1h8k - Revision history

OCA at 12:20, 13 December 2023

OCA — Wed, 13 Dec 2023 12:20:36 GMT

←Older revision		Revision as of 12:20, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='1h8k' size='340' side='right'caption='[[1h8k]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1h8k' size='340' side='right'caption='[[1h8k]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h8k]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Chick Chick~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1H8K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h8k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H8K FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[1aey\|1aey]]~~, [[~~1aj3~~\|~~1aj3]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1hd3\|1hd3]], [[1pwt\|1pwt]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1h8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8k OCA], [~~http~~://pdbe.org/1h8k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1h8k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1h8k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1h8k ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8k OCA], [https://pdbe.org/1h8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h8k RCSB], [https://www.ebi.ac.uk/pdbsum/1h8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h8k ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:

	==See Also==		==See Also==
-	*[[Spectrin\|Spectrin]]	+	*[[Spectrin 3D structures\|Spectrin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chick~~]]	+	[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Serrano, L]]	+	[[Category: Serrano L]]
-	[[Category: Vega~~, M C]]~~	+	[[Category: Vega MC]]
-	~~[[Category: Actin-binding]]~~	+
-	~~[[Category: Calmodulin-binding]]~~	+
-	~~[[Category: Cytoskeleton]]~~	+
-	~~[[Category: Sh3-domain~~]]	+

OCA at 11:48, 29 July 2020

OCA — Wed, 29 Jul 2020 11:48:12 GMT

←Older revision		Revision as of 11:48, 29 July 2020
Line 1:		Line 1:

	==A-SPECTRIN SH3 DOMAIN A11V, V23L, M25V, V53I, V58L MUTANT==		==A-SPECTRIN SH3 DOMAIN A11V, V23L, M25V, V53I, V58L MUTANT==
-	<StructureSection load='1h8k' size='340' side='right' caption='[[1h8k]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='1h8k' size='340' side='right'caption='[[1h8k]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h8k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8K OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1H8K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h8k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8K OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1H8K FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aey\|1aey]], [[1aj3\|1aj3]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1hd3\|1hd3]], [[1pwt\|1pwt]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aey\|1aey]], [[1aj3\|1aj3]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1hd3\|1hd3]], [[1pwt\|1pwt]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1h8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8k OCA], [http://pdbe.org/1h8k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h8k RCSB], [http://www.ebi.ac.uk/pdbsum/1h8k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1h8k ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1h8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8k OCA], [http://pdbe.org/1h8k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h8k RCSB], [http://www.ebi.ac.uk/pdbsum/1h8k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1h8k ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Chick]]		[[Category: Chick]]
		+	[[Category: Large Structures]]
	[[Category: Serrano, L]]		[[Category: Serrano, L]]
	[[Category: Vega, M C]]		[[Category: Vega, M C]]

OCA at 06:13, 4 April 2018

OCA — Wed, 04 Apr 2018 06:13:06 GMT

←Older revision		Revision as of 06:13, 4 April 2018
Line 3:		Line 3:
	<StructureSection load='1h8k' size='340' side='right' caption='[[1h8k]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1h8k' size='340' side='right' caption='[[1h8k]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h8k]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H8K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h8k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H8K FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aey\|1aey]], [[1aj3\|1aj3]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1hd3\|1hd3]], [[1pwt\|1pwt]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aey\|1aey]], [[1aj3\|1aj3]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1hd3\|1hd3]], [[1pwt\|1pwt]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8k OCA], [http://pdbe.org/1h8k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h8k RCSB], [http://www.ebi.ac.uk/pdbsum/1h8k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1h8k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8k OCA], [http://pdbe.org/1h8k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h8k RCSB], [http://www.ebi.ac.uk/pdbsum/1h8k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1h8k ProSAT]</span></td></tr>
Line 11:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/1h8k_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/1h8k_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Chick]]
	[[Category: Serrano, L]]		[[Category: Serrano, L]]
	[[Category: Vega, M C]]		[[Category: Vega, M C]]

OCA at 04:33, 21 September 2017

OCA — Thu, 21 Sep 2017 04:33:54 GMT

←Older revision		Revision as of 04:33, 21 September 2017
Line 1:		Line 1:
		+
	==A-SPECTRIN SH3 DOMAIN A11V, V23L, M25V, V53I, V58L MUTANT==		==A-SPECTRIN SH3 DOMAIN A11V, V23L, M25V, V53I, V58L MUTANT==
	<StructureSection load='1h8k' size='340' side='right' caption='[[1h8k]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1h8k' size='340' side='right' caption='[[1h8k]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h8k]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Chick Chick]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H8K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h8k]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H8K FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aey\|1aey]], [[1aj3\|1aj3]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1hd3\|1hd3]], [[1pwt\|1pwt]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aey\|1aey]], [[1aj3\|1aj3]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1hd3\|1hd3]], [[1pwt\|1pwt]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8k OCA], [http://pdbe.org/1h8k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h8k RCSB], [http://www.ebi.ac.uk/pdbsum/1h8k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8k OCA], [http://pdbe.org/1h8k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h8k RCSB], [http://www.ebi.ac.uk/pdbsum/1h8k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1h8k ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h8k ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Chick]]
	[[Category: Serrano, L]]		[[Category: Serrano, L]]
	[[Category: Vega, M C]]		[[Category: Vega, M C]]

OCA at 14:22, 11 September 2015

OCA — Fri, 11 Sep 2015 14:22:29 GMT

←Older revision		Revision as of 14:22, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1h8k' size='340' side='right' caption='[[1h8k]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1h8k' size='340' side='right' caption='[[1h8k]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h8k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Gallus_gallus Gallus gallus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H8K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h8k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H8K FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aey\|1aey]], [[1aj3\|1aj3]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1hd3\|1hd3]], [[1pwt\|1pwt]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aey\|1aey]], [[1aj3\|1aj3]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1hd3\|1hd3]], [[1pwt\|1pwt]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h8k RCSB], [http://www.ebi.ac.uk/pdbsum/1h8k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8k OCA], [http://pdbe.org/1h8k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h8k RCSB], [http://www.ebi.ac.uk/pdbsum/1h8k PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1h8k" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Gallus gallus~~]]	+	[[Category: Chick]]
	[[Category: Serrano, L]]		[[Category: Serrano, L]]
	[[Category: Vega, M C]]		[[Category: Vega, M C]]

OCA at 22:40, 22 December 2014

OCA — Mon, 22 Dec 2014 22:40:47 GMT

←Older revision		Revision as of 22:40, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1h8k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H8K FirstGlance]. <br>		<table><tr><td colspan='2'>[[1h8k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H8K FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aey\|1aey]], [[1aj3\|1aj3]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1hd3\|1hd3]], [[1pwt\|1pwt]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aey\|1aey]], [[1aj3\|1aj3]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1hd3\|1hd3]], [[1pwt\|1pwt]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h8k RCSB], [http://www.ebi.ac.uk/pdbsum/1h8k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h8k RCSB], [http://www.ebi.ac.uk/pdbsum/1h8k PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
-	[[Category: Serrano, L.]]	+	[[Category: Serrano, L]]
-	[[Category: Vega, M C.]]	+	[[Category: Vega, M C]]
	[[Category: Actin-binding]]		[[Category: Actin-binding]]
	[[Category: Calmodulin-binding]]		[[Category: Calmodulin-binding]]
	[[Category: Cytoskeleton]]		[[Category: Cytoskeleton]]
	[[Category: Sh3-domain]]		[[Category: Sh3-domain]]

OCA at 12:28, 28 September 2014

OCA — Sun, 28 Sep 2014 12:28:15 GMT

←Older revision		Revision as of 12:28, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1h8k.~~png~~\|~~left~~\|200px]]	+	==A-SPECTRIN SH3 DOMAIN A11V, V23L, M25V, V53I, V58L MUTANT==
		+	<StructureSection load='1h8k' size='340' side='right' caption='[[1h8k]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1h8k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H8K FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aey\|1aey]], [[1aj3\|1aj3]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1hd3\|1hd3]], [[1pwt\|1pwt]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h8k RCSB], [http://www.ebi.ac.uk/pdbsum/1h8k PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/1h8k_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We have designed de novo 13 divergent spectrin SH3 core sequences to determine their folding properties. Kinetic analysis of the variants with stability similar to that of the wild type protein shows accelerated unfolding and refolding rates compatible with a preferential stabilization of the transition state. This is most likely caused by conformational strain in the native state, as deletion of a methyl group (Ile-->Val) leads to deceleration in unfolding and increased stability (up to 2 kcal x mol(-1)). Several of these Ile-->Val mutants have negative phi(-U) values, indicating that some noncanonical phi(-U) values might result from conformational strain. Thus, producing a stable protein does not necessarily mean that the design process has been entirely successful. Strained interactions could have been introduced, and a reduction in the buried volume could result in a large increase in stability and a reduction in unfolding rates.

-	~~{{STRUCTURE_1h8k\| PDB=1h8k \| SCENE= }}~~	+	Conformational strain in the hydrophobic core and its implications for protein folding and design.,Ventura S, Vega MC, Lacroix E, Angrand I, Spagnolo L, Serrano L Nat Struct Biol. 2002 Jun;9(6):485-93. PMID:12006985<ref>PMID:12006985</ref>

-	~~===A-SPECTRIN SH3 DOMAIN A11V~~, ~~V23L, M25V, V53I, V58L MUTANT===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12006985}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1h8k]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Gallus_gallus Gallus gallus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1H8K OCA].~~	+

	==See Also==		==See Also==
	*[[Spectrin\|Spectrin]]		*[[Spectrin\|Spectrin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012006985<~~/~~ref~~><~~ref group="xtra">PMID:001279434</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Serrano, L.]]		[[Category: Serrano, L.]]

OCA at 19:33, 20 October 2012

OCA — Sat, 20 Oct 2012 19:33:23 GMT

←Older revision		Revision as of 19:33, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1h8k]] is a 1 chain structure ~~of [[Spectrin]]~~ with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8K OCA].	+	[[1h8k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8K OCA].

	==See Also==		==See Also==

OCA at 07:43, 27 July 2012

OCA — Fri, 27 Jul 2012 07:43:54 GMT

←Older revision		Revision as of 07:43, 27 July 2012
Line 1:		Line 1:
	[[Image:1h8k.png\|left\|200px]]		[[Image:1h8k.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1h8k", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1h8k\| PDB=1h8k \| SCENE= }}		{{STRUCTURE_1h8k\| PDB=1h8k \| SCENE= }}

	===A-SPECTRIN SH3 DOMAIN A11V, V23L, M25V, V53I, V58L MUTANT===		===A-SPECTRIN SH3 DOMAIN A11V, V23L, M25V, V53I, V58L MUTANT===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12006985}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12006985 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12006985}}		{{ABSTRACT_PUBMED_12006985}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Spectrin]]	+	*[[Spectrin\|Spectrin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12006985~~</ref><ref group="xtra">PMID:~~1279434~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012006985</ref><ref group="xtra">PMID:001279434</ref><references group="xtra"/>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Serrano, L.]]		[[Category: Serrano, L.]]

OCA: Protected "1h8k" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 19:48:23 GMT

Protected "1h8k" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:48, 14 March 2011