1gw5 - Revision history

OCA: Redirecting to 2vgl

OCA — Sun, 23 Mar 2008 14:17:20 GMT

Redirecting to 2vgl

←Older revision		Revision as of 14:17, 23 March 2008
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-	[[~~Image:1gw5.jpg\|left\|200px~~]]	+	#REDIRECT [[2vgl]] This PDB entry is obsolete and replaced by 2vgl
-		+
-	~~{{Structure~~	+
-	\|PDB~~= 1gw5 \|SIZE=350\|CAPTION= <scene name='initialview01'>1gw5</scene>~~	+
-	~~\|SITE=~~	+
-	~~\|LIGAND=~~	+
-	~~\|ACTIVITY=~~	+
-	~~\|GENE=~~	+
-	}}	+
-		+
-	~~''''''~~	+
-		+
-		+
-	~~==About this Structure==~~	+
-	is ~~a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA].~~	+
-	~~[[Category: Protein complex]]~~	+
-		+
-	~~''Page seeded~~ by ~~[http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 11:59:57 2008''~~	+

OCA at 09:59, 23 March 2008

OCA — Sun, 23 Mar 2008 09:59:58 GMT

←Older revision		Revision as of 09:59, 23 March 2008
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-	~~#REDIRECT~~ [[~~2vgl~~]] ~~This~~ PDB ~~entry~~ is ~~obsolete and replaced~~ by ~~2vgl~~	+	[[Image:1gw5.jpg\|left\|200px]]
		+
		+	{{Structure
		+	\|PDB= 1gw5 \|SIZE=350\|CAPTION= <scene name='initialview01'>1gw5</scene>
		+	\|SITE=
		+	\|LIGAND=
		+	\|ACTIVITY=
		+	\|GENE=
		+	}}
		+
		+	''''''
		+
		+
		+	==About this Structure==
		+	is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA].
		+	[[Category: Protein complex]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 11:59:57 2008''

OCA: Redirecting to 2vgl

OCA — Wed, 19 Mar 2008 11:55:22 GMT

Redirecting to 2vgl

←Older revision		Revision as of 11:55, 19 March 2008
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-	[[~~Image:1gw5.jpg\|left\|200px~~]]~~<br /><applet load="1gw5" size="350" color="white" frame="true" align="right" spinBox="true"~~	+	#REDIRECT [[2vgl]] This PDB entry is obsolete and replaced by 2vgl
-	~~caption="1gw5" />~~	+
-	~~''''''<br />~~	+
-		+
-	~~==About this Structure==~~	+
-	is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA].	+
-	~~[[Category: Protein complex]]~~	+
-		+
-	~~''Page seeded~~ by ~~[http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:43:19 2008''~~	+

OCA at 07:43, 3 February 2008

OCA — Sun, 03 Feb 2008 07:43:19 GMT

←Older revision		Revision as of 07:43, 3 February 2008
Line 1:		Line 1:
-	[[Image:1gw5.jpg\|left\|200px]]<br /><applet load="1gw5" size="~~450~~" color="white" frame="true" align="right" spinBox="true"	+	[[Image:1gw5.jpg\|left\|200px]]<br /><applet load="1gw5" size="350" color="white" frame="true" align="right" spinBox="true"
-	caption="1gw5~~, resolution 2.59Å~~" />	+	caption="1gw5" />
-	'''~~AP2 CLATHRIN ADAPTOR CORE~~'''<br />	+	''''''<br />
-		+
-	~~==Overview==~~	+
-	AP2 is the best-characterized member of the family of heterotetrameric, clathrin adaptor complexes that play pivotal roles in many vesicle, trafficking pathways within the cell. AP2 functions in clathrin-mediated, endocytosis, the process whereby cargo enters the endosomal system from, the plasma membrane. We describe the structure of the 200 kDa AP2 "core", (alpha trunk, beta2 trunk, mu2, and sigma2) complexed with the, polyphosphatidylinositol headgroup mimic inositolhexakisphosphate at 2.6 A, resolution. Two potential polyphosphatidylinositide binding sites are, observed, one on alpha and one on mu2. The binding site for Yxxphi, endocytic motifs is buried, indicating that a conformational change, probably triggered by phosphorylation in the disordered mu2 linker, is, necessary to allow Yxxphi motif binding. A model for AP2 recruitment and, activation is proposed.	+

	==About this Structure==		==About this Structure==
-	~~1GW5~~ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~], [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with IHP as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1GW5 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb88_1.html Clathrin]]. Known structural/functional Site: <scene name='pdbsite=IHP:Ihp Binding Site For Chain A'>IHP</scene>. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=~~1GW5~~ OCA].	+	is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA].
-		+
-	~~==Reference==~~	+
-	Molecular architecture and functional model of the endocytic AP2 complex., Collins BM, McCoy AJ, Kent HM, Evans PR, Owen DJ, Cell. 2002 May 17;109(4):523-35. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12086608 12086608]	+
-	~~[[Category: Clathrin]]~~	+
-	~~[[Category: Homo sapiens]]~~	+
-	~~[[Category: Mus musculus]]~~	+
	[[Category: Protein complex]]		[[Category: Protein complex]]
-	[[Category: Rattus norvegicus]]
-	[[Category: Collins, B.M.]]
-	[[Category: Evans, P.R.]]
-	[[Category: Mccoy, A.J.]]
-	[[Category: Owen, D.J.]]
-	[[Category: IHP]]
-	[[Category: adaptor]]
-	[[Category: endocytosis]]

-	''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Dec 18 15~~:41:~~12 2007~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:43:19 2008''

OCA at 13:31, 18 December 2007

OCA — Tue, 18 Dec 2007 13:31:26 GMT

←Older revision		Revision as of 13:31, 18 December 2007
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-	[[Image:1gw5.~~gif~~\|left\|200px]]<br />	+	[[Image:1gw5.jpg\|left\|200px]]<br /><applet load="1gw5" size="450" color="white" frame="true" align="right" spinBox="true"
-	<applet load="1gw5" size="450" color="white" frame="true" align="right" spinBox="true"	+
	caption="1gw5, resolution 2.59Å" />		caption="1gw5, resolution 2.59Å" />
	'''AP2 CLATHRIN ADAPTOR CORE'''<br />		'''AP2 CLATHRIN ADAPTOR CORE'''<br />
Line 8:		Line 7:

	==About this Structure==		==About this Structure==
-	1GW5 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with IHP as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1GW5 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb88_1.html Clathrin]]. ~~Structure known Active~~ Site: IHP. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GW5 OCA].	+	1GW5 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with IHP as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1GW5 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb88_1.html Clathrin]]. Known structural/functional Site: <scene name='pdbsite=IHP:Ihp Binding Site For Chain A'>IHP</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GW5 OCA].

	==Reference==		==Reference==
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	[[Category: endocytosis]]		[[Category: endocytosis]]

-	''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 17~~:09:39 2007''	+	''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 15:41:12 2007''

OCA at 15:03, 12 November 2007

OCA — Mon, 12 Nov 2007 15:03:13 GMT

←Older revision		Revision as of 15:03, 12 November 2007
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	[[Category: endocytosis]]		[[Category: endocytosis]]

-	''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov ~~5 16~~:20:59 2007''	+	''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:09:39 2007''

OCA at 14:15, 5 November 2007

OCA — Mon, 05 Nov 2007 14:15:40 GMT

←Older revision		Revision as of 14:15, 5 November 2007
Line 25:		Line 25:
	[[Category: endocytosis]]		[[Category: endocytosis]]

-	''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 12:36:30 2007''	+	''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 16:20:59 2007''

OCA at 10:31, 5 November 2007

OCA — Mon, 05 Nov 2007 10:31:11 GMT

←Older revision		Revision as of 10:31, 5 November 2007
Line 5:		Line 5:

	==Overview==		==Overview==
-	AP2 is the best-characterized member of the family of heterotetrameric, clathrin adaptor complexes that play pivotal roles in many vesicle, trafficking pathways within the cell. AP2 functions in clathrin-mediated, endocytosis, the process whereby cargo enters the endosomal system from, the plasma membrane. We describe the structure of the 200 kDa AP2 "core", (alpha trunk, beta2 trunk, mu2, and sigma2) complexed with the, polyphosphatidylinositol headgroup mimic inositolhexakisphosphate at 2.6 A, resolution. Two potential polyphosphatidylinositide binding sites are, observed, one on alpha and one on mu2. The binding site for Yxxphi, endocytic motifs is buried, indicating that a conformational change, probably triggered by phosphorylation in the disordered mu2 linker, is, necessary to allow ..~~. [[http://ispc.weizmann.ac.il/pmbin/getpm?12086608 (full description)]]~~	+	AP2 is the best-characterized member of the family of heterotetrameric, clathrin adaptor complexes that play pivotal roles in many vesicle, trafficking pathways within the cell. AP2 functions in clathrin-mediated, endocytosis, the process whereby cargo enters the endosomal system from, the plasma membrane. We describe the structure of the 200 kDa AP2 "core", (alpha trunk, beta2 trunk, mu2, and sigma2) complexed with the, polyphosphatidylinositol headgroup mimic inositolhexakisphosphate at 2.6 A, resolution. Two potential polyphosphatidylinositide binding sites are, observed, one on alpha and one on mu2. The binding site for Yxxphi, endocytic motifs is buried, indicating that a conformational change, probably triggered by phosphorylation in the disordered mu2 linker, is, necessary to allow Yxxphi motif binding. A model for AP2 recruitment and, activation is proposed.

	==About this Structure==		==About this Structure==
-	1GW5 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]], [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] and [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with IHP as [[http://en.wikipedia.org/wiki/ligand ligand]]. The following page contains interesting information on the relation of 1GW5 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb88_1.html Clathrin]]. Structure known Active Site: IHP. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GW5 OCA]].	+	1GW5 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with IHP as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1GW5 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb88_1.html Clathrin]]. Structure known Active Site: IHP. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GW5 OCA].

	==Reference==		==Reference==
Line 25:		Line 25:
	[[Category: endocytosis]]		[[Category: endocytosis]]

-	''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on ~~Tue Oct 30 15~~:20:57 2007''	+	''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 12:36:30 2007''

OCA at 13:16, 30 October 2007

OCA — Tue, 30 Oct 2007 13:16:14 GMT

←Older revision		Revision as of 13:16, 30 October 2007
Line 25:		Line 25:
	[[Category: endocytosis]]		[[Category: endocytosis]]

-	''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:32:43 2007''	+	''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:20:57 2007''

OCA at 08:28, 30 October 2007

OCA — Tue, 30 Oct 2007 08:28:01 GMT

←Older revision		Revision as of 08:28, 30 October 2007
Line 25:		Line 25:
	[[Category: endocytosis]]		[[Category: endocytosis]]

-	''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:34:10 2007''	+	''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:32:43 2007''