1glv - Revision history

OCA at 07:25, 7 February 2024

OCA — Wed, 07 Feb 2024 07:25:34 GMT

←Older revision		Revision as of 07:25, 7 February 2024
Line 3:		Line 3:
	<StructureSection load='1glv' size='340' side='right'caption='[[1glv]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1glv' size='340' side='right'caption='[[1glv]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1glv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GLV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1glv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GLV FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>[~~https://en.wikipedia.org/wiki/Glutathione_synthase Glutathione synthase~~]~~, with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.~~2.~~3 6.3.2.3] </span>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1glv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1glv OCA], [https://pdbe.org/1glv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1glv RCSB], [https://www.ebi.ac.uk/pdbsum/1glv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1glv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1glv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1glv OCA], [https://pdbe.org/1glv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1glv RCSB], [https://www.ebi.ac.uk/pdbsum/1glv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1glv ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GSHB_ECOLI GSHB_ECOLI]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1glv ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1glv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Glutathione synthetase (gamma-L-glutamyl-L-cysteine: glycine ligase (ADP-forming) EC 6.3.2.3: GSHase) catalyzes the synthesis of glutathione from gamma-L-glutamyl-L-cysteine and Gly in the presence of ATP. The enzyme from Escherichia coli is a tetramer with four identical subunits of 316 amino acid residues. The crystal structure of the enzyme has been determined by isomorphous replacement and refined to a 2.0 A resolution. Two regions, Gly164 to Gly167 and Ile226 to Arg241, are invisible on the electron density map. The refined model of the subunit includes 296 amino acid residues and 107 solvent molecules. The crystallographic R-factor is 18.6% for 17.914 reflections with F > 3 sigma between 6.0 A and 2.0 A. The structure consists of three domains: the N-terminal, central, and C-terminal domains. In the tetrameric molecule, two subunits that are in close contact form a tight dimer, two tight dimers forming a tetramer with two solvent regions. The ATP molecule is located in the cleft between the central and C-terminal domains. The ATP binding site is surrounded by two sets of the structural motif that belong to those respective domains. Each motif consists of an anti-parallel beta-sheet and a glycine-rich loop.
-
-	Three-dimensional structure of the glutathione synthetase from Escherichia coli B at 2.0 A resolution.,Yamaguchi H, Kato H, Hata Y, Nishioka T, Kimura A, Oda J, Katsube Y J Mol Biol. 1993 Feb 20;229(4):1083-100. PMID:8445637<ref>PMID:8445637</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1glv" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Glutathione synthetase\|Glutathione synthetase]]		*[[Glutathione synthetase\|Glutathione synthetase]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895]]~~	+	[[Category: Escherichia coli]]
-	~~[[Category: Glutathione synthase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kato, H]]	+	[[Category: Kato H]]
-	[[Category: Katsube, Y]]	+	[[Category: Katsube Y]]
-	[[Category: Tanaka, T]]	+	[[Category: Tanaka T]]
-	[[Category: Yamaguchi, H]]	+	[[Category: Yamaguchi H]]
-	~~[[Category: Glutathione biosynthesis ligase~~]]	+

OCA at 11:25, 28 July 2021

OCA — Wed, 28 Jul 2021 11:25:38 GMT

←Older revision		Revision as of 11:25, 28 July 2021
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	<StructureSection load='1glv' size='340' side='right'caption='[[1glv]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1glv' size='340' side='right'caption='[[1glv]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1glv]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GLV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1GLV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1glv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GLV FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glutathione_synthase Glutathione synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.3 6.3.2.3] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutathione_synthase Glutathione synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.3 6.3.2.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1glv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1glv OCA], [~~http~~://pdbe.org/1glv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1glv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1glv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1glv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1glv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1glv OCA], [https://pdbe.org/1glv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1glv RCSB], [https://www.ebi.ac.uk/pdbsum/1glv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1glv ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 09:01, 23 October 2019

OCA — Wed, 23 Oct 2019 09:01:16 GMT

←Older revision		Revision as of 09:01, 23 October 2019
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	==THREE-DIMENSIONAL STRUCTURE OF THE GLUTATHIONE SYNTHETASE FROM ESCHERICHIA COLI B AT 2.0 ANGSTROMS RESOLUTION==		==THREE-DIMENSIONAL STRUCTURE OF THE GLUTATHIONE SYNTHETASE FROM ESCHERICHIA COLI B AT 2.0 ANGSTROMS RESOLUTION==
-	<StructureSection load='1glv' size='340' side='right' caption='[[1glv]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='1glv' size='340' side='right'caption='[[1glv]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1glv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GLV FirstGlance]. <br>		<table><tr><td colspan='2'>[[1glv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GLV FirstGlance]. <br>
Line 11:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gl/1glv_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gl/1glv_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 26:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 1glv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1glv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glutathione synthetase\|Glutathione synthetase]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 35:
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Glutathione synthase]]		[[Category: Glutathione synthase]]
		+	[[Category: Large Structures]]
	[[Category: Kato, H]]		[[Category: Kato, H]]
	[[Category: Katsube, Y]]		[[Category: Katsube, Y]]

OCA at 06:35, 29 November 2017

OCA — Wed, 29 Nov 2017 06:35:46 GMT

←Older revision		Revision as of 06:35, 29 November 2017
Line 1:		Line 1:
		+
	==THREE-DIMENSIONAL STRUCTURE OF THE GLUTATHIONE SYNTHETASE FROM ESCHERICHIA COLI B AT 2.0 ANGSTROMS RESOLUTION==		==THREE-DIMENSIONAL STRUCTURE OF THE GLUTATHIONE SYNTHETASE FROM ESCHERICHIA COLI B AT 2.0 ANGSTROMS RESOLUTION==
	<StructureSection load='1glv' size='340' side='right' caption='[[1glv]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1glv' size='340' side='right' caption='[[1glv]], [[Resolution\|resolution]] 2.70Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1glv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GLV FirstGlance]. <br>		<table><tr><td colspan='2'>[[1glv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GLV FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_synthase Glutathione synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.3 6.3.2.3] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_synthase Glutathione synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.3 6.3.2.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1glv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1glv OCA], [http://pdbe.org/1glv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1glv RCSB], [http://www.ebi.ac.uk/pdbsum/1glv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1glv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1glv OCA], [http://pdbe.org/1glv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1glv RCSB], [http://www.ebi.ac.uk/pdbsum/1glv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1glv ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</div>		</div>
	<div class="pdbe-citations 1glv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1glv" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Glutathione synthetase\|Glutathione synthetase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:10, 10 February 2016

OCA — Wed, 10 Feb 2016 05:10:50 GMT

←Older revision		Revision as of 05:10, 10 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1glv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:41, 11 September 2015

OCA — Fri, 11 Sep 2015 05:41:45 GMT

←Older revision		Revision as of 05:41, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1glv' size='340' side='right' caption='[[1glv]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1glv' size='340' side='right' caption='[[1glv]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1glv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GLV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1glv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GLV FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_synthase Glutathione synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.3 6.3.2.3] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_synthase Glutathione synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.3 6.3.2.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1glv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1glv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1glv RCSB], [http://www.ebi.ac.uk/pdbsum/1glv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1glv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1glv OCA], [http://pdbe.org/1glv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1glv RCSB], [http://www.ebi.ac.uk/pdbsum/1glv PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1glv" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Glutathione synthase]]		[[Category: Glutathione synthase]]
	[[Category: Kato, H]]		[[Category: Kato, H]]

OCA at 19:45, 22 December 2014

OCA — Mon, 22 Dec 2014 19:45:18 GMT

←Older revision		Revision as of 19:45, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1glv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GLV FirstGlance]. <br>		<table><tr><td colspan='2'>[[1glv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GLV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_synthase Glutathione synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.3 6.3.2.3] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_synthase Glutathione synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.3 6.3.2.3] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1glv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1glv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1glv RCSB], [http://www.ebi.ac.uk/pdbsum/1glv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1glv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1glv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1glv RCSB], [http://www.ebi.ac.uk/pdbsum/1glv PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Glutathione synthase]]		[[Category: Glutathione synthase]]
-	[[Category: Kato, H.]]	+	[[Category: Kato, H]]
-	[[Category: Katsube, Y.]]	+	[[Category: Katsube, Y]]
-	[[Category: Tanaka, T.]]	+	[[Category: Tanaka, T]]
-	[[Category: Yamaguchi, H.]]	+	[[Category: Yamaguchi, H]]
	[[Category: Glutathione biosynthesis ligase]]		[[Category: Glutathione biosynthesis ligase]]

OCA at 09:37, 28 September 2014

OCA — Sun, 28 Sep 2014 09:37:23 GMT

←Older revision		Revision as of 09:37, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1glv.~~png\|left~~\|200px]]	+	==THREE-DIMENSIONAL STRUCTURE OF THE GLUTATHIONE SYNTHETASE FROM ESCHERICHIA COLI B AT 2.0 ANGSTROMS RESOLUTION==
		+	<StructureSection load='1glv' size='340' side='right' caption='[[1glv]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1glv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GLV FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_synthase Glutathione synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.3 6.3.2.3] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1glv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1glv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1glv RCSB], [http://www.ebi.ac.uk/pdbsum/1glv PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gl/1glv_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glutathione synthetase (gamma-L-glutamyl-L-cysteine: glycine ligase (ADP-forming) EC 6.3.2.3: GSHase) catalyzes the synthesis of glutathione from gamma-L-glutamyl-L-cysteine and Gly in the presence of ATP. The enzyme from Escherichia coli is a tetramer with four identical subunits of 316 amino acid residues. The crystal structure of the enzyme has been determined by isomorphous replacement and refined to a 2.0 A resolution. Two regions, Gly164 to Gly167 and Ile226 to Arg241, are invisible on the electron density map. The refined model of the subunit includes 296 amino acid residues and 107 solvent molecules. The crystallographic R-factor is 18.6% for 17.914 reflections with F > 3 sigma between 6.0 A and 2.0 A. The structure consists of three domains: the N-terminal, central, and C-terminal domains. In the tetrameric molecule, two subunits that are in close contact form a tight dimer, two tight dimers forming a tetramer with two solvent regions. The ATP molecule is located in the cleft between the central and C-terminal domains. The ATP binding site is surrounded by two sets of the structural motif that belong to those respective domains. Each motif consists of an anti-parallel beta-sheet and a glycine-rich loop.

-	~~{{STRUCTURE_1glv\| PDB=1glv \| SCENE= }}~~	+	Three-dimensional structure of the glutathione synthetase from Escherichia coli B at 2.0 A resolution.,Yamaguchi H, Kato H, Hata Y, Nishioka T, Kimura A, Oda J, Katsube Y J Mol Biol. 1993 Feb 20;229(4):1083-100. PMID:8445637<ref>PMID:8445637</ref>

-	~~===THREE-DIMENSIONAL STRUCTURE OF THE GLUTATHIONE SYNTHETASE FROM ESCHERICHIA COLI B AT 2.0 ANGSTROMS RESOLUTION===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_8445637}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1glv]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1GLV OCA].~~	+

	==See Also==		==See Also==
	*[[Glutathione synthetase\|Glutathione synthetase]]		*[[Glutathione synthetase\|Glutathione synthetase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:008445637<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Glutathione synthase]]		[[Category: Glutathione synthase]]

OCA at 16:26, 20 October 2012

OCA — Sat, 20 Oct 2012 16:26:42 GMT

←Older revision		Revision as of 16:26, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1glv]] is a 1 chain structure ~~of [[Glutathione synthetase]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GLV OCA].	+	[[1glv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GLV OCA].

	==See Also==		==See Also==

OCA: Protected "1glv" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 21:42:38 GMT

Protected "1glv" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:42, 26 July 2012