1h0j - Revision history

OCA at 12:12, 13 December 2023

OCA — Wed, 13 Dec 2023 12:12:25 GMT

←Older revision		Revision as of 12:12, 13 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1h0j]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H0J FirstGlance]. <br>		<table><tr><td colspan='2'>[[1h0j]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H0J FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SDS:DODECYL+SULFATE'>SDS</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2crs\|2crs]], [[2crt\|2crt]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SDS:DODECYL+SULFATE'>SDS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0j OCA], [https://pdbe.org/1h0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h0j RCSB], [https://www.ebi.ac.uk/pdbsum/1h0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h0j ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0j OCA], [https://pdbe.org/1h0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h0j RCSB], [https://www.ebi.ac.uk/pdbsum/1h0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h0j ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/3SA3_NAJAT 3SA3_NAJAT] Basic protein that binds to cell membrane and depolarizes cardiomyocytes. This cytotoxin also possesses lytic activity on many other cells, including red blood cells (PubMed:8182052). Interaction with sulfatides in the cell membrane induces pore formation and cell internalization. Cytotoxicity is due to pore formation, and to another mechanism independent of membrane-damaging activity. When internalized, it targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation. It inhibits protein kinases C. It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity (PubMed:16407244). It also binds with high affinity to heparin (PubMed:17685633).<ref>PMID:15922335</ref> <ref>PMID:16263708</ref> <ref>PMID:16407244</ref> <ref>PMID:17714752</ref> <ref>PMID:8182052</ref> <ref>PMID:8448165</ref> <ref>PMID:9245415</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Naja atra]]		[[Category: Naja atra]]
-	[[Category: Chien, K Y]]	+	[[Category: Chien K-Y]]
-	[[Category: Forouhar, F]]	+	[[Category: Forouhar F]]
-	[[Category: Hsiao, C D]]	+	[[Category: Hsiao C-D]]
-	[[Category: Huang, W N]]	+	[[Category: Huang W-N]]
-	[[Category: Liu, J H]]	+	[[Category: Liu J-H]]
-	[[Category: Wu, W G]]	+	[[Category: Wu W-G]]
-	~~[[Category: Cardiotoxin]]~~	+
-	~~[[Category: Cytotoxin]]~~	+
-	~~[[Category: Sodium dodecyl sulfate]]~~	+
-	~~[[Category: Venom~~]]	+

OCA at 11:30, 28 July 2021

OCA — Wed, 28 Jul 2021 11:30:54 GMT

←Older revision		Revision as of 11:30, 28 July 2021
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	<StructureSection load='1h0j' size='340' side='right'caption='[[1h0j]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1h0j' size='340' side='right'caption='[[1h0j]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h0j]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1H0J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h0j]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H0J FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SDS:DODECYL+SULFATE'>SDS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SDS:DODECYL+SULFATE'>SDS</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2crs\|2crs]], [[2crt\|2crt]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2crs\|2crs]], [[2crt\|2crt]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1h0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0j OCA], [~~http~~://pdbe.org/1h0j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1h0j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1h0j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1h0j ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0j OCA], [https://pdbe.org/1h0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h0j RCSB], [https://www.ebi.ac.uk/pdbsum/1h0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h0j ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:23, 23 October 2019

OCA — Wed, 23 Oct 2019 08:23:37 GMT

←Older revision		Revision as of 08:23, 23 October 2019
Line 1:		Line 1:

	==Structural Basis of the Membrane-induced Cardiotoxin A3 Oligomerization==		==Structural Basis of the Membrane-induced Cardiotoxin A3 Oligomerization==
-	<StructureSection load='1h0j' size='340' side='right' caption='[[1h0j]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='1h0j' size='340' side='right'caption='[[1h0j]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1h0j]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H0J FirstGlance]. <br>		<table><tr><td colspan='2'>[[1h0j]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H0J FirstGlance]. <br>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1h0j" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1h0j" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cardiotoxin 3D structures\|Cardiotoxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Naja atra]]		[[Category: Naja atra]]
	[[Category: Chien, K Y]]		[[Category: Chien, K Y]]

OCA at 06:13, 3 January 2018

OCA — Wed, 03 Jan 2018 06:13:52 GMT

←Older revision		Revision as of 06:13, 3 January 2018
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-	==~~STRUCTURAL BASIS OF THE MEMBRANE~~-~~INDUCED CARDIOTOXIN~~ A3 ~~OLIGOMERIZATION~~==	+
		+	==Structural Basis of the Membrane-induced Cardiotoxin A3 Oligomerization==
	<StructureSection load='1h0j' size='340' side='right' caption='[[1h0j]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1h0j' size='340' side='right' caption='[[1h0j]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SDS:DODECYL+SULFATE'>SDS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SDS:DODECYL+SULFATE'>SDS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2crs\|2crs]], [[2crt\|2crt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2crs\|2crs]], [[2crt\|2crt]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0j OCA], [http://pdbe.org/1h0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h0j RCSB], [http://www.ebi.ac.uk/pdbsum/1h0j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0j OCA], [http://pdbe.org/1h0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h0j RCSB], [http://www.ebi.ac.uk/pdbsum/1h0j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1h0j ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/1h0j_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/1h0j_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 26:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1h0j" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1h0j" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cardiotoxin\|Cardiotoxin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:35, 7 February 2016

OCA — Sun, 07 Feb 2016 01:35:15 GMT

←Older revision		Revision as of 01:35, 7 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h0j ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:22, 9 September 2015

OCA — Wed, 09 Sep 2015 20:22:54 GMT

←Older revision		Revision as of 20:22, 9 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SDS:DODECYL+SULFATE'>SDS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SDS:DODECYL+SULFATE'>SDS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2crs\|2crs]], [[2crt\|2crt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2crs\|2crs]], [[2crt\|2crt]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h0j RCSB], [http://www.ebi.ac.uk/pdbsum/1h0j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0j OCA], [http://pdbe.org/1h0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h0j RCSB], [http://www.ebi.ac.uk/pdbsum/1h0j PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1h0j" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 18:10, 22 December 2014

OCA — Mon, 22 Dec 2014 18:10:55 GMT

←Older revision		Revision as of 18:10, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1h0j]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H0J FirstGlance]. <br>		<table><tr><td colspan='2'>[[1h0j]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H0J FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SDS:DODECYL+SULFATE'>SDS</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SDS:DODECYL+SULFATE'>SDS</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2crs\|2crs]], [[2crt\|2crt]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2crs\|2crs]], [[2crt\|2crt]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h0j RCSB], [http://www.ebi.ac.uk/pdbsum/1h0j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h0j RCSB], [http://www.ebi.ac.uk/pdbsum/1h0j PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Naja atra]]		[[Category: Naja atra]]
-	[[Category: Chien, K Y.]]	+	[[Category: Chien, K Y]]
-	[[Category: Forouhar, F.]]	+	[[Category: Forouhar, F]]
-	[[Category: Hsiao, C D.]]	+	[[Category: Hsiao, C D]]
-	[[Category: Huang, W N.]]	+	[[Category: Huang, W N]]
-	[[Category: Liu, J H.]]	+	[[Category: Liu, J H]]
-	[[Category: Wu, W G.]]	+	[[Category: Wu, W G]]
	[[Category: Cardiotoxin]]		[[Category: Cardiotoxin]]
	[[Category: Cytotoxin]]		[[Category: Cytotoxin]]
	[[Category: Sodium dodecyl sulfate]]		[[Category: Sodium dodecyl sulfate]]
	[[Category: Venom]]		[[Category: Venom]]

OCA at 08:16, 28 September 2014

OCA — Sun, 28 Sep 2014 08:16:11 GMT

←Older revision		Revision as of 08:16, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1h0j.~~png~~\|~~left~~\|200px]]	+	==STRUCTURAL BASIS OF THE MEMBRANE-INDUCED CARDIOTOXIN A3 OLIGOMERIZATION==
		+	<StructureSection load='1h0j' size='340' side='right' caption='[[1h0j]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1h0j]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H0J FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SDS:DODECYL+SULFATE'>SDS</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2crs\|2crs]], [[2crt\|2crt]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h0j RCSB], [http://www.ebi.ac.uk/pdbsum/1h0j PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/1h0j_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cobra cardiotoxins (CTXs) have previously been shown to induce membrane fusion of vesicles formed by phospholipids such as cardiolipin or sphingomyelin. CTX can also form a pore in membrane bilayers containing a anionic lipid such as phosphatidylserine or phosphatidylglycerol. Herein, we show that the interaction of CTX with negatively charged lipids causes CTX dimerization, an important intermediate for the eventual oligomerization of CTX during the CTX-induced fusion and pore formation process. The structural basis of the lipid-induced oligomerization of CTX A3, a major CTX from Naja atra, is then illustrated by the crystal structure of CTX A3 in complex with SDS; SDS likely mimics anionic lipids of the membrane under micelle conditions at 1.9-A resolution. The crystal packing reveals distinct SDS-free and SDS-rich regions; in the latter two types of interconnecting CTX A3 dimers, D1 and D2, and several SDS molecules can be identified to stabilize D1 and D2 by simultaneously interacting with residues at each dimer interface. When the three CTXSDS complexes in the asymmetric unit are overlaid, the orientation of CTX A3 monomers relative to the SDS molecules in the crystal is strikingly similar to that of the toxin with respect to model membranes as determined by NMR and Fourier transform infrared methods. These results not only illustrate how lipid-induced CTX dimer formation may be transformed into oligomers either as inverted micelles of fusion intermediates or as membrane pore of anionic lipid bilayers but also underscore a potential role for SDS in x-ray diffraction study of protein-membrane interactions in the future.

-	~~{{STRUCTURE_1h0j\| PDB=1h0j \| SCENE= }}~~	+	Structural basis of membrane-induced cardiotoxin A3 oligomerization.,Forouhar F, Huang WN, Liu JH, Chien KY, Wu WG, Hsiao CD J Biol Chem. 2003 Jun 13;278(24):21980-8. Epub 2003 Mar 26. PMID:12660250<ref>PMID:12660250</ref>

-	~~===STRUCTURAL BASIS OF THE MEMBRANE-INDUCED CARDIOTOXIN A3 OLIGOMERIZATION===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12660250}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1h0j]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Naja_atra Naja atra]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1H0J OCA].~~	+

	==See Also==		==See Also==
	*[[Cardiotoxin\|Cardiotoxin]]		*[[Cardiotoxin\|Cardiotoxin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012660250<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Naja atra]]		[[Category: Naja atra]]
	[[Category: Chien, K Y.]]		[[Category: Chien, K Y.]]

OCA at 05:14, 20 October 2012

OCA — Sat, 20 Oct 2012 05:14:29 GMT

←Older revision		Revision as of 05:14, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1h0j]] is a 3 chain structure ~~of [[Cardiotoxin]]~~ with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0J OCA].	+	[[1h0j]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0J OCA].

	==See Also==		==See Also==

OCA at 09:25, 25 July 2012

OCA — Wed, 25 Jul 2012 09:25:52 GMT

←Older revision		Revision as of 09:25, 25 July 2012
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	[[Image:1h0j.png\|left\|200px]]		[[Image:1h0j.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1h0j\| PDB=1h0j \| SCENE= }}		{{STRUCTURE_1h0j\| PDB=1h0j \| SCENE= }}

	===STRUCTURAL BASIS OF THE MEMBRANE-INDUCED CARDIOTOXIN A3 OLIGOMERIZATION===		===STRUCTURAL BASIS OF THE MEMBRANE-INDUCED CARDIOTOXIN A3 OLIGOMERIZATION===

-
-	<!--
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	==See Also==		==See Also==
-	*[[Cardiotoxin]]	+	*[[Cardiotoxin\|Cardiotoxin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12660250~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012660250</ref><references group="xtra"/>
	[[Category: Naja atra]]		[[Category: Naja atra]]
	[[Category: Chien, K Y.]]		[[Category: Chien, K Y.]]