1heu - Revision history

OCA at 12:24, 13 December 2023

OCA — Wed, 13 Dec 2023 12:24:45 GMT

←Older revision		Revision as of 12:24, 13 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1heu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HEU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1heu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HEU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MRD:(4R)~~-~~2-METHYLPENTANE-2~~,~~4-DIOL'>MRD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.15Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1het\|1het]], [[1a71\|1a71]], [[1a72\|1a72]], [[1axe\|1axe]], [[1axg\|1axg]], [[1bto\|1bto]], [[1lde\|1lde]], [[1ldy\|1ldy]], [[1qlh\|1qlh]], [[1qlj\|1qlj]], [[3bto\|3bto]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1heu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1heu OCA], [https://pdbe.org/1heu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1heu RCSB], [https://www.ebi.ac.uk/pdbsum/1heu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1heu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1heu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1heu OCA], [https://pdbe.org/1heu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1heu RCSB], [https://www.ebi.ac.uk/pdbsum/1heu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1heu ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ADH1E_HORSE ADH1E_HORSE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Alcohol dehydrogenase]]
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Adolph~~, H W~~]]	+	[[Category: Adolph HW]]
-	[[Category: Cedergen-Zeppezauer~~, E S~~]]	+	[[Category: Cedergen-Zeppezauer ES]]
-	[[Category: Lamzin~~, V S~~]]	+	[[Category: Lamzin VS]]
-	[[Category: Meijers, R]]	+	[[Category: Meijers R]]
-	[[Category: Merli, A]]	+	[[Category: Merli A]]
-	[[Category: Morris~~, R J]]~~	+	[[Category: Morris RJ]]
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 05:49, 28 April 2021

OCA — Wed, 28 Apr 2021 05:49:16 GMT

←Older revision		Revision as of 05:49, 28 April 2021
Line 3:		Line 3:
	<StructureSection load='1heu' size='340' side='right'caption='[[1heu]], [[Resolution\|resolution]] 1.15Å' scene=''>		<StructureSection load='1heu' size='340' side='right'caption='[[1heu]], [[Resolution\|resolution]] 1.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1heu]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HEU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1HEU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1heu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HEU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1het\|1het]], [[1a71\|1a71]], [[1a72\|1a72]], [[1axe\|1axe]], [[1axg\|1axg]], [[1bto\|1bto]], [[1lde\|1lde]], [[1ldy\|1ldy]], [[1qlh\|1qlh]], [[1qlj\|1qlj]], [[3bto\|3bto]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1het\|1het]], [[1a71\|1a71]], [[1a72\|1a72]], [[1axe\|1axe]], [[1axg\|1axg]], [[1bto\|1bto]], [[1lde\|1lde]], [[1ldy\|1ldy]], [[1qlh\|1qlh]], [[1qlj\|1qlj]], [[3bto\|3bto]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1heu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1heu OCA], [~~http~~://pdbe.org/1heu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1heu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1heu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1heu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1heu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1heu OCA], [https://pdbe.org/1heu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1heu RCSB], [https://www.ebi.ac.uk/pdbsum/1heu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1heu ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 06:45, 24 July 2019

OCA — Wed, 24 Jul 2019 06:45:04 GMT

←Older revision		Revision as of 06:45, 24 July 2019
Line 1:		Line 1:

	==ATOMIC X-RAY STRUCTURE OF LIVER ALCOHOL DEHYDROGENASE CONTAINING Cadmium and a hydroxide adduct to NADH==		==ATOMIC X-RAY STRUCTURE OF LIVER ALCOHOL DEHYDROGENASE CONTAINING Cadmium and a hydroxide adduct to NADH==
-	<StructureSection load='1heu' size='340' side='right' caption='[[1heu]], [[Resolution\|resolution]] 1.15Å' scene=''>	+	<StructureSection load='1heu' size='340' side='right'caption='[[1heu]], [[Resolution\|resolution]] 1.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1heu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HEU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1heu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HEU FirstGlance]. <br>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1heu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1heu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Alcohol dehydrogenase 3D structures\|Alcohol dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	[[Category: Alcohol dehydrogenase]]		[[Category: Alcohol dehydrogenase]]
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
		+	[[Category: Large Structures]]
	[[Category: Adolph, H W]]		[[Category: Adolph, H W]]
	[[Category: Cedergen-Zeppezauer, E S]]		[[Category: Cedergen-Zeppezauer, E S]]

OCA at 08:53, 10 January 2018

OCA — Wed, 10 Jan 2018 08:53:59 GMT

←Older revision		Revision as of 08:53, 10 January 2018
Line 1:		Line 1:
-	==ATOMIC X-RAY STRUCTURE OF LIVER ALCOHOL DEHYDROGENASE CONTAINING ~~CADMIUM AND A HYDROXIDE ADDUCT TO~~ NADH==	+
		+	==ATOMIC X-RAY STRUCTURE OF LIVER ALCOHOL DEHYDROGENASE CONTAINING Cadmium and a hydroxide adduct to NADH==
	<StructureSection load='1heu' size='340' side='right' caption='[[1heu]], [[Resolution\|resolution]] 1.15Å' scene=''>		<StructureSection load='1heu' size='340' side='right' caption='[[1heu]], [[Resolution\|resolution]] 1.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1het\|1het]], [[1a71\|1a71]], [[1a72\|1a72]], [[1axe\|1axe]], [[1axg\|1axg]], [[1bto\|1bto]], [[1lde\|1lde]], [[1ldy\|1ldy]], [[1qlh\|1qlh]], [[1qlj\|1qlj]], [[3bto\|3bto]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1het\|1het]], [[1a71\|1a71]], [[1a72\|1a72]], [[1axe\|1axe]], [[1axg\|1axg]], [[1bto\|1bto]], [[1lde\|1lde]], [[1ldy\|1ldy]], [[1qlh\|1qlh]], [[1qlj\|1qlj]], [[3bto\|3bto]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1heu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1heu OCA], [http://pdbe.org/1heu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1heu RCSB], [http://www.ebi.ac.uk/pdbsum/1heu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1heu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1heu OCA], [http://pdbe.org/1heu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1heu RCSB], [http://www.ebi.ac.uk/pdbsum/1heu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1heu ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/1heu_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/1heu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1heu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1heu" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Alcohol dehydrogenase\|Alcohol dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:30, 10 February 2016

OCA — Wed, 10 Feb 2016 02:30:04 GMT

←Older revision		Revision as of 02:30, 10 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1heu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:29, 11 September 2015

OCA — Fri, 11 Sep 2015 04:29:43 GMT

←Older revision		Revision as of 04:29, 11 September 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1het\|1het]], [[1a71\|1a71]], [[1a72\|1a72]], [[1axe\|1axe]], [[1axg\|1axg]], [[1bto\|1bto]], [[1lde\|1lde]], [[1ldy\|1ldy]], [[1qlh\|1qlh]], [[1qlj\|1qlj]], [[3bto\|3bto]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1het\|1het]], [[1a71\|1a71]], [[1a72\|1a72]], [[1axe\|1axe]], [[1axg\|1axg]], [[1bto\|1bto]], [[1lde\|1lde]], [[1ldy\|1ldy]], [[1qlh\|1qlh]], [[1qlj\|1qlj]], [[3bto\|3bto]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1heu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1heu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1heu RCSB], [http://www.ebi.ac.uk/pdbsum/1heu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1heu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1heu OCA], [http://pdbe.org/1heu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1heu RCSB], [http://www.ebi.ac.uk/pdbsum/1heu PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1heu" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 18:15, 22 December 2014

OCA — Mon, 22 Dec 2014 18:15:16 GMT

←Older revision		Revision as of 18:15, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1heu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HEU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1heu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HEU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1het\|1het]], [[1a71\|1a71]], [[1a72\|1a72]], [[1axe\|1axe]], [[1axg\|1axg]], [[1bto\|1bto]], [[1lde\|1lde]], [[1ldy\|1ldy]], [[1qlh\|1qlh]], [[1qlj\|1qlj]], [[3bto\|3bto]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1het\|1het]], [[1a71\|1a71]], [[1a72\|1a72]], [[1axe\|1axe]], [[1axg\|1axg]], [[1bto\|1bto]], [[1lde\|1lde]], [[1ldy\|1ldy]], [[1qlh\|1qlh]], [[1qlj\|1qlj]], [[3bto\|3bto]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1heu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1heu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1heu RCSB], [http://www.ebi.ac.uk/pdbsum/1heu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1heu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1heu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1heu RCSB], [http://www.ebi.ac.uk/pdbsum/1heu PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Alcohol dehydrogenase]]		[[Category: Alcohol dehydrogenase]]
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
-	[[Category: Adolph, H W.]]	+	[[Category: Adolph, H W]]
-	[[Category: Cedergen-Zeppezauer, E S.]]	+	[[Category: Cedergen-Zeppezauer, E S]]
-	[[Category: Lamzin, V S.]]	+	[[Category: Lamzin, V S]]
-	[[Category: Meijers, R.]]	+	[[Category: Meijers, R]]
-	[[Category: Merli, A.]]	+	[[Category: Merli, A]]
-	[[Category: Morris, R J.]]	+	[[Category: Morris, R J]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 08:19, 28 September 2014

OCA — Sun, 28 Sep 2014 08:19:14 GMT

←Older revision		Revision as of 08:19, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1heu.~~png~~\|~~left~~\|200px]]	+	==ATOMIC X-RAY STRUCTURE OF LIVER ALCOHOL DEHYDROGENASE CONTAINING CADMIUM AND A HYDROXIDE ADDUCT TO NADH==
		+	<StructureSection load='1heu' size='340' side='right' caption='[[1heu]], [[Resolution\|resolution]] 1.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1heu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HEU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1het\|1het]], [[1a71\|1a71]], [[1a72\|1a72]], [[1axe\|1axe]], [[1axg\|1axg]], [[1bto\|1bto]], [[1lde\|1lde]], [[1ldy\|1ldy]], [[1qlh\|1qlh]], [[1qlj\|1qlj]], [[3bto\|3bto]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1heu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1heu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1heu RCSB], [http://www.ebi.ac.uk/pdbsum/1heu PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/1heu_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Atomic (1 A) resolution x-ray structures of horse liver alcohol dehydrogenase in complex with NADH revealed the formation of an adduct in the active site between a metal-bound water and NADH. Furthermore, a pronounced distortion of the pyridine ring of NADH was observed. A series of quantum chemical calculations on the water-nicotinamide adduct showed that the puckering of the pyridine ring in the crystal structures can only be reproduced when the water is considered a hydroxide ion. These observations provide fundamental insight into the enzymatic activation of NADH for hydride transfer.

-	~~{{STRUCTURE_1heu\| PDB=1heu \| SCENE= }}~~	+	On the enzymatic activation of NADH.,Meijers R, Morris RJ, Adolph HW, Merli A, Lamzin VS, Cedergren-Zeppezauer ES J Biol Chem. 2001 Mar 23;276(12):9316-21. Epub 2000 Dec 28. PMID:11134046<ref>PMID:11134046</ref>

-	~~===ATOMIC X-RAY STRUCTURE OF LIVER ALCOHOL DEHYDROGENASE CONTAINING CADMIUM AND A HYDROXIDE ADDUCT TO NADH===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11134046}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1heu]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Equus_caballus Equus caballus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1HEU OCA].~~	+

	==See Also==		==See Also==
	*[[Alcohol dehydrogenase\|Alcohol dehydrogenase]]		*[[Alcohol dehydrogenase\|Alcohol dehydrogenase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011134046<~~/~~ref~~><~~ref group="xtra">PMID:010529241</ref><ref group="xtra">PMID:009220961</ref><ref group="xtra">PMID:015299346</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Alcohol dehydrogenase]]		[[Category: Alcohol dehydrogenase]]
	[[Category: Equus caballus]]		[[Category: Equus caballus]]

OCA at 16:00, 20 October 2012

OCA — Sat, 20 Oct 2012 16:00:47 GMT

←Older revision		Revision as of 16:00, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1heu]] is a 2 chain structure ~~of [[Alcohol dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HEU OCA].	+	[[1heu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HEU OCA].

	==See Also==		==See Also==
Line 14:		Line 14:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:011134046</ref><ref group="xtra">PMID:010529241</ref><ref group="xtra">PMID:009220961</ref><ref group="xtra">PMID:015299346~~</ref><ref group="xtra">PMID:006351056</ref><ref group="xtra">PMID:006362718~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011134046</ref><ref group="xtra">PMID:010529241</ref><ref group="xtra">PMID:009220961</ref><ref group="xtra">PMID:015299346</ref><references group="xtra"/>
	[[Category: Alcohol dehydrogenase]]		[[Category: Alcohol dehydrogenase]]
	[[Category: Equus caballus]]		[[Category: Equus caballus]]

OCA at 20:18, 26 July 2012

OCA — Thu, 26 Jul 2012 20:18:36 GMT

←Older revision		Revision as of 20:18, 26 July 2012
Line 1:		Line 1:
	[[Image:1heu.png\|left\|200px]]		[[Image:1heu.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1heu", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1heu\| PDB=1heu \| SCENE= }}		{{STRUCTURE_1heu\| PDB=1heu \| SCENE= }}

	===ATOMIC X-RAY STRUCTURE OF LIVER ALCOHOL DEHYDROGENASE CONTAINING CADMIUM AND A HYDROXIDE ADDUCT TO NADH===		===ATOMIC X-RAY STRUCTURE OF LIVER ALCOHOL DEHYDROGENASE CONTAINING CADMIUM AND A HYDROXIDE ADDUCT TO NADH===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11134046}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11134046 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11134046}}		{{ABSTRACT_PUBMED_11134046}}

	==About this Structure==		==About this Structure==
-	[[1heu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HEU OCA].	+	[[1heu]] is a 2 chain structure of [[Alcohol dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HEU OCA].
		+
		+	==See Also==
		+	*[[Alcohol dehydrogenase\|Alcohol dehydrogenase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11134046~~</ref><ref group="xtra">PMID:~~10529241~~</ref><ref group="xtra">PMID:~~9220961~~</ref><ref group="xtra">PMID:~~15299346~~</ref><ref group="xtra">PMID:~~6351056~~</ref><ref group="xtra">PMID:~~6362718~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011134046</ref><ref group="xtra">PMID:010529241</ref><ref group="xtra">PMID:009220961</ref><ref group="xtra">PMID:015299346</ref><ref group="xtra">PMID:006351056</ref><ref group="xtra">PMID:006362718</ref><references group="xtra"/>
	[[Category: Alcohol dehydrogenase]]		[[Category: Alcohol dehydrogenase]]
	[[Category: Equus caballus]]		[[Category: Equus caballus]]