOZYME CONFORMATIONAL CHANGE===~~	+	== References ==
-		+	<references/>
-	~~{{ABSTRACT_PUBMED_10656816}}~~	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	<~~ref group="xtra">PMID:010656816<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Murray, J B]]		[[Category: Murray, J B]]
	[[Category: Scott, W G]]		[[Category: Scott, W G]]

OCA: Protected "1fg1" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 10:05:53 GMT

Protected "1fg1" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:05, 21 October 2012

OCA at 10:05, 21 October 2012

OCA — Sun, 21 Oct 2012 10:05:49 GMT

←Older revision		Revision as of 10:05, 21 October 2012
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	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:1fg1.png\|left\|200px]]		[[Image:1fg1.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1fg1", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1fg1\| PDB=1fg1 \| SCENE= }}		{{STRUCTURE_1fg1\| PDB=1fg1 \| SCENE= }}

	===MODEL OF A HYPOTHESIZED HAMMERHEAD RIBOZYME CONFORMATIONAL CHANGE===		===MODEL OF A HYPOTHESIZED HAMMERHEAD RIBOZYME CONFORMATIONAL CHANGE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10656816}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10656816 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_10656816}}		{{ABSTRACT_PUBMED_10656816}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FG1 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~10656816~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010656816</ref><references group="xtra"/>
	[[Category: Murray, J B]]		[[Category: Murray, J B]]
	[[Category: Scott, W G]]		[[Category: Scott, W G]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 09:32:23 2010''

OCA at 06:32, 8 April 2010

OCA — Thu, 08 Apr 2010 06:32:24 GMT

←Older revision		Revision as of 06:32, 8 April 2010
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-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:1fg1.png\|left\|200px]]

-	The ~~entry 1FG1~~ is ~~a Theoretical Model titled 'MODEL OF A HYPOTHESIZED HAMMERHEAD RIBOZYME CONFORMATIONAL CHANGE'~~.	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_1fg1", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_1fg1\| PDB=1fg1 \| SCENE= }}

-	~~[[Category:Theoretical Model]]~~	+	===MODEL OF A HYPOTHESIZED HAMMERHEAD RIBOZYME CONFORMATIONAL CHANGE===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30~~ 09:49:~~44 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_10656816}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 10656816 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_10656816}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FG1 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:10656816</ref><references group="xtra"/>
		+	[[Category: Murray, J B]]
		+	[[Category: Scott, W G]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 09:32:23 2010''