1fnw - Revision history

OCA at 14:15, 29 November 2023

OCA — Wed, 29 Nov 2023 14:15:37 GMT

←Older revision		Revision as of 14:15, 29 November 2023
Line 3:		Line 3:
	<StructureSection load='1fnw' size='340' side='right'caption='[[1fnw]], [[Resolution\|resolution]] 3.90Å' scene=''>		<StructureSection load='1fnw' size='340' side='right'caption='[[1fnw]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1fnw]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Streptococcus_pyogenes_phage_t12~~ Streptococcus ~~pyogenes~~ phage ~~t12~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FNW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1fnw]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_phage_T12 Streptococcus phage T12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FNW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1fnv\|1fnv]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnw OCA], [https://pdbe.org/1fnw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fnw RCSB], [https://www.ebi.ac.uk/pdbsum/1fnw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fnw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnw OCA], [https://pdbe.org/1fnw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fnw RCSB], [https://www.ebi.ac.uk/pdbsum/1fnw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fnw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SPEA_STRPY SPEA_STRPY]] Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever.	+	[https://www.uniprot.org/uniprot/SPEA_STRPY SPEA_STRPY] Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Streptococcus ~~pyogenes~~ phage ~~t12~~]]	+	[[Category: Streptococcus phage T12]]
-	[[Category: Earhart~~, C A~~]]	+	[[Category: Earhart CA]]
-	[[Category: Ohlendorf~~, D H~~]]	+	[[Category: Ohlendorf DH]]
-	[[Category: Roggiani, M]]	+	[[Category: Roggiani M]]
-	[[Category: Schlivert~~, P M~~]]	+	[[Category: Schlivert PM]]
-	[[Category: Vath~~, G M]]~~	+	[[Category: Vath GM]]
-	~~[[Category: Exotoxin some]]~~	+
-	~~[[Category: Superantigen]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 11:12, 28 July 2021

OCA — Wed, 28 Jul 2021 11:12:20 GMT

←Older revision		Revision as of 11:12, 28 July 2021
Line 3:		Line 3:
	<StructureSection load='1fnw' size='340' side='right'caption='[[1fnw]], [[Resolution\|resolution]] 3.90Å' scene=''>		<StructureSection load='1fnw' size='340' side='right'caption='[[1fnw]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1fnw]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Streptococcus_pyogenes_phage_t12 Streptococcus pyogenes phage t12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1FNW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1fnw]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_phage_t12 Streptococcus pyogenes phage t12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FNW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fnv\|1fnv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fnv\|1fnv]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1fnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnw OCA], [~~http~~://pdbe.org/1fnw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1fnw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1fnw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1fnw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnw OCA], [https://pdbe.org/1fnw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fnw RCSB], [https://www.ebi.ac.uk/pdbsum/1fnw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fnw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SPEA_STRPY SPEA_STRPY]] Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever.	+	[[https://www.uniprot.org/uniprot/SPEA_STRPY SPEA_STRPY]] Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:47, 23 October 2019

OCA — Wed, 23 Oct 2019 08:47:51 GMT

←Older revision		Revision as of 08:47, 23 October 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF STREPTOCOCCAL PYROGENIC EXOTOXIN A==		==CRYSTAL STRUCTURE OF STREPTOCOCCAL PYROGENIC EXOTOXIN A==
-	<StructureSection load='1fnw' size='340' side='right' caption='[[1fnw]], [[Resolution\|resolution]] 3.90Å' scene=''>	+	<StructureSection load='1fnw' size='340' side='right'caption='[[1fnw]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1fnw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_phage_t12 Streptococcus pyogenes phage t12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FNW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1fnw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_phage_t12 Streptococcus pyogenes phage t12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FNW FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 1fnw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1fnw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Exotoxin 3D structures\|Exotoxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Streptococcus pyogenes phage t12]]		[[Category: Streptococcus pyogenes phage t12]]
	[[Category: Earhart, C A]]		[[Category: Earhart, C A]]

OCA at 09:34, 27 December 2017

OCA — Wed, 27 Dec 2017 09:34:23 GMT

←Older revision		Revision as of 09:34, 27 December 2017
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF STREPTOCOCCAL PYROGENIC EXOTOXIN A==		==CRYSTAL STRUCTURE OF STREPTOCOCCAL PYROGENIC EXOTOXIN A==
	<StructureSection load='1fnw' size='340' side='right' caption='[[1fnw]], [[Resolution\|resolution]] 3.90Å' scene=''>		<StructureSection load='1fnw' size='340' side='right' caption='[[1fnw]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1fnw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_phage_t12~~ Streptococcus phage t12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FNW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1fnw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_phage_t12 Streptococcus pyogenes phage t12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FNW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fnv\|1fnv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fnv\|1fnv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnw OCA], [http://pdbe.org/1fnw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fnw RCSB], [http://www.ebi.ac.uk/pdbsum/1fnw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnw OCA], [http://pdbe.org/1fnw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fnw RCSB], [http://www.ebi.ac.uk/pdbsum/1fnw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1fnw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fn/1fnw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fn/1fnw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1fnw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1fnw" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Exotoxin\|Exotoxin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Streptococcus phage t12]]	+	[[Category: Streptococcus pyogenes phage t12]]
	[[Category: Earhart, C A]]		[[Category: Earhart, C A]]
	[[Category: Ohlendorf, D H]]		[[Category: Ohlendorf, D H]]

OCA at 15:03, 9 February 2016

OCA — Tue, 09 Feb 2016 15:03:15 GMT

←Older revision		Revision as of 15:03, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fnw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:24, 10 September 2015

OCA — Thu, 10 Sep 2015 23:24:01 GMT

←Older revision		Revision as of 23:24, 10 September 2015
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	<StructureSection load='1fnw' size='340' side='right' caption='[[1fnw]], [[Resolution\|resolution]] 3.90Å' scene=''>		<StructureSection load='1fnw' size='340' side='right' caption='[[1fnw]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1fnw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_pyogenes_phage_t12~~ Streptococcus ~~pyogenes~~ phage t12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FNW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1fnw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_phage_t12 Streptococcus phage t12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FNW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fnv\|1fnv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fnv\|1fnv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fnw RCSB], [http://www.ebi.ac.uk/pdbsum/1fnw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnw OCA], [http://pdbe.org/1fnw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fnw RCSB], [http://www.ebi.ac.uk/pdbsum/1fnw PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1fnw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Streptococcus ~~pyogenes~~ phage t12]]	+	[[Category: Streptococcus phage t12]]
	[[Category: Earhart, C A]]		[[Category: Earhart, C A]]
	[[Category: Ohlendorf, D H]]		[[Category: Ohlendorf, D H]]

OCA at 07:34, 25 December 2014

OCA — Thu, 25 Dec 2014 07:34:14 GMT

←Older revision		Revision as of 07:34, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fnw RCSB], [http://www.ebi.ac.uk/pdbsum/1fnw PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fnw RCSB], [http://www.ebi.ac.uk/pdbsum/1fnw PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SPEA_STRPY SPEA_STRPY]] Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 19:31, 22 December 2014

OCA — Mon, 22 Dec 2014 19:31:25 GMT

←Older revision		Revision as of 19:31, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1fnw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_phage_t12 Streptococcus pyogenes phage t12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FNW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1fnw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_phage_t12 Streptococcus pyogenes phage t12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FNW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fnv\|1fnv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fnv\|1fnv]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fnw RCSB], [http://www.ebi.ac.uk/pdbsum/1fnw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fnw RCSB], [http://www.ebi.ac.uk/pdbsum/1fnw PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Streptococcus pyogenes phage t12]]		[[Category: Streptococcus pyogenes phage t12]]
-	[[Category: Earhart, C A.]]	+	[[Category: Earhart, C A]]
-	[[Category: Ohlendorf, D H.]]	+	[[Category: Ohlendorf, D H]]
-	[[Category: Roggiani, M.]]	+	[[Category: Roggiani, M]]
-	[[Category: Schlivert, P M.]]	+	[[Category: Schlivert, P M]]
-	[[Category: Vath, G M.]]	+	[[Category: Vath, G M]]
	[[Category: Exotoxin some]]		[[Category: Exotoxin some]]
	[[Category: Superantigen]]		[[Category: Superantigen]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 09:24, 28 September 2014

OCA — Sun, 28 Sep 2014 09:24:27 GMT

←Older revision		Revision as of 09:24, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1fnw.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF STREPTOCOCCAL PYROGENIC EXOTOXIN A==
		+	<StructureSection load='1fnw' size='340' side='right' caption='[[1fnw]], [[Resolution\|resolution]] 3.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1fnw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_phage_t12 Streptococcus pyogenes phage t12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FNW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fnv\|1fnv]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fnw RCSB], [http://www.ebi.ac.uk/pdbsum/1fnw PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fn/1fnw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The streptococcal pyrogenic toxins A, B, and C (SPEA, SPEB, and SPEC) are responsible for the fever, rash, and other toxicities associated with scarlet fever and streptococcal toxic shock syndrome. This role, together with the ubiquity of diseases caused by Streptococcus pyogenes, have prompted structural analyses of SPEA by several groups. Papageorgiou et al. (1999) have recently reported the structure of SPEA crystallized in the absence of zinc. Zinc has been shown to be important in the ability of some staphylococcal and streptococcal toxins to stimulate proliferation of CD4+ T-cells. Since cadmium is more electron dense than zinc and typically binds interchangeably, we grew crystals in the presence of 10 mM CdCl2. Crystals have been obtained in three space groups, and the structure in the P2(1)2(1)2(1) crystal form has been refined to 1.9 A resolution. The structural analysis revealed an identical tetramer as well as a novel tetrahedral cluster of cadmium in all three crystal forms on a disulfide loop encompassing residues 87-98. No cadmium was bound at the site homologous to the zinc site in staphylococcal enterotoxins C (SECs) despite the high structural homology between SPEA and SECs. Subsequent soaking of crystals grown in the presence of cadmium in 10 mM ZnCl2 showed that zinc binds in this site (indicating it can discriminate between zinc and cadmium ions) using the three ligands (Asp77, His106, and His110) homologous to the SECs plus a fourth ligand (Glu33).

-	~~{{STRUCTURE_1fnw\| PDB=1fnw \| SCENE= }}~~	+	Structure of streptococcal pyrogenic exotoxin A reveals a novel metal cluster.,Earhart CA, Vath GM, Roggiani M, Schlievert PM, Ohlendorf DH Protein Sci. 2000 Sep;9(9):1847-51. PMID:11045630<ref>PMID:11045630</ref>

-	~~===CRYSTAL STRUCTURE OF STREPTOCOCCAL PYROGENIC EXOTOXIN A===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_11045630}}~~	+	==See Also==
-		+	*[[Exotoxin\|Exotoxin]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1fnw~~]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_phage_t12 Streptococcus pyogenes phage t12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNW OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:011045630<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Streptococcus pyogenes phage t12]]		[[Category: Streptococcus pyogenes phage t12]]
	[[Category: Earhart, C A.]]		[[Category: Earhart, C A.]]

OCA: Protected "1fnw" [edit=sysop:move=sysop]

OCA — Wed, 21 Nov 2012 10:16:48 GMT

Protected "1fnw" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:16, 21 November 2012