1hf2 - Revision history

OCA at 08:55, 9 May 2024

OCA — Thu, 09 May 2024 08:55:58 GMT

←Older revision		Revision as of 08:55, 9 May 2024
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hf2 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hf2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacterial cell division requires accurate selection of the middle of the cell, where the bacterial tubulin homologue FtsZ polymerizes into a ring structure. In Escherichia coli, site selection is dependent on MinC, MinD and MINE: MinC acts, with MinD, to inhibit division at sites other than the midcell by directly interacting with FTSZ: Here we report the crystal structure to 2.2 A of MinC from Thermotoga maritima. MinC consists of two domains separated by a short linker. The C-terminal domain is a right-handed beta-helix and is involved in dimer formation. The crystals contain two different MinC dimers, demonstrating flexibility in the linker region. The two-domain architecture and dimerization of MinC can be rationalized with a model of cell division inhibition. MinC does not act like SulA, which affects the GTPase activity of FtsZ, and the model can explain how MinC would select for the FtsZ polymer rather than the monomer.
		+
		+	Crystal structure of the bacterial cell division inhibitor MinC.,Cordell SC, Anderson RE, Lowe J EMBO J. 2001 May 15;20(10):2454-61. PMID:11350934<ref>PMID:11350934</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 1hf2" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:31, 27 March 2024

OCA — Wed, 27 Mar 2024 11:31:09 GMT

←Older revision		Revision as of 11:31, 27 March 2024
Line 3:		Line 3:
	<StructureSection load='1hf2' size='340' side='right'caption='[[1hf2]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1hf2' size='340' side='right'caption='[[1hf2]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1hf2]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_43589 Atcc 43589~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HF2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1HF2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1hf2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HF2 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~MINC (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=2336 ATCC 43589])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1hf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hf2 OCA], [~~http~~://pdbe.org/1hf2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1hf2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1hf2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1hf2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hf2 OCA], [https://pdbe.org/1hf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hf2 RCSB], [https://www.ebi.ac.uk/pdbsum/1hf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hf2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MINC_THEMA MINC_THEMA]] Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity).	+	[https://www.uniprot.org/uniprot/MINC_THEMA MINC_THEMA] Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hf2 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hf2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Bacterial cell division requires accurate selection of the middle of the cell, where the bacterial tubulin homologue FtsZ polymerizes into a ring structure. In Escherichia coli, site selection is dependent on MinC, MinD and MINE: MinC acts, with MinD, to inhibit division at sites other than the midcell by directly interacting with FTSZ: Here we report the crystal structure to 2.2 A of MinC from Thermotoga maritima. MinC consists of two domains separated by a short linker. The C-terminal domain is a right-handed beta-helix and is involved in dimer formation. The crystals contain two different MinC dimers, demonstrating flexibility in the linker region. The two-domain architecture and dimerization of MinC can be rationalized with a model of cell division inhibition. MinC does not act like SulA, which affects the GTPase activity of FtsZ, and the model can explain how MinC would select for the FtsZ polymer rather than the monomer.
-
-	Crystal structure of the bacterial cell division inhibitor MinC.,Cordell SC, Anderson RE, Lowe J EMBO J. 2001 May 15;20(10):2454-61. PMID:11350934<ref>PMID:11350934</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1hf2" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 43589]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Anderson, R E~~]]	+	[[Category: Thermotoga maritima]]
-	[[Category: ~~Cordell, S C~~]]	+	[[Category: Anderson RE]]
-	[[Category: ~~Lowe, J~~]]	+	[[Category: Cordell SC]]
-	[[Category: ~~Bacterial cell division]]~~	+	[[Category: Lowe J]]
-	~~[[Category: Beta helix]]~~	+
-	~~[[Category: Cell division protein]]~~	+
-	~~[[Category: Ftsz]]~~	+
-	~~[[Category: Septum~~]]	+

OCA at 10:31, 18 November 2020

OCA — Wed, 18 Nov 2020 10:31:59 GMT

←Older revision		Revision as of 10:31, 18 November 2020
Line 1:		Line 1:

	==Crystal structure of the bacterial cell-division inhibitor MinC from T. maritima==		==Crystal structure of the bacterial cell-division inhibitor MinC from T. maritima==
-	<StructureSection load='1hf2' size='340' side='right' caption='[[1hf2]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='1hf2' size='340' side='right'caption='[[1hf2]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1hf2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HF2 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1HF2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1hf2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HF2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1HF2 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MINC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MINC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1hf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hf2 OCA], [http://pdbe.org/1hf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hf2 RCSB], [http://www.ebi.ac.uk/pdbsum/1hf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1hf2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1hf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hf2 OCA], [http://pdbe.org/1hf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hf2 RCSB], [http://www.ebi.ac.uk/pdbsum/1hf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1hf2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 43589]]		[[Category: Atcc 43589]]
		+	[[Category: Large Structures]]
	[[Category: Anderson, R E]]		[[Category: Anderson, R E]]
	[[Category: Cordell, S C]]		[[Category: Cordell, S C]]

OCA at 09:37, 10 January 2018

OCA — Wed, 10 Jan 2018 09:37:45 GMT

←Older revision		Revision as of 09:37, 10 January 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF THE BACTERIAL CELL~~-~~DIVISION INHIBITOR MINC FROM~~ T. ~~MARITIMA~~==	+
		+	==Crystal structure of the bacterial cell-division inhibitor MinC from T. maritima==
	<StructureSection load='1hf2' size='340' side='right' caption='[[1hf2]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1hf2' size='340' side='right' caption='[[1hf2]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1hf2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HF2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1hf2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HF2 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MINC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MINC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hf2 OCA], [http://pdbe.org/1hf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hf2 RCSB], [http://www.ebi.ac.uk/pdbsum/1hf2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hf2 OCA], [http://pdbe.org/1hf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hf2 RCSB], [http://www.ebi.ac.uk/pdbsum/1hf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1hf2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hf/1hf2_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hf/1hf2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:00, 10 February 2016

OCA — Wed, 10 Feb 2016 04:00:35 GMT

←Older revision		Revision as of 04:00, 10 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hf2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:10, 11 September 2015

OCA — Fri, 11 Sep 2015 05:10:40 GMT

←Older revision		Revision as of 05:10, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1hf2' size='340' side='right' caption='[[1hf2]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1hf2' size='340' side='right' caption='[[1hf2]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1hf2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermotoga_maritima Thermotoga maritima~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HF2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1hf2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HF2 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MINC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ~~Thermotoga maritima~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MINC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hf2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hf2 RCSB], [http://www.ebi.ac.uk/pdbsum/1hf2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hf2 OCA], [http://pdbe.org/1hf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hf2 RCSB], [http://www.ebi.ac.uk/pdbsum/1hf2 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MINC_THEMA MINC_THEMA]] Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1hf2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Thermotoga maritima~~]]	+	[[Category: Atcc 43589]]
	[[Category: Anderson, R E]]		[[Category: Anderson, R E]]
	[[Category: Cordell, S C]]		[[Category: Cordell, S C]]

OCA at 19:08, 22 December 2014

OCA — Mon, 22 Dec 2014 19:08:51 GMT

←Older revision		Revision as of 19:08, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1hf2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HF2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1hf2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HF2 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MINC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MINC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hf2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hf2 RCSB], [http://www.ebi.ac.uk/pdbsum/1hf2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hf2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hf2 RCSB], [http://www.ebi.ac.uk/pdbsum/1hf2 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]
-	[[Category: Anderson, R E.]]	+	[[Category: Anderson, R E]]
-	[[Category: Cordell, S C.]]	+	[[Category: Cordell, S C]]
-	[[Category: Lowe, J.]]	+	[[Category: Lowe, J]]
	[[Category: Bacterial cell division]]		[[Category: Bacterial cell division]]
	[[Category: Beta helix]]		[[Category: Beta helix]]

OCA at 09:07, 28 September 2014

OCA — Sun, 28 Sep 2014 09:07:49 GMT

←Older revision		Revision as of 09:07, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1hf2.~~png\|left~~\|200px]]	+	==CRYSTAL STRUCTURE OF THE BACTERIAL CELL-DIVISION INHIBITOR MINC FROM T. MARITIMA==
		+	<StructureSection load='1hf2' size='340' side='right' caption='[[1hf2]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1hf2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HF2 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MINC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hf2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hf2 RCSB], [http://www.ebi.ac.uk/pdbsum/1hf2 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hf/1hf2_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacterial cell division requires accurate selection of the middle of the cell, where the bacterial tubulin homologue FtsZ polymerizes into a ring structure. In Escherichia coli, site selection is dependent on MinC, MinD and MINE: MinC acts, with MinD, to inhibit division at sites other than the midcell by directly interacting with FTSZ: Here we report the crystal structure to 2.2 A of MinC from Thermotoga maritima. MinC consists of two domains separated by a short linker. The C-terminal domain is a right-handed beta-helix and is involved in dimer formation. The crystals contain two different MinC dimers, demonstrating flexibility in the linker region. The two-domain architecture and dimerization of MinC can be rationalized with a model of cell division inhibition. MinC does not act like SulA, which affects the GTPase activity of FtsZ, and the model can explain how MinC would select for the FtsZ polymer rather than the monomer.

-	~~{{STRUCTURE_1hf2\| PDB=1hf2 \| SCENE= }}~~	+	Crystal structure of the bacterial cell division inhibitor MinC.,Cordell SC, Anderson RE, Lowe J EMBO J. 2001 May 15;20(10):2454-61. PMID:11350934<ref>PMID:11350934</ref>

-	~~===CRYSTAL STRUCTURE OF THE BACTERIAL CELL-DIVISION INHIBITOR MINC FROM T. MARITIMA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11350934}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1hf2]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermotoga_maritima Thermotoga maritima]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1HF2 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011350934<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]
	[[Category: Anderson, R E.]]		[[Category: Anderson, R E.]]

OCA: Protected "1hf2" [edit=sysop:move=sysop]

OCA — Wed, 21 Nov 2012 16:26:56 GMT

Protected "1hf2" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:26, 21 November 2012

OCA at 16:26, 21 November 2012

OCA — Wed, 21 Nov 2012 16:26:54 GMT

←Older revision		Revision as of 16:26, 21 November 2012
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	[[Image:1hf2.png\|left\|200px]]		[[Image:1hf2.png\|left\|200px]]

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	===CRYSTAL STRUCTURE OF THE BACTERIAL CELL-DIVISION INHIBITOR MINC FROM T. MARITIMA===		===CRYSTAL STRUCTURE OF THE BACTERIAL CELL-DIVISION INHIBITOR MINC FROM T. MARITIMA===

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	{{ABSTRACT_PUBMED_11350934}}		{{ABSTRACT_PUBMED_11350934}}

	==About this Structure==		==About this Structure==
-	~~1HF2~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HF2 OCA].	+	[[1hf2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HF2 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11350934~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011350934</ref><references group="xtra"/>
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]
	[[Category: Anderson, R E.]]		[[Category: Anderson, R E.]]
Line 30:		Line 18:
	[[Category: Bacterial cell division]]		[[Category: Bacterial cell division]]
	[[Category: Beta helix]]		[[Category: Beta helix]]
		+	[[Category: Cell division protein]]
	[[Category: Ftsz]]		[[Category: Ftsz]]
	[[Category: Septum]]		[[Category: Septum]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:15:54 2009''