1hk7 - Revision history

OCA at 08:56, 9 May 2024

OCA — Thu, 09 May 2024 08:56:38 GMT

←Older revision		Revision as of 08:56, 9 May 2024
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hk7 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hk7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Activation of client proteins by the Hsp90 molecular chaperone is dependent on binding and hydrolysis of ATP, which drives a molecular clamp via transient dimerization of the N-terminal domains. The crystal structure of the middle segment of yeast Hsp90 reveals considerable evolutionary divergence from the equivalent regions of other GHKL protein family members such as MutL and GyrB, including an additional domain of new fold. Using the known structure of the N-terminal nucleotide binding domain, a model for the Hsp90 dimer has been constructed. From this structure, residues implicated in the ATPase-coupled conformational cycle and in interactions with client proteins and the activating cochaperone Aha1 have been identified, and their roles functionally characterized in vitro and in vivo.
		+
		+	Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions.,Meyer P, Prodromou C, Hu B, Vaughan C, Roe SM, Panaretou B, Piper PW, Pearl LH Mol Cell. 2003 Mar;11(3):647-58. PMID:12667448<ref>PMID:12667448</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 1hk7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 11:32, 27 March 2024

OCA — Wed, 27 Mar 2024 11:32:40 GMT

←Older revision		Revision as of 11:32, 27 March 2024
Line 3:		Line 3:
	<StructureSection load='1hk7' size='340' side='right'caption='[[1hk7]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1hk7' size='340' side='right'caption='[[1hk7]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1hk7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HK7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HK7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1hk7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HK7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HK7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1a4h\|1a4h]]~~, ~~[[1ah6\|1ah6]], [[1ah8\|1ah8]], [[1am1\|1am1]], [[1amw\|1amw]], [[1bgq\|1bgq]], [[1us7\|1us7]], [[1usu\|1usu]], [[1usv\|1usv]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hk7 OCA], [https://pdbe.org/1hk7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hk7 RCSB], [https://www.ebi.ac.uk/pdbsum/1hk7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hk7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hk7 OCA], [https://pdbe.org/1hk7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hk7 RCSB], [https://www.ebi.ac.uk/pdbsum/1hk7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hk7 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HSP82_YEAST HSP82_YEAST] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. The nucleotide-free form of the dimer is found in an open conformation in which the N-termini are not dimerized and the complex is ready for client protein binding. Binding of ATP induces large conformational changes, resulting in the formation of a ring-like closed structure in which the N-terminal domains associate intramolecularly with the middle domain and also dimerize with each other, stimulating their intrinsic ATPase activity and acting as a clamp on the substrate. Finally, ATP hydrolysis results in the release of the substrate. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for growth at high temperatures.<ref>PMID:17114002</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hk7 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hk7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Activation of client proteins by the Hsp90 molecular chaperone is dependent on binding and hydrolysis of ATP, which drives a molecular clamp via transient dimerization of the N-terminal domains. The crystal structure of the middle segment of yeast Hsp90 reveals considerable evolutionary divergence from the equivalent regions of other GHKL protein family members such as MutL and GyrB, including an additional domain of new fold. Using the known structure of the N-terminal nucleotide binding domain, a model for the Hsp90 dimer has been constructed. From this structure, residues implicated in the ATPase-coupled conformational cycle and in interactions with client proteins and the activating cochaperone Aha1 have been identified, and their roles functionally characterized in vitro and in vivo.
-
-	Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions.,Meyer P, Prodromou C, Hu B, Vaughan C, Roe SM, Panaretou B, Piper PW, Pearl LH Mol Cell. 2003 Mar;11(3):647-58. PMID:12667448<ref>PMID:12667448</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1hk7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Meyer, P~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Pearl, L H~~]]	+	[[Category: Meyer P]]
-	[[Category: ~~Prodromou, C~~]]	+	[[Category: Pearl LH]]
-	[[Category: ~~Roe, S M~~]]	+	[[Category: Prodromou C]]
-	[[Category: ~~Atpase]]~~	+	[[Category: Roe SM]]
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Heat shock protein~~]]	+

OCA at 10:26, 17 February 2021

OCA — Wed, 17 Feb 2021 10:26:13 GMT

←Older revision		Revision as of 10:26, 17 February 2021
Line 3:		Line 3:
	<StructureSection load='1hk7' size='340' side='right'caption='[[1hk7]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1hk7' size='340' side='right'caption='[[1hk7]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1hk7]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HK7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1HK7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1hk7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HK7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HK7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a4h\|1a4h]], [[1ah6\|1ah6]], [[1ah8\|1ah8]], [[1am1\|1am1]], [[1amw\|1amw]], [[1bgq\|1bgq]], [[1us7\|1us7]], [[1usu\|1usu]], [[1usv\|1usv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a4h\|1a4h]], [[1ah6\|1ah6]], [[1ah8\|1ah8]], [[1am1\|1am1]], [[1amw\|1amw]], [[1bgq\|1bgq]], [[1us7\|1us7]], [[1usu\|1usu]], [[1usv\|1usv]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1hk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hk7 OCA], [~~http~~://pdbe.org/1hk7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1hk7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1hk7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1hk7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hk7 OCA], [https://pdbe.org/1hk7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hk7 RCSB], [https://www.ebi.ac.uk/pdbsum/1hk7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hk7 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[Heat Shock ~~Proteins~~\|Heat Shock ~~Proteins~~]]	+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:39, 10 May 2019

OCA — Fri, 10 May 2019 11:39:03 GMT

←Older revision		Revision as of 11:39, 10 May 2019
Line 1:		Line 1:

	==Middle Domain of HSP90==		==Middle Domain of HSP90==
-	<StructureSection load='1hk7' size='340' side='right' caption='[[1hk7]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='1hk7' size='340' side='right'caption='[[1hk7]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1hk7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HK7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1hk7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HK7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a4h\|1a4h]], [[1ah6\|1ah6]], [[1ah8\|1ah8]], [[1am1\|1am1]], [[1amw\|1amw]], [[1bgq\|1bgq]], [[1us7\|1us7]], [[1usu\|1usu]], [[1usv\|1usv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a4h\|1a4h]], [[1ah6\|1ah6]], [[1ah8\|1ah8]], [[1am1\|1am1]], [[1amw\|1amw]], [[1bgq\|1bgq]], [[1us7\|1us7]], [[1usu\|1usu]], [[1usv\|1usv]]</td></tr>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/1hk7_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/1hk7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Meyer, P]]		[[Category: Meyer, P]]
	[[Category: Pearl, L H]]		[[Category: Pearl, L H]]

OCA at 04:45, 21 September 2017

OCA — Thu, 21 Sep 2017 04:45:03 GMT

←Older revision		Revision as of 04:45, 21 September 2017
Line 1:		Line 1:
-	==~~MIDDLE DOMAIN OF~~ HSP90==	+
		+	==Middle Domain of HSP90==
	<StructureSection load='1hk7' size='340' side='right' caption='[[1hk7]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1hk7' size='340' side='right' caption='[[1hk7]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1hk7]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HK7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1hk7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HK7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a4h\|1a4h]], [[1ah6\|1ah6]], [[1ah8\|1ah8]], [[1am1\|1am1]], [[1amw\|1amw]], [[1bgq\|1bgq]], [[1us7\|1us7]], [[1usu\|1usu]], [[1usv\|1usv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a4h\|1a4h]], [[1ah6\|1ah6]], [[1ah8\|1ah8]], [[1am1\|1am1]], [[1amw\|1amw]], [[1bgq\|1bgq]], [[1us7\|1us7]], [[1usu\|1usu]], [[1usv\|1usv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hk7 OCA], [http://pdbe.org/1hk7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hk7 RCSB], [http://www.ebi.ac.uk/pdbsum/1hk7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hk7 OCA], [http://pdbe.org/1hk7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hk7 RCSB], [http://www.ebi.ac.uk/pdbsum/1hk7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1hk7 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hk7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Meyer, P]]		[[Category: Meyer, P]]
	[[Category: Pearl, L H]]		[[Category: Pearl, L H]]

OCA at 01:09, 12 September 2015

OCA — Sat, 12 Sep 2015 01:09:55 GMT

←Older revision		Revision as of 01:09, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1hk7' size='340' side='right' caption='[[1hk7]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1hk7' size='340' side='right' caption='[[1hk7]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1hk7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HK7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1hk7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HK7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a4h\|1a4h]], [[1ah6\|1ah6]], [[1ah8\|1ah8]], [[1am1\|1am1]], [[1amw\|1amw]], [[1bgq\|1bgq]], [[1us7\|1us7]], [[1usu\|1usu]], [[1usv\|1usv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a4h\|1a4h]], [[1ah6\|1ah6]], [[1ah8\|1ah8]], [[1am1\|1am1]], [[1amw\|1amw]], [[1bgq\|1bgq]], [[1us7\|1us7]], [[1usu\|1usu]], [[1usv\|1usv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hk7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hk7 RCSB], [http://www.ebi.ac.uk/pdbsum/1hk7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hk7 OCA], [http://pdbe.org/1hk7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hk7 RCSB], [http://www.ebi.ac.uk/pdbsum/1hk7 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1hk7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Meyer, P]]		[[Category: Meyer, P]]
	[[Category: Pearl, L H]]		[[Category: Pearl, L H]]

OCA at 23:18, 22 December 2014

OCA — Mon, 22 Dec 2014 23:18:38 GMT

←Older revision		Revision as of 23:18, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1hk7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HK7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1hk7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HK7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a4h\|1a4h]], [[1ah6\|1ah6]], [[1ah8\|1ah8]], [[1am1\|1am1]], [[1amw\|1amw]], [[1bgq\|1bgq]], [[1us7\|1us7]], [[1usu\|1usu]], [[1usv\|1usv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a4h\|1a4h]], [[1ah6\|1ah6]], [[1ah8\|1ah8]], [[1am1\|1am1]], [[1amw\|1amw]], [[1bgq\|1bgq]], [[1us7\|1us7]], [[1usu\|1usu]], [[1usv\|1usv]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hk7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hk7 RCSB], [http://www.ebi.ac.uk/pdbsum/1hk7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hk7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hk7 RCSB], [http://www.ebi.ac.uk/pdbsum/1hk7 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Meyer, P.]]	+	[[Category: Meyer, P]]
-	[[Category: Pearl, L H.]]	+	[[Category: Pearl, L H]]
-	[[Category: Prodromou, C.]]	+	[[Category: Prodromou, C]]
-	[[Category: Roe, S M.]]	+	[[Category: Roe, S M]]
	[[Category: Atpase]]		[[Category: Atpase]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Heat shock protein]]		[[Category: Heat shock protein]]

OCA at 13:01, 28 September 2014

OCA — Sun, 28 Sep 2014 13:01:02 GMT

←Older revision		Revision as of 13:01, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1hk7.~~png~~\|~~left~~\|200px]]	+	==MIDDLE DOMAIN OF HSP90==
		+	<StructureSection load='1hk7' size='340' side='right' caption='[[1hk7]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1hk7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HK7 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a4h\|1a4h]], [[1ah6\|1ah6]], [[1ah8\|1ah8]], [[1am1\|1am1]], [[1amw\|1amw]], [[1bgq\|1bgq]], [[1us7\|1us7]], [[1usu\|1usu]], [[1usv\|1usv]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hk7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hk7 RCSB], [http://www.ebi.ac.uk/pdbsum/1hk7 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/1hk7_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Activation of client proteins by the Hsp90 molecular chaperone is dependent on binding and hydrolysis of ATP, which drives a molecular clamp via transient dimerization of the N-terminal domains. The crystal structure of the middle segment of yeast Hsp90 reveals considerable evolutionary divergence from the equivalent regions of other GHKL protein family members such as MutL and GyrB, including an additional domain of new fold. Using the known structure of the N-terminal nucleotide binding domain, a model for the Hsp90 dimer has been constructed. From this structure, residues implicated in the ATPase-coupled conformational cycle and in interactions with client proteins and the activating cochaperone Aha1 have been identified, and their roles functionally characterized in vitro and in vivo.

-	~~{{STRUCTURE_1hk7\| PDB=1hk7 \| SCENE= }}~~	+	Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions.,Meyer P, Prodromou C, Hu B, Vaughan C, Roe SM, Panaretou B, Piper PW, Pearl LH Mol Cell. 2003 Mar;11(3):647-58. PMID:12667448<ref>PMID:12667448</ref>

-	~~===MIDDLE DOMAIN OF HSP90===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12667448}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1hk7]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1HK7 OCA].~~	+

	==See Also==		==See Also==
	*[[Heat Shock Proteins\|Heat Shock Proteins]]		*[[Heat Shock Proteins\|Heat Shock Proteins]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012667448<~~/~~ref~~><~~ref group="xtra">PMID:015274928</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Meyer, P.]]		[[Category: Meyer, P.]]

OCA at 22:03, 20 October 2012

OCA — Sat, 20 Oct 2012 22:03:30 GMT

←Older revision		Revision as of 22:03, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1hk7]] is a 2 chain structure ~~of [[Heat Shock Proteins]]~~ with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HK7 OCA].	+	[[1hk7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HK7 OCA].

	==See Also==		==See Also==

OCA at 15:07, 27 July 2012

OCA — Fri, 27 Jul 2012 15:07:31 GMT

←Older revision		Revision as of 15:07, 27 July 2012
Line 1:		Line 1:
	[[Image:1hk7.png\|left\|200px]]		[[Image:1hk7.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1hk7", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_1hk7\| PDB=1hk7 \| SCENE= }}		{{STRUCTURE_1hk7\| PDB=1hk7 \| SCENE= }}

	===MIDDLE DOMAIN OF HSP90===		===MIDDLE DOMAIN OF HSP90===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12667448}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12667448 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_12667448}}		{{ABSTRACT_PUBMED_12667448}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Heat Shock Proteins]]	+	*[[Heat Shock Proteins\|Heat Shock Proteins]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12667448~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012667448</ref><ref group="xtra">PMID:015274928</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Meyer, P.]]		[[Category: Meyer, P.]]