1gyc - Revision history

OCA at 12:10, 13 December 2023

OCA — Wed, 13 Dec 2023 12:10:27 GMT

←Older revision		Revision as of 12:10, 13 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gyc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trametes_versicolor Trametes versicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GYC FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gyc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trametes_versicolor Trametes versicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GYC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Laccase Laccase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyc OCA], [https://pdbe.org/1gyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gyc RCSB], [https://www.ebi.ac.uk/pdbsum/1gyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gyc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyc OCA], [https://pdbe.org/1gyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gyc RCSB], [https://www.ebi.ac.uk/pdbsum/1gyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gyc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LAC2_TRAVE LAC2_TRAVE]] Lignin degradation and detoxification of lignin-derived products (Probable).	+	[https://www.uniprot.org/uniprot/LAC2_TRAVE LAC2_TRAVE] Lignin degradation and detoxification of lignin-derived products (Probable).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Laccase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Trametes versicolor]]		[[Category: Trametes versicolor]]
-	[[Category: Antorini, M]]	+	[[Category: Antorini M]]
-	[[Category: Choinowski, T]]	+	[[Category: Choinowski T]]
-	[[Category: Piontek, K]]	+	[[Category: Piontek K]]
-	~~[[Category: Diphenol oxidase]]~~	+
-	~~[[Category: Lignin degradation]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 05:48, 28 April 2021

OCA — Wed, 28 Apr 2021 05:48:03 GMT

←Older revision		Revision as of 05:48, 28 April 2021
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	<StructureSection load='1gyc' size='340' side='right'caption='[[1gyc]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1gyc' size='340' side='right'caption='[[1gyc]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gyc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Trametes_versicolor Trametes versicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1GYC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gyc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trametes_versicolor Trametes versicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GYC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Laccase Laccase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Laccase Laccase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1gyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyc OCA], [~~http~~://pdbe.org/1gyc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1gyc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1gyc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1gyc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyc OCA], [https://pdbe.org/1gyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gyc RCSB], [https://www.ebi.ac.uk/pdbsum/1gyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gyc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LAC2_TRAVE LAC2_TRAVE]] Lignin degradation and detoxification of lignin-derived products (Probable).	+	[[https://www.uniprot.org/uniprot/LAC2_TRAVE LAC2_TRAVE]] Lignin degradation and detoxification of lignin-derived products (Probable).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:59, 26 June 2019

OCA — Wed, 26 Jun 2019 07:59:13 GMT

←Older revision		Revision as of 07:59, 26 June 2019
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	==CRYSTAL STRUCTURE DETERMINATION AT ROOM TEMPERATURE OF A LACCASE FROM TRAMETES VERSICOLOR IN ITS OXIDISED FORM CONTAINING A FULL COMPLEMENT OF COPPER IONS==		==CRYSTAL STRUCTURE DETERMINATION AT ROOM TEMPERATURE OF A LACCASE FROM TRAMETES VERSICOLOR IN ITS OXIDISED FORM CONTAINING A FULL COMPLEMENT OF COPPER IONS==
-	<StructureSection load='1gyc' size='340' side='right' caption='[[1gyc]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='1gyc' size='340' side='right'caption='[[1gyc]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gyc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trametes_versicolor Trametes versicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GYC FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gyc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trametes_versicolor Trametes versicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GYC FirstGlance]. <br>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gy/1gyc_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gy/1gyc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1gyc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1gyc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Laccase 3D structures\|Laccase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Laccase]]		[[Category: Laccase]]
		+	[[Category: Large Structures]]
	[[Category: Trametes versicolor]]		[[Category: Trametes versicolor]]
	[[Category: Antorini, M]]		[[Category: Antorini, M]]

OCA at 04:32, 21 September 2017

OCA — Thu, 21 Sep 2017 04:32:08 GMT

←Older revision		Revision as of 04:32, 21 September 2017
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		+
	==CRYSTAL STRUCTURE DETERMINATION AT ROOM TEMPERATURE OF A LACCASE FROM TRAMETES VERSICOLOR IN ITS OXIDISED FORM CONTAINING A FULL COMPLEMENT OF COPPER IONS==		==CRYSTAL STRUCTURE DETERMINATION AT ROOM TEMPERATURE OF A LACCASE FROM TRAMETES VERSICOLOR IN ITS OXIDISED FORM CONTAINING A FULL COMPLEMENT OF COPPER IONS==
	<StructureSection load='1gyc' size='340' side='right' caption='[[1gyc]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1gyc' size='340' side='right' caption='[[1gyc]], [[Resolution\|resolution]] 1.90Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Laccase Laccase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Laccase Laccase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyc OCA], [http://pdbe.org/1gyc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gyc RCSB], [http://www.ebi.ac.uk/pdbsum/1gyc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyc OCA], [http://pdbe.org/1gyc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gyc RCSB], [http://www.ebi.ac.uk/pdbsum/1gyc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gyc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gyc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:42, 11 September 2015

OCA — Fri, 11 Sep 2015 12:42:56 GMT

←Older revision		Revision as of 12:42, 11 September 2015
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Laccase Laccase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Laccase Laccase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gyc RCSB], [http://www.ebi.ac.uk/pdbsum/1gyc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyc OCA], [http://pdbe.org/1gyc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gyc RCSB], [http://www.ebi.ac.uk/pdbsum/1gyc PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1gyc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:36, 25 December 2014

OCA — Thu, 25 Dec 2014 16:36:30 GMT

←Older revision		Revision as of 16:36, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gyc RCSB], [http://www.ebi.ac.uk/pdbsum/1gyc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gyc RCSB], [http://www.ebi.ac.uk/pdbsum/1gyc PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LAC2_TRAVE LAC2_TRAVE]] Lignin degradation and detoxification of lignin-derived products (Probable).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 20:59, 22 December 2014

OCA — Mon, 22 Dec 2014 20:59:33 GMT

←Older revision		Revision as of 20:59, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gyc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trametes_versicolor Trametes versicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GYC FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gyc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trametes_versicolor Trametes versicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GYC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Laccase Laccase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Laccase Laccase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gyc RCSB], [http://www.ebi.ac.uk/pdbsum/1gyc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gyc RCSB], [http://www.ebi.ac.uk/pdbsum/1gyc PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	[[Category: Laccase]]		[[Category: Laccase]]
	[[Category: Trametes versicolor]]		[[Category: Trametes versicolor]]
-	[[Category: Antorini, M.]]	+	[[Category: Antorini, M]]
-	[[Category: Choinowski, T.]]	+	[[Category: Choinowski, T]]
-	[[Category: Piontek, K.]]	+	[[Category: Piontek, K]]
	[[Category: Diphenol oxidase]]		[[Category: Diphenol oxidase]]
-	[[Category: Laccase]]
	[[Category: Lignin degradation]]		[[Category: Lignin degradation]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 09:44, 3 October 2014

OCA — Fri, 03 Oct 2014 09:44:32 GMT

←Older revision		Revision as of 09:44, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1gyc\| PDB=1gyc \| SCENE= }}~~	+	==CRYSTAL STRUCTURE DETERMINATION AT ROOM TEMPERATURE OF A LACCASE FROM TRAMETES VERSICOLOR IN ITS OXIDISED FORM CONTAINING A FULL COMPLEMENT OF COPPER IONS==
-	===CRYSTAL STRUCTURE DETERMINATION AT ROOM TEMPERATURE OF A LACCASE FROM TRAMETES VERSICOLOR IN ITS OXIDISED FORM CONTAINING A FULL COMPLEMENT OF COPPER IONS===	+	<StructureSection load='1gyc' size='340' side='right' caption='[[1gyc]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_12163489}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1gyc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trametes_versicolor Trametes versicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GYC FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Laccase Laccase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gyc RCSB], [http://www.ebi.ac.uk/pdbsum/1gyc PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gy/1gyc_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Laccase is a polyphenol oxidase, which belongs to the family of blue multicopper oxidases. These enzymes catalyze the one-electron oxidation of four reducing-substrate molecules concomitant with the four-electron reduction of molecular oxygen to water. Laccases oxidize a broad range of substrates, preferably phenolic compounds. In the presence of mediators, fungal laccases exhibit an enlarged substrate range and are then able to oxidize compounds with a redox potential exceeding their own. Until now, only one crystal structure of a laccase in an inactive, type-2 copper-depleted form has been reported. We present here the first crystal structure of an active laccase containing a full complement of coppers, the complete polypeptide chain together with seven carbohydrate moieties. Despite the presence of all coppers in the new structure, the folds of the two laccases are quite similar. The coordination of the type-3 coppers, however, is distinctly different. The geometry of the trinuclear copper cluster in the Trametes versicolor laccase is similar to that found in the ascorbate oxidase and that of mammalian ceruloplasmin structures, suggesting a common reaction mechanism for the copper oxidation and the O(2) reduction. In contrast to most blue copper proteins, the type-1 copper in the T. versicolor laccase has no axial ligand and is only 3-fold coordinated. Previously, a modest elevation of the redox potential was attributed to the lack of an axial ligand. Based on the present structural data and sequence comparisons, a mechanism is presented to explain how laccases could tune their redox potential by as much as 200 mV.

-	~~==Function==~~	+	Crystal structure of a laccase from the fungus Trametes versicolor at 1.90-A resolution containing a full complement of coppers.,Piontek K, Antorini M, Choinowski T J Biol Chem. 2002 Oct 4;277(40):37663-9. Epub 2002 Aug 5. PMID:12163489<ref>PMID:12163489</ref>
-	~~[[http://www.uniprot.org/uniprot/LAC2_TRAVE LAC2_TRAVE]] Lignin degradation and detoxification~~ of ~~lignin~~-~~derived products~~ (~~Probable~~).	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[1gyc]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Trametes_versicolor Trametes versicolor]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1GYC OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:012163489</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Laccase]]		[[Category: Laccase]]
	[[Category: Trametes versicolor]]		[[Category: Trametes versicolor]]

OCA at 10:36, 16 April 2014

OCA — Wed, 16 Apr 2014 10:36:19 GMT

←Older revision		Revision as of 10:36, 16 April 2014
Line 1:		Line 1:
-	[[Image:1gyc.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1gyc", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1gyc\| PDB=1gyc \| SCENE= }}		{{STRUCTURE_1gyc\| PDB=1gyc \| SCENE= }}
-
	===CRYSTAL STRUCTURE DETERMINATION AT ROOM TEMPERATURE OF A LACCASE FROM TRAMETES VERSICOLOR IN ITS OXIDISED FORM CONTAINING A FULL COMPLEMENT OF COPPER IONS===		===CRYSTAL STRUCTURE DETERMINATION AT ROOM TEMPERATURE OF A LACCASE FROM TRAMETES VERSICOLOR IN ITS OXIDISED FORM CONTAINING A FULL COMPLEMENT OF COPPER IONS===
		+	{{ABSTRACT_PUBMED_12163489}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/LAC2_TRAVE LAC2_TRAVE]] Lignin degradation and detoxification of lignin-derived products (Probable).
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_12163489}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~)~~, where 12163489 is the PubMed ID number~~.	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_12163489}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:012163489</ref><~~ref~~ group="xtra"~~>PMID:011825613<~~/~~ref><ref group="xtra">PMID:012051905</ref~~><references ~~group="xtra"~~/>	+	<ref group="xtra">PMID:012163489</ref><references group="xtra"/><references/>
	[[Category: Laccase]]		[[Category: Laccase]]
	[[Category: Trametes versicolor]]		[[Category: Trametes versicolor]]

OCA at 05:27, 7 September 2011

OCA — Wed, 07 Sep 2011 05:27:35 GMT

←Older revision		Revision as of 05:27, 7 September 2011
Line 22:		Line 22:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12163489~~</ref><ref group="xtra">PMID:~~11825613~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012163489</ref><ref group="xtra">PMID:011825613</ref><ref group="xtra">PMID:012051905</ref><references group="xtra"/>
	[[Category: Laccase]]		[[Category: Laccase]]
	[[Category: Trametes versicolor]]		[[Category: Trametes versicolor]]