1fv3 - Revision history

OCA at 11:16, 27 March 2024

OCA — Wed, 27 Mar 2024 11:16:52 GMT

←Older revision		Revision as of 11:16, 27 March 2024
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	<StructureSection load='1fv3' size='340' side='right'caption='[[1fv3]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1fv3' size='340' side='right'caption='[[1fv3]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1fv3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_tetani"_flugge_1886 "bacillus~~ tetani~~" flugge 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FV3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1fv3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FV3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CEQ:ETHYL-TRIMETHYL-SILANE'>CEQ~~</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4~~</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	~~<tr id~~='~~NonStdRes'><td class~~=~~"sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res~~:~~]]</b~~></~~td><td class="sblockDat"~~><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene~~></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CEQ:ETHYL-TRIMETHYL-SILANE'>CEQ</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1d0h\|1d0h]], [[1dll\|1dll]], [[1diw\|1diw]], [[1dfq\|1dfq]], [[1af9\|1af9]], [[1a8d\|1a8d]], [[1fv2\|1fv2]]</div></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fv3 OCA], [https://pdbe.org/1fv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fv3 RCSB], [https://www.ebi.ac.uk/pdbsum/1fv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fv3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fv3 OCA], [https://pdbe.org/1fv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fv3 RCSB], [https://www.ebi.ac.uk/pdbsum/1fv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fv3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE]] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-\|-Phe-77' bond of synaptobrevin-2.	+	[https://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-\|-Phe-77' bond of synaptobrevin-2.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fv3 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fv3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Tetanus toxin, a member of the family of Clostridial neurotoxins, is one of the most potent toxins known. The crystal structure of the complex of the COOH-terminal fragment of the heavy chain with an analogue of its ganglioside receptor, GT1b, provides the first direct identification and characterization of the ganglioside-binding sites. The ganglioside induces cross-linking by binding to two distinct sites on the Hc molecule. The structure sheds new light on the binding of Clostridial neurotoxins to receptors on neuronal cells and provides important information relevant to the design of anti-tetanus and anti-botulism therapeutic agents.
-
-	The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin.,Fotinou C, Emsley P, Black I, Ando H, Ishida H, Kiso M, Sinha KA, Fairweather NF, Isaacs NW J Biol Chem. 2001 Aug 24;276(34):32274-81. Epub 2001 Jun 19. PMID:11418600<ref>PMID:11418600</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1fv3" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Tetanus toxin\|Tetanus toxin]]		*[[Tetanus toxin\|Tetanus toxin]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ tetani ~~flugge 1886~~]]	+	[[Category: Clostridium tetani]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ando, H]]	+	[[Category: Ando H]]
-	[[Category: Black, I]]	+	[[Category: Black I]]
-	[[Category: Emsley, P]]	+	[[Category: Emsley P]]
-	[[Category: Fairweather~~, N F~~]]	+	[[Category: Fairweather NF]]
-	[[Category: Fotinou, C]]	+	[[Category: Fotinou C]]
-	[[Category: Isaacs~~, N W~~]]	+	[[Category: Isaacs NW]]
-	[[Category: Ishida, H]]	+	[[Category: Ishida H]]
-	[[Category: Kiso, M]]	+	[[Category: Kiso M]]
-	[[Category: Sinha~~, K A]]~~	+	[[Category: Sinha KA]]
-	~~[[Category: Carbohydrate]]~~	+
-	~~[[Category: Ganglioside]]~~	+
-	~~[[Category: Multi-valent binding]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 09:18, 29 September 2021

OCA — Wed, 29 Sep 2021 09:18:25 GMT

←Older revision		Revision as of 09:18, 29 September 2021
Line 3:		Line 3:
	<StructureSection load='1fv3' size='340' side='right'caption='[[1fv3]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1fv3' size='340' side='right'caption='[[1fv3]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1fv3]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_tetani"_flugge_1886 "bacillus tetani" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FV3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1FV3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1fv3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tetani"_flugge_1886 "bacillus tetani" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FV3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CEQ:ETHYL-TRIMETHYL-SILANE'>CEQ</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <~~scene name~~='~~pdbligand~~=~~PO4~~:~~PHOSPHATE+ION'~~>~~PO4~~</~~scene~~>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CEQ:ETHYL-TRIMETHYL-SILANE'>CEQ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0h\|1d0h]], [[1dll\|1dll]], [[1diw\|1diw]], [[1dfq\|1dfq]], [[1af9\|1af9]], [[1a8d\|1a8d]], [[1fv2\|1fv2]]</td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1fv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fv3 OCA], [~~http~~://pdbe.org/1fv3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1fv3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1fv3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1fv3 ProSAT]</span></td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1d0h\|1d0h]], [[1dll\|1dll]], [[1diw\|1diw]], [[1dfq\|1dfq]], [[1af9\|1af9]], [[1a8d\|1a8d]], [[1fv2\|1fv2]]</div></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fv3 OCA], [https://pdbe.org/1fv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fv3 RCSB], [https://www.ebi.ac.uk/pdbsum/1fv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fv3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE]] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-\|-Phe-77' bond of synaptobrevin-2.	+	[[https://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE]] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-\|-Phe-77' bond of synaptobrevin-2.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:29, 25 December 2019

OCA — Wed, 25 Dec 2019 13:29:58 GMT

←Older revision		Revision as of 13:29, 25 December 2019
Line 1:		Line 1:

	==THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH AN ANALOGUE OF ITS GANGLIOSIDE RECEPTOR GT1B==		==THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH AN ANALOGUE OF ITS GANGLIOSIDE RECEPTOR GT1B==
-	<StructureSection load='1fv3' size='340' side='right' caption='[[1fv3]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='1fv3' size='340' side='right'caption='[[1fv3]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1fv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tetani"_flugge_1886 "bacillus tetani" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FV3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1fv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tetani"_flugge_1886 "bacillus tetani" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FV3 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus tetani flugge 1886]]		[[Category: Bacillus tetani flugge 1886]]
		+	[[Category: Large Structures]]
	[[Category: Ando, H]]		[[Category: Ando, H]]
	[[Category: Black, I]]		[[Category: Black, I]]

OCA at 08:22, 21 March 2018

OCA — Wed, 21 Mar 2018 08:22:51 GMT

←Older revision		Revision as of 08:22, 21 March 2018
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1fv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tetani"_flugge_1886 "bacillus tetani" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FV3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1fv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tetani"_flugge_1886 "bacillus tetani" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FV3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CEQ:ETHYL-TRIMETHYL-SILANE'>CEQ~~</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4~~</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene><~~/td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CEQ:ETHYL-TRIMETHYL-SILANE'>CEQ</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>
-	~~<tr id~~='~~NonStdRes'><td class~~=~~"sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res~~:~~]]</b~~></~~td><td class="sblockDat"~~><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>	+
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0h\|1d0h]], [[1dll\|1dll]], [[1diw\|1diw]], [[1dfq\|1dfq]], [[1af9\|1af9]], [[1a8d\|1a8d]], [[1fv2\|1fv2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0h\|1d0h]], [[1dll\|1dll]], [[1diw\|1diw]], [[1dfq\|1dfq]], [[1af9\|1af9]], [[1a8d\|1a8d]], [[1fv2\|1fv2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fv3 OCA], [http://pdbe.org/1fv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1fv3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fv3 OCA], [http://pdbe.org/1fv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1fv3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1fv3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/1fv3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/1fv3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:27, 20 June 2016

OCA — Mon, 20 Jun 2016 07:27:39 GMT

←Older revision		Revision as of 07:27, 20 June 2016
Line 1:		Line 1:
		+
	==THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH AN ANALOGUE OF ITS GANGLIOSIDE RECEPTOR GT1B==		==THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH AN ANALOGUE OF ITS GANGLIOSIDE RECEPTOR GT1B==
	<StructureSection load='1fv3' size='340' side='right' caption='[[1fv3]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1fv3' size='340' side='right' caption='[[1fv3]], [[Resolution\|resolution]] 2.30Å' scene=''>

OCA at 06:01, 7 February 2016

OCA — Sun, 07 Feb 2016 06:01:57 GMT

←Older revision		Revision as of 06:01, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fv3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:33, 9 September 2015

OCA — Wed, 09 Sep 2015 22:33:12 GMT

←Older revision		Revision as of 22:33, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1fv3' size='340' side='right' caption='[[1fv3]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1fv3' size='340' side='right' caption='[[1fv3]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1fv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Clostridium_tetani Clostridium~~ tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FV3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1fv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tetani"_flugge_1886 "bacillus tetani" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FV3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CEQ:ETHYL-TRIMETHYL-SILANE'>CEQ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CEQ:ETHYL-TRIMETHYL-SILANE'>CEQ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0h\|1d0h]], [[1dll\|1dll]], [[1diw\|1diw]], [[1dfq\|1dfq]], [[1af9\|1af9]], [[1a8d\|1a8d]], [[1fv2\|1fv2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0h\|1d0h]], [[1dll\|1dll]], [[1diw\|1diw]], [[1dfq\|1dfq]], [[1af9\|1af9]], [[1a8d\|1a8d]], [[1fv2\|1fv2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1fv3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fv3 OCA], [http://pdbe.org/1fv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1fv3 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1fv3" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Clostridium~~ tetani]]	+	[[Category: Bacillus tetani flugge 1886]]
	[[Category: Ando, H]]		[[Category: Ando, H]]
	[[Category: Black, I]]		[[Category: Black, I]]

OCA at 08:28, 24 December 2014

OCA — Wed, 24 Dec 2014 08:28:09 GMT

←Older revision		Revision as of 08:28, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1fv3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1fv3 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE]] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-\|-Phe-77' bond of synaptobrevin-2.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 20:03, 22 December 2014

OCA — Mon, 22 Dec 2014 20:03:36 GMT

←Older revision		Revision as of 20:03, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1fv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FV3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1fv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FV3 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CEQ:ETHYL-TRIMETHYL-SILANE'>CEQ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CEQ:ETHYL-TRIMETHYL-SILANE'>CEQ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0h\|1d0h]], [[1dll\|1dll]], [[1diw\|1diw]], [[1dfq\|1dfq]], [[1af9\|1af9]], [[1a8d\|1a8d]], [[1fv2\|1fv2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0h\|1d0h]], [[1dll\|1dll]], [[1diw\|1diw]], [[1dfq\|1dfq]], [[1af9\|1af9]], [[1a8d\|1a8d]], [[1fv2\|1fv2]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1fv3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1fv3 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Clostridium tetani]]		[[Category: Clostridium tetani]]
-	[[Category: Ando, H.]]	+	[[Category: Ando, H]]
-	[[Category: Black, I.]]	+	[[Category: Black, I]]
-	[[Category: Emsley, P.]]	+	[[Category: Emsley, P]]
-	[[Category: Fairweather, N F.]]	+	[[Category: Fairweather, N F]]
-	[[Category: Fotinou, C.]]	+	[[Category: Fotinou, C]]
-	[[Category: Isaacs, N W.]]	+	[[Category: Isaacs, N W]]
-	[[Category: Ishida, H.]]	+	[[Category: Ishida, H]]
-	[[Category: Kiso, M.]]	+	[[Category: Kiso, M]]
-	[[Category: Sinha, K A.]]	+	[[Category: Sinha, K A]]
	[[Category: Carbohydrate]]		[[Category: Carbohydrate]]
	[[Category: Ganglioside]]		[[Category: Ganglioside]]

OCA at 09:54, 28 September 2014

OCA — Sun, 28 Sep 2014 09:54:29 GMT

←Older revision		Revision as of 09:54, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1fv3.~~png~~\|~~left~~\|200px]]	+	==THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH AN ANALOGUE OF ITS GANGLIOSIDE RECEPTOR GT1B==
		+	<StructureSection load='1fv3' size='340' side='right' caption='[[1fv3]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1fv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FV3 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CEQ:ETHYL-TRIMETHYL-SILANE'>CEQ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0h\|1d0h]], [[1dll\|1dll]], [[1diw\|1diw]], [[1dfq\|1dfq]], [[1af9\|1af9]], [[1a8d\|1a8d]], [[1fv2\|1fv2]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1fv3 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/1fv3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tetanus toxin, a member of the family of Clostridial neurotoxins, is one of the most potent toxins known. The crystal structure of the complex of the COOH-terminal fragment of the heavy chain with an analogue of its ganglioside receptor, GT1b, provides the first direct identification and characterization of the ganglioside-binding sites. The ganglioside induces cross-linking by binding to two distinct sites on the Hc molecule. The structure sheds new light on the binding of Clostridial neurotoxins to receptors on neuronal cells and provides important information relevant to the design of anti-tetanus and anti-botulism therapeutic agents.

-	~~{{STRUCTURE_1fv3\| PDB=1fv3 \| SCENE= }}~~	+	The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin.,Fotinou C, Emsley P, Black I, Ando H, Ishida H, Kiso M, Sinha KA, Fairweather NF, Isaacs NW J Biol Chem. 2001 Aug 24;276(34):32274-81. Epub 2001 Jun 19. PMID:11418600<ref>PMID:11418600</ref>

-	~~===THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH AN ANALOGUE OF ITS GANGLIOSIDE RECEPTOR GT1B===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11418600}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1fv3]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Clostridium_tetani Clostridium tetani]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1FV3 OCA].~~	+

	==See Also==		==See Also==
	*[[Tetanus toxin\|Tetanus toxin]]		*[[Tetanus toxin\|Tetanus toxin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011418600<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Clostridium tetani]]		[[Category: Clostridium tetani]]
	[[Category: Ando, H.]]		[[Category: Ando, H.]]