1gyq - Revision history

OCA at 06:12, 9 August 2023

OCA — Wed, 09 Aug 2023 06:12:28 GMT

←Older revision		Revision as of 06:12, 9 August 2023
Line 3:		Line 3:
	<StructureSection load='1gyq' size='340' side='right'caption='[[1gyq]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='1gyq' size='340' side='right'caption='[[1gyq]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gyq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GYQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gyq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_mexicana Leishmania mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GYQ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NBD:N6~~-~~BENZYL-NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NBD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.4Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Glyceraldehyde~~-3-~~phosphate_dehydrogenase_(phosphorylating) Glyceraldehyde~~-3-~~phosphate dehydrogenase (phosphorylating)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.12 1.2.1.12]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NBD:N6-BENZYL-NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NBD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyq OCA], [https://pdbe.org/1gyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gyq RCSB], [https://www.ebi.ac.uk/pdbsum/1gyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gyq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyq OCA], [https://pdbe.org/1gyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gyq RCSB], [https://www.ebi.ac.uk/pdbsum/1gyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gyq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/G3PG_LEIME G3PG_LEIME]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Hol, W~~]]	+	[[Category: Leishmania mexicana]]
-	[[Category: ~~Suresh, S~~]]	+	[[Category: Hol W]]
-	[[Category: ~~Oxidoreductase~~]]	+	[[Category: Suresh S]]

OCA at 11:04, 31 March 2021

OCA — Wed, 31 Mar 2021 11:04:20 GMT

←Older revision		Revision as of 11:04, 31 March 2021
Line 3:		Line 3:
	<StructureSection load='1gyq' size='340' side='right'caption='[[1gyq]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='1gyq' size='340' side='right'caption='[[1gyq]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gyq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1GYQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gyq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GYQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NBD:N6-BENZYL-NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NBD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NBD:N6-BENZYL-NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NBD</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(phosphorylating) Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.12 1.2.1.12] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(phosphorylating) Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.12 1.2.1.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1gyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyq OCA], [~~http~~://pdbe.org/1gyq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1gyq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1gyq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1gyq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyq OCA], [https://pdbe.org/1gyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gyq RCSB], [https://www.ebi.ac.uk/pdbsum/1gyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gyq ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:
	==See Also==		==See Also==
	*[[Aldehyde dehydrogenase 3D structures\|Aldehyde dehydrogenase 3D structures]]		*[[Aldehyde dehydrogenase 3D structures\|Aldehyde dehydrogenase 3D structures]]
-	*[[Glyceraldehyde-3-~~Phosphate Dehydrogenase~~\|Glyceraldehyde-3-~~Phosphate Dehydrogenase~~]]	+	*[[Glyceraldehyde-3-phosphate dehydrogenase 3D structures\|Glyceraldehyde-3-phosphate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:01, 26 June 2019

OCA — Wed, 26 Jun 2019 08:01:04 GMT

←Older revision		Revision as of 08:01, 26 June 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF GLYCOSOMAL GLYCERALDEHYDE FROM LEISHMANIA MEXICANA IN COMPLEX WITH N6-BENZYL-NAD==		==CRYSTAL STRUCTURE OF GLYCOSOMAL GLYCERALDEHYDE FROM LEISHMANIA MEXICANA IN COMPLEX WITH N6-BENZYL-NAD==
-	<StructureSection load='1gyq' size='340' side='right' caption='[[1gyq]], [[Resolution\|resolution]] 3.40Å' scene=''>	+	<StructureSection load='1gyq' size='340' side='right'caption='[[1gyq]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gyq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GYQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gyq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GYQ FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gy/1gyq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gy/1gyq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[Aldehyde dehydrogenase\|Aldehyde dehydrogenase]]	+	*[[Aldehyde dehydrogenase 3D structures\|Aldehyde dehydrogenase 3D structures]]
	*[[Glyceraldehyde-3-Phosphate Dehydrogenase\|Glyceraldehyde-3-Phosphate Dehydrogenase]]		*[[Glyceraldehyde-3-Phosphate Dehydrogenase\|Glyceraldehyde-3-Phosphate Dehydrogenase]]
	== References ==		== References ==
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Hol, W]]		[[Category: Hol, W]]
	[[Category: Suresh, S]]		[[Category: Suresh, S]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 04:33, 21 September 2017

OCA — Thu, 21 Sep 2017 04:33:00 GMT

←Older revision		Revision as of 04:33, 21 September 2017
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF GLYCOSOMAL GLYCERALDEHYDE FROM LEISHMANIA MEXICANA IN COMPLEX WITH N6-BENZYL-NAD==		==CRYSTAL STRUCTURE OF GLYCOSOMAL GLYCERALDEHYDE FROM LEISHMANIA MEXICANA IN COMPLEX WITH N6-BENZYL-NAD==
	<StructureSection load='1gyq' size='340' side='right' caption='[[1gyq]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='1gyq' size='340' side='right' caption='[[1gyq]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gyq]] is a 4 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Leime Leime]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GYQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gyq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GYQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NBD:N6-BENZYL-NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NBD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NBD:N6-BENZYL-NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NBD</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLYCERALDEHYDE-3-PHOSPHATEURCE 6 DEHYDROGENASE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5665 LEIME])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(phosphorylating) Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.12 1.2.1.12] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(phosphorylating) Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.12 1.2.1.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyq OCA], [http://pdbe.org/1gyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gyq RCSB], [http://www.ebi.ac.uk/pdbsum/1gyq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyq OCA], [http://pdbe.org/1gyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gyq RCSB], [http://www.ebi.ac.uk/pdbsum/1gyq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gyq ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gyq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Leime]]
	[[Category: Hol, W]]		[[Category: Hol, W]]
	[[Category: Suresh, S]]		[[Category: Suresh, S]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 12:44, 11 September 2015

OCA — Fri, 11 Sep 2015 12:44:26 GMT

←Older revision		Revision as of 12:44, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1gyq' size='340' side='right' caption='[[1gyq]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='1gyq' size='340' side='right' caption='[[1gyq]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gyq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Leishmania_mexicana Leishmania mexicana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GYQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gyq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Leime Leime]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GYQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NBD:N6-BENZYL-NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NBD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NBD:N6-BENZYL-NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NBD</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLYCERALDEHYDE-3-PHOSPHATEURCE 6 DEHYDROGENASE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5665 ~~Leishmania mexicana~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLYCERALDEHYDE-3-PHOSPHATEURCE 6 DEHYDROGENASE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5665 LEIME])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(phosphorylating) Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.12 1.2.1.12] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(phosphorylating) Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.12 1.2.1.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gyq RCSB], [http://www.ebi.ac.uk/pdbsum/1gyq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyq OCA], [http://pdbe.org/1gyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gyq RCSB], [http://www.ebi.ac.uk/pdbsum/1gyq PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1gyq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
		+	*[[Aldehyde dehydrogenase\|Aldehyde dehydrogenase]]
	*[[Glyceraldehyde-3-Phosphate Dehydrogenase\|Glyceraldehyde-3-Phosphate Dehydrogenase]]		*[[Glyceraldehyde-3-Phosphate Dehydrogenase\|Glyceraldehyde-3-Phosphate Dehydrogenase]]
	== References ==		== References ==
Line 33:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Leishmania mexicana~~]]	+	[[Category: Leime]]
	[[Category: Hol, W]]		[[Category: Hol, W]]
	[[Category: Suresh, S]]		[[Category: Suresh, S]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 21:01, 22 December 2014

OCA — Mon, 22 Dec 2014 21:01:07 GMT

←Older revision		Revision as of 21:01, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gyq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_mexicana Leishmania mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GYQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gyq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_mexicana Leishmania mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GYQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NBD:N6-BENZYL-NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NBD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NBD:N6-BENZYL-NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NBD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLYCERALDEHYDE-3-PHOSPHATEURCE 6 DEHYDROGENASE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5665 Leishmania mexicana])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLYCERALDEHYDE-3-PHOSPHATEURCE 6 DEHYDROGENASE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5665 Leishmania mexicana])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(phosphorylating) Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.12 1.2.1.12] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(phosphorylating) Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.12 1.2.1.12] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gyq RCSB], [http://www.ebi.ac.uk/pdbsum/1gyq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gyq RCSB], [http://www.ebi.ac.uk/pdbsum/1gyq PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Leishmania mexicana]]		[[Category: Leishmania mexicana]]
-	[[Category: Hol, W.]]	+	[[Category: Hol, W]]
-	[[Category: Suresh, S.]]	+	[[Category: Suresh, S]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 10:51, 28 September 2014

OCA — Sun, 28 Sep 2014 10:51:29 GMT

←Older revision		Revision as of 10:51, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1gyq.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF GLYCOSOMAL GLYCERALDEHYDE FROM LEISHMANIA MEXICANA IN COMPLEX WITH N6-BENZYL-NAD==
		+	<StructureSection load='1gyq' size='340' side='right' caption='[[1gyq]], [[Resolution\|resolution]] 3.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1gyq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_mexicana Leishmania mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GYQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NBD:N6-BENZYL-NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NBD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLYCERALDEHYDE-3-PHOSPHATEURCE 6 DEHYDROGENASE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5665 Leishmania mexicana])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(phosphorylating) Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.12 1.2.1.12] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gyq RCSB], [http://www.ebi.ac.uk/pdbsum/1gyq PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gy/1gyq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The bloodstream stage of Trypanosoma brucei and probably the intracellular (amastigote) stage of Trypanosoma cruzi derive all of their energy from glycolysis. Inhibiting glycolytic enzymes may be a novel approach for the development of antitrypanosomatid drugs provided that sufficient parasite versus host selectivity can be obtained. Guided by the crystal structures of human, T. brucei, and Leishmania mexicana glyceraldehyde-3-phosphate dehydrogenase, we designed adenosine analogs as tight binding inhibitors that occupy the pocket on the enzyme that accommodates the adenosyl moiety of the NAD+ cosubstrate. Although adenosine is a very poor inhibitor, IC50 approximately 50 mM, addition of substituents to the 2' position of ribose and the N6-position of adenosine led to disubstituted nucleosides with micromolar to submicromolar potency in glyceraldehyde-3-phosphate dehydrogenase assays, an improvement of 5 orders of magnitude over the lead. The designed compounds do not inhibit the human glycolytic enzyme when tested up to their solubility limit (approximately 40 microM). When tested against cultured bloodstream T. brucei and intracellular T. cruzi, N6-(1-naphthalenemethyl)-2'-(3-chlorobenzamido)adenosine inhibited growth in the low micromolar range. Within minutes after adding this compound to bloodstream T. brucei, production of glucose-derived pyruvate ceased, parasite motility was lost, and a mixture of grossly deformed and lysed parasites was observed. These studies underscore the feasibility of using structure-based drug design to transform a mediocre lead compound into a potent enzyme inhibitor. They also suggest that energy production can be blocked in trypanosomatids with a tight binding competitive inhibitor of an enzyme in the glycolytic pathway.

-	~~{{STRUCTURE_1gyq\| PDB=1gyq \| SCENE= }}~~	+	Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase.,Aronov AM, Suresh S, Buckner FS, Van Voorhis WC, Verlinde CL, Opperdoes FR, Hol WG, Gelb MH Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4273-8. PMID:10200252<ref>PMID:10200252</ref>

-	~~===CRYSTAL STRUCTURE OF GLYCOSOMAL GLYCERALDEHYDE FROM LEISHMANIA MEXICANA IN COMPLEX WITH N6-BENZYL-NAD===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10200252}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1gyq]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Leishmania_mexicana Leishmania mexicana]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1GYQ OCA].~~	+

	==See Also==		==See Also==
-	*[[~~Aldehyde dehydrogenase~~\|~~Aldehyde dehydrogenase~~]]	+	*[[Glyceraldehyde-3-Phosphate Dehydrogenase\|Glyceraldehyde-3-Phosphate Dehydrogenase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:010200252<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Leishmania mexicana]]		[[Category: Leishmania mexicana]]
	[[Category: Hol, W.]]		[[Category: Hol, W.]]
	[[Category: Suresh, S.]]		[[Category: Suresh, S.]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 18:59, 20 October 2012

OCA — Sat, 20 Oct 2012 18:59:16 GMT

←Older revision		Revision as of 18:59, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1gyq]] is a 4 chain structure ~~of [[Aldehyde dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Leishmania_mexicana Leishmania mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYQ OCA].	+	[[1gyq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_mexicana Leishmania mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYQ OCA].

	==See Also==		==See Also==

OCA at 05:55, 27 July 2012

OCA — Fri, 27 Jul 2012 05:55:24 GMT

←Older revision		Revision as of 05:55, 27 July 2012
Line 1:		Line 1:
	[[Image:1gyq.png\|left\|200px]]		[[Image:1gyq.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1gyq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1gyq\| PDB=1gyq \| SCENE= }}		{{STRUCTURE_1gyq\| PDB=1gyq \| SCENE= }}

	===CRYSTAL STRUCTURE OF GLYCOSOMAL GLYCERALDEHYDE FROM LEISHMANIA MEXICANA IN COMPLEX WITH N6-BENZYL-NAD===		===CRYSTAL STRUCTURE OF GLYCOSOMAL GLYCERALDEHYDE FROM LEISHMANIA MEXICANA IN COMPLEX WITH N6-BENZYL-NAD===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10200252}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10200252 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_10200252}}		{{ABSTRACT_PUBMED_10200252}}

OCA: Protected "1gyq" [edit=sysop:move=sysop]

OCA — Sat, 02 Jun 2012 09:12:53 GMT

Protected "1gyq" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:12, 2 June 2012