1fnl - Revision history

OCA at 11:14, 27 March 2024

OCA — Wed, 27 Mar 2024 11:14:34 GMT

←Older revision		Revision as of 11:14, 27 March 2024
Line 3:		Line 3:
	<StructureSection load='1fnl' size='340' side='right'caption='[[1fnl]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1fnl' size='340' side='right'caption='[[1fnl]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1fnl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FNL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1fnl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FNL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnl OCA], [https://pdbe.org/1fnl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fnl RCSB], [https://www.ebi.ac.uk/pdbsum/1fnl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fnl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnl OCA], [https://pdbe.org/1fnl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fnl RCSB], [https://www.ebi.ac.uk/pdbsum/1fnl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fnl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FCG3B_HUMAN FCG3B_HUMAN]] Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.	+	[https://www.uniprot.org/uniprot/FCG3B_HUMAN FCG3B_HUMAN] Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fnl ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fnl ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Fc receptors play a major role in immune defenses against pathogens and in inflammatory processes. The crystal structure of a human immunoglobulin receptor, FcgammaRIIIb, has been determined to 1.8 A resolution. The overall fold consists of two immunoglobulin-like domains with an acute interdomain hinge angle of approximately 50 degrees. Trp-113, wedged between the N-terminal D1 and the C-terminal D2 domains, appears to further restrict the hinge angle. The putative Fc binding region of the receptor carries a net positive charge complementary to the negative-charged receptor binding regions on Fc. A 1:1 binding stoichiometry between the receptor and Fc was measured by both the equilibrium and nonequilibrium size-exclusion chromatography. Two separate parallel dimers are observed in the crystal lattice, offering intriguing models for receptor aggregation.
-
-	Crystal structure of the extracellular domain of a human Fc gamma RIII.,Zhang Y, Boesen CC, Radaev S, Brooks AG, Fridman WH, Sautes-Fridman C, Sun PD Immunity. 2000 Sep;13(3):387-95. PMID:11021536<ref>PMID:11021536</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1fnl" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Boesen~~, C C~~]]	+	[[Category: Boesen CC]]
-	[[Category: Brooks~~, A G~~]]	+	[[Category: Brooks AG]]
-	[[Category: Fridman~~, W H~~]]	+	[[Category: Fridman WH]]
-	[[Category: Radaev, S]]	+	[[Category: Radaev S]]
-	[[Category: Sautes-Fridman, C]]	+	[[Category: Sautes-Fridman C]]
-	[[Category: Sun~~, P D~~]]	+	[[Category: Sun PD]]
-	[[Category: Zhang, Y]]	+	[[Category: Zhang Y]]
-	~~[[Category: Beta sandwich]]~~	+
-	~~[[Category: Immune system receptor]]~~	+
-	~~[[Category: Immunoglobulin-like]]~~	+
-	~~[[Category: Receptor~~]]	+

OCA at 07:06, 24 March 2021

OCA — Wed, 24 Mar 2021 07:06:33 GMT

←Older revision		Revision as of 07:06, 24 March 2021
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	<StructureSection load='1fnl' size='340' side='right'caption='[[1fnl]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1fnl' size='340' side='right'caption='[[1fnl]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1fnl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1FNL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1fnl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FNL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1fnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnl OCA], [~~http~~://pdbe.org/1fnl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1fnl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1fnl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1fnl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnl OCA], [https://pdbe.org/1fnl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fnl RCSB], [https://www.ebi.ac.uk/pdbsum/1fnl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fnl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FCG3B_HUMAN FCG3B_HUMAN]] Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.	+	[[https://www.uniprot.org/uniprot/FCG3B_HUMAN FCG3B_HUMAN]] Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:13, 19 June 2019

OCA — Wed, 19 Jun 2019 07:13:57 GMT

←Older revision		Revision as of 07:13, 19 June 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII==		==CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII==
-	<StructureSection load='1fnl' size='340' side='right' caption='[[1fnl]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1fnl' size='340' side='right'caption='[[1fnl]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1fnl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FNL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1fnl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FNL FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fn/1fnl_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fn/1fnl_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Boesen, C C]]		[[Category: Boesen, C C]]
	[[Category: Brooks, A G]]		[[Category: Brooks, A G]]

OCA at 10:39, 13 September 2017

OCA — Wed, 13 Sep 2017 10:39:09 GMT

←Older revision		Revision as of 10:39, 13 September 2017
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII==		==CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII==
	<StructureSection load='1fnl' size='340' side='right' caption='[[1fnl]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1fnl' size='340' side='right' caption='[[1fnl]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1fnl]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FNL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1fnl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FNL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnl OCA], [http://pdbe.org/1fnl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fnl RCSB], [http://www.ebi.ac.uk/pdbsum/1fnl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnl OCA], [http://pdbe.org/1fnl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fnl RCSB], [http://www.ebi.ac.uk/pdbsum/1fnl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1fnl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fnl ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Boesen, C C]]		[[Category: Boesen, C C]]
	[[Category: Brooks, A G]]		[[Category: Brooks, A G]]

OCA at 13:50, 11 September 2015

OCA — Fri, 11 Sep 2015 13:50:51 GMT

←Older revision		Revision as of 13:50, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1fnl' size='340' side='right' caption='[[1fnl]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1fnl' size='340' side='right' caption='[[1fnl]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1fnl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FNL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1fnl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FNL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fnl RCSB], [http://www.ebi.ac.uk/pdbsum/1fnl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnl OCA], [http://pdbe.org/1fnl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fnl RCSB], [http://www.ebi.ac.uk/pdbsum/1fnl PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1fnl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Boesen, C C]]		[[Category: Boesen, C C]]
	[[Category: Brooks, A G]]		[[Category: Brooks, A G]]

OCA at 17:19, 25 December 2014

OCA — Thu, 25 Dec 2014 17:19:24 GMT

←Older revision		Revision as of 17:19, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fnl RCSB], [http://www.ebi.ac.uk/pdbsum/1fnl PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fnl RCSB], [http://www.ebi.ac.uk/pdbsum/1fnl PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FCG3B_HUMAN FCG3B_HUMAN]] Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 22:08, 22 December 2014

OCA — Mon, 22 Dec 2014 22:08:09 GMT

←Older revision		Revision as of 22:08, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1fnl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FNL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1fnl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FNL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fnl RCSB], [http://www.ebi.ac.uk/pdbsum/1fnl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fnl RCSB], [http://www.ebi.ac.uk/pdbsum/1fnl PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Boesen, C C.]]	+	[[Category: Boesen, C C]]
-	[[Category: Brooks, A G.]]	+	[[Category: Brooks, A G]]
-	[[Category: Fridman, W H.]]	+	[[Category: Fridman, W H]]
-	[[Category: Radaev, S.]]	+	[[Category: Radaev, S]]
-	[[Category: Sautes-Fridman, C.]]	+	[[Category: Sautes-Fridman, C]]
-	[[Category: Sun, P D.]]	+	[[Category: Sun, P D]]
-	[[Category: Zhang, Y.]]	+	[[Category: Zhang, Y]]
	[[Category: Beta sandwich]]		[[Category: Beta sandwich]]
	[[Category: Immune system receptor]]		[[Category: Immune system receptor]]
	[[Category: Immunoglobulin-like]]		[[Category: Immunoglobulin-like]]
	[[Category: Receptor]]		[[Category: Receptor]]

OCA at 12:00, 28 September 2014

OCA — Sun, 28 Sep 2014 12:00:56 GMT

←Older revision		Revision as of 12:00, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1fnl.~~png\|left~~\|200px]]	+	==CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII==
		+	<StructureSection load='1fnl' size='340' side='right' caption='[[1fnl]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1fnl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FNL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fnl RCSB], [http://www.ebi.ac.uk/pdbsum/1fnl PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fn/1fnl_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Fc receptors play a major role in immune defenses against pathogens and in inflammatory processes. The crystal structure of a human immunoglobulin receptor, FcgammaRIIIb, has been determined to 1.8 A resolution. The overall fold consists of two immunoglobulin-like domains with an acute interdomain hinge angle of approximately 50 degrees. Trp-113, wedged between the N-terminal D1 and the C-terminal D2 domains, appears to further restrict the hinge angle. The putative Fc binding region of the receptor carries a net positive charge complementary to the negative-charged receptor binding regions on Fc. A 1:1 binding stoichiometry between the receptor and Fc was measured by both the equilibrium and nonequilibrium size-exclusion chromatography. Two separate parallel dimers are observed in the crystal lattice, offering intriguing models for receptor aggregation.

-	~~{{STRUCTURE_1fnl\| PDB=1fnl \| SCENE= }}~~	+	Crystal structure of the extracellular domain of a human Fc gamma RIII.,Zhang Y, Boesen CC, Radaev S, Brooks AG, Fridman WH, Sautes-Fridman C, Sun PD Immunity. 2000 Sep;13(3):387-95. PMID:11021536<ref>PMID:11021536</ref>

-	~~===CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11021536}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1fnl]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011021536<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Boesen, C C.]]		[[Category: Boesen, C C.]]

OCA: Protected "1fnl" [edit=sysop:move=sysop]

OCA — Wed, 21 Nov 2012 10:01:54 GMT

Protected "1fnl" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:01, 21 November 2012

OCA at 10:01, 21 November 2012

OCA — Wed, 21 Nov 2012 10:01:51 GMT

←Older revision		Revision as of 10:01, 21 November 2012
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-	{{Seed}}
	[[Image:1fnl.png\|left\|200px]]		[[Image:1fnl.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1fnl", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1fnl\| PDB=1fnl \| SCENE= }}		{{STRUCTURE_1fnl\| PDB=1fnl \| SCENE= }}

	===CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII===		===CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11021536}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11021536 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11021536}}		{{ABSTRACT_PUBMED_11021536}}

	==About this Structure==		==About this Structure==
-	~~1FNL~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA].	+	[[1fnl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11021536~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011021536</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Boesen, C C.]]		[[Category: Boesen, C C.]]
Line 33:		Line 21:
	[[Category: Zhang, Y.]]		[[Category: Zhang, Y.]]
	[[Category: Beta sandwich]]		[[Category: Beta sandwich]]
		+	[[Category: Immune system receptor]]
	[[Category: Immunoglobulin-like]]		[[Category: Immunoglobulin-like]]
	[[Category: Receptor]]		[[Category: Receptor]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:00:31 2009''