1g5z - Revision history

OCA at 07:23, 7 February 2024

OCA — Wed, 07 Feb 2024 07:23:17 GMT

←Older revision		Revision as of 07:23, 7 February 2024
Line 3:		Line 3:
	<StructureSection load='1g5z' size='340' side='right'caption='[[1g5z]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='1g5z' size='340' side='right'caption='[[1g5z]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1g5z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G5Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1g5z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi Borreliella burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G5Z FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g5z OCA], [https://pdbe.org/1g5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g5z RCSB], [https://www.ebi.ac.uk/pdbsum/1g5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g5z ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.51Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g5z OCA], [https://pdbe.org/1g5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g5z RCSB], [https://www.ebi.ac.uk/pdbsum/1g5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g5z ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q44717_BORBG Q44717_BORBG]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g5z ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g5z ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The outer surface protein C (OspC) is one of the major host-induced antigens of Borrelia burgdorferi, the causative agent of Lyme disease. We have solved the crystal structure of recombinant OspC to a resolution of 2.5 A. OspC, a largely alpha-helical protein, is a dimer with a characteristic central four-helical bundle formed by association of the two longest helices from each subunit. OspC is very different from OspA and similar to the extracellular domain of the bacterial aspartate receptor and the variant surface glycoprotein from Trypanosoma brucei. Most of the surface-exposed residues of OspC are highly variable among different OspC isolates. The membrane proximal halves of the two long alpha-helices are the only conserved regions that are solvent accessible. As vaccination with recombinant OspC has been shown to elicit a protective immune response in mice, these regions are candidates for peptide-based vaccines.
-
-	Crystal structure of Lyme disease antigen outer surface protein C from Borrelia burgdorferi.,Eicken C, Sharma V, Klabunde T, Owens RT, Pikas DS, Hook M, Sacchettini JC J Biol Chem. 2001 Mar 30;276(13):10010-5. Epub 2001 Jan 3. PMID:11139584<ref>PMID:11139584</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1g5z" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Outer surface protein\|Outer surface protein]]		*[[Outer surface protein\|Outer surface protein]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Borreliella burgdorferi]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Eicken, C]]	+	[[Category: Eicken C]]
-	[[Category: Hook, M]]	+	[[Category: Hook M]]
-	[[Category: Klabunde, T]]	+	[[Category: Klabunde T]]
-	[[Category: Owens~~, R T~~]]	+	[[Category: Owens RT]]
-	[[Category: Pikas~~, D S~~]]	+	[[Category: Pikas DS]]
-	[[Category: Sacchettini~~, J C~~]]	+	[[Category: Sacchettini JC]]
-	[[Category: Sharma, V]]	+	[[Category: Sharma V]]
-	~~[[Category: Alpha helix protein]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Surface protein~~]]	+

OCA at 07:12, 24 March 2021

OCA — Wed, 24 Mar 2021 07:12:10 GMT

←Older revision		Revision as of 07:12, 24 March 2021
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	<StructureSection load='1g5z' size='340' side='right'caption='[[1g5z]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='1g5z' size='340' side='right'caption='[[1g5z]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1g5z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1G5Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1g5z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G5Z FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1g5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g5z OCA], [~~http~~://pdbe.org/1g5z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1g5z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1g5z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1g5z ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g5z OCA], [https://pdbe.org/1g5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g5z RCSB], [https://www.ebi.ac.uk/pdbsum/1g5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g5z ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:10, 19 June 2019

OCA — Wed, 19 Jun 2019 07:10:10 GMT

←Older revision		Revision as of 07:10, 19 June 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF LYME DISEASE ANTIGEN OUTER SURFACE PROTEIN C (OSPC) FROM BORRELIA BURGDORFERI STRAIN N40==		==CRYSTAL STRUCTURE OF LYME DISEASE ANTIGEN OUTER SURFACE PROTEIN C (OSPC) FROM BORRELIA BURGDORFERI STRAIN N40==
-	<StructureSection load='1g5z' size='340' side='right' caption='[[1g5z]], [[Resolution\|resolution]] 2.51Å' scene=''>	+	<StructureSection load='1g5z' size='340' side='right'caption='[[1g5z]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1g5z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G5Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[1g5z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G5Z FirstGlance]. <br>
Line 10:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g5/1g5z_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g5/1g5z_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Eicken, C]]		[[Category: Eicken, C]]
	[[Category: Hook, M]]		[[Category: Hook, M]]

OCA at 10:59, 13 September 2017

OCA — Wed, 13 Sep 2017 10:59:00 GMT

←Older revision		Revision as of 10:59, 13 September 2017
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF LYME DISEASE ANTIGEN OUTER SURFACE PROTEIN C (OSPC) FROM BORRELIA BURGDORFERI STRAIN N40==		==CRYSTAL STRUCTURE OF LYME DISEASE ANTIGEN OUTER SURFACE PROTEIN C (OSPC) FROM BORRELIA BURGDORFERI STRAIN N40==
	<StructureSection load='1g5z' size='340' side='right' caption='[[1g5z]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='1g5z' size='340' side='right' caption='[[1g5z]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1g5z]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Atcc_35210 Atcc 35210]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G5Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1g5z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G5Z FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g5z OCA], [http://pdbe.org/1g5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1g5z RCSB], [http://www.ebi.ac.uk/pdbsum/1g5z PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g5z OCA], [http://pdbe.org/1g5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1g5z RCSB], [http://www.ebi.ac.uk/pdbsum/1g5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1g5z ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g5z ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 35210]]
	[[Category: Eicken, C]]		[[Category: Eicken, C]]
	[[Category: Hook, M]]		[[Category: Hook, M]]

OCA at 16:04, 11 September 2015

OCA — Fri, 11 Sep 2015 16:04:02 GMT

←Older revision		Revision as of 16:04, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1g5z' size='340' side='right' caption='[[1g5z]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='1g5z' size='340' side='right' caption='[[1g5z]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1g5z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Borrelia_burgdorferi Borrelia burgdorferi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G5Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1g5z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35210 Atcc 35210]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G5Z FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g5z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1g5z RCSB], [http://www.ebi.ac.uk/pdbsum/1g5z PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g5z OCA], [http://pdbe.org/1g5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1g5z RCSB], [http://www.ebi.ac.uk/pdbsum/1g5z PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1g5z" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 30:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Borrelia burgdorferi~~]]	+	[[Category: Atcc 35210]]
	[[Category: Eicken, C]]		[[Category: Eicken, C]]
	[[Category: Hook, M]]		[[Category: Hook, M]]

OCA at 00:25, 23 December 2014

OCA — Tue, 23 Dec 2014 00:25:40 GMT

←Older revision		Revision as of 00:25, 23 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1g5z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G5Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[1g5z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G5Z FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g5z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1g5z RCSB], [http://www.ebi.ac.uk/pdbsum/1g5z PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g5z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1g5z RCSB], [http://www.ebi.ac.uk/pdbsum/1g5z PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Borrelia burgdorferi]]		[[Category: Borrelia burgdorferi]]
-	[[Category: Eicken, C.]]	+	[[Category: Eicken, C]]
-	[[Category: Hook, M.]]	+	[[Category: Hook, M]]
-	[[Category: Klabunde, T.]]	+	[[Category: Klabunde, T]]
-	[[Category: Owens, R T.]]	+	[[Category: Owens, R T]]
-	[[Category: Pikas, D S.]]	+	[[Category: Pikas, D S]]
-	[[Category: Sacchettini, J C.]]	+	[[Category: Sacchettini, J C]]
-	[[Category: Sharma, V.]]	+	[[Category: Sharma, V]]
	[[Category: Alpha helix protein]]		[[Category: Alpha helix protein]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Surface protein]]		[[Category: Surface protein]]

OCA at 14:12, 28 September 2014

OCA — Sun, 28 Sep 2014 14:12:33 GMT

←Older revision		Revision as of 14:12, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1g5z.~~png\|left~~\|200px]]	+	==CRYSTAL STRUCTURE OF LYME DISEASE ANTIGEN OUTER SURFACE PROTEIN C (OSPC) FROM BORRELIA BURGDORFERI STRAIN N40==
		+	<StructureSection load='1g5z' size='340' side='right' caption='[[1g5z]], [[Resolution\|resolution]] 2.51Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1g5z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G5Z FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g5z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1g5z RCSB], [http://www.ebi.ac.uk/pdbsum/1g5z PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g5/1g5z_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The outer surface protein C (OspC) is one of the major host-induced antigens of Borrelia burgdorferi, the causative agent of Lyme disease. We have solved the crystal structure of recombinant OspC to a resolution of 2.5 A. OspC, a largely alpha-helical protein, is a dimer with a characteristic central four-helical bundle formed by association of the two longest helices from each subunit. OspC is very different from OspA and similar to the extracellular domain of the bacterial aspartate receptor and the variant surface glycoprotein from Trypanosoma brucei. Most of the surface-exposed residues of OspC are highly variable among different OspC isolates. The membrane proximal halves of the two long alpha-helices are the only conserved regions that are solvent accessible. As vaccination with recombinant OspC has been shown to elicit a protective immune response in mice, these regions are candidates for peptide-based vaccines.

-	~~{{STRUCTURE_1g5z\| PDB=1g5z \| SCENE= }}~~	+	Crystal structure of Lyme disease antigen outer surface protein C from Borrelia burgdorferi.,Eicken C, Sharma V, Klabunde T, Owens RT, Pikas DS, Hook M, Sacchettini JC J Biol Chem. 2001 Mar 30;276(13):10010-5. Epub 2001 Jan 3. PMID:11139584<ref>PMID:11139584</ref>

-	~~===CRYSTAL STRUCTURE OF LYME DISEASE ANTIGEN OUTER SURFACE PROTEIN C (OSPC) FROM BORRELIA BURGDORFERI STRAIN N40===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11139584}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1g5z]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1G5Z OCA].~~	+

	==See Also==		==See Also==
	*[[Outer surface protein\|Outer surface protein]]		*[[Outer surface protein\|Outer surface protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011139584<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Borrelia burgdorferi]]		[[Category: Borrelia burgdorferi]]
	[[Category: Eicken, C.]]		[[Category: Eicken, C.]]

OCA: Protected "1g5z" [edit=sysop:move=sysop]

OCA — Sat, 20 Oct 2012 20:09:24 GMT

Protected "1g5z" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:09, 20 October 2012

OCA at 20:09, 20 October 2012

OCA — Sat, 20 Oct 2012 20:09:22 GMT

←Older revision		Revision as of 20:09, 20 October 2012
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-	{{Seed}}
	[[Image:1g5z.png\|left\|200px]]		[[Image:1g5z.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1g5z\| PDB=1g5z \| SCENE= }}		{{STRUCTURE_1g5z\| PDB=1g5z \| SCENE= }}

	===CRYSTAL STRUCTURE OF LYME DISEASE ANTIGEN OUTER SURFACE PROTEIN C (OSPC) FROM BORRELIA BURGDORFERI STRAIN N40===		===CRYSTAL STRUCTURE OF LYME DISEASE ANTIGEN OUTER SURFACE PROTEIN C (OSPC) FROM BORRELIA BURGDORFERI STRAIN N40===

-
-	<!--
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-	(as it appears on PubMed at http://www.pubmed.gov), where 11139584 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_11139584}}		{{ABSTRACT_PUBMED_11139584}}

	==About this Structure==		==About this Structure==
-	~~1G5Z~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5Z OCA].	+	[[1g5z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5Z OCA].
		+
		+	==See Also==
		+	*[[Outer surface protein\|Outer surface protein]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11139584~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011139584</ref><references group="xtra"/>
	[[Category: Borrelia burgdorferi]]		[[Category: Borrelia burgdorferi]]
	[[Category: Eicken, C.]]		[[Category: Eicken, C.]]
Line 33:		Line 24:
	[[Category: Sharma, V.]]		[[Category: Sharma, V.]]
	[[Category: Alpha helix protein]]		[[Category: Alpha helix protein]]
		+	[[Category: Immune system]]
	[[Category: Surface protein]]		[[Category: Surface protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:55:53 2009''

OCA at 00:55, 18 February 2009

OCA — Wed, 18 Feb 2009 00:55:55 GMT

←Older revision		Revision as of 00:55, 18 February 2009
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	==About this Structure==		==About this Structure==
-	1G5Z is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5Z OCA].	+	1G5Z is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5Z OCA].

	==Reference==		==Reference==
-	Crystal structure of Lyme disease antigen outer surface protein C from Borrelia burgdorferi., Eicken C, Sharma V, Klabunde T, Owens RT, Pikas DS, Hook M, Sacchettini JC, J Biol Chem. 2001 Mar 30;276(13):10010-5. Epub 2001 Jan 3. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/11139584 11139584]~~	+	<ref group="xtra">PMID:11139584</ref><references group="xtra"/>
	[[Category: Borrelia burgdorferi]]		[[Category: Borrelia burgdorferi]]
-	[[Category: Single protein]]
	[[Category: Eicken, C.]]		[[Category: Eicken, C.]]
	[[Category: Hook, M.]]		[[Category: Hook, M.]]
Line 36:		Line 35:
	[[Category: Surface protein]]		[[Category: Surface protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 1 04~~:30:~~17 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:55:53 2009''