1gvl - Revision history

OCA at 12:08, 13 December 2023

OCA — Wed, 13 Dec 2023 12:08:39 GMT

←Older revision		Revision as of 12:08, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='1gvl' size='340' side='right'caption='[[1gvl]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1gvl' size='340' side='right'caption='[[1gvl]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gvl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GVL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gvl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GVL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gvl OCA], [https://pdbe.org/1gvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gvl RCSB], [https://www.ebi.ac.uk/pdbsum/1gvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gvl ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gvl OCA], [https://pdbe.org/1gvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gvl RCSB], [https://www.ebi.ac.uk/pdbsum/1gvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gvl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/KLK6_HUMAN KLK6_HUMAN]] Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.<ref>PMID:12878203</ref> <ref>PMID:12928483</ref> <ref>PMID:15557757</ref> <ref>PMID:16987227</ref> <ref>PMID:16321973</ref> <ref>PMID:11983703</ref>	+	[https://www.uniprot.org/uniprot/KLK6_HUMAN KLK6_HUMAN] Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.<ref>PMID:12878203</ref> <ref>PMID:12928483</ref> <ref>PMID:15557757</ref> <ref>PMID:16987227</ref> <ref>PMID:16321973</ref> <ref>PMID:11983703</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aviles~~, F X~~]]	+	[[Category: Aviles FX]]
-	[[Category: Bayes, A]]	+	[[Category: Bayes A]]
-	[[Category: Coll, M]]	+	[[Category: Coll M]]
-	[[Category: Gomis-Ruth~~, F X~~]]	+	[[Category: Gomis-Ruth FX]]
-	[[Category: Pampalakis, G]]	+	[[Category: Pampalakis G]]
-	[[Category: Sotiropoulou, G]]	+	[[Category: Sotiropoulou G]]
-	[[Category: Tsetsenis, T]]	+	[[Category: Tsetsenis T]]
-	[[Category: Villegas, V]]	+	[[Category: Villegas V]]
-	~~[[Category: Human kallikrein]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Zymogen~~]]	+

OCA at 11:29, 28 July 2021

OCA — Wed, 28 Jul 2021 11:29:10 GMT

←Older revision		Revision as of 11:29, 28 July 2021
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	<StructureSection load='1gvl' size='340' side='right'caption='[[1gvl]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1gvl' size='340' side='right'caption='[[1gvl]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gvl]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GVL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1GVL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gvl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GVL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1gvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gvl OCA], [~~http~~://pdbe.org/1gvl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1gvl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1gvl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1gvl ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gvl OCA], [https://pdbe.org/1gvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gvl RCSB], [https://www.ebi.ac.uk/pdbsum/1gvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gvl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KLK6_HUMAN KLK6_HUMAN]] Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.<ref>PMID:12878203</ref> <ref>PMID:12928483</ref> <ref>PMID:15557757</ref> <ref>PMID:16987227</ref> <ref>PMID:16321973</ref> <ref>PMID:11983703</ref>	+	[[https://www.uniprot.org/uniprot/KLK6_HUMAN KLK6_HUMAN]] Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.<ref>PMID:12878203</ref> <ref>PMID:12928483</ref> <ref>PMID:15557757</ref> <ref>PMID:16987227</ref> <ref>PMID:16321973</ref> <ref>PMID:11983703</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:18, 23 October 2019

OCA — Wed, 23 Oct 2019 09:18:38 GMT

←Older revision		Revision as of 09:18, 23 October 2019
Line 1:		Line 1:

	==Human prokallikrein 6 (hK6)/ prozyme/ proprotease M/ proneurosin==		==Human prokallikrein 6 (hK6)/ prozyme/ proprotease M/ proneurosin==
-	<StructureSection load='1gvl' size='340' side='right' caption='[[1gvl]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1gvl' size='340' side='right'caption='[[1gvl]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gvl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GVL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gvl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GVL FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 1gvl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1gvl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Kallikrein 3D structures\|Kallikrein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Aviles, F X]]		[[Category: Aviles, F X]]
	[[Category: Bayes, A]]		[[Category: Bayes, A]]

OCA at 06:54, 3 January 2018

OCA — Wed, 03 Jan 2018 06:54:01 GMT

←Older revision		Revision as of 06:54, 3 January 2018
Line 1:		Line 1:
-	==~~HUMAN PROKALLIKREIN~~ 6 (~~HK6~~)/ ~~PROZYME~~/ ~~PROPROTEASE~~ M/ ~~PRONEUROSIN~~==	+
		+	==Human prokallikrein 6 (hK6)/ prozyme/ proprotease M/ proneurosin==
	<StructureSection load='1gvl' size='340' side='right' caption='[[1gvl]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1gvl' size='340' side='right' caption='[[1gvl]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gvl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GVL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gvl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GVL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gvl OCA], [http://pdbe.org/1gvl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gvl RCSB], [http://www.ebi.ac.uk/pdbsum/1gvl PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gvl OCA], [http://pdbe.org/1gvl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gvl RCSB], [http://www.ebi.ac.uk/pdbsum/1gvl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gvl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gv/1gvl_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gv/1gvl_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 1gvl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1gvl" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Kallikrein\|Kallikrein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:55, 7 February 2016

OCA — Sun, 07 Feb 2016 23:55:26 GMT

←Older revision		Revision as of 23:55, 7 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gvl ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:01, 10 September 2015

OCA — Thu, 10 Sep 2015 06:01:14 GMT

←Older revision		Revision as of 06:01, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1gvl' size='340' side='right' caption='[[1gvl]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1gvl' size='340' side='right' caption='[[1gvl]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gvl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GVL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gvl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GVL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gvl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gvl RCSB], [http://www.ebi.ac.uk/pdbsum/1gvl PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gvl OCA], [http://pdbe.org/1gvl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gvl RCSB], [http://www.ebi.ac.uk/pdbsum/1gvl PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1gvl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Kallikrein\|Kallikrein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Aviles, F X]]		[[Category: Aviles, F X]]
	[[Category: Bayes, A]]		[[Category: Bayes, A]]

OCA at 19:06, 24 December 2014

OCA — Wed, 24 Dec 2014 19:06:08 GMT

←Older revision		Revision as of 19:06, 24 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gvl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gvl RCSB], [http://www.ebi.ac.uk/pdbsum/1gvl PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gvl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gvl RCSB], [http://www.ebi.ac.uk/pdbsum/1gvl PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KLK6_HUMAN KLK6_HUMAN]] Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.<ref>PMID:12878203</ref> <ref>PMID:12928483</ref> <ref>PMID:15557757</ref> <ref>PMID:16987227</ref> <ref>PMID:16321973</ref> <ref>PMID:11983703</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 20:53, 22 December 2014

OCA — Mon, 22 Dec 2014 20:53:08 GMT

←Older revision		Revision as of 20:53, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gvl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GVL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gvl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GVL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gvl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gvl RCSB], [http://www.ebi.ac.uk/pdbsum/1gvl PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gvl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gvl RCSB], [http://www.ebi.ac.uk/pdbsum/1gvl PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Aviles, F X.]]	+	[[Category: Aviles, F X]]
-	[[Category: Bayes, A.]]	+	[[Category: Bayes, A]]
-	[[Category: Coll, M.]]	+	[[Category: Coll, M]]
-	[[Category: Gomis-Ruth, F X.]]	+	[[Category: Gomis-Ruth, F X]]
-	[[Category: Pampalakis, G.]]	+	[[Category: Pampalakis, G]]
-	[[Category: Sotiropoulou, G.]]	+	[[Category: Sotiropoulou, G]]
-	[[Category: Tsetsenis, T.]]	+	[[Category: Tsetsenis, T]]
-	[[Category: Villegas, V.]]	+	[[Category: Villegas, V]]
	[[Category: Human kallikrein]]		[[Category: Human kallikrein]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Zymogen]]		[[Category: Zymogen]]

OCA at 10:44, 28 September 2014

OCA — Sun, 28 Sep 2014 10:44:55 GMT

←Older revision		Revision as of 10:44, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1gvl.~~png\|left~~\|200px]]	+	==HUMAN PROKALLIKREIN 6 (HK6)/ PROZYME/ PROPROTEASE M/ PRONEUROSIN==
		+	<StructureSection load='1gvl' size='340' side='right' caption='[[1gvl]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1gvl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GVL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gvl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gvl RCSB], [http://www.ebi.ac.uk/pdbsum/1gvl PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gv/1gvl_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Zyme/protease M/neurosin/human kallikrein 6 (hK6) is a member of the human kallikrein family of trypsin-like serine proteinases and was originally identified as being down-regulated in metastatic breast and ovarian tumors when compared with corresponding primary tumors. Recent evidence suggests that hK6 may serve as a circulating tumor marker in ovarian cancers. In addition, it was described in the brain of Parkinson's disease and Alzheimer's disease patients, where it is implicated in amyloid precursor protein processing. It is thus a biomarker for these diseases. To examine the mechanism of activation of hK6, we have solved the structure of its proform, the first of a human kallikrein family member. The proenzyme displays a fold that exhibits chimeric features between those of trypsinogen and other family members. It lacks the characteristic "kallikrein loop" and forms the six disulfide bridges of trypsin. Pro-hK6 displays a completely closed specificity pocket and a unique conformation of the regions involved in structural rearrangements upon proteolytic cleavage activation. This points to a novel activation mechanism, which could be extrapolated to other human kallikreins.

-	~~{{STRUCTURE_1gvl\| PDB=1gvl \| SCENE= }}~~	+	The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family.,Gomis-Ruth FX, Bayes A, Sotiropoulou G, Pampalakis G, Tsetsenis T, Villegas V, Aviles FX, Coll M J Biol Chem. 2002 Jul 26;277(30):27273-81. Epub 2002 May 16. PMID:12016211<ref>PMID:12016211</ref>

-	~~===HUMAN PROKALLIKREIN 6 (HK6)~~/ ~~PROZYME/ PROPROTEASE M/ PRONEUROSIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12016211}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1gvl]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1GVL OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012016211<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Aviles, F X.]]		[[Category: Aviles, F X.]]

OCA: Protected "1gvl" [edit=sysop:move=sysop]

OCA — Wed, 21 Nov 2012 16:26:40 GMT

Protected "1gvl" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:26, 21 November 2012