1fzw - Revision history

OCA at 07:21, 7 February 2024

OCA — Wed, 07 Feb 2024 07:21:02 GMT

←Older revision		Revision as of 07:21, 7 February 2024
Line 3:		Line 3:
	<StructureSection load='1fzw' size='340' side='right'caption='[[1fzw]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1fzw' size='340' side='right'caption='[[1fzw]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1fzw]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FZW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1fzw]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FZW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1fxo\|1fxo]], [[1g0r\|1g0r]], [[1g1l\|1g1l]], [[1g23\|1g23]], [[1g2v\|1g2v]], [[1g31\|1g31]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>[https://en.wikipedia.org/wiki/Glucose-1-phosphate_thymidylyltransferase Glucose-1-phosphate thymidylyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.24 2.7.7.24] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fzw OCA], [https://pdbe.org/1fzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fzw RCSB], [https://www.ebi.ac.uk/pdbsum/1fzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fzw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fzw OCA], [https://pdbe.org/1fzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fzw RCSB], [https://www.ebi.ac.uk/pdbsum/1fzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fzw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q9HU22_PSEAE Q9HU22_PSEAE]] Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity).[RuleBase:RU003706]	+	[https://www.uniprot.org/uniprot/Q9HU22_PSEAE Q9HU22_PSEAE] Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity).[RuleBase:RU003706]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fzw ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fzw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The synthesis of deoxy-thymidine di-phosphate (dTDP)-L-rhamnose, an important component of the cell wall of many microorganisms, is a target for therapeutic intervention. The first enzyme in the dTDP-L-rhamnose biosynthetic pathway is glucose-1-phosphate thymidylyltransferase (RmlA). RmlA is inhibited by dTDP-L-rhamnose thereby regulating L-rhamnose production in bacteria. The structure of Pseudomonas aeruginosa RmlA has been solved to 1.66 A resolution. RmlA is a homotetramer, with the monomer consisting of three functional subdomains. The sugar binding and dimerization subdomains are unique to RmlA-like enzymes. The sequence of the core subdomain is found not only in sugar nucleotidyltransferases but also in other nucleotidyltransferases. The structures of five distinct enzyme substrate- product complexes reveal the enzyme mechanism that involves precise positioning of the nucleophile and activation of the electrophile. All the key residues are within the core subdomain, suggesting that the basic mechanism is found in many nucleotidyltransferases. The dTDP-L-rhamnose complex identifies how the protein is controlled by its natural inhibitor. This work provides a platform for the design of novel drugs against pathogenic bacteria.
-
-	The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (RmlA).,Blankenfeldt W, Asuncion M, Lam JS, Naismith JH EMBO J. 2000 Dec 15;19(24):6652-63. PMID:11118200<ref>PMID:11118200</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1fzw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Glucose-1-phosphate thymidylyltransferase 3D structures\|Glucose-1-phosphate thymidylyltransferase 3D structures]]		*[[Glucose-1-phosphate thymidylyltransferase 3D structures\|Glucose-1-phosphate thymidylyltransferase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Glucose-1-phosphate thymidylyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Asuncion, M~~]]	+	[[Category: Pseudomonas aeruginosa]]
-	[[Category: ~~Blankenfeldt, W~~]]	+	[[Category: Asuncion M]]
-	[[Category: ~~Lam, J S~~]]	+	[[Category: Blankenfeldt W]]
-	[[Category: ~~Naismith, J H~~]]	+	[[Category: Lam JS]]
-	[[Category: ~~Allostery]]~~	+	[[Category: Naismith JH]]
-	~~[[Category: Nucleotidyltransferase]]~~	+
-	~~[[Category: Pyrophosphorylase]]~~	+
-	~~[[Category: Rhamnose]]~~	+
-	~~[[Category: Thymidylyltransferase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 11:17, 28 July 2021

OCA — Wed, 28 Jul 2021 11:17:23 GMT

←Older revision		Revision as of 11:17, 28 July 2021
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	<StructureSection load='1fzw' size='340' side='right'caption='[[1fzw]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1fzw' size='340' side='right'caption='[[1fzw]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1fzw]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1FZW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1fzw]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FZW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fxo\|1fxo]], [[1g0r\|1g0r]], [[1g1l\|1g1l]], [[1g23\|1g23]], [[1g2v\|1g2v]], [[1g31\|1g31]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fxo\|1fxo]], [[1g0r\|1g0r]], [[1g1l\|1g1l]], [[1g23\|1g23]], [[1g2v\|1g2v]], [[1g31\|1g31]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glucose-1-phosphate_thymidylyltransferase Glucose-1-phosphate thymidylyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.24 2.7.7.24] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glucose-1-phosphate_thymidylyltransferase Glucose-1-phosphate thymidylyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.24 2.7.7.24] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1fzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fzw OCA], [~~http~~://pdbe.org/1fzw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1fzw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1fzw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1fzw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fzw OCA], [https://pdbe.org/1fzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fzw RCSB], [https://www.ebi.ac.uk/pdbsum/1fzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fzw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q9HU22_PSEAE Q9HU22_PSEAE]] Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity).[RuleBase:RU003706]	+	[[https://www.uniprot.org/uniprot/Q9HU22_PSEAE Q9HU22_PSEAE]] Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity).[RuleBase:RU003706]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:38, 23 October 2019

OCA — Wed, 23 Oct 2019 08:38:43 GMT

←Older revision		Revision as of 08:38, 23 October 2019
Line 1:		Line 1:

	==THE STRUCTURAL BASIS OF THE CATALYTIC MECHANISM AND REGULATION OF GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE (RMLA). APO ENZYME.==		==THE STRUCTURAL BASIS OF THE CATALYTIC MECHANISM AND REGULATION OF GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE (RMLA). APO ENZYME.==
-	<StructureSection load='1fzw' size='340' side='right' caption='[[1fzw]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='1fzw' size='340' side='right'caption='[[1fzw]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1fzw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FZW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1fzw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FZW FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 1fzw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1fzw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glucose-1-phosphate thymidylyltransferase 3D structures\|Glucose-1-phosphate thymidylyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Glucose-1-phosphate thymidylyltransferase]]		[[Category: Glucose-1-phosphate thymidylyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Asuncion, M]]		[[Category: Asuncion, M]]
	[[Category: Blankenfeldt, W]]		[[Category: Blankenfeldt, W]]

OCA at 06:24, 3 January 2018

OCA — Wed, 03 Jan 2018 06:24:16 GMT

←Older revision		Revision as of 06:24, 3 January 2018
Line 1:		Line 1:
		+
	==THE STRUCTURAL BASIS OF THE CATALYTIC MECHANISM AND REGULATION OF GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE (RMLA). APO ENZYME.==		==THE STRUCTURAL BASIS OF THE CATALYTIC MECHANISM AND REGULATION OF GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE (RMLA). APO ENZYME.==
	<StructureSection load='1fzw' size='340' side='right' caption='[[1fzw]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1fzw' size='340' side='right' caption='[[1fzw]], [[Resolution\|resolution]] 1.90Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fxo\|1fxo]], [[1g0r\|1g0r]], [[1g1l\|1g1l]], [[1g23\|1g23]], [[1g2v\|1g2v]], [[1g31\|1g31]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fxo\|1fxo]], [[1g0r\|1g0r]], [[1g1l\|1g1l]], [[1g23\|1g23]], [[1g2v\|1g2v]], [[1g31\|1g31]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose-1-phosphate_thymidylyltransferase Glucose-1-phosphate thymidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.24 2.7.7.24] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose-1-phosphate_thymidylyltransferase Glucose-1-phosphate thymidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.24 2.7.7.24] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fzw OCA], [http://pdbe.org/1fzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fzw RCSB], [http://www.ebi.ac.uk/pdbsum/1fzw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fzw OCA], [http://pdbe.org/1fzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fzw RCSB], [http://www.ebi.ac.uk/pdbsum/1fzw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1fzw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fz/1fzw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fz/1fzw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1fzw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1fzw" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Glucose-1-phosphate thymidylyltransferase\|Glucose-1-phosphate thymidylyltransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:56, 9 February 2016

OCA — Tue, 09 Feb 2016 12:56:02 GMT

←Older revision		Revision as of 12:56, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fzw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:27, 10 September 2015

OCA — Thu, 10 Sep 2015 22:27:51 GMT

←Older revision		Revision as of 22:27, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1fzw' size='340' side='right' caption='[[1fzw]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1fzw' size='340' side='right' caption='[[1fzw]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1fzw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_aeruginosa Pseudomonas aeruginosa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FZW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1fzw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FZW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fxo\|1fxo]], [[1g0r\|1g0r]], [[1g1l\|1g1l]], [[1g23\|1g23]], [[1g2v\|1g2v]], [[1g31\|1g31]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fxo\|1fxo]], [[1g0r\|1g0r]], [[1g1l\|1g1l]], [[1g23\|1g23]], [[1g2v\|1g2v]], [[1g31\|1g31]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose-1-phosphate_thymidylyltransferase Glucose-1-phosphate thymidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.24 2.7.7.24] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose-1-phosphate_thymidylyltransferase Glucose-1-phosphate thymidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.24 2.7.7.24] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fzw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fzw RCSB], [http://www.ebi.ac.uk/pdbsum/1fzw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fzw OCA], [http://pdbe.org/1fzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fzw RCSB], [http://www.ebi.ac.uk/pdbsum/1fzw PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1fzw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Glucose-1-phosphate thymidylyltransferase]]		[[Category: Glucose-1-phosphate thymidylyltransferase]]
-	[[Category: Pseudomonas aeruginosa]]
	[[Category: Asuncion, M]]		[[Category: Asuncion, M]]
	[[Category: Blankenfeldt, W]]		[[Category: Blankenfeldt, W]]

OCA at 06:57, 25 December 2014

OCA — Thu, 25 Dec 2014 06:57:59 GMT

←Older revision		Revision as of 06:57, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fzw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fzw RCSB], [http://www.ebi.ac.uk/pdbsum/1fzw PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fzw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fzw RCSB], [http://www.ebi.ac.uk/pdbsum/1fzw PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q9HU22_PSEAE Q9HU22_PSEAE]] Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity).[RuleBase:RU003706]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 18:26, 22 December 2014

OCA — Mon, 22 Dec 2014 18:26:07 GMT

←Older revision		Revision as of 18:26, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1fzw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FZW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1fzw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FZW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fxo\|1fxo]], [[1g0r\|1g0r]], [[1g1l\|1g1l]], [[1g23\|1g23]], [[1g2v\|1g2v]], [[1g31\|1g31]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fxo\|1fxo]], [[1g0r\|1g0r]], [[1g1l\|1g1l]], [[1g23\|1g23]], [[1g2v\|1g2v]], [[1g31\|1g31]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose-1-phosphate_thymidylyltransferase Glucose-1-phosphate thymidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.24 2.7.7.24] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose-1-phosphate_thymidylyltransferase Glucose-1-phosphate thymidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.24 2.7.7.24] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fzw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fzw RCSB], [http://www.ebi.ac.uk/pdbsum/1fzw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fzw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fzw RCSB], [http://www.ebi.ac.uk/pdbsum/1fzw PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Glucose-1-phosphate thymidylyltransferase]]		[[Category: Glucose-1-phosphate thymidylyltransferase]]
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
-	[[Category: Asuncion, M.]]	+	[[Category: Asuncion, M]]
-	[[Category: Blankenfeldt, W.]]	+	[[Category: Blankenfeldt, W]]
-	[[Category: Lam, J S.]]	+	[[Category: Lam, J S]]
-	[[Category: Naismith, J H.]]	+	[[Category: Naismith, J H]]
	[[Category: Allostery]]		[[Category: Allostery]]
	[[Category: Nucleotidyltransferase]]		[[Category: Nucleotidyltransferase]]

OCA at 08:30, 28 September 2014

OCA — Sun, 28 Sep 2014 08:30:12 GMT

←Older revision		Revision as of 08:30, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1fzw.~~png~~\|~~left~~\|200px]]	+	==THE STRUCTURAL BASIS OF THE CATALYTIC MECHANISM AND REGULATION OF GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE (RMLA). APO ENZYME.==
		+	<StructureSection load='1fzw' size='340' side='right' caption='[[1fzw]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1fzw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FZW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fxo\|1fxo]], [[1g0r\|1g0r]], [[1g1l\|1g1l]], [[1g23\|1g23]], [[1g2v\|1g2v]], [[1g31\|1g31]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose-1-phosphate_thymidylyltransferase Glucose-1-phosphate thymidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.24 2.7.7.24] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fzw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fzw RCSB], [http://www.ebi.ac.uk/pdbsum/1fzw PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fz/1fzw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The synthesis of deoxy-thymidine di-phosphate (dTDP)-L-rhamnose, an important component of the cell wall of many microorganisms, is a target for therapeutic intervention. The first enzyme in the dTDP-L-rhamnose biosynthetic pathway is glucose-1-phosphate thymidylyltransferase (RmlA). RmlA is inhibited by dTDP-L-rhamnose thereby regulating L-rhamnose production in bacteria. The structure of Pseudomonas aeruginosa RmlA has been solved to 1.66 A resolution. RmlA is a homotetramer, with the monomer consisting of three functional subdomains. The sugar binding and dimerization subdomains are unique to RmlA-like enzymes. The sequence of the core subdomain is found not only in sugar nucleotidyltransferases but also in other nucleotidyltransferases. The structures of five distinct enzyme substrate- product complexes reveal the enzyme mechanism that involves precise positioning of the nucleophile and activation of the electrophile. All the key residues are within the core subdomain, suggesting that the basic mechanism is found in many nucleotidyltransferases. The dTDP-L-rhamnose complex identifies how the protein is controlled by its natural inhibitor. This work provides a platform for the design of novel drugs against pathogenic bacteria.

-	~~{{STRUCTURE_1fzw\| PDB=1fzw \| SCENE= }}~~	+	The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (RmlA).,Blankenfeldt W, Asuncion M, Lam JS, Naismith JH EMBO J. 2000 Dec 15;19(24):6652-63. PMID:11118200<ref>PMID:11118200</ref>

-	~~===THE STRUCTURAL BASIS OF THE CATALYTIC MECHANISM AND REGULATION OF GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE (RMLA)~~. ~~APO ENZYME~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_11118200}}~~	+	==See Also==
-		+	*[[Glucose-1-phosphate thymidylyltransferase\|Glucose-1-phosphate thymidylyltransferase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1fzw~~]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZW OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:011118200<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Glucose-1-phosphate thymidylyltransferase]]		[[Category: Glucose-1-phosphate thymidylyltransferase]]
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]

OCA: Protected "1fzw" [edit=sysop:move=sysop]

OCA — Wed, 21 Nov 2012 10:10:41 GMT

Protected "1fzw" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:10, 21 November 2012