1gwn - Revision history

OCA at 12:09, 13 December 2023

OCA — Wed, 13 Dec 2023 12:09:27 GMT

←Older revision		Revision as of 12:09, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='1gwn' size='340' side='right'caption='[[1gwn]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1gwn' size='340' side='right'caption='[[1gwn]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gwn]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1GWN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gwn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GWN FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GTP:GUANOSINE~~-~~5-TRIPHOSPHATE'>GTP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Rnd3, Arhe, Rhoe ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=5~~&id~~=~~10090 LK3 transgenic mice])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwn OCA], [~~http~~://pdbe.org/1gwn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1gwn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1gwn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1gwn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwn OCA], [https://pdbe.org/1gwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gwn RCSB], [https://www.ebi.ac.uk/pdbsum/1gwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gwn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RND3_MOUSE RND3_MOUSE]] Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.	+	[https://www.uniprot.org/uniprot/RND3_MOUSE RND3_MOUSE] Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Garavini, H]]	+	[[Category: Garavini H]]
-	[[Category: Keep~~, N H~~]]	+	[[Category: Keep NH]]
-	[[Category: McAlister~~, M S.B~~]]	+	[[Category: McAlister MSB]]
-	[[Category: Phelan~~, J P~~]]	+	[[Category: Phelan JP]]
-	[[Category: Ridley~~, A J~~]]	+	[[Category: Ridley AJ]]
-	[[Category: Riento, K]]	+	[[Category: Riento K]]
-	~~[[Category: Gtpase]]~~	+
-	~~[[Category: Inactive gtpase]]~~	+
-	~~[[Category: Signal transduction~~]]	+

OCA at 10:30, 18 November 2020

OCA — Wed, 18 Nov 2020 10:30:38 GMT

←Older revision		Revision as of 10:30, 18 November 2020
Line 1:		Line 1:

	==The crystal structure of the core domain of RhoE/Rnd3 - a constitutively activated small G protein==		==The crystal structure of the core domain of RhoE/Rnd3 - a constitutively activated small G protein==
-	<StructureSection load='1gwn' size='340' side='right' caption='[[1gwn]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1gwn' size='340' side='right'caption='[[1gwn]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWN OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1GWN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1GWN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rnd3, Arhe, Rhoe ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rnd3, Arhe, Rhoe ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwn OCA], [http://pdbe.org/1gwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gwn RCSB], [http://www.ebi.ac.uk/pdbsum/1gwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gwn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwn OCA], [http://pdbe.org/1gwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gwn RCSB], [http://www.ebi.ac.uk/pdbsum/1gwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gwn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[GTP-binding protein\|GTP-binding protein]]	+	*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]
-	*[[Rho GTPase\|Rho GTPase]]	+	*[[Rho GTPase 3D structures\|Rho GTPase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Garavini, H]]		[[Category: Garavini, H]]

OCA at 05:58, 20 June 2018

OCA — Wed, 20 Jun 2018 05:58:24 GMT

←Older revision		Revision as of 05:58, 20 June 2018
Line 3:		Line 3:
	<StructureSection load='1gwn' size='340' side='right' caption='[[1gwn]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1gwn' size='340' side='right' caption='[[1gwn]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gwn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GWN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GWN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rnd3, Arhe, Rhoe ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwn OCA], [http://pdbe.org/1gwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gwn RCSB], [http://www.ebi.ac.uk/pdbsum/1gwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gwn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwn OCA], [http://pdbe.org/1gwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gwn RCSB], [http://www.ebi.ac.uk/pdbsum/1gwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gwn ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RND3_MOUSE RND3_MOUSE]] Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/1gwn_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/1gwn_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Garavini, H]]		[[Category: Garavini, H]]
	[[Category: Keep, N H]]		[[Category: Keep, N H]]
-	[[Category: ~~Mcalister~~, M S.B]]	+	[[Category: McAlister, M S.B]]
	[[Category: Phelan, J P]]		[[Category: Phelan, J P]]
	[[Category: Ridley, A J]]		[[Category: Ridley, A J]]

OCA at 04:42, 21 September 2017

OCA — Thu, 21 Sep 2017 04:42:30 GMT

←Older revision		Revision as of 04:42, 21 September 2017
Line 1:		Line 1:
-	==~~THE CRYSTAL STRUCTURE OF THE CORE DOMAIN OF RHOE~~/~~RND3~~ - ~~A CONSTITUTIVELY ACTIVATED SMALL~~ G ~~PROTEIN~~==	+
		+	==The crystal structure of the core domain of RhoE/Rnd3 - a constitutively activated small G protein==
	<StructureSection load='1gwn' size='340' side='right' caption='[[1gwn]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1gwn' size='340' side='right' caption='[[1gwn]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gwn]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GWN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gwn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GWN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwn OCA], [http://pdbe.org/1gwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gwn RCSB], [http://www.ebi.ac.uk/pdbsum/1gwn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwn OCA], [http://pdbe.org/1gwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gwn RCSB], [http://www.ebi.ac.uk/pdbsum/1gwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gwn ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gwn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	==See Also==		==See Also==
	*[[GTP-binding protein\|GTP-binding protein]]		*[[GTP-binding protein\|GTP-binding protein]]
		+	*[[Rho GTPase\|Rho GTPase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Lk3 transgenic mice]]
	[[Category: Garavini, H]]		[[Category: Garavini, H]]
	[[Category: Keep, N H]]		[[Category: Keep, N H]]

OCA at 02:16, 12 September 2015

OCA — Sat, 12 Sep 2015 02:16:08 GMT

←Older revision		Revision as of 02:16, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1gwn' size='340' side='right' caption='[[1gwn]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1gwn' size='340' side='right' caption='[[1gwn]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GWN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GWN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gwn RCSB], [http://www.ebi.ac.uk/pdbsum/1gwn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwn OCA], [http://pdbe.org/1gwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gwn RCSB], [http://www.ebi.ac.uk/pdbsum/1gwn PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1gwn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Garavini, H]]		[[Category: Garavini, H]]
	[[Category: Keep, N H]]		[[Category: Keep, N H]]

OCA at 00:22, 23 December 2014

OCA — Tue, 23 Dec 2014 00:22:30 GMT

←Older revision		Revision as of 00:22, 23 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GWN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GWN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gwn RCSB], [http://www.ebi.ac.uk/pdbsum/1gwn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gwn RCSB], [http://www.ebi.ac.uk/pdbsum/1gwn PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Garavini, H.]]	+	[[Category: Garavini, H]]
-	[[Category: Keep, N H.]]	+	[[Category: Keep, N H]]
-	[[Category: Mcalister, M S.B.]]	+	[[Category: Mcalister, M S.B]]
-	[[Category: Phelan, J P.]]	+	[[Category: Phelan, J P]]
-	[[Category: Ridley, A J.]]	+	[[Category: Ridley, A J]]
-	[[Category: Riento, K.]]	+	[[Category: Riento, K]]
	[[Category: Gtpase]]		[[Category: Gtpase]]
	[[Category: Inactive gtpase]]		[[Category: Inactive gtpase]]
	[[Category: Signal transduction]]		[[Category: Signal transduction]]

OCA at 14:10, 28 September 2014

OCA — Sun, 28 Sep 2014 14:10:02 GMT

←Older revision		Revision as of 14:10, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1gwn.~~png\|left~~\|200px]]	+	==THE CRYSTAL STRUCTURE OF THE CORE DOMAIN OF RHOE/RND3 - A CONSTITUTIVELY ACTIVATED SMALL G PROTEIN==
		+	<StructureSection load='1gwn' size='340' side='right' caption='[[1gwn]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1gwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GWN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gwn RCSB], [http://www.ebi.ac.uk/pdbsum/1gwn PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/1gwn_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We report the 2.1 A crystal structure of the core G protein domain of the unusual Rho family member RhoE/Rnd3 in complex with endogenous GTP and magnesium. Unlike other small G proteins, RhoE, along with two other proteins Rnd1/Rho6 and Rnd2/RhoN, does not hydrolyze GTP. The main reason for this is the presence of serines in the positions equivalent to Ala59 and Gln61 in Ras. The structure shows that there are still water molecules in similar positions to the waters thought to be involved in the hydrolysis reaction in other G proteins. The structure suggests three not necessarily exclusive explanations for the lack of hydrolysis. The lack of the conserved glutamine raises the energy of the transition state inhibiting hydrolysis. The serines may restrain the waters from moving closer to the GTP, a step that is required to attain the transition state. They also stabilize the GTP-bound conformation of switch II and could prevent conformational changes required during hydrolysis. By superposition of the RhoE structure on structures of Rho family proteins in complex with binding partners, we make predictions on RhoE interactions with these partners.

-	~~{{STRUCTURE_1gwn\| PDB=1gwn \| SCENE= }}~~	+	Crystal structure of the core domain of RhoE/Rnd3: a constitutively activated small G protein.,Garavini H, Riento K, Phelan JP, McAlister MS, Ridley AJ, Keep NH Biochemistry. 2002 May 21;41(20):6303-10. PMID:12009891<ref>PMID:12009891</ref>

-	~~===THE CRYSTAL STRUCTURE OF THE CORE DOMAIN OF RHOE~~/~~RND3 - A CONSTITUTIVELY ACTIVATED SMALL G PROTEIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12009891}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1gwn]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1GWN OCA].~~	+

	==See Also==		==See Also==
	*[[GTP-binding protein\|GTP-binding protein]]		*[[GTP-binding protein\|GTP-binding protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012009891<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Garavini, H.]]		[[Category: Garavini, H.]]

OCA at 22:26, 20 October 2012

OCA — Sat, 20 Oct 2012 22:26:27 GMT

←Older revision		Revision as of 22:26, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1gwn]] is a 2 chain structure ~~of [[GTP-binding protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWN OCA].	+	[[1gwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWN OCA].

	==See Also==		==See Also==

OCA at 16:17, 27 July 2012

OCA — Fri, 27 Jul 2012 16:17:51 GMT

←Older revision		Revision as of 16:17, 27 July 2012
Line 1:		Line 1:
	[[Image:1gwn.png\|left\|200px]]		[[Image:1gwn.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1gwn", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1gwn\| PDB=1gwn \| SCENE= }}		{{STRUCTURE_1gwn\| PDB=1gwn \| SCENE= }}

	===THE CRYSTAL STRUCTURE OF THE CORE DOMAIN OF RHOE/RND3 - A CONSTITUTIVELY ACTIVATED SMALL G PROTEIN===		===THE CRYSTAL STRUCTURE OF THE CORE DOMAIN OF RHOE/RND3 - A CONSTITUTIVELY ACTIVATED SMALL G PROTEIN===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12009891}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12009891 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12009891}}		{{ABSTRACT_PUBMED_12009891}}

	==About this Structure==		==About this Structure==
-	[[1gwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWN OCA].	+	[[1gwn]] is a 2 chain structure of [[GTP-binding protein]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWN OCA].
		+
		+	==See Also==
		+	*[[GTP-binding protein\|GTP-binding protein]]

	==Reference==		==Reference==

OCA: Protected "1gwn" [edit=sysop:move=sysop]

OCA — Wed, 24 Aug 2011 05:40:27 GMT

Protected "1gwn" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:40, 24 August 2011