1h7d - Revision history

OCA at 05:30, 15 May 2024

OCA — Wed, 15 May 2024 05:30:52 GMT

←Older revision		Revision as of 05:30, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1h7d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H7D FirstGlance]. <br>		<table><tr><td colspan='2'>[[1h7d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H7D FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7d OCA], [https://pdbe.org/1h7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h7d RCSB], [https://www.ebi.ac.uk/pdbsum/1h7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h7d ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7d OCA], [https://pdbe.org/1h7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h7d RCSB], [https://www.ebi.ac.uk/pdbsum/1h7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h7d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:01, 11 January 2023

OCA — Wed, 11 Jan 2023 08:01:13 GMT

←Older revision		Revision as of 08:01, 11 January 2023
Line 1:		Line 1:

	==Solution structure of the 49 aa presequence of 5-ALAS==		==Solution structure of the 49 aa presequence of 5-ALAS==
-	<StructureSection load='1h7d' size='340' side='right'caption='[[1h7d~~]], [[NMR_Ensembles_of_Models \| 30 NMR models~~]]' scene=''>	+	<StructureSection load='1h7d' size='340' side='right'caption='[[1h7d]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h7d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H7D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h7d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H7D FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7d OCA], [https://pdbe.org/1h7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h7d RCSB], [https://www.ebi.ac.uk/pdbsum/1h7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h7d ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7d OCA], [https://pdbe.org/1h7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h7d RCSB], [https://www.ebi.ac.uk/pdbsum/1h7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h7d ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HEM0_MOUSE HEM0_MOUSE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 5-aminolevulinate synthase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dias~~, J S~~]]	+	[[Category: Mus musculus]]
-	[[Category: Ferreira~~, G C~~]]	+	[[Category: Dias JS]]
-	[[Category: Goodfellow~~, B J~~]]	+	[[Category: Ferreira GC]]
-	[[Category: Henklein, P]]	+	[[Category: Goodfellow BJ]]
-	[[Category: Macedo~~, A L~~]]	+	[[Category: Henklein P]]
-	[[Category: Wray, V]]	+	[[Category: Macedo AL]]
-	~~[[Category: Acyltransferase]]~~	+	[[Category: Wray V]]
-	~~[[Category: Ala]]~~	+
-	~~[[Category: Presequence~~]]	+

OCA at 11:05, 31 March 2021

OCA — Wed, 31 Mar 2021 11:05:52 GMT

←Older revision		Revision as of 11:05, 31 March 2021
Line 3:		Line 3:
	<StructureSection load='1h7d' size='340' side='right'caption='[[1h7d]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>		<StructureSection load='1h7d' size='340' side='right'caption='[[1h7d]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h7d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1H7D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h7d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H7D FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1h7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7d OCA], [~~http~~://pdbe.org/1h7d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1h7d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1h7d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1h7d ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7d OCA], [https://pdbe.org/1h7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h7d RCSB], [https://www.ebi.ac.uk/pdbsum/1h7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h7d ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:30, 26 June 2019

OCA — Wed, 26 Jun 2019 08:30:49 GMT

←Older revision		Revision as of 08:30, 26 June 2019
Line 1:		Line 1:

	==Solution structure of the 49 aa presequence of 5-ALAS==		==Solution structure of the 49 aa presequence of 5-ALAS==
-	<StructureSection load='1h7d' size='340' side='right' caption='[[1h7d]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>	+	<StructureSection load='1h7d' size='340' side='right'caption='[[1h7d]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1h7d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7D FirstGlance]. <br>		<table><tr><td colspan='2'>[[1h7d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7D FirstGlance]. <br>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: 5-aminolevulinate synthase]]		[[Category: 5-aminolevulinate synthase]]
		+	[[Category: Large Structures]]
	[[Category: Dias, J S]]		[[Category: Dias, J S]]
	[[Category: Ferreira, G C]]		[[Category: Ferreira, G C]]

OCA at 04:32, 21 September 2017

OCA — Thu, 21 Sep 2017 04:32:54 GMT

←Older revision		Revision as of 04:32, 21 September 2017
Line 1:		Line 1:
-	==~~SOLUTION STRUCTURE OF THE~~ 49 ~~AA PRESEQUENCE OF~~ 5-ALAS==	+
		+	==Solution structure of the 49 aa presequence of 5-ALAS==
	<StructureSection load='1h7d' size='340' side='right' caption='[[1h7d]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>		<StructureSection load='1h7d' size='340' side='right' caption='[[1h7d]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1h7d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7D FirstGlance]. <br>		<table><tr><td colspan='2'>[[1h7d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7D FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7d OCA], [http://pdbe.org/1h7d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h7d RCSB], [http://www.ebi.ac.uk/pdbsum/1h7d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7d OCA], [http://pdbe.org/1h7d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h7d RCSB], [http://www.ebi.ac.uk/pdbsum/1h7d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1h7d ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:16, 10 September 2015

OCA — Thu, 10 Sep 2015 17:16:18 GMT

←Older revision		Revision as of 17:16, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1h7d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7D FirstGlance]. <br>		<table><tr><td colspan='2'>[[1h7d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7D FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h7d RCSB], [http://www.ebi.ac.uk/pdbsum/1h7d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7d OCA], [http://pdbe.org/1h7d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h7d RCSB], [http://www.ebi.ac.uk/pdbsum/1h7d PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1h7d" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:32, 22 December 2014

OCA — Mon, 22 Dec 2014 06:32:48 GMT

←Older revision		Revision as of 06:32, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1h7d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7D FirstGlance]. <br>		<table><tr><td colspan='2'>[[1h7d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7D FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h7d RCSB], [http://www.ebi.ac.uk/pdbsum/1h7d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h7d RCSB], [http://www.ebi.ac.uk/pdbsum/1h7d PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: 5-aminolevulinate synthase]]		[[Category: 5-aminolevulinate synthase]]
-	[[Category: Dias, J S.]]	+	[[Category: Dias, J S]]
-	[[Category: Ferreira, G C.]]	+	[[Category: Ferreira, G C]]
-	[[Category: Goodfellow, B J.]]	+	[[Category: Goodfellow, B J]]
-	[[Category: Henklein, P.]]	+	[[Category: Henklein, P]]
-	[[Category: Macedo, A L.]]	+	[[Category: Macedo, A L]]
-	[[Category: Wray, V.]]	+	[[Category: Wray, V]]
	[[Category: Acyltransferase]]		[[Category: Acyltransferase]]
	[[Category: Ala]]		[[Category: Ala]]
	[[Category: Presequence]]		[[Category: Presequence]]

OCA at 05:36, 8 June 2014

OCA — Sun, 08 Jun 2014 05:36:29 GMT

←Older revision		Revision as of 05:36, 8 June 2014
Line 1:		Line 1:
-	[[~~Image~~:1h7d.~~png\|left\|200px~~]]	+	==SOLUTION STRUCTURE OF THE 49 AA PRESEQUENCE OF 5-ALAS==
		+	<StructureSection load='1h7d' size='340' side='right' caption='[[1h7d]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1h7d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7D FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h7d RCSB], [http://www.ebi.ac.uk/pdbsum/1h7d PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The mitochondrial import of 5-aminolevulinate synthase (ALAS), the first enzyme of the mammalian heme biosynthetic pathway, requires the N-terminal presequence. The 49 amino acid presequence transit peptide (psALAS) for murine erythroid ALAS was chemically synthesized, and circular dichroism and (1)H nuclear magnetic resonance (NMR) spectroscopies used to determine structural elements in trifluoroethanol/H(2)O solutions and micellar environments. A well defined amphipathic alpha-helix, spanning L22 to F33, was present in psALAS in 50% trifluoroethanol. Further, a short alpha-helix, defined by A5-L8, was also apparent in the 26 amino acid N-terminus peptide, when its structure was determined in sodium dodecyl sulfate. Heme inhibition of ALAS mitochondrial import has been reported to be mediated through cysteine residues in presequence heme regulatory motifs (HRMs). A UV/visible and (1)H NMR study of hemin and psALAS indicated that a heme-peptide interaction occurs and demonstrates, for the first time, that heme interacts with the HRMs of psALAS.

-	~~{{STRUCTURE_1h7d\| PDB=1h7d \| SCENE= }}~~	+	The solution structure and heme binding of the presequence of murine 5-aminolevulinate synthase.,Goodfellow BJ, Dias JS, Ferreira GC, Henklein P, Wray V, Macedo AL FEBS Lett. 2001 Sep 14;505(2):325-31. PMID:11566198<ref>PMID:11566198</ref>

-	~~===SOLUTION STRUCTURE OF THE 49 AA PRESEQUENCE OF 5-ALAS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11566198}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1h7d]] is~~ a ~~1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1H7D OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011566198<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: 5-aminolevulinate synthase]]		[[Category: 5-aminolevulinate synthase]]
	[[Category: Dias, J S.]]		[[Category: Dias, J S.]]

OCA: Protected "1h7d" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 18:44:53 GMT

Protected "1h7d" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:44, 14 August 2012

OCA at 18:44, 14 August 2012

OCA — Tue, 14 Aug 2012 18:44:51 GMT

←Older revision		Revision as of 18:44, 14 August 2012
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-	{{Seed}}
	[[Image:1h7d.png\|left\|200px]]		[[Image:1h7d.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1h7d", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_1h7d\| PDB=1h7d \| SCENE= }}		{{STRUCTURE_1h7d\| PDB=1h7d \| SCENE= }}

	===SOLUTION STRUCTURE OF THE 49 AA PRESEQUENCE OF 5-ALAS===		===SOLUTION STRUCTURE OF THE 49 AA PRESEQUENCE OF 5-ALAS===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11566198}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11566198 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_11566198}}		{{ABSTRACT_PUBMED_11566198}}

	==About this Structure==		==About this Structure==
-	~~1H7D is a~~ [[~~Single protein~~]] structure ~~of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7D OCA].	+	[[1h7d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7D OCA].

	==Reference==		==Reference==
-	The solution structure and heme binding of the presequence of murine 5-aminolevulinate synthase., Goodfellow BJ, Dias JS, Ferreira GC, Henklein P, Wray V, Macedo AL, FEBS Lett. 2001 Sep 14;505(2):325-31. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~11566198 11566198]~~	+	<ref group="xtra">PMID:011566198</ref><references group="xtra"/>
	[[Category: 5-aminolevulinate synthase]]		[[Category: 5-aminolevulinate synthase]]
-	[[Category: Mus musculus]]
-	[[Category: Single protein]]
	[[Category: Dias, J S.]]		[[Category: Dias, J S.]]
	[[Category: Ferreira, G C.]]		[[Category: Ferreira, G C.]]
Line 33:		Line 19:
	[[Category: Macedo, A L.]]		[[Category: Macedo, A L.]]
	[[Category: Wray, V.]]		[[Category: Wray, V.]]
		+	[[Category: Acyltransferase]]
	[[Category: Ala]]		[[Category: Ala]]
-	[[Category: Nmr structure]]
	[[Category: Presequence]]		[[Category: Presequence]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:44:46 2008''