1fyo - Revision history

OCA at 18:36, 29 November 2023

OCA — Wed, 29 Nov 2023 18:36:30 GMT

←Older revision		Revision as of 18:36, 29 November 2023
Line 1:		Line 1:

	==EUKARYOTIC DECODING REGION A-SITE RNA==		==EUKARYOTIC DECODING REGION A-SITE RNA==
-	<StructureSection load='1fyo' size='340' side='right'caption='[[1fyo~~]], [[NMR_Ensembles_of_Models \| 25 NMR models~~]]' scene=''>	+	<StructureSection load='1fyo' size='340' side='right'caption='[[1fyo]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1fyo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FYO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1fyo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FYO FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[1fyp\|1fyp]], [[1a3m\|1a3m]], [[1pbr\|1pbr]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyo OCA], [https://pdbe.org/1fyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fyo RCSB], [https://www.ebi.ac.uk/pdbsum/1fyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fyo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyo OCA], [https://pdbe.org/1fyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fyo RCSB], [https://www.ebi.ac.uk/pdbsum/1fyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fyo ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lynch~~, S R~~]]	+	[[Category: Lynch SR]]
-	[[Category: Puglisi~~, J D]]~~	+	[[Category: Puglisi JD]]
-	~~[[Category: Bulged some]]~~	+
-	~~[[Category: G-a base pair]]~~	+
-	~~[[Category: Rna]]~~	+
-	~~[[Category: Stem-internal loop-stem-tetraloop rna~~]]	+

OCA at 07:09, 24 March 2021

OCA — Wed, 24 Mar 2021 07:09:51 GMT

←Older revision		Revision as of 07:09, 24 March 2021
Line 3:		Line 3:
	<StructureSection load='1fyo' size='340' side='right'caption='[[1fyo]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>		<StructureSection load='1fyo' size='340' side='right'caption='[[1fyo]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1fyo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1FYO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1fyo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FYO FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fyp\|1fyp]], [[1a3m\|1a3m]], [[1pbr\|1pbr]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fyp\|1fyp]], [[1a3m\|1a3m]], [[1pbr\|1pbr]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1fyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyo OCA], [~~http~~://pdbe.org/1fyo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1fyo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1fyo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1fyo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyo OCA], [https://pdbe.org/1fyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fyo RCSB], [https://www.ebi.ac.uk/pdbsum/1fyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fyo ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:25, 19 June 2019

OCA — Wed, 19 Jun 2019 07:25:39 GMT

←Older revision		Revision as of 07:25, 19 June 2019
Line 1:		Line 1:

	==EUKARYOTIC DECODING REGION A-SITE RNA==		==EUKARYOTIC DECODING REGION A-SITE RNA==
-	<StructureSection load='1fyo' size='340' side='right' caption='[[1fyo]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>	+	<StructureSection load='1fyo' size='340' side='right'caption='[[1fyo]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1fyo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FYO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1fyo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FYO FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lynch, S R]]		[[Category: Lynch, S R]]
	[[Category: Puglisi, J D]]		[[Category: Puglisi, J D]]

OCA at 10:49, 13 September 2017

OCA — Wed, 13 Sep 2017 10:49:22 GMT

←Older revision		Revision as of 10:49, 13 September 2017
Line 1:		Line 1:
		+
	==EUKARYOTIC DECODING REGION A-SITE RNA==		==EUKARYOTIC DECODING REGION A-SITE RNA==
	<StructureSection load='1fyo' size='340' side='right' caption='[[1fyo]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>		<StructureSection load='1fyo' size='340' side='right' caption='[[1fyo]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1fyo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FYO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1fyo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FYO FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fyp\|1fyp]], [[1a3m\|1a3m]], [[1pbr\|1pbr]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fyp\|1fyp]], [[1a3m\|1a3m]], [[1pbr\|1pbr]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyo OCA], [http://pdbe.org/1fyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fyo RCSB], [http://www.ebi.ac.uk/pdbsum/1fyo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyo OCA], [http://pdbe.org/1fyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fyo RCSB], [http://www.ebi.ac.uk/pdbsum/1fyo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1fyo ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:16, 10 September 2015

OCA — Thu, 10 Sep 2015 07:16:09 GMT

←Older revision		Revision as of 07:16, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1fyo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FYO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1fyo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FYO FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fyp\|1fyp]], [[1a3m\|1a3m]], [[1pbr\|1pbr]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fyp\|1fyp]], [[1a3m\|1a3m]], [[1pbr\|1pbr]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fyo RCSB], [http://www.ebi.ac.uk/pdbsum/1fyo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyo OCA], [http://pdbe.org/1fyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fyo RCSB], [http://www.ebi.ac.uk/pdbsum/1fyo PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1fyo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:52, 22 December 2014

OCA — Mon, 22 Dec 2014 05:52:46 GMT

←Older revision		Revision as of 05:52, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1fyo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FYO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1fyo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FYO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fyp\|1fyp]], [[1a3m\|1a3m]], [[1pbr\|1pbr]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fyp\|1fyp]], [[1a3m\|1a3m]], [[1pbr\|1pbr]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fyo RCSB], [http://www.ebi.ac.uk/pdbsum/1fyo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fyo RCSB], [http://www.ebi.ac.uk/pdbsum/1fyo PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Lynch, S R.]]	+	[[Category: Lynch, S R]]
-	[[Category: Puglisi, J D.]]	+	[[Category: Puglisi, J D]]
	[[Category: Bulged some]]		[[Category: Bulged some]]
	[[Category: G-a base pair]]		[[Category: G-a base pair]]
	[[Category: Rna]]		[[Category: Rna]]
	[[Category: Stem-internal loop-stem-tetraloop rna]]		[[Category: Stem-internal loop-stem-tetraloop rna]]

OCA at 05:43, 8 June 2014

OCA — Sun, 08 Jun 2014 05:43:02 GMT

←Older revision		Revision as of 05:43, 8 June 2014
Line 1:		Line 1:
-	[[~~Image:~~1fyo.~~png~~\|~~left~~\|~~200px~~]]	+	==EUKARYOTIC DECODING REGION A-SITE RNA==
		+	<StructureSection load='1fyo' size='340' side='right' caption='[[1fyo]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1fyo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FYO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fyp\|1fyp]], [[1a3m\|1a3m]], [[1pbr\|1pbr]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fyo RCSB], [http://www.ebi.ac.uk/pdbsum/1fyo PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The aminoglycoside antibiotics target a region of highly conserved nucleotides in the aminoacyl-tRNA site (A site) of 16 S RNA on the 30 S subunit. The structures of a prokaryotic decoding region A-site oligonucleotide free in solution and bound to the aminoglycosides paromomycin and gentamicin C1A have been determined. Here, the structure of a eukaryotic decoding region A-site oligonucleotide has been determined using homonuclear and heteronuclear NMR spectroscopy, and compared to the unbound prokaryotic rRNA structure. The two structures are similar, with a U1406-U1495 base-pair, a C1407-G1494 Watson-Crick base-pair, and a G1408-A1493 base-pair instead of the A1408-A1493 base-pair of the prokaryotic structure. The two structures differ in the orientation of the 1408 position with respect to A1493; G1408 is rotated toward the major groove, which is the binding pocket for aminoglycosides. The structures also differ in the stacking geometry of G1494 on A1493, which could have slight long-range conformational effects.

-	~~{{STRUCTURE_1fyo\| PDB=1fyo \| SCENE= }}~~	+	Structure of a eukaryotic decoding region A-site RNA.,Lynch SR, Puglisi JD J Mol Biol. 2001 Mar 9;306(5):1023-35. PMID:11237616<ref>PMID:11237616</ref>

-	~~===EUKARYOTIC DECODING REGION A-SITE RNA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11237616}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1fyo]] is~~ a ~~1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1FYO OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011237616<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Lynch, S R.]]		[[Category: Lynch, S R.]]
	[[Category: Puglisi, J D.]]		[[Category: Puglisi, J D.]]

OCA: Protected "1fyo" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 16:18:51 GMT

Protected "1fyo" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:18, 14 August 2012

OCA at 16:18, 14 August 2012

OCA — Tue, 14 Aug 2012 16:18:50 GMT

←Older revision		Revision as of 16:18, 14 August 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1fyo.png\|left\|200px]]		[[Image:1fyo.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1fyo", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1fyo\| PDB=1fyo \| SCENE= }}		{{STRUCTURE_1fyo\| PDB=1fyo \| SCENE= }}

	===EUKARYOTIC DECODING REGION A-SITE RNA===		===EUKARYOTIC DECODING REGION A-SITE RNA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11237616}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11237616 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11237616}}		{{ABSTRACT_PUBMED_11237616}}

	==About this Structure==		==About this Structure==
-	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYO OCA].	+	[[1fyo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYO OCA].

	==Reference==		==Reference==
-	~~Structure of a eukaryotic decoding region A-site RNA., Lynch SR, Puglisi JD, J Mol Biol. 2001 Mar 9;306(5):1023-35.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~11237616 11237616]~~	+	<ref group="xtra">PMID:011237616</ref><references group="xtra"/>
	[[Category: Lynch, S R.]]		[[Category: Lynch, S R.]]
	[[Category: Puglisi, J D.]]		[[Category: Puglisi, J D.]]
	[[Category: Bulged some]]		[[Category: Bulged some]]
	[[Category: G-a base pair]]		[[Category: G-a base pair]]
		+	[[Category: Rna]]
	[[Category: Stem-internal loop-stem-tetraloop rna]]		[[Category: Stem-internal loop-stem-tetraloop rna]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:08:25 2008''

OCA at 01:08, 1 July 2008

OCA — Tue, 01 Jul 2008 01:08:28 GMT

←Older revision		Revision as of 01:08, 1 July 2008
Line 1:		Line 1:
-	[[Image:1fyo.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1fyo.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1fyo\| PDB=1fyo \| SCENE= }}		{{STRUCTURE_1fyo\| PDB=1fyo \| SCENE= }}

-	~~'''~~EUKARYOTIC DECODING REGION A-SITE RNA~~'''~~	+	===EUKARYOTIC DECODING REGION A-SITE RNA===


-	~~==Overview==~~	+	<!--
-	~~The aminoglycoside antibiotics target a region of highly conserved nucleotides in the aminoacyl~~-~~tRNA site (A site) of 16 S RNA on the 30 S subunit. The structures of a prokaryotic decoding region A~~-site oligonucleotide free in solution and bound to the aminoglycosides paromomycin and gentamicin C1A have been determined. Here, the structure of a eukaryotic decoding region A-site oligonucleotide has been determined using homonuclear and heteronuclear NMR spectroscopy, and compared to the unbound prokaryotic rRNA structure. The ~~two structures are similar~~, ~~with a U1406-U1495 base-pair~~, ~~a C1407-G1494 Watson-Crick base-pair, and a G1408-A1493 base-pair instead of~~ the ~~A1408-A1493 base-pair of~~ the ~~prokaryotic structure~~. ~~The two structures differ in the orientation of the 1408 position with respect to A1493; G1408 is rotated toward the major groove~~, ~~which~~ is the ~~binding pocket for aminoglycosides~~. ~~The structures also differ in the stacking geometry of G1494 on A1493, which could have slight long~~-~~range conformational effects.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_11237616}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 11237616 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_11237616}}

	==About this Structure==		==About this Structure==
-	Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYO OCA].	+	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYO OCA].

	==Reference==		==Reference==
Line 25:		Line 29:
	[[Category: G-a base pair]]		[[Category: G-a base pair]]
	[[Category: Stem-internal loop-stem-tetraloop rna]]		[[Category: Stem-internal loop-stem-tetraloop rna]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 16~~:54:56 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:08:25 2008''