1h0l - Revision history

OCA at 11:26, 27 March 2024

OCA — Wed, 27 Mar 2024 11:26:33 GMT

←Older revision		Revision as of 11:26, 27 March 2024
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	==HUMAN PRION PROTEIN 121-230 M166C/E221C==		==HUMAN PRION PROTEIN 121-230 M166C/E221C==
-	<StructureSection load='1h0l' size='340' side='right'caption='[[1h0l~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1h0l' size='340' side='right'caption='[[1h0l]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h0l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H0L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h0l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H0L FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[1fkc\|1fkc]], [[1fo7\|1fo7]], [[1i4m\|1i4m]], [[1qlx\|1qlx]], [[1qlz\|1qlz]], [[1qm0\|1qm0]], [[1qm1\|1qm1]], [[1qm2\|1qm2]], [[1qm3\|1qm3]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0l OCA], [https://pdbe.org/1h0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h0l RCSB], [https://www.ebi.ac.uk/pdbsum/1h0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h0l ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0l OCA], [https://pdbe.org/1h0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h0l RCSB], [https://www.ebi.ac.uk/pdbsum/1h0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h0l ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/PRIO_HUMAN PRIO_HUMAN] Note=PrP is found in high quantity in the brain of humans and animals infected with neurodegenerative diseases known as transmissible spongiform encephalopathies or prion diseases, like: Creutzfeldt-Jakob disease (CJD), fatal familial insomnia (FFI), Gerstmann-Straussler disease (GSD), Huntington disease-like type 1 (HDL1) and kuru in humans; scrapie in sheep and goat; bovine spongiform encephalopathy (BSE) in cattle; transmissible mink encephalopathy (TME); chronic wasting disease (CWD) of mule deer and elk; feline spongiform encephalopathy (FSE) in cats and exotic ungulate encephalopathy (EUE) in nyala and greater kudu. The prion diseases illustrate three manifestations of CNS degeneration: (1) infectious (2) sporadic and (3) dominantly inherited forms. TME, CWD, BSE, FSE, EUE are all thought to occur after consumption of prion-infected foodstuffs.<ref>PMID:19936054</ref> <ref>PMID:1671440</ref> <ref>PMID:1975028</ref> <ref>PMID:8461023</ref> <ref>PMID:7902693</ref> <ref>PMID:7906019</ref> <ref>PMID:7913755</ref> <ref>PMID:8909447</ref> <ref>PMID:9266722</ref> <ref>PMID:10790216</ref> Defects in PRNP are the cause of Creutzfeldt-Jakob disease (CJD) [MIM:[https://omim.org/entry/123400 123400]. CJD occurs primarily as a sporadic disorder (1 per million), while 10-15% are familial. Accidental transmission of CJD to humans appears to be iatrogenic (contaminated human growth hormone (HGH), corneal transplantation, electroencephalographic electrode implantation, etc.). Epidemiologic studies have failed to implicate the ingestion of infected annimal meat in the pathogenesis of CJD in human. The triad of microscopic features that characterize the prion diseases consists of (1) spongiform degeneration of neurons, (2) severe astrocytic gliosis that often appears to be out of proportion to the degree of nerve cell loss, and (3) amyloid plaque formation. CJD is characterized by progressive dementia and myoclonic seizures, affecting adults in mid-life. Some patients present sleep disorders, abnormalities of high cortical function, cerebellar and corticospinal disturbances. The disease ends in death after a 3-12 months illness.<ref>PMID:19936054</ref> <ref>PMID:1671440</ref> <ref>PMID:1975028</ref> <ref>PMID:8461023</ref> <ref>PMID:7902693</ref> <ref>PMID:7906019</ref> <ref>PMID:7913755</ref> <ref>PMID:8909447</ref> <ref>PMID:9266722</ref> <ref>PMID:10790216</ref> Defects in PRNP are the cause of fatal familial insomnia (FFI) [MIM:[https://omim.org/entry/600072 600072]. FFI is an autosomal dominant disorder and is characterized by neuronal degeneration limited to selected thalamic nuclei and progressive insomnia.<ref>PMID:19936054</ref> <ref>PMID:19927125</ref> <ref>PMID:1347910</ref> Defects in PRNP are the cause of Gerstmann-Straussler disease (GSD) [MIM:[https://omim.org/entry/137440 137440]. GSD is a heterogeneous disorder and was defined as a spinocerebellar ataxia with dementia and plaquelike deposits. GSD incidence is less than 2 per 100 million live births.<ref>PMID:19936054</ref> <ref>PMID:19927125</ref> <ref>PMID:10581485</ref> <ref>PMID:2564168</ref> <ref>PMID:1363810</ref> <ref>PMID:7902972</ref> <ref>PMID:7699395</ref> <ref>PMID:7783876</ref> <ref>PMID:8797472</ref> <ref>PMID:9786248</ref> <ref>PMID:11709001</ref> Defects in PRNP are the cause of Huntington disease-like type 1 (HDL1) [MIM:[https://omim.org/entry/603218 603218]. HDL1 is an autosomal dominant, early onset neurodegenerative disorder with prominent psychiatric features.<ref>PMID:19936054</ref> Defects in PRNP are the cause of kuru (KURU) [MIM:[https://omim.org/entry/245300 245300]. Kuru is transmitted during ritualistic cannibalism, among natives of the New Guinea highlands. Patients exhibit various movement disorders like cerebellar abnormalities, rigidity of the limbs, and clonus. Emotional lability is present, and dementia is conspicuously absent. Death usually occurs from 3 to 12 month after onset.<ref>PMID:19936054</ref> Defects in PRNP are the cause of spongiform encephalopathy with neuropsychiatric features (SENF) [MIM:[https://omim.org/entry/606688 606688]; an autosomal dominant presenile dementia with a rapidly progressive and protracted clinical course. The dementia was characterized clinically by frontotemporal features, including early personality changes. Some patients had memory loss, several showed aggressiveness, hyperorality and verbal stereotypy, others had parkinsonian symptoms.<ref>PMID:19936054</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PRIO_HUMAN PRIO_HUMAN] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).<ref>PMID:12732622</ref> <ref>PMID:19936054</ref> <ref>PMID:20564047</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h0l ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h0l ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The nuclear magnetic resonance structure of the globular domain with residues 121-230 of a variant human prion protein with two disulfide bonds, hPrP(M166C/E221C), shows the same global fold as wild-type hPrP(121-230). It contains three alpha-helices of residues 144-154, 173-194 and 200-228, an anti-parallel beta-sheet of residues 128-131 and 161-164, and the disulfides Cys166-Cys221 and Cys179-Cys214. The engineered extra disulfide bond in the presumed "protein X"-binding site is accommodated with slight, strictly localized conformational changes. High compatibility of hPrP with insertion of a second disulfide bridge in the protein X epitope was further substantiated by model calculations with additional variant structures. The ease with which the hPrP structure can accommodate a variety of locations for a second disulfide bond within the presumed protein X-binding epitope suggests a functional role for the extensive perturbation by a natural second disulfide bond of the corresponding region in the human doppel protein.
-
-	NMR structure of a variant human prion protein with two disulfide bridges.,Zahn R, Guntert P, von Schroetter C, Wuthrich K J Mol Biol. 2003 Feb 7;326(1):225-34. PMID:12547204<ref>PMID:12547204</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1h0l" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Guntert, P]]	+	[[Category: Guntert P]]
-	[[Category: Wuthrich, K]]	+	[[Category: Wuthrich K]]
-	[[Category: Zahn, R]]	+	[[Category: Zahn R]]
-	~~[[Category: Brain]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Gpi-anchor]]~~	+
-	~~[[Category: Polymorphism~~]]	+

OCA at 11:30, 28 July 2021

OCA — Wed, 28 Jul 2021 11:30:54 GMT

←Older revision		Revision as of 11:30, 28 July 2021
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	<StructureSection load='1h0l' size='340' side='right'caption='[[1h0l]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1h0l' size='340' side='right'caption='[[1h0l]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h0l]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0L OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1H0L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h0l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H0L FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fkc\|1fkc]], [[1fo7\|1fo7]], [[1i4m\|1i4m]], [[1qlx\|1qlx]], [[1qlz\|1qlz]], [[1qm0\|1qm0]], [[1qm1\|1qm1]], [[1qm2\|1qm2]], [[1qm3\|1qm3]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fkc\|1fkc]], [[1fo7\|1fo7]], [[1i4m\|1i4m]], [[1qlx\|1qlx]], [[1qlz\|1qlz]], [[1qm0\|1qm0]], [[1qm1\|1qm1]], [[1qm2\|1qm2]], [[1qm3\|1qm3]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1h0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0l OCA], [~~http~~://pdbe.org/1h0l PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1h0l RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1h0l PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1h0l ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0l OCA], [https://pdbe.org/1h0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h0l RCSB], [https://www.ebi.ac.uk/pdbsum/1h0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h0l ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
-	*[[Doppel\|Doppel]]	+	*[[Prion 3D structures\|Prion 3D structures]]
-	*[[Prion\|Prion]]	+
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:08, 23 October 2019

OCA — Wed, 23 Oct 2019 09:08:14 GMT

←Older revision		Revision as of 09:08, 23 October 2019
Line 1:		Line 1:

	==HUMAN PRION PROTEIN 121-230 M166C/E221C==		==HUMAN PRION PROTEIN 121-230 M166C/E221C==
-	<StructureSection load='1h0l' size='340' side='right' caption='[[1h0l]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1h0l' size='340' side='right'caption='[[1h0l]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1h0l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H0L FirstGlance]. <br>		<table><tr><td colspan='2'>[[1h0l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H0L FirstGlance]. <br>
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	==See Also==		==See Also==
	*[[Doppel\|Doppel]]		*[[Doppel\|Doppel]]
		+	*[[Prion\|Prion]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Guntert, P]]		[[Category: Guntert, P]]
	[[Category: Wuthrich, K]]		[[Category: Wuthrich, K]]

OCA at 06:46, 3 January 2018

OCA — Wed, 03 Jan 2018 06:46:48 GMT

←Older revision		Revision as of 06:46, 3 January 2018
Line 1:		Line 1:
		+
	==HUMAN PRION PROTEIN 121-230 M166C/E221C==		==HUMAN PRION PROTEIN 121-230 M166C/E221C==
	<StructureSection load='1h0l' size='340' side='right' caption='[[1h0l]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1h0l' size='340' side='right' caption='[[1h0l]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1h0l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H0L FirstGlance]. <br>		<table><tr><td colspan='2'>[[1h0l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H0L FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fkc\|1fkc]], [[1fo7\|1fo7]], [[1i4m\|1i4m]], [[1qlx\|1qlx]], [[1qlz\|1qlz]], [[1qm0\|1qm0]], [[1qm1\|1qm1]], [[1qm2\|1qm2]], [[1qm3\|1qm3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fkc\|1fkc]], [[1fo7\|1fo7]], [[1i4m\|1i4m]], [[1qlx\|1qlx]], [[1qlz\|1qlz]], [[1qm0\|1qm0]], [[1qm1\|1qm1]], [[1qm2\|1qm2]], [[1qm3\|1qm3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0l OCA], [http://pdbe.org/1h0l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h0l RCSB], [http://www.ebi.ac.uk/pdbsum/1h0l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0l OCA], [http://pdbe.org/1h0l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h0l RCSB], [http://www.ebi.ac.uk/pdbsum/1h0l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1h0l ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/1h0l_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/1h0l_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	==See Also==		==See Also==
	*[[Doppel\|Doppel]]		*[[Doppel\|Doppel]]
-	*[[Prion\|Prion]]
	== References ==		== References ==
	<references/>		<references/>
Line 42:		Line 42:
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Gpi-anchor]]		[[Category: Gpi-anchor]]
		+	[[Category: Polymorphism]]

OCA at 13:47, 8 February 2016

OCA — Mon, 08 Feb 2016 13:47:21 GMT

←Older revision		Revision as of 13:47, 8 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h0l ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:09, 10 September 2015

OCA — Thu, 10 Sep 2015 12:09:22 GMT

←Older revision		Revision as of 12:09, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1h0l' size='340' side='right' caption='[[1h0l]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1h0l' size='340' side='right' caption='[[1h0l]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h0l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H0L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h0l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H0L FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fkc\|1fkc]], [[1fo7\|1fo7]], [[1i4m\|1i4m]], [[1qlx\|1qlx]], [[1qlz\|1qlz]], [[1qm0\|1qm0]], [[1qm1\|1qm1]], [[1qm2\|1qm2]], [[1qm3\|1qm3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fkc\|1fkc]], [[1fo7\|1fo7]], [[1i4m\|1i4m]], [[1qlx\|1qlx]], [[1qlz\|1qlz]], [[1qm0\|1qm0]], [[1qm1\|1qm1]], [[1qm2\|1qm2]], [[1qm3\|1qm3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h0l RCSB], [http://www.ebi.ac.uk/pdbsum/1h0l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0l OCA], [http://pdbe.org/1h0l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h0l RCSB], [http://www.ebi.ac.uk/pdbsum/1h0l PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1h0l" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Guntert, P]]		[[Category: Guntert, P]]
	[[Category: Wuthrich, K]]		[[Category: Wuthrich, K]]

OCA at 20:42, 22 December 2014

OCA — Mon, 22 Dec 2014 20:42:40 GMT

←Older revision		Revision as of 20:42, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1h0l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H0L FirstGlance]. <br>		<table><tr><td colspan='2'>[[1h0l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H0L FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fkc\|1fkc]], [[1fo7\|1fo7]], [[1i4m\|1i4m]], [[1qlx\|1qlx]], [[1qlz\|1qlz]], [[1qm0\|1qm0]], [[1qm1\|1qm1]], [[1qm2\|1qm2]], [[1qm3\|1qm3]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fkc\|1fkc]], [[1fo7\|1fo7]], [[1i4m\|1i4m]], [[1qlx\|1qlx]], [[1qlz\|1qlz]], [[1qm0\|1qm0]], [[1qm1\|1qm1]], [[1qm2\|1qm2]], [[1qm3\|1qm3]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h0l RCSB], [http://www.ebi.ac.uk/pdbsum/1h0l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h0l RCSB], [http://www.ebi.ac.uk/pdbsum/1h0l PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Guntert, P.]]	+	[[Category: Guntert, P]]
-	[[Category: Wuthrich, K.]]	+	[[Category: Wuthrich, K]]
-	[[Category: Zahn, R.]]	+	[[Category: Zahn, R]]
	[[Category: Brain]]		[[Category: Brain]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]

OCA at 04:25, 3 October 2014

OCA — Fri, 03 Oct 2014 04:25:11 GMT

←Older revision		Revision as of 04:25, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1h0l\| PDB=1h0l \| SCENE= }}~~	+	==HUMAN PRION PROTEIN 121-230 M166C/E221C==
-	===HUMAN PRION PROTEIN 121-230 M166C/E221C===	+	<StructureSection load='1h0l' size='340' side='right' caption='[[1h0l]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_12547204}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1h0l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H0L FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fkc\|1fkc]], [[1fo7\|1fo7]], [[1i4m\|1i4m]], [[1qlx\|1qlx]], [[1qlz\|1qlz]], [[1qm0\|1qm0]], [[1qm1\|1qm1]], [[1qm2\|1qm2]], [[1qm3\|1qm3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h0l RCSB], [http://www.ebi.ac.uk/pdbsum/1h0l PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/1h0l_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The nuclear magnetic resonance structure of the globular domain with residues 121-230 of a variant human prion protein with two disulfide bonds, hPrP(M166C/E221C), shows the same global fold as wild-type hPrP(121-230). It contains three alpha-helices of residues 144-154, 173-194 and 200-228, an anti-parallel beta-sheet of residues 128-131 and 161-164, and the disulfides Cys166-Cys221 and Cys179-Cys214. The engineered extra disulfide bond in the presumed "protein X"-binding site is accommodated with slight, strictly localized conformational changes. High compatibility of hPrP with insertion of a second disulfide bridge in the protein X epitope was further substantiated by model calculations with additional variant structures. The ease with which the hPrP structure can accommodate a variety of locations for a second disulfide bond within the presumed protein X-binding epitope suggests a functional role for the extensive perturbation by a natural second disulfide bond of the corresponding region in the human doppel protein.

-	~~==About this Structure==~~	+	NMR structure of a variant human prion protein with two disulfide bridges.,Zahn R, Guntert P, von Schroetter C, Wuthrich K J Mol Biol. 2003 Feb 7;326(1):225-34. PMID:12547204<ref>PMID:12547204</ref>
-	~~[[1h0l]] is~~ a ~~1 chain structure~~ with ~~sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1H0L OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Doppel\|Doppel]]		*[[Doppel\|Doppel]]
	*[[Prion\|Prion]]		*[[Prion\|Prion]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:012547204</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Guntert, P.]]		[[Category: Guntert, P.]]

OCA at 06:13, 16 May 2013

OCA — Thu, 16 May 2013 06:13:52 GMT

←Older revision		Revision as of 06:13, 16 May 2013
Line 17:		Line 17:
	[[Category: Zahn, R.]]		[[Category: Zahn, R.]]
	[[Category: Brain]]		[[Category: Brain]]
		+	[[Category: Cell cycle]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Gpi-anchor]]		[[Category: Gpi-anchor]]
-	[[Category: Major prion protein]]
-	[[Category: Prion]]
-	[[Category: Prion protein]]

OCA at 16:45, 24 March 2013

OCA — Sun, 24 Mar 2013 16:45:17 GMT

←Older revision		Revision as of 16:45, 24 March 2013
Line 11:		Line 11:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:012547204</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012547204</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Guntert, P.]]		[[Category: Guntert, P.]]