1gd4 - Revision history

OCA at 23:29, 27 December 2023

OCA — Wed, 27 Dec 2023 23:29:56 GMT

←Older revision		Revision as of 23:29, 27 December 2023
Line 1:		Line 1:

	==SOLUTION STRUCTURE OF P25S CYSTATIN A==		==SOLUTION STRUCTURE OF P25S CYSTATIN A==
-	<StructureSection load='1gd4' size='340' side='right'caption='[[1gd4~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='1gd4' size='340' side='right'caption='[[1gd4]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gd4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GD4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GD4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gd4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GD4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GD4 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[1cyu\|1cyu]], [[1cyv\|1cyv]], [[1gd3\|1gd3]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gd4 OCA], [https://pdbe.org/1gd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gd4 RCSB], [https://www.ebi.ac.uk/pdbsum/1gd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gd4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gd4 OCA], [https://pdbe.org/1gd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gd4 RCSB], [https://www.ebi.ac.uk/pdbsum/1gd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gd4 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/CYTA_HUMAN CYTA_HUMAN]] Defects in CSTA are the cause of ichthyosis exfoliative autosomal recessive ichthyosis bullosa of Siemens-like (AREI) [MIM:[https://omim.org/entry/607936 607936]]. A form of congenital exfoliative ichthyosis, sharing some features with ichthyosis bullosa of Siemens and annular epidermolytic ichthyosis. AREI presents shortly after birth as dry, scaly skin over most of the body with coarse peeling of non-erythematous skin on the palms and soles, which is exacerbated by excessive moisture and minor trauma. Electron microscopy analysis of skin biopsies, reveals mostly normal-appearing upper layers of the epidermis, but prominent intercellular edema of the basal and suprabasal cell layers with aggregates of tonofilaments in the basal keratinocytes.<ref>PMID:21944047</ref>	+	[https://www.uniprot.org/uniprot/CYTA_HUMAN CYTA_HUMAN] Defects in CSTA are the cause of ichthyosis exfoliative autosomal recessive ichthyosis bullosa of Siemens-like (AREI) [MIM:[https://omim.org/entry/607936 607936]. A form of congenital exfoliative ichthyosis, sharing some features with ichthyosis bullosa of Siemens and annular epidermolytic ichthyosis. AREI presents shortly after birth as dry, scaly skin over most of the body with coarse peeling of non-erythematous skin on the palms and soles, which is exacerbated by excessive moisture and minor trauma. Electron microscopy analysis of skin biopsies, reveals mostly normal-appearing upper layers of the epidermis, but prominent intercellular edema of the basal and suprabasal cell layers with aggregates of tonofilaments in the basal keratinocytes.<ref>PMID:21944047</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CYTA_HUMAN CYTA_HUMAN]] This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.<ref>PMID:21944047</ref>	+	[https://www.uniprot.org/uniprot/CYTA_HUMAN CYTA_HUMAN] This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.<ref>PMID:21944047</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kainosho, M]]	+	[[Category: Kainosho M]]
-	[[Category: Kaji, H]]	+	[[Category: Kaji H]]
-	[[Category: Kariya, E]]	+	[[Category: Kariya E]]
-	[[Category: Shimba, N]]	+	[[Category: Shimba N]]
-	[[Category: Tate, S]]	+	[[Category: Tate S]]
-	~~[[Category: Cystatin some]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Thiol protease inhibitor~~]]	+

OCA at 11:21, 28 July 2021

OCA — Wed, 28 Jul 2021 11:21:29 GMT

←Older revision		Revision as of 11:21, 28 July 2021
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	<StructureSection load='1gd4' size='340' side='right'caption='[[1gd4]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1gd4' size='340' side='right'caption='[[1gd4]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gd4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GD4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1GD4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gd4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GD4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GD4 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cyu\|1cyu]], [[1cyv\|1cyv]], [[1gd3\|1gd3]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cyu\|1cyu]], [[1cyv\|1cyv]], [[1gd3\|1gd3]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1gd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gd4 OCA], [~~http~~://pdbe.org/1gd4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1gd4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1gd4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1gd4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gd4 OCA], [https://pdbe.org/1gd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gd4 RCSB], [https://www.ebi.ac.uk/pdbsum/1gd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gd4 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/CYTA_HUMAN CYTA_HUMAN]] Defects in CSTA are the cause of ichthyosis exfoliative autosomal recessive ichthyosis bullosa of Siemens-like (AREI) [MIM:[~~http~~://omim.org/entry/607936 607936]]. A form of congenital exfoliative ichthyosis, sharing some features with ichthyosis bullosa of Siemens and annular epidermolytic ichthyosis. AREI presents shortly after birth as dry, scaly skin over most of the body with coarse peeling of non-erythematous skin on the palms and soles, which is exacerbated by excessive moisture and minor trauma. Electron microscopy analysis of skin biopsies, reveals mostly normal-appearing upper layers of the epidermis, but prominent intercellular edema of the basal and suprabasal cell layers with aggregates of tonofilaments in the basal keratinocytes.<ref>PMID:21944047</ref>	+	[[https://www.uniprot.org/uniprot/CYTA_HUMAN CYTA_HUMAN]] Defects in CSTA are the cause of ichthyosis exfoliative autosomal recessive ichthyosis bullosa of Siemens-like (AREI) [MIM:[https://omim.org/entry/607936 607936]]. A form of congenital exfoliative ichthyosis, sharing some features with ichthyosis bullosa of Siemens and annular epidermolytic ichthyosis. AREI presents shortly after birth as dry, scaly skin over most of the body with coarse peeling of non-erythematous skin on the palms and soles, which is exacerbated by excessive moisture and minor trauma. Electron microscopy analysis of skin biopsies, reveals mostly normal-appearing upper layers of the epidermis, but prominent intercellular edema of the basal and suprabasal cell layers with aggregates of tonofilaments in the basal keratinocytes.<ref>PMID:21944047</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CYTA_HUMAN CYTA_HUMAN]] This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.<ref>PMID:21944047</ref>	+	[[https://www.uniprot.org/uniprot/CYTA_HUMAN CYTA_HUMAN]] This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.<ref>PMID:21944047</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:53, 23 October 2019

OCA — Wed, 23 Oct 2019 08:53:28 GMT

←Older revision		Revision as of 08:53, 23 October 2019
Line 1:		Line 1:

	==SOLUTION STRUCTURE OF P25S CYSTATIN A==		==SOLUTION STRUCTURE OF P25S CYSTATIN A==
-	<StructureSection load='1gd4' size='340' side='right' caption='[[1gd4]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='1gd4' size='340' side='right'caption='[[1gd4]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GD4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GD4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GD4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GD4 FirstGlance]. <br>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Kainosho, M]]		[[Category: Kainosho, M]]
	[[Category: Kaji, H]]		[[Category: Kaji, H]]

OCA at 06:35, 3 January 2018

OCA — Wed, 03 Jan 2018 06:35:46 GMT

←Older revision		Revision as of 06:35, 3 January 2018
Line 1:		Line 1:
		+
	==SOLUTION STRUCTURE OF P25S CYSTATIN A==		==SOLUTION STRUCTURE OF P25S CYSTATIN A==
	<StructureSection load='1gd4' size='340' side='right' caption='[[1gd4]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1gd4' size='340' side='right' caption='[[1gd4]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1gd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GD4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GD4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GD4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GD4 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cyu\|1cyu]], [[1cyv\|1cyv]], [[1gd3\|1gd3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cyu\|1cyu]], [[1cyv\|1cyv]], [[1gd3\|1gd3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gd4 OCA], [http://pdbe.org/1gd4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gd4 RCSB], [http://www.ebi.ac.uk/pdbsum/1gd4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gd4 OCA], [http://pdbe.org/1gd4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gd4 RCSB], [http://www.ebi.ac.uk/pdbsum/1gd4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gd4 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gd/1gd4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gd/1gd4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:18, 9 February 2016

OCA — Tue, 09 Feb 2016 01:18:00 GMT

←Older revision		Revision as of 01:18, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gd4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:12, 10 September 2015

OCA — Thu, 10 Sep 2015 17:12:24 GMT

←Older revision		Revision as of 17:12, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1gd4' size='340' side='right' caption='[[1gd4]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1gd4' size='340' side='right' caption='[[1gd4]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GD4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GD4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GD4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GD4 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cyu\|1cyu]], [[1cyv\|1cyv]], [[1gd3\|1gd3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cyu\|1cyu]], [[1cyv\|1cyv]], [[1gd3\|1gd3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gd4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gd4 RCSB], [http://www.ebi.ac.uk/pdbsum/1gd4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gd4 OCA], [http://pdbe.org/1gd4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gd4 RCSB], [http://www.ebi.ac.uk/pdbsum/1gd4 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1gd4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Kainosho, M]]		[[Category: Kainosho, M]]
	[[Category: Kaji, H]]		[[Category: Kaji, H]]

OCA at 19:36, 22 December 2014

OCA — Mon, 22 Dec 2014 19:36:33 GMT

←Older revision		Revision as of 19:36, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GD4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GD4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GD4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GD4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cyu\|1cyu]], [[1cyv\|1cyv]], [[1gd3\|1gd3]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cyu\|1cyu]], [[1cyv\|1cyv]], [[1gd3\|1gd3]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gd4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gd4 RCSB], [http://www.ebi.ac.uk/pdbsum/1gd4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gd4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gd4 RCSB], [http://www.ebi.ac.uk/pdbsum/1gd4 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/CYTA_HUMAN CYTA_HUMAN]] Defects in CSTA are the cause of ichthyosis exfoliative autosomal recessive ichthyosis bullosa of Siemens-like (AREI) [MIM:[http://omim.org/entry/607936 607936]]. A form of congenital exfoliative ichthyosis, sharing some features with ichthyosis bullosa of Siemens and annular epidermolytic ichthyosis. AREI presents shortly after birth as dry, scaly skin over most of the body with coarse peeling of non-erythematous skin on the palms and soles, which is exacerbated by excessive moisture and minor trauma. Electron microscopy analysis of skin biopsies, reveals mostly normal-appearing upper layers of the epidermis, but prominent intercellular edema of the basal and suprabasal cell layers with aggregates of tonofilaments in the basal keratinocytes.<ref>PMID:21944047</ref>		[[http://www.uniprot.org/uniprot/CYTA_HUMAN CYTA_HUMAN]] Defects in CSTA are the cause of ichthyosis exfoliative autosomal recessive ichthyosis bullosa of Siemens-like (AREI) [MIM:[http://omim.org/entry/607936 607936]]. A form of congenital exfoliative ichthyosis, sharing some features with ichthyosis bullosa of Siemens and annular epidermolytic ichthyosis. AREI presents shortly after birth as dry, scaly skin over most of the body with coarse peeling of non-erythematous skin on the palms and soles, which is exacerbated by excessive moisture and minor trauma. Electron microscopy analysis of skin biopsies, reveals mostly normal-appearing upper layers of the epidermis, but prominent intercellular edema of the basal and suprabasal cell layers with aggregates of tonofilaments in the basal keratinocytes.<ref>PMID:21944047</ref>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Kainosho, M.]]	+	[[Category: Kainosho, M]]
-	[[Category: Kaji, H.]]	+	[[Category: Kaji, H]]
-	[[Category: Kariya, E.]]	+	[[Category: Kariya, E]]
-	[[Category: Shimba, N.]]	+	[[Category: Shimba, N]]
-	[[Category: Tate, S.]]	+	[[Category: Tate, S]]
	[[Category: Cystatin some]]		[[Category: Cystatin some]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Thiol protease inhibitor]]		[[Category: Thiol protease inhibitor]]

OCA at 14:38, 29 September 2014

OCA — Mon, 29 Sep 2014 14:38:59 GMT

←Older revision		Revision as of 14:38, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1gd4~~\| ~~PDB~~=1gd4 \| ~~SCENE~~= }}	+	==SOLUTION STRUCTURE OF P25S CYSTATIN A==
-	===~~SOLUTION STRUCTURE OF P25S CYSTATIN A~~===	+	<StructureSection load='1gd4' size='340' side='right' caption='[[1gd4]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_12836678}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1gd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GD4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GD4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cyu\|1cyu]], [[1cyv\|1cyv]], [[1gd3\|1gd3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gd4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gd4 RCSB], [http://www.ebi.ac.uk/pdbsum/1gd4 PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CYTA_HUMAN CYTA_HUMAN]] Defects in CSTA are the cause of ichthyosis exfoliative autosomal recessive ichthyosis bullosa of Siemens-like (AREI) [MIM:[http://omim.org/entry/607936 607936]]. A form of congenital exfoliative ichthyosis, sharing some features with ichthyosis bullosa of Siemens and annular epidermolytic ichthyosis. AREI presents shortly after birth as dry, scaly skin over most of the body with coarse peeling of non-erythematous skin on the palms and soles, which is exacerbated by excessive moisture and minor trauma. Electron microscopy analysis of skin biopsies, reveals mostly normal-appearing upper layers of the epidermis, but prominent intercellular edema of the basal and suprabasal cell layers with aggregates of tonofilaments in the basal keratinocytes.<ref>PMID:21944047</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CYTA_HUMAN CYTA_HUMAN]] This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.<ref>PMID:21944047</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gd/1gd4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The effect of substituting Pro25, located in the alpha-helical region of the cystatin A structure, with Ser has been studied. The structures of wild type and P25S cystatin A were determined by multidimensional NMR spectroscopy under comparable conditions. These two structures were virtually identical, and the alpha-helix between Glu15-Lys30 exists with uninterrupted continuity, with a slight bend at residue 25. In order to characterize the possible substitution effects of Pro25 with Ser on the alpha-helix, the chemical shifts of the amide nitrogens and protons, the generalized order parameters obtained by the analyses of the 15N-1H relaxation data, the amide proton exchange rates, and the NOE networks among the alpha-helical and surrounding residues were carefully compared. None of these parameters indicated any significant static or dynamic structural differences between the alpha-helical regions of the wild-type and P25S cystatin A proteins. We therefore conclude that our previous structure of the wild-type cystatin A, in which the alpha-helix exhibited a sharp kink at Pro25, must be revised. The asymmetric distribution of hydrophobic interactions between the side-chain residues of the alpha-helix and the rolled beta-sheet surface, as revealed by NOEs, may be responsible for the slight bend of the alpha-helix in both variants and for the destabilized hydrogen bonding of the alpha-helical residues that follow Pro25/Ser25, as evidenced by increased amide exchange rates.

-	~~==Disease==~~	+	Structural comparison between wild-type and P25S human cystatin A by NMR spectroscopy. Does this mutation affect the alpha-helix conformation?,Shimba N, Kariya E, Tate S, Kaji H, Kainosho M J Struct Funct Genomics. 2000;1(1):26-42. PMID:12836678<ref>PMID:12836678</ref>
-	~~[[http://www.uniprot.org/uniprot/CYTA_HUMAN CYTA_HUMAN]] Defects in CSTA are the cause of ichthyosis exfoliative autosomal recessive ichthyosis bullosa of Siemens~~-~~like (AREI) [MIM:[http://omim.org/entry/607936 607936]].~~ A ~~form of congenital exfoliative ichthyosis, sharing some features with ichthyosis bullosa of Siemens and annular epidermolytic ichthyosis~~. ~~AREI presents shortly after birth as dry, scaly skin over most of~~ the ~~body with coarse peeling of non~~-~~erythematous skin on the palms and soles~~, ~~which is exacerbated by excessive moisture and minor trauma. Electron microscopy analysis of skin biopsies~~, ~~reveals mostly normal-appearing upper layers of the epidermis~~, ~~but prominent intercellular edema of the basal and suprabasal cell layers with aggregates of tonofilaments in the basal keratinocytes~~.<ref>PMID:~~21944047~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www~~.~~uniprot~~.~~org/uniprot/CYTA_HUMAN CYTA_HUMAN]] This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels~~ of ~~the epidermis~~.<~~ref~~>~~PMID:21944047~~</~~ref~~>	+	</div>
-		+	== References ==
-	==~~About this Structure==~~	+	<references/>
-	[[1gd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GD4 OCA].	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	~~<ref group="xtra">PMID:012836678</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kainosho, M.]]		[[Category: Kainosho, M.]]

OCA at 00:24, 25 March 2013

OCA — Mon, 25 Mar 2013 00:24:21 GMT

←Older revision		Revision as of 00:24, 25 March 2013
Line 1:		Line 1:
-	[[Image:1gd4.png\|left\|200px]]
-
	{{STRUCTURE_1gd4\| PDB=1gd4 \| SCENE= }}		{{STRUCTURE_1gd4\| PDB=1gd4 \| SCENE= }}
-
	===SOLUTION STRUCTURE OF P25S CYSTATIN A===		===SOLUTION STRUCTURE OF P25S CYSTATIN A===
		+	{{ABSTRACT_PUBMED_12836678}}

-	~~{{ABSTRACT_PUBMED_12836678}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CYTA_HUMAN CYTA_HUMAN]] Defects in CSTA are the cause of ichthyosis exfoliative autosomal recessive ichthyosis bullosa of Siemens-like (AREI) [MIM:[http://omim.org/entry/607936 607936]]. A form of congenital exfoliative ichthyosis, sharing some features with ichthyosis bullosa of Siemens and annular epidermolytic ichthyosis. AREI presents shortly after birth as dry, scaly skin over most of the body with coarse peeling of non-erythematous skin on the palms and soles, which is exacerbated by excessive moisture and minor trauma. Electron microscopy analysis of skin biopsies, reveals mostly normal-appearing upper layers of the epidermis, but prominent intercellular edema of the basal and suprabasal cell layers with aggregates of tonofilaments in the basal keratinocytes.<ref>PMID:21944047</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/CYTA_HUMAN CYTA_HUMAN]] This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.<ref>PMID:21944047</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:012836678</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012836678</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kainosho, M.]]		[[Category: Kainosho, M.]]

OCA: Protected "1gd4" [edit=sysop:move=sysop]

OCA — Wed, 21 Nov 2012 16:00:11 GMT

Protected "1gd4" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:00, 21 November 2012