1h7o - Revision history

OCA at 07:52, 15 November 2023

OCA — Wed, 15 Nov 2023 07:52:05 GMT

←Older revision		Revision as of 07:52, 15 November 2023
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	<StructureSection load='1h7o' size='340' side='right'caption='[[1h7o]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='1h7o' size='340' side='right'caption='[[1h7o]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h7o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H7O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h7o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H7O FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=DAV:DELTA~~-~~AMINO+VALERIC+ACID'>DAV</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1aw5\|1aw5]], [[1h7n\|1h7n]], [[1qml\|1qml]], [[1qnv\|1qnv]], [[1ylv\|1ylv]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAV:DELTA-AMINO+VALERIC+ACID'>DAV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7o OCA], [https://pdbe.org/1h7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h7o RCSB], [https://www.ebi.ac.uk/pdbsum/1h7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h7o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7o OCA], [https://pdbe.org/1h7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h7o RCSB], [https://www.ebi.ac.uk/pdbsum/1h7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h7o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HEM2_YEAST HEM2_YEAST]] Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.	+	[https://www.uniprot.org/uniprot/HEM2_YEAST HEM2_YEAST] Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Porphobilinogen synthase~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Brindley~~, A A~~]]	+	[[Category: Brindley AA]]
-	[[Category: Cooper~~, J B~~]]	+	[[Category: Cooper JB]]
-	[[Category: Erskine~~, P T~~]]	+	[[Category: Erskine PT]]
-	[[Category: Newbold, R]]	+	[[Category: Newbold R]]
-	[[Category: Shoolingin-Jordan~~, P M~~]]	+	[[Category: Shoolingin-Jordan PM]]
-	[[Category: Warren~~, M J~~]]	+	[[Category: Warren MJ]]
-	[[Category: Wood~~, S P]]~~	+	[[Category: Wood SP]]
-	~~[[Category: Aldolase]]~~	+
-	~~[[Category: Dehydratase]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Tetrapyrrole synthesis]]~~	+
-	~~[[Category: Tim barrel~~]]	+

OCA at 05:48, 28 April 2021

OCA — Wed, 28 Apr 2021 05:48:37 GMT

←Older revision		Revision as of 05:48, 28 April 2021
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	<StructureSection load='1h7o' size='340' side='right'caption='[[1h7o]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='1h7o' size='340' side='right'caption='[[1h7o]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h7o]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1H7O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h7o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H7O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAV:DELTA-AMINO+VALERIC+ACID'>DAV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAV:DELTA-AMINO+VALERIC+ACID'>DAV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aw5\|1aw5]], [[1h7n\|1h7n]], [[1qml\|1qml]], [[1qnv\|1qnv]], [[1ylv\|1ylv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1aw5\|1aw5]], [[1h7n\|1h7n]], [[1qml\|1qml]], [[1qnv\|1qnv]], [[1ylv\|1ylv]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1h7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7o OCA], [~~http~~://pdbe.org/1h7o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1h7o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1h7o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1h7o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7o OCA], [https://pdbe.org/1h7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h7o RCSB], [https://www.ebi.ac.uk/pdbsum/1h7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h7o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HEM2_YEAST HEM2_YEAST]] Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.	+	[[https://www.uniprot.org/uniprot/HEM2_YEAST HEM2_YEAST]] Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:03, 23 May 2019

OCA — Thu, 23 May 2019 07:03:27 GMT

←Older revision		Revision as of 07:03, 23 May 2019
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	==SCHIFF-BASE COMPLEX OF YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE WITH 5-AMINOLAEVULINIC ACID AT 1.7 A RESOLUTION==		==SCHIFF-BASE COMPLEX OF YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE WITH 5-AMINOLAEVULINIC ACID AT 1.7 A RESOLUTION==
-	<StructureSection load='1h7o' size='340' side='right' caption='[[1h7o]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='1h7o' size='340' side='right'caption='[[1h7o]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h7o]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h7o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAV:DELTA-AMINO+VALERIC+ACID'>DAV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAV:DELTA-AMINO+VALERIC+ACID'>DAV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aw5\|1aw5]], [[1h7n\|1h7n]], [[1qml\|1qml]], [[1qnv\|1qnv]], [[1ylv\|1ylv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aw5\|1aw5]], [[1h7n\|1h7n]], [[1qml\|1qml]], [[1qnv\|1qnv]], [[1ylv\|1ylv]]</td></tr>
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h7/1h7o_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h7/1h7o_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 37:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Porphobilinogen synthase]]		[[Category: Porphobilinogen synthase]]
	[[Category: Brindley, A A]]		[[Category: Brindley, A A]]

OCA at 04:31, 21 September 2017

OCA — Thu, 21 Sep 2017 04:31:34 GMT

←Older revision		Revision as of 04:31, 21 September 2017
Line 1:		Line 1:
		+
	==SCHIFF-BASE COMPLEX OF YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE WITH 5-AMINOLAEVULINIC ACID AT 1.7 A RESOLUTION==		==SCHIFF-BASE COMPLEX OF YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE WITH 5-AMINOLAEVULINIC ACID AT 1.7 A RESOLUTION==
	<StructureSection load='1h7o' size='340' side='right' caption='[[1h7o]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='1h7o' size='340' side='right' caption='[[1h7o]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h7o]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h7o]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAV:DELTA-AMINO+VALERIC+ACID'>DAV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAV:DELTA-AMINO+VALERIC+ACID'>DAV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aw5\|1aw5]], [[1h7n\|1h7n]], [[1qml\|1qml]], [[1qnv\|1qnv]], [[1ylv\|1ylv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aw5\|1aw5]], [[1h7n\|1h7n]], [[1qml\|1qml]], [[1qnv\|1qnv]], [[1ylv\|1ylv]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7o OCA], [http://pdbe.org/1h7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h7o RCSB], [http://www.ebi.ac.uk/pdbsum/1h7o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7o OCA], [http://pdbe.org/1h7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h7o RCSB], [http://www.ebi.ac.uk/pdbsum/1h7o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1h7o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h7o ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Porphobilinogen synthase]]		[[Category: Porphobilinogen synthase]]
	[[Category: Brindley, A A]]		[[Category: Brindley, A A]]

OCA at 01:16, 12 September 2015

OCA — Sat, 12 Sep 2015 01:16:54 GMT

←Older revision		Revision as of 01:16, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1h7o' size='340' side='right' caption='[[1h7o]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='1h7o' size='340' side='right' caption='[[1h7o]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h7o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h7o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAV:DELTA-AMINO+VALERIC+ACID'>DAV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAV:DELTA-AMINO+VALERIC+ACID'>DAV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aw5\|1aw5]], [[1h7n\|1h7n]], [[1qml\|1qml]], [[1qnv\|1qnv]], [[1ylv\|1ylv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aw5\|1aw5]], [[1h7n\|1h7n]], [[1qml\|1qml]], [[1qnv\|1qnv]], [[1ylv\|1ylv]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h7o RCSB], [http://www.ebi.ac.uk/pdbsum/1h7o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7o OCA], [http://pdbe.org/1h7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h7o RCSB], [http://www.ebi.ac.uk/pdbsum/1h7o PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1h7o" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 18824]]
	[[Category: Porphobilinogen synthase]]		[[Category: Porphobilinogen synthase]]
-	[[Category: Saccharomyces cerevisiae]]
	[[Category: Brindley, A A]]		[[Category: Brindley, A A]]
	[[Category: Cooper, J B]]		[[Category: Cooper, J B]]

OCA at 21:53, 25 December 2014

OCA — Thu, 25 Dec 2014 21:53:24 GMT

←Older revision		Revision as of 21:53, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h7o RCSB], [http://www.ebi.ac.uk/pdbsum/1h7o PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h7o RCSB], [http://www.ebi.ac.uk/pdbsum/1h7o PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HEM2_YEAST HEM2_YEAST]] Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 23:24, 22 December 2014

OCA — Mon, 22 Dec 2014 23:24:23 GMT

←Older revision		Revision as of 23:24, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1h7o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7O FirstGlance]. <br>		<table><tr><td colspan='2'>[[1h7o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7O FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAV:DELTA-AMINO+VALERIC+ACID'>DAV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAV:DELTA-AMINO+VALERIC+ACID'>DAV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aw5\|1aw5]], [[1h7n\|1h7n]], [[1qml\|1qml]], [[1qnv\|1qnv]], [[1ylv\|1ylv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aw5\|1aw5]], [[1h7n\|1h7n]], [[1qml\|1qml]], [[1qnv\|1qnv]], [[1ylv\|1ylv]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h7o RCSB], [http://www.ebi.ac.uk/pdbsum/1h7o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h7o RCSB], [http://www.ebi.ac.uk/pdbsum/1h7o PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Porphobilinogen synthase]]		[[Category: Porphobilinogen synthase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Brindley, A A.]]	+	[[Category: Brindley, A A]]
-	[[Category: Cooper, J B.]]	+	[[Category: Cooper, J B]]
-	[[Category: Erskine, P T.]]	+	[[Category: Erskine, P T]]
-	[[Category: Newbold, R.]]	+	[[Category: Newbold, R]]
-	[[Category: Shoolingin-Jordan, P M.]]	+	[[Category: Shoolingin-Jordan, P M]]
-	[[Category: Warren, M J.]]	+	[[Category: Warren, M J]]
-	[[Category: Wood, S P.]]	+	[[Category: Wood, S P]]
	[[Category: Aldolase]]		[[Category: Aldolase]]
	[[Category: Dehydratase]]		[[Category: Dehydratase]]

OCA at 13:06, 28 September 2014

OCA — Sun, 28 Sep 2014 13:06:44 GMT

←Older revision		Revision as of 13:06, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1h7o.~~png~~\|~~left~~\|200px]]	+	==SCHIFF-BASE COMPLEX OF YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE WITH 5-AMINOLAEVULINIC ACID AT 1.7 A RESOLUTION==
		+	<StructureSection load='1h7o' size='340' side='right' caption='[[1h7o]], [[Resolution\|resolution]] 1.75Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1h7o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7O FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAV:DELTA-AMINO+VALERIC+ACID'>DAV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aw5\|1aw5]], [[1h7n\|1h7n]], [[1qml\|1qml]], [[1qnv\|1qnv]], [[1ylv\|1ylv]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h7o RCSB], [http://www.ebi.ac.uk/pdbsum/1h7o PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h7/1h7o_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structures of 5-aminolaevulinic acid dehydratase (ALAD) complexed with substrate (5-aminolaevulinic acid) and three inhibitors: laevulinic acid, succinylacetone and 4-keto-5-aminolaevulinic acid, have been solved at high resolution. The ligands all bind by forming a covalent link with Lys263 at the active site. The structures define the interactions made by one of the two substrate moieties that bind to the enzyme during catalysis. All of the inhibitors induce a significant ordering of the flap covering the active site. Succinylacetone appears to be unique by inducing a number of conformational changes in loops covering the active site, which may be important for understanding the co-operative properties of ALAD enzymes. Succinylacetone is produced in large amounts by patients suffering from the hereditary disease type I tyrosinaemia and its potent inhibition of ALAD also has implications for the pathology of this disease. The most intriguing result is that obtained with 4-keto-5-amino-hexanoic acid, which seems to form a stable carbinolamine intermediate with Lys263. It appears that we have defined the structure of an intermediate of Schiff base formation that the substrate forms upon binding to the P-site of the enzyme.

-	~~{{STRUCTURE_1h7o\| PDB=1h7o \| SCENE= }}~~	+	The x-ray structure of yeast 5-aminolaevulinic acid dehydratase complexed with substrate and three inhibitors.,Erskine PT, Newbold R, Brindley AA, Wood SP, Shoolingin-Jordan PM, Warren MJ, Cooper JB J Mol Biol. 2001 Sep 7;312(1):133-41. PMID:11545591<ref>PMID:11545591</ref>

-	~~===SCHIFF-BASE COMPLEX OF YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE WITH 5-AMINOLAEVULINIC ACID AT 1~~.~~7 A RESOLUTION===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_11545591}}~~	+	==See Also==
-		+	*[[Porphobilinogen synthase\|Porphobilinogen synthase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1h7o~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7O OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:011545591<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Porphobilinogen synthase]]		[[Category: Porphobilinogen synthase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]

OCA: Protected "1h7o" [edit=sysop:move=sysop]

OCA — Wed, 21 Nov 2012 15:31:58 GMT

Protected "1h7o" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:31, 21 November 2012

OCA at 15:31, 21 November 2012

OCA — Wed, 21 Nov 2012 15:31:55 GMT

←Older revision		Revision as of 15:31, 21 November 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1h7o.png\|left\|200px]]		[[Image:1h7o.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1h7o", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1h7o\| PDB=1h7o \| SCENE= }}		{{STRUCTURE_1h7o\| PDB=1h7o \| SCENE= }}

	===SCHIFF-BASE COMPLEX OF YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE WITH 5-AMINOLAEVULINIC ACID AT 1.7 A RESOLUTION===		===SCHIFF-BASE COMPLEX OF YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE WITH 5-AMINOLAEVULINIC ACID AT 1.7 A RESOLUTION===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11545591}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11545591 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11545591}}		{{ABSTRACT_PUBMED_11545591}}

	==About this Structure==		==About this Structure==
-	~~1H7O~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7O OCA].	+	[[1h7o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7O OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11545591~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011545591</ref><references group="xtra"/>
	[[Category: Porphobilinogen synthase]]		[[Category: Porphobilinogen synthase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
Line 38:		Line 26:
	[[Category: Tetrapyrrole synthesis]]		[[Category: Tetrapyrrole synthesis]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:01:13 2009''