1gnb - Revision history

OCA at 07:55, 3 May 2023

OCA — Wed, 03 May 2023 07:55:31 GMT

←Older revision		Revision as of 07:55, 3 May 2023
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	==DETERMINATION OF THE SOLUTION STRUCTURE OF THE PEPTIDE HORMONE GUANYLIN: OBSERVATION OF A NOVEL FORM OF TOPOLOGICAL STEREOISOMERISM==		==DETERMINATION OF THE SOLUTION STRUCTURE OF THE PEPTIDE HORMONE GUANYLIN: OBSERVATION OF A NOVEL FORM OF TOPOLOGICAL STEREOISOMERISM==
-	<StructureSection load='1gnb' size='340' side='right'caption='[[1gnb~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1gnb' size='340' side='right'caption='[[1gnb]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gnb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GNB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gnb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GNB FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnb OCA], [https://pdbe.org/1gnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gnb RCSB], [https://www.ebi.ac.uk/pdbsum/1gnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gnb ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnb OCA], [https://pdbe.org/1gnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gnb RCSB], [https://www.ebi.ac.uk/pdbsum/1gnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gnb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GUC2A_HUMAN GUC2A_HUMAN]] Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.	+	[https://www.uniprot.org/uniprot/GUC2A_HUMAN GUC2A_HUMAN] Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Garcia~~, K C~~]]	+	[[Category: Garcia KC]]
-	[[Category: Skelton~~, N J]]~~	+	[[Category: Skelton NJ]]
-	~~[[Category: Hormone~~]]	+

OCA at 11:26, 28 July 2021

OCA — Wed, 28 Jul 2021 11:26:04 GMT

←Older revision		Revision as of 11:26, 28 July 2021
Line 3:		Line 3:
	<StructureSection load='1gnb' size='340' side='right'caption='[[1gnb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1gnb' size='340' side='right'caption='[[1gnb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gnb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1GNB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gnb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GNB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1gnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnb OCA], [~~http~~://pdbe.org/1gnb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1gnb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1gnb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1gnb ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnb OCA], [https://pdbe.org/1gnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gnb RCSB], [https://www.ebi.ac.uk/pdbsum/1gnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gnb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GUC2A_HUMAN GUC2A_HUMAN]] Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.	+	[[https://www.uniprot.org/uniprot/GUC2A_HUMAN GUC2A_HUMAN]] Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:16, 23 October 2019

OCA — Wed, 23 Oct 2019 09:16:21 GMT

←Older revision		Revision as of 09:16, 23 October 2019
Line 1:		Line 1:

	==DETERMINATION OF THE SOLUTION STRUCTURE OF THE PEPTIDE HORMONE GUANYLIN: OBSERVATION OF A NOVEL FORM OF TOPOLOGICAL STEREOISOMERISM==		==DETERMINATION OF THE SOLUTION STRUCTURE OF THE PEPTIDE HORMONE GUANYLIN: OBSERVATION OF A NOVEL FORM OF TOPOLOGICAL STEREOISOMERISM==
-	<StructureSection load='1gnb' size='340' side='right' caption='[[1gnb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1gnb' size='340' side='right'caption='[[1gnb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gnb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GNB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gnb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GNB FirstGlance]. <br>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Garcia, K C]]		[[Category: Garcia, K C]]
	[[Category: Skelton, N J]]		[[Category: Skelton, N J]]
	[[Category: Hormone]]		[[Category: Hormone]]

OCA at 06:35, 29 November 2017

OCA — Wed, 29 Nov 2017 06:35:55 GMT

←Older revision		Revision as of 06:35, 29 November 2017
Line 3:		Line 3:
	<StructureSection load='1gnb' size='340' side='right' caption='[[1gnb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1gnb' size='340' side='right' caption='[[1gnb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gnb]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GNB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gnb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GNB FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnb OCA], [http://pdbe.org/1gnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gnb RCSB], [http://www.ebi.ac.uk/pdbsum/1gnb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gnb ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnb OCA], [http://pdbe.org/1gnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gnb RCSB], [http://www.ebi.ac.uk/pdbsum/1gnb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gnb ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Garcia, K C]]		[[Category: Garcia, K C]]
	[[Category: Skelton, N J]]		[[Category: Skelton, N J]]
	[[Category: Hormone]]		[[Category: Hormone]]

OCA at 04:45, 21 September 2017

OCA — Thu, 21 Sep 2017 04:45:01 GMT

←Older revision		Revision as of 04:45, 21 September 2017
Line 1:		Line 1:
		+
	==DETERMINATION OF THE SOLUTION STRUCTURE OF THE PEPTIDE HORMONE GUANYLIN: OBSERVATION OF A NOVEL FORM OF TOPOLOGICAL STEREOISOMERISM==		==DETERMINATION OF THE SOLUTION STRUCTURE OF THE PEPTIDE HORMONE GUANYLIN: OBSERVATION OF A NOVEL FORM OF TOPOLOGICAL STEREOISOMERISM==
	<StructureSection load='1gnb' size='340' side='right' caption='[[1gnb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1gnb' size='340' side='right' caption='[[1gnb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gnb]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GNB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gnb]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GNB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnb OCA], [http://pdbe.org/1gnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gnb RCSB], [http://www.ebi.ac.uk/pdbsum/1gnb PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnb OCA], [http://pdbe.org/1gnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gnb RCSB], [http://www.ebi.ac.uk/pdbsum/1gnb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gnb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Garcia, K C]]		[[Category: Garcia, K C]]
	[[Category: Skelton, N J]]		[[Category: Skelton, N J]]
	[[Category: Hormone]]		[[Category: Hormone]]

OCA at 00:18, 12 September 2015

OCA — Sat, 12 Sep 2015 00:18:39 GMT

←Older revision		Revision as of 00:18, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1gnb' size='340' side='right' caption='[[1gnb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1gnb' size='340' side='right' caption='[[1gnb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gnb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GNB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gnb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GNB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gnb RCSB], [http://www.ebi.ac.uk/pdbsum/1gnb PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnb OCA], [http://pdbe.org/1gnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gnb RCSB], [http://www.ebi.ac.uk/pdbsum/1gnb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1gnb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Garcia, K C]]		[[Category: Garcia, K C]]
	[[Category: Skelton, N J]]		[[Category: Skelton, N J]]
	[[Category: Hormone]]		[[Category: Hormone]]

OCA at 21:18, 25 December 2014

OCA — Thu, 25 Dec 2014 21:18:50 GMT

←Older revision		Revision as of 21:18, 25 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gnb RCSB], [http://www.ebi.ac.uk/pdbsum/1gnb PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gnb RCSB], [http://www.ebi.ac.uk/pdbsum/1gnb PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GUC2A_HUMAN GUC2A_HUMAN]] Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 22:30, 22 December 2014

OCA — Mon, 22 Dec 2014 22:30:05 GMT

←Older revision		Revision as of 22:30, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gnb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GNB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gnb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GNB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gnb RCSB], [http://www.ebi.ac.uk/pdbsum/1gnb PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gnb RCSB], [http://www.ebi.ac.uk/pdbsum/1gnb PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Garcia, K C.]]	+	[[Category: Garcia, K C]]
-	[[Category: Skelton, N J.]]	+	[[Category: Skelton, N J]]
	[[Category: Hormone]]		[[Category: Hormone]]

OCA at 05:55, 8 June 2014

OCA — Sun, 08 Jun 2014 05:55:01 GMT

←Older revision		Revision as of 05:55, 8 June 2014
Line 1:		Line 1:
-	[[~~Image~~:1gnb.~~png\|left\|200px~~]]	+	==DETERMINATION OF THE SOLUTION STRUCTURE OF THE PEPTIDE HORMONE GUANYLIN: OBSERVATION OF A NOVEL FORM OF TOPOLOGICAL STEREOISOMERISM==
		+	<StructureSection load='1gnb' size='340' side='right' caption='[[1gnb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1gnb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GNB FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gnb RCSB], [http://www.ebi.ac.uk/pdbsum/1gnb PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Guanylin is a 15 amino acid mammalian hormone containing two disulfide bonds. Guanylin shares sequence similarity with the bacterial heat-stable enterotoxin (STa) and is capable of binding to and stimulating the STa guanylyl cyclase receptor. Biologically active peptides have been prepared by two methods: (1) enzymatic treatment of a 99 residue proprotein (denoted proguanylin) expressed in Escherichia coli and (2) solid-phase chemical synthesis. Although both sources yield material that is pure by high-performance liquid chromatography and mass spectrometry, analysis by nuclear magnetic resonance (NMR) indicates that peptides from both sources contain two conformationally distinct species present in a 1:1 ratio. The chemical shift differences between the two species are large, allowing unambiguous sequential NMR assignments to be made for both sets of resonances. Exchange between the two forms was not observed even at 70 degrees C. Structural restraints have been generated from nuclear Overhauser effects and scalar coupling constants and used to calculate structures for both forms using distance geometry and restrained energy minimization. The resulting structures for the first isoform are well defined (root-mean-square deviation from the average structure for backbone atoms of 0.47 A) and adopt a right-handed spiral conformation, similar to that observed for heat stable enterotoxin. The second isoform is less well defined (root-mean-square deviation from the average structure for backbone atoms of 1.07 A) but clearly adopts a very different fold consisting of a left-hand spiral. The differences in structure suggest that the two forms may have very different affinities toward the STa receptor. The observation of such isomerism has important implications for the common practice of introducing multiple disulfide bonds into small peptides to limit conformational flexibility and enhance bioactivity.

-	~~{{STRUCTURE_1gnb\| PDB=1gnb \| SCENE= }}~~	+	Determination of the solution structure of the peptide hormone guanylin: observation of a novel form of topological stereoisomerism.,Skelton NJ, Garcia KC, Goeddel DV, Quan C, Burnier JP Biochemistry. 1994 Nov 22;33(46):13581-92. PMID:7947768<ref>PMID:7947768</ref>

-	~~===DETERMINATION OF THE SOLUTION STRUCTURE OF THE PEPTIDE HORMONE GUANYLIN: OBSERVATION OF A NOVEL FORM OF TOPOLOGICAL STEREOISOMERISM===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_7947768}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1gnb]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1GNB OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:007947768<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Garcia, K C.]]		[[Category: Garcia, K C.]]
	[[Category: Skelton, N J.]]		[[Category: Skelton, N J.]]
	[[Category: Hormone]]		[[Category: Hormone]]

OCA: Protected "1gnb" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 16:59:54 GMT

Protected "1gnb" [edit=sysop:move=sysop]

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Revision as of 16:59, 14 August 2012