1gnj - Revision history

OCA at 12:00, 13 December 2023

OCA — Wed, 13 Dec 2023 12:00:54 GMT

←Older revision		Revision as of 12:00, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='1gnj' size='340' side='right'caption='[[1gnj]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1gnj' size='340' side='right'caption='[[1gnj]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gnj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. The January 2003 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serum Albumin'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2003_1 10.2210/rcsb_pdb/mom_2003_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GNJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gnj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The January 2003 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serum Albumin'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2003_1 10.2210/rcsb_pdb/mom_2003_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GNJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>[[1ao6\|1ao6]], [[1bj5\|1bj5]], [[1bke\|1bke]], [[1bm0\|1bm0]], [[1e78\|1e78]], [[1e7a\|1e7a]], [[1e7b\|1e7b]], [[1e7c\|1e7c]], [[1e7e\|1e7e]], [[1e7f\|1e7f]], [[1e7g\|1e7g]], [[1e7h\|1e7h]], [[1e7i\|1e7i]], [[1h9z\|1h9z]], [[1ha2\|1ha2]], [[1gni\|1gni]], [[1uor\|1uor]]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnj OCA], [https://pdbe.org/1gnj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gnj RCSB], [https://www.ebi.ac.uk/pdbsum/1gnj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gnj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnj OCA], [https://pdbe.org/1gnj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gnj RCSB], [https://www.ebi.ac.uk/pdbsum/1gnj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gnj ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>	+	[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>	+	[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Serum Albumin]]		[[Category: Serum Albumin]]
-	[[Category: Bhattacharya~~, A A~~]]	+	[[Category: Bhattacharya AA]]
-	[[Category: Curry, S]]	+	[[Category: Curry S]]
-	[[Category: Gruene, T]]	+	[[Category: Gruene T]]
-	[[Category: Petitpas, I]]	+	[[Category: Petitpas I]]
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Lipid-binding]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Plasma protein~~]]	+

OCA at 05:47, 28 April 2021

OCA — Wed, 28 Apr 2021 05:47:16 GMT

OCA at 06:40, 24 July 2019

OCA — Wed, 24 Jul 2019 06:40:03 GMT

←Older revision		Revision as of 06:40, 24 July 2019
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	==HUMAN SERUM ALBUMIN COMPLEXED WITH cis-5,8,11,14-EICOSATETRAENOIC ACID (ARACHIDONIC ACID)==		==HUMAN SERUM ALBUMIN COMPLEXED WITH cis-5,8,11,14-EICOSATETRAENOIC ACID (ARACHIDONIC ACID)==
-	<StructureSection load='1gnj' size='340' side='right' caption='[[1gnj]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='1gnj' size='340' side='right'caption='[[1gnj]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gnj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. The January 2003 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serum Albumin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2003_1 10.2210/rcsb_pdb/mom_2003_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GNJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gnj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. The January 2003 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serum Albumin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2003_1 10.2210/rcsb_pdb/mom_2003_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GNJ FirstGlance]. <br>
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 1gnj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1gnj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Albumin 3D structures\|Albumin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Serum Albumin]]		[[Category: Serum Albumin]]

OCA at 06:22, 3 January 2018

OCA — Wed, 03 Jan 2018 06:22:03 GMT

←Older revision		Revision as of 06:22, 3 January 2018
Line 1:		Line 1:
-	==HUMAN SERUM ALBUMIN COMPLEXED WITH ~~CIS~~-5,8,11,14-EICOSATETRAENOIC ACID (ARACHIDONIC ACID)==	+
		+	==HUMAN SERUM ALBUMIN COMPLEXED WITH cis-5,8,11,14-EICOSATETRAENOIC ACID (ARACHIDONIC ACID)==
	<StructureSection load='1gnj' size='340' side='right' caption='[[1gnj]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1gnj' size='340' side='right' caption='[[1gnj]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ao6\|1ao6]], [[1bj5\|1bj5]], [[1bke\|1bke]], [[1bm0\|1bm0]], [[1e78\|1e78]], [[1e7a\|1e7a]], [[1e7b\|1e7b]], [[1e7c\|1e7c]], [[1e7e\|1e7e]], [[1e7f\|1e7f]], [[1e7g\|1e7g]], [[1e7h\|1e7h]], [[1e7i\|1e7i]], [[1h9z\|1h9z]], [[1ha2\|1ha2]], [[1gni\|1gni]], [[1uor\|1uor]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ao6\|1ao6]], [[1bj5\|1bj5]], [[1bke\|1bke]], [[1bm0\|1bm0]], [[1e78\|1e78]], [[1e7a\|1e7a]], [[1e7b\|1e7b]], [[1e7c\|1e7c]], [[1e7e\|1e7e]], [[1e7f\|1e7f]], [[1e7g\|1e7g]], [[1e7h\|1e7h]], [[1e7i\|1e7i]], [[1h9z\|1h9z]], [[1ha2\|1ha2]], [[1gni\|1gni]], [[1uor\|1uor]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnj OCA], [http://pdbe.org/1gnj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gnj RCSB], [http://www.ebi.ac.uk/pdbsum/1gnj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnj OCA], [http://pdbe.org/1gnj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gnj RCSB], [http://www.ebi.ac.uk/pdbsum/1gnj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gnj ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gn/1gnj_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gn/1gnj_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 1gnj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1gnj" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Albumin\|Albumin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:37, 10 February 2016

OCA — Wed, 10 Feb 2016 07:37:01 GMT

←Older revision		Revision as of 07:37, 10 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gnj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:45, 11 September 2015

OCA — Fri, 11 Sep 2015 06:45:38 GMT

←Older revision		Revision as of 06:45, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1gnj' size='340' side='right' caption='[[1gnj]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1gnj' size='340' side='right' caption='[[1gnj]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gnj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. The January 2003 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serum Albumin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2003_1 10.2210/rcsb_pdb/mom_2003_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GNJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gnj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. The January 2003 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serum Albumin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2003_1 10.2210/rcsb_pdb/mom_2003_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GNJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ao6\|1ao6]], [[1bj5\|1bj5]], [[1bke\|1bke]], [[1bm0\|1bm0]], [[1e78\|1e78]], [[1e7a\|1e7a]], [[1e7b\|1e7b]], [[1e7c\|1e7c]], [[1e7e\|1e7e]], [[1e7f\|1e7f]], [[1e7g\|1e7g]], [[1e7h\|1e7h]], [[1e7i\|1e7i]], [[1h9z\|1h9z]], [[1ha2\|1ha2]], [[1gni\|1gni]], [[1uor\|1uor]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ao6\|1ao6]], [[1bj5\|1bj5]], [[1bke\|1bke]], [[1bm0\|1bm0]], [[1e78\|1e78]], [[1e7a\|1e7a]], [[1e7b\|1e7b]], [[1e7c\|1e7c]], [[1e7e\|1e7e]], [[1e7f\|1e7f]], [[1e7g\|1e7g]], [[1e7h\|1e7h]], [[1e7i\|1e7i]], [[1h9z\|1h9z]], [[1ha2\|1ha2]], [[1gni\|1gni]], [[1uor\|1uor]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gnj RCSB], [http://www.ebi.ac.uk/pdbsum/1gnj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnj OCA], [http://pdbe.org/1gnj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gnj RCSB], [http://www.ebi.ac.uk/pdbsum/1gnj PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1gnj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Serum Albumin]]		[[Category: Serum Albumin]]

OCA at 21:03, 22 December 2014

OCA — Mon, 22 Dec 2014 21:03:42 GMT

←Older revision		Revision as of 21:03, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gnj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The January 2003 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serum Albumin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2003_1 10.2210/rcsb_pdb/mom_2003_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GNJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gnj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The January 2003 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serum Albumin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2003_1 10.2210/rcsb_pdb/mom_2003_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GNJ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ao6\|1ao6]], [[1bj5\|1bj5]], [[1bke\|1bke]], [[1bm0\|1bm0]], [[1e78\|1e78]], [[1e7a\|1e7a]], [[1e7b\|1e7b]], [[1e7c\|1e7c]], [[1e7e\|1e7e]], [[1e7f\|1e7f]], [[1e7g\|1e7g]], [[1e7h\|1e7h]], [[1e7i\|1e7i]], [[1h9z\|1h9z]], [[1ha2\|1ha2]], [[1gni\|1gni]], [[1uor\|1uor]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ao6\|1ao6]], [[1bj5\|1bj5]], [[1bke\|1bke]], [[1bm0\|1bm0]], [[1e78\|1e78]], [[1e7a\|1e7a]], [[1e7b\|1e7b]], [[1e7c\|1e7c]], [[1e7e\|1e7e]], [[1e7f\|1e7f]], [[1e7g\|1e7g]], [[1e7h\|1e7h]], [[1e7i\|1e7i]], [[1h9z\|1h9z]], [[1ha2\|1ha2]], [[1gni\|1gni]], [[1uor\|1uor]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gnj RCSB], [http://www.ebi.ac.uk/pdbsum/1gnj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gnj RCSB], [http://www.ebi.ac.uk/pdbsum/1gnj PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>		[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
Line 39:		Line 39:
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Serum Albumin]]		[[Category: Serum Albumin]]
-	[[Category: Bhattacharya, A A.]]	+	[[Category: Bhattacharya, A A]]
-	[[Category: Curry, S.]]	+	[[Category: Curry, S]]
-	[[Category: Gruene, T.]]	+	[[Category: Gruene, T]]
-	[[Category: Petitpas, I.]]	+	[[Category: Petitpas, I]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Lipid-binding]]		[[Category: Lipid-binding]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Plasma protein]]		[[Category: Plasma protein]]

OCA at 15:26, 29 September 2014

OCA — Mon, 29 Sep 2014 15:26:14 GMT

←Older revision		Revision as of 15:26, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1gnj\| PDB=1gnj \| SCENE= }}~~	+	==HUMAN SERUM ALBUMIN COMPLEXED WITH CIS-5,8,11,14-EICOSATETRAENOIC ACID (ARACHIDONIC ACID)==
-	===HUMAN SERUM ALBUMIN COMPLEXED WITH CIS-5,8,11,14-EICOSATETRAENOIC ACID (ARACHIDONIC ACID)===	+	<StructureSection load='1gnj' size='340' side='right' caption='[[1gnj]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_11743713}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1gnj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The January 2003 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serum Albumin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2003_1 10.2210/rcsb_pdb/mom_2003_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GNJ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ao6\|1ao6]], [[1bj5\|1bj5]], [[1bke\|1bke]], [[1bm0\|1bm0]], [[1e78\|1e78]], [[1e7a\|1e7a]], [[1e7b\|1e7b]], [[1e7c\|1e7c]], [[1e7e\|1e7e]], [[1e7f\|1e7f]], [[1e7g\|1e7g]], [[1e7h\|1e7h]], [[1e7i\|1e7i]], [[1h9z\|1h9z]], [[1ha2\|1ha2]], [[1gni\|1gni]], [[1uor\|1uor]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gnj RCSB], [http://www.ebi.ac.uk/pdbsum/1gnj PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gn/1gnj_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The primary ligands of human serum albumin (HSA), an abundant plasma protein, are non-esterified fatty acids. In vivo, the majority of fatty acids associated with the protein are unsaturated. We present here the first high-resolution crystal structures of HSA complexed with two important unsaturated fatty acids, the monounsaturated oleic acid (C18:1) and the polyunsaturated arachidonic acid (C20:4). Both compounds are observed to occupy the seven binding sites distributed across the protein that are also bound by medium and long-chain saturated fatty acids. Although C18:1 fatty acid binds each site on HSA in a conformation almost identical with that of the corresponding saturated compound (C18:0), the presence of multiple cis double bonds in C20:4 induces distinct binding configurations at some sites. The observed restriction on binding configurations plausibly accounts for differences in the pattern of binding affinities for the primary sites between polyunsaturated fatty acids and their saturated or monounsaturated counterparts.

-	~~==Disease==~~	+	Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids.,Petitpas I, Grune T, Bhattacharya AA, Curry S J Mol Biol. 2001 Dec 14;314(5):955-60. PMID:11743713<ref>PMID:11743713</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia~~ (~~FDH~~) ~~[MIM~~:~~[http://omim~~.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:~~8048949</ref><ref>PMID:7852505</ref><ref>PMID:9329347</ref>~~<ref>PMID:~~9589637~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http://www.uniprot.org/uniprot~~/~~ALBU_HUMAN ALBU_HUMAN]] Serum albumin~~, ~~the main protein of plasma, has~~ a ~~good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation~~ of the ~~colloidal osmotic pressure of blood~~. ~~Major zinc transporter in plasma, typically binds about 80%~~ of ~~all plasma zinc~~.<~~ref~~>~~PMID:19021548~~</~~ref~~>	+	</div>
-		+
-	~~==About this Structure==~~	+
-	[[1gnj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The January 2003 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serum Albumin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2003_1 10.2210/rcsb_pdb/mom_2003_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNJ OCA].	+

	==See Also==		==See Also==
	*[[Albumin\|Albumin]]		*[[Albumin\|Albumin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:011743713</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]

OCA at 02:13, 25 March 2013

OCA — Mon, 25 Mar 2013 02:13:40 GMT

←Older revision		Revision as of 02:13, 25 March 2013
Line 1:		Line 1:
-	[[Image:1gnj.png\|left\|200px]]
-
	{{STRUCTURE_1gnj\| PDB=1gnj \| SCENE= }}		{{STRUCTURE_1gnj\| PDB=1gnj \| SCENE= }}
-
	===HUMAN SERUM ALBUMIN COMPLEXED WITH CIS-5,8,11,14-EICOSATETRAENOIC ACID (ARACHIDONIC ACID)===		===HUMAN SERUM ALBUMIN COMPLEXED WITH CIS-5,8,11,14-EICOSATETRAENOIC ACID (ARACHIDONIC ACID)===
		+	{{ABSTRACT_PUBMED_11743713}}

-	~~{{ABSTRACT_PUBMED_11743713}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref><ref>PMID:7852505</ref><ref>PMID:9329347</ref><ref>PMID:9589637</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:011743713</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011743713</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]

OCA at 16:50, 20 October 2012

OCA — Sat, 20 Oct 2012 16:50:06 GMT

←Older revision		Revision as of 16:50, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1gnj]] is a 1 chain structure ~~of [[Albumin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The January 2003 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serum Albumin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2003_1 10.2210/rcsb_pdb/mom_2003_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNJ OCA].	+	[[1gnj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The January 2003 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serum Albumin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2003_1 10.2210/rcsb_pdb/mom_2003_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNJ OCA].

	==See Also==		==See Also==

←Older revision		Revision as of 05:47, 28 April 2021
Line 3:		Line 3:
	<StructureSection load='1gnj' size='340' side='right'caption='[[1gnj]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1gnj' size='340' side='right'caption='[[1gnj]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gnj]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. The January 2003 RCSB PDB [~~http~~://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serum Albumin'' by David S. Goodsell is [~~http~~://dx.doi.org/10.2210/rcsb_pdb/mom_2003_1 10.2210/rcsb_pdb/mom_2003_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1GNJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gnj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. The January 2003 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serum Albumin'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2003_1 10.2210/rcsb_pdb/mom_2003_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GNJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ao6\|1ao6]], [[1bj5\|1bj5]], [[1bke\|1bke]], [[1bm0\|1bm0]], [[1e78\|1e78]], [[1e7a\|1e7a]], [[1e7b\|1e7b]], [[1e7c\|1e7c]], [[1e7e\|1e7e]], [[1e7f\|1e7f]], [[1e7g\|1e7g]], [[1e7h\|1e7h]], [[1e7i\|1e7i]], [[1h9z\|1h9z]], [[1ha2\|1ha2]], [[1gni\|1gni]], [[1uor\|1uor]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ao6\|1ao6]], [[1bj5\|1bj5]], [[1bke\|1bke]], [[1bm0\|1bm0]], [[1e78\|1e78]], [[1e7a\|1e7a]], [[1e7b\|1e7b]], [[1e7c\|1e7c]], [[1e7e\|1e7e]], [[1e7f\|1e7f]], [[1e7g\|1e7g]], [[1e7h\|1e7h]], [[1e7i\|1e7i]], [[1h9z\|1h9z]], [[1ha2\|1ha2]], [[1gni\|1gni]], [[1uor\|1uor]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1gnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnj OCA], [~~http~~://pdbe.org/1gnj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1gnj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1gnj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1gnj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnj OCA], [https://pdbe.org/1gnj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gnj RCSB], [https://www.ebi.ac.uk/pdbsum/1gnj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gnj ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[~~http~~://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>	+	[[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>	+	[[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]