1foz - Revision history

OCA at 09:31, 28 December 2022

OCA — Wed, 28 Dec 2022 09:31:30 GMT

←Older revision		Revision as of 09:31, 28 December 2022
Line 1:		Line 1:

	==STRUCTURE OF CYCLIC PEPTIDE INHIBITORS OF MAMMALIAN RIBONUCLEOTIDE REDUCTASE==		==STRUCTURE OF CYCLIC PEPTIDE INHIBITORS OF MAMMALIAN RIBONUCLEOTIDE REDUCTASE==
-	<StructureSection load='1foz' size='340' side='right'caption='[[1foz~~]], [[NMR_Ensembles_of_Models \| 3 NMR models~~]]' scene=''>	+	<StructureSection load='1foz' size='340' side='right'caption='[[1foz]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1foz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FOZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1foz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FOZ FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1foz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1foz OCA], [https://pdbe.org/1foz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1foz RCSB], [https://www.ebi.ac.uk/pdbsum/1foz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1foz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1foz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1foz OCA], [https://pdbe.org/1foz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1foz RCSB], [https://www.ebi.ac.uk/pdbsum/1foz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1foz ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cooperman~~, B S~~]]	+	[[Category: Cooperman BS]]
-	[[Category: Fisher~~, A L~~]]	+	[[Category: Fisher AL]]
-	[[Category: Liehr, S]]	+	[[Category: Liehr S]]
-	[[Category: Mierke~~, D F~~]]	+	[[Category: Mierke DF]]
-	[[Category: Pellegrini, M]]	+	[[Category: Pellegrini M]]
-	~~[[Category: Irma refinement]]~~	+
-	~~[[Category: Oxidoreductase inhibitor]]~~	+
-	~~[[Category: Ribonucleotide reductase inhibitor]]~~	+
-	~~[[Category: Transferred no~~]]	+

OCA at 07:07, 24 March 2021

OCA — Wed, 24 Mar 2021 07:07:02 GMT

←Older revision		Revision as of 07:07, 24 March 2021
Line 3:		Line 3:
	<StructureSection load='1foz' size='340' side='right'caption='[[1foz]], [[NMR_Ensembles_of_Models \| 3 NMR models]]' scene=''>		<StructureSection load='1foz' size='340' side='right'caption='[[1foz]], [[NMR_Ensembles_of_Models \| 3 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1foz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1FOZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1foz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FOZ FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1foz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1foz OCA], [~~http~~://pdbe.org/1foz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1foz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1foz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1foz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1foz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1foz OCA], [https://pdbe.org/1foz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1foz RCSB], [https://www.ebi.ac.uk/pdbsum/1foz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1foz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:24, 19 June 2019

OCA — Wed, 19 Jun 2019 07:24:06 GMT

←Older revision		Revision as of 07:24, 19 June 2019
Line 1:		Line 1:

	==STRUCTURE OF CYCLIC PEPTIDE INHIBITORS OF MAMMALIAN RIBONUCLEOTIDE REDUCTASE==		==STRUCTURE OF CYCLIC PEPTIDE INHIBITORS OF MAMMALIAN RIBONUCLEOTIDE REDUCTASE==
-	<StructureSection load='1foz' size='340' side='right' caption='[[1foz]], [[NMR_Ensembles_of_Models \| 3 NMR models]]' scene=''>	+	<StructureSection load='1foz' size='340' side='right'caption='[[1foz]], [[NMR_Ensembles_of_Models \| 3 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1foz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FOZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1foz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FOZ FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Cooperman, B S]]		[[Category: Cooperman, B S]]
	[[Category: Fisher, A L]]		[[Category: Fisher, A L]]

OCA at 10:48, 13 September 2017

OCA — Wed, 13 Sep 2017 10:48:24 GMT

←Older revision		Revision as of 10:48, 13 September 2017
Line 1:		Line 1:
		+
	==STRUCTURE OF CYCLIC PEPTIDE INHIBITORS OF MAMMALIAN RIBONUCLEOTIDE REDUCTASE==		==STRUCTURE OF CYCLIC PEPTIDE INHIBITORS OF MAMMALIAN RIBONUCLEOTIDE REDUCTASE==
	<StructureSection load='1foz' size='340' side='right' caption='[[1foz]], [[NMR_Ensembles_of_Models \| 3 NMR models]]' scene=''>		<StructureSection load='1foz' size='340' side='right' caption='[[1foz]], [[NMR_Ensembles_of_Models \| 3 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1foz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FOZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1foz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FOZ FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1foz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1foz OCA], [http://pdbe.org/1foz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1foz RCSB], [http://www.ebi.ac.uk/pdbsum/1foz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1foz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1foz OCA], [http://pdbe.org/1foz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1foz RCSB], [http://www.ebi.ac.uk/pdbsum/1foz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1foz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:22, 10 September 2015

OCA — Thu, 10 Sep 2015 20:22:12 GMT

←Older revision		Revision as of 20:22, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1foz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FOZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1foz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FOZ FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1foz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1foz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1foz RCSB], [http://www.ebi.ac.uk/pdbsum/1foz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1foz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1foz OCA], [http://pdbe.org/1foz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1foz RCSB], [http://www.ebi.ac.uk/pdbsum/1foz PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1foz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:37, 22 December 2014

OCA — Mon, 22 Dec 2014 06:37:49 GMT

←Older revision		Revision as of 06:37, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1foz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FOZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1foz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FOZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1foz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1foz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1foz RCSB], [http://www.ebi.ac.uk/pdbsum/1foz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1foz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1foz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1foz RCSB], [http://www.ebi.ac.uk/pdbsum/1foz PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cooperman, B S.]]	+	[[Category: Cooperman, B S]]
-	[[Category: Fisher, A L.]]	+	[[Category: Fisher, A L]]
-	[[Category: Liehr, S.]]	+	[[Category: Liehr, S]]
-	[[Category: Mierke, D F.]]	+	[[Category: Mierke, D F]]
-	[[Category: Pellegrini, M.]]	+	[[Category: Pellegrini, M]]
	[[Category: Irma refinement]]		[[Category: Irma refinement]]
	[[Category: Oxidoreductase inhibitor]]		[[Category: Oxidoreductase inhibitor]]
	[[Category: Ribonucleotide reductase inhibitor]]		[[Category: Ribonucleotide reductase inhibitor]]
	[[Category: Transferred no]]		[[Category: Transferred no]]

OCA at 05:40, 8 June 2014

OCA — Sun, 08 Jun 2014 05:40:31 GMT

←Older revision		Revision as of 05:40, 8 June 2014
Line 1:		Line 1:
-	[[~~Image:~~1foz.~~png~~\|~~left\|200px~~]]	+	==STRUCTURE OF CYCLIC PEPTIDE INHIBITORS OF MAMMALIAN RIBONUCLEOTIDE REDUCTASE==
		+	<StructureSection load='1foz' size='340' side='right' caption='[[1foz]], [[NMR_Ensembles_of_Models \| 3 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1foz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FOZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1foz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1foz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1foz RCSB], [http://www.ebi.ac.uk/pdbsum/1foz PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mammalian ribonucleotide reductase (mRR), a potential target for cancer intervention, is composed of two subunits, mR1 and mR2, whose association is critical for enzyme activity. In this article we describe the structural features of the mRR-inhibitor Ac-F-c[ELAK]-DF (Peptide 3) while bound to the mR1 subunit as determined by transferred NOEs. Peptide 3 is a cyclic analogue of the N-acetylated form of the heptapeptide C-terminus of the mR2 subunit (Ac-FTLDADF), which is the link between the two subunits and previously shown to be the minimal sequence inhibitor mRR by competing with mR2 for binding to mR1. Structural refinement employing an ensemble-based, full-relaxation matrix approach resulted in two structures varying in the conformations of F(1) and the cyclic lactam side chains of E(2) and K(5). The remainder of the molecule, both backbone and side chains, is extremely well-defined, with an RMSD of 0.54 A. The structural features of this conformationally constrained analogue provide unique insight into the requirements for binding to mR1, critical for further inhibitor development.

-	~~{{STRUCTURE_1foz\| PDB=1foz \| SCENE= }}~~	+	Structure-based optimization of peptide inhibitors of mammalian ribonucleotide reductase.,Pellegrini M, Liehr S, Fisher AL, Laub PB, Cooperman BS, Mierke DF Biochemistry. 2000 Oct 10;39(40):12210-5. PMID:11015199<ref>PMID:11015199</ref>

-	~~===STRUCTURE OF CYCLIC PEPTIDE INHIBITORS OF MAMMALIAN RIBONUCLEOTIDE REDUCTASE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11015199}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1foz]] is~~ a ~~1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1FOZ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011015199<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Cooperman, B S.]]		[[Category: Cooperman, B S.]]
	[[Category: Fisher, A L.]]		[[Category: Fisher, A L.]]

OCA: Protected "1foz" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 18:53:51 GMT

Protected "1foz" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:53, 14 August 2012

OCA at 18:53, 14 August 2012

OCA — Tue, 14 Aug 2012 18:53:49 GMT

←Older revision		Revision as of 18:53, 14 August 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1foz.png\|left\|200px]]		[[Image:1foz.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1foz", creates the "Structure Box" on the page.
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-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1foz\| PDB=1foz \| SCENE= }}		{{STRUCTURE_1foz\| PDB=1foz \| SCENE= }}

	===STRUCTURE OF CYCLIC PEPTIDE INHIBITORS OF MAMMALIAN RIBONUCLEOTIDE REDUCTASE===		===STRUCTURE OF CYCLIC PEPTIDE INHIBITORS OF MAMMALIAN RIBONUCLEOTIDE REDUCTASE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11015199}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11015199 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11015199}}		{{ABSTRACT_PUBMED_11015199}}

	==About this Structure==		==About this Structure==
-	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOZ OCA].	+	[[1foz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOZ OCA].

	==Reference==		==Reference==
-	~~Structure-based optimization of peptide inhibitors of mammalian ribonucleotide reductase., Pellegrini M, Liehr S, Fisher AL, Laub PB, Cooperman BS, Mierke DF, Biochemistry. 2000 Oct 10;39(40):12210-5.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~11015199 11015199]~~	+	<ref group="xtra">PMID:011015199</ref><references group="xtra"/>
	[[Category: Cooperman, B S.]]		[[Category: Cooperman, B S.]]
	[[Category: Fisher, A L.]]		[[Category: Fisher, A L.]]
Line 30:		Line 18:
	[[Category: Pellegrini, M.]]		[[Category: Pellegrini, M.]]
	[[Category: Irma refinement]]		[[Category: Irma refinement]]
		+	[[Category: Oxidoreductase inhibitor]]
	[[Category: Ribonucleotide reductase inhibitor]]		[[Category: Ribonucleotide reductase inhibitor]]
	[[Category: Transferred no]]		[[Category: Transferred no]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:42:48 2008''

OCA at 00:42, 1 July 2008

OCA — Tue, 01 Jul 2008 00:42:49 GMT

←Older revision		Revision as of 00:42, 1 July 2008
Line 1:		Line 1:
-	[[Image:1foz.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1foz.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1foz\| PDB=1foz \| SCENE= }}		{{STRUCTURE_1foz\| PDB=1foz \| SCENE= }}

-	~~'''~~STRUCTURE OF CYCLIC PEPTIDE INHIBITORS OF MAMMALIAN RIBONUCLEOTIDE REDUCTASE~~'''~~	+	===STRUCTURE OF CYCLIC PEPTIDE INHIBITORS OF MAMMALIAN RIBONUCLEOTIDE REDUCTASE===


-	~~==Overview==~~	+	<!--
-	~~Mammalian ribonucleotide reductase (mRR)~~, ~~a potential target for cancer intervention~~, ~~is composed of two subunits, mR1 and mR2, whose association is critical for enzyme activity. In this article we describe~~ the ~~structural features of~~ the ~~mRR-inhibitor Ac-F-c[ELAK]-DF~~ (~~Peptide 3) while bound to the mR1 subunit~~ as ~~determined by transferred NOEs~~. ~~Peptide 3 is a cyclic analogue of the N-acetylated form of the heptapeptide C-terminus of the mR2 subunit (Ac-FTLDADF~~), ~~which~~ is the ~~link between the two subunits and previously shown to be the minimal sequence inhibitor mRR by competing with mR2 for binding to mR1~~. ~~Structural refinement employing an ensemble~~-~~based, full~~-relaxation matrix approach resulted in two structures varying in the conformations of F(1) and the cyclic lactam side chains of E(2) and K(5). The remainder of the molecule, both backbone and side chains, is extremely well-defined, with an RMSD of 0.54 A. The structural features of this conformationally constrained analogue provide unique insight into the requirements for binding to mR1, critical for further inhibitor development.	+	The line below this paragraph, {{ABSTRACT_PUBMED_11015199}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 11015199 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_11015199}}

	==About this Structure==		==About this Structure==
-	Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOZ OCA].	+	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOZ OCA].

	==Reference==		==Reference==
Line 28:		Line 32:
	[[Category: Ribonucleotide reductase inhibitor]]		[[Category: Ribonucleotide reductase inhibitor]]
	[[Category: Transferred no]]		[[Category: Transferred no]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 16~~:35:40 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:42:48 2008''