1ho5 - Revision history

OCA at 05:28, 9 February 2016

OCA — Tue, 09 Feb 2016 05:28:39 GMT

←Older revision		Revision as of 05:28, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ho5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:05, 10 September 2015

OCA — Thu, 10 Sep 2015 19:05:17 GMT

←Older revision		Revision as of 19:05, 10 September 2015
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	<StructureSection load='1ho5' size='340' side='right' caption='[[1ho5]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1ho5' size='340' side='right' caption='[[1ho5]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ho5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HO5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ho5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HO5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ush\|1ush]], [[2ush\|2ush]], [[1hpu\|1hpu]], [[1hp1\|1hp1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ush\|1ush]], [[2ush\|2ush]], [[1hpu\|1hpu]], [[1hp1\|1hp1]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">USHA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">USHA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ho5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ho5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ho5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ho5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ho5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ho5 OCA], [http://pdbe.org/1ho5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ho5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ho5 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ho5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Knoefel, T]]		[[Category: Knoefel, T]]
	[[Category: Straeter, N]]		[[Category: Straeter, N]]

OCA at 04:44, 25 December 2014

OCA — Thu, 25 Dec 2014 04:44:53 GMT

←Older revision		Revision as of 04:44, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ho5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HO5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ho5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HO5 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ush\|1ush]], [[2ush\|2ush]], [[1hpu\|1hpu]], [[1hp1\|1hp1]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ush\|1ush]], [[2ush\|2ush]], [[1hpu\|1hpu]], [[1hp1\|1hp1]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">USHA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">USHA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ho5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ho5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ho5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ho5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ho5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ho5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ho5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ho5 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/USHA_ECOLI USHA_ECOLI]] Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Knoefel, T.]]	+	[[Category: Knoefel, T]]
-	[[Category: Straeter, N.]]	+	[[Category: Straeter, N]]
	[[Category: Domain movement]]		[[Category: Domain movement]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Metalloprotein]]		[[Category: Metalloprotein]]

OCA at 11:36, 28 September 2014

OCA — Sun, 28 Sep 2014 11:36:50 GMT

←Older revision		Revision as of 11:36, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1ho5.~~png~~\|~~left~~\|200px]]	+	==5'-NUCLEOTIDASE (E. COLI) IN COMPLEX WITH ADENOSINE AND PHOSPHATE==
		+	<StructureSection load='1ho5' size='340' side='right' caption='[[1ho5]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ho5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HO5 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ush\|1ush]], [[2ush\|2ush]], [[1hpu\|1hpu]], [[1hp1\|1hp1]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">USHA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ho5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ho5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ho5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ho5 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ho/1ho5_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	5'-Nucleotidase belongs to a large superfamily of distantly related dinuclear metallophosphatases including the Ser/Thr protein phosphatases and purple acid phosphatases. The protein undergoes a 96 degrees domain rotation between an open (inactive) and a closed (active) enzyme form. Complex structures of the closed form with the products adenosine and phosphate, and with the substrate analogue inhibitor alpha,beta-methylene ADP, have been determined at 2.1 A and 1.85 A resolution, respectively. In addition, a complex of the open form of 5'-nucleotidase with ATP was analyzed at a resolution of 1.7 A. These structures show that the adenosine group binds to a specific binding pocket of the C-terminal domain. The adenine ring is stacked between Phe429 and Phe498. The N-terminal domain provides the ligands to the dimetal cluster and the conserved His117, which together form the catalytic core structure. However, the three C-terminal arginine residues 375, 379 and 410, which are involved in substrate binding, may also play a role in transition-state stabilization. The beta-phosphate group of the inhibitor is terminally coordinated to the site 2 metal ion. The site 1 metal ion coordinates a water molecule which is in an ideal position for a nucleophilic attack on the phosphorus atom, assuming an in-line mechanism of phosphoryl transfer. Another water molecule bridges the two metal ions.

-	~~{{STRUCTURE_1ho5\| PDB=1ho5 \| SCENE= }}~~	+	Mechanism of hydrolysis of phosphate esters by the dimetal center of 5'-nucleotidase based on crystal structures.,Knofel T, Strater N J Mol Biol. 2001 May 25;309(1):239-54. PMID:11491293<ref>PMID:11491293</ref>

-	~~===5'-NUCLEOTIDASE (E. COLI) IN COMPLEX WITH ADENOSINE AND PHOSPHATE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11491293}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1ho5]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1HO5 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011491293<~~/~~ref~~><~~ref group="xtra">PMID:011491294</ref><references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Knoefel, T.]]		[[Category: Knoefel, T.]]

OCA: Protected "1ho5" [edit=sysop:move=sysop]

OCA — Wed, 21 Nov 2012 15:28:32 GMT

Protected "1ho5" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:28, 21 November 2012

OCA at 15:28, 21 November 2012

OCA — Wed, 21 Nov 2012 15:28:27 GMT

←Older revision		Revision as of 15:28, 21 November 2012
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-	{{Seed}}
	[[Image:1ho5.png\|left\|200px]]		[[Image:1ho5.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1ho5", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1ho5\| PDB=1ho5 \| SCENE= }}		{{STRUCTURE_1ho5\| PDB=1ho5 \| SCENE= }}

	===5'-NUCLEOTIDASE (E. COLI) IN COMPLEX WITH ADENOSINE AND PHOSPHATE===		===5'-NUCLEOTIDASE (E. COLI) IN COMPLEX WITH ADENOSINE AND PHOSPHATE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11491293}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11491293 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11491293}}		{{ABSTRACT_PUBMED_11491293}}

	==About this Structure==		==About this Structure==
-	~~1HO5~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HO5 OCA].	+	[[1ho5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HO5 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11491293~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011491293</ref><ref group="xtra">PMID:011491294</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Knoefel, T.]]		[[Category: Knoefel, T.]]
	[[Category: Straeter, N.]]		[[Category: Straeter, N.]]
	[[Category: Domain movement]]		[[Category: Domain movement]]
		+	[[Category: Hydrolase]]
	[[Category: Metalloprotein]]		[[Category: Metalloprotein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:50:38 2009''

OCA at 04:50, 17 February 2009

OCA — Tue, 17 Feb 2009 04:50:39 GMT

←Older revision		Revision as of 04:50, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1HO5 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HO5 OCA].	+	1HO5 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HO5 OCA].

	==Reference==		==Reference==
-	~~Mechanism of hydrolysis of phosphate esters by the dimetal center of 5'-nucleotidase based on crystal structures., Knofel T, Strater N, J Mol Biol. 2001 May 25;309(1):239-54.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/11491293 11491293]~~	+	<ref group="xtra">PMID:11491293</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Single protein]]
	[[Category: Knoefel, T.]]		[[Category: Knoefel, T.]]
	[[Category: Straeter, N.]]		[[Category: Straeter, N.]]
Line 31:		Line 30:
	[[Category: Metalloprotein]]		[[Category: Metalloprotein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 1 08~~:27:38 ~~2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:50:38 2009''

OCA at 05:27, 1 July 2008

OCA — Tue, 01 Jul 2008 05:27:39 GMT

←Older revision		Revision as of 05:27, 1 July 2008
Line 1:		Line 1:
-	[[Image:1ho5.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1ho5.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1ho5\| PDB=1ho5 \| SCENE= }}		{{STRUCTURE_1ho5\| PDB=1ho5 \| SCENE= }}

-	~~'''~~5'-NUCLEOTIDASE (E. COLI) IN COMPLEX WITH ADENOSINE AND PHOSPHATE~~'''~~	+	===5'-NUCLEOTIDASE (E. COLI) IN COMPLEX WITH ADENOSINE AND PHOSPHATE===


-	~~==Overview==~~	+	<!--
-	~~5'-Nucleotidase belongs to a large superfamily of distantly related dinuclear metallophosphatases including the Ser/Thr protein phosphatases and purple acid phosphatases.~~ The ~~protein undergoes a 96 degrees domain rotation between an open (inactive) and a closed (active) enzyme form. Complex structures of the closed form with the products adenosine and phosphate~~, ~~and with the substrate analogue inhibitor alpha~~,~~beta-methylene ADP, have been determined at 2.1 A and 1.85 A resolution, respectively. In addition, a complex of~~ the ~~open form of 5'-nucleotidase with ATP was analyzed at a resolution of 1.7 A. These structures show that the adenosine group binds~~ to ~~a specific binding pocket of~~ the ~~C-terminal domain~~. ~~The adenine ring is stacked between Phe429 and Phe498~~. ~~The N-terminal domain provides the ligands to the dimetal cluster and the conserved His117~~, ~~which together form~~ the ~~catalytic core structure~~. ~~However, the three C~~-~~terminal arginine residues 375, 379 and 410, which are involved in substrate binding, may also play a role in transition~~-state stabilization. The beta-phosphate group of the inhibitor is terminally coordinated to the site 2 metal ion. The site 1 metal ion coordinates a water molecule which is in an ideal position for a nucleophilic attack on the phosphorus atom, assuming an in-line mechanism of phosphoryl transfer. Another water molecule bridges the two metal ions.	+	The line below this paragraph, {{ABSTRACT_PUBMED_11491293}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 11491293 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_11491293}}

	==About this Structure==		==About this Structure==
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	[[Category: Domain movement]]		[[Category: Domain movement]]
	[[Category: Metalloprotein]]		[[Category: Metalloprotein]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 19~~:03:39 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:27:38 2008''

OCA at 16:03, 2 May 2008

OCA — Fri, 02 May 2008 16:03:41 GMT

←Older revision		Revision as of 16:03, 2 May 2008
Line 1:		Line 1:
	[[Image:1ho5.gif\|left\|200px]]		[[Image:1ho5.gif\|left\|200px]]

-	~~{{Structure~~	+	<!--
-	~~\|PDB= 1ho5 \|SIZE=350\|CAPTION= <scene name='initialview01'>1ho5</scene>~~, ~~resolution 2~~.~~10Å~~	+	The line below this paragraph, containing "STRUCTURE_1ho5", creates the "Structure Box" on the page.
-	~~\|SITE=~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	~~\|LIGAND= <scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=MN:MANGANESE+~~(II)~~+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	~~\|ACTIVITY=~~	+	or leave the SCENE parameter empty for the default display.
-	~~\|GENE= USHA~~ (~~[http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]~~)	+	-->
-	~~\|DOMAIN=~~	+	{{STRUCTURE_1ho5\| PDB=1ho5 \| SCENE= }}
-	~~\|RELATEDENTRY=[[1ush\|1ush]]~~, ~~[[2ush\|2ush]], [[1hpu\|1HPU]], [[1hp1\|1HP1]]~~	+
-	~~\|RESOURCES=<span class='plainlinks'>[http://oca~~.~~weizmann.ac.il/oca~~-~~docs/fgij/fg.htm?mol=1ho5 FirstGlance], [http://oca.weizmann.ac.il/oca~~-~~bin/ocaids?id~~=1ho5 ~~OCA], [http://www.ebi.ac.uk/pdbsum/1ho5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId~~=~~1ho5 RCSB]</span>~~	+
-	}}	+

	'''5'-NUCLEOTIDASE (E. COLI) IN COMPLEX WITH ADENOSINE AND PHOSPHATE'''		'''5'-NUCLEOTIDASE (E. COLI) IN COMPLEX WITH ADENOSINE AND PHOSPHATE'''
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	[[Category: Knoefel, T.]]		[[Category: Knoefel, T.]]
	[[Category: Straeter, N.]]		[[Category: Straeter, N.]]
-	[[Category: ~~domain~~ movement]]	+	[[Category: Domain movement]]
-	[[Category: ~~metalloprotein~~]]	+	[[Category: Metalloprotein]]
-		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:03:39 2008''
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Mar 30 21~~:08:15 2008''	+

OCA at 18:08, 30 March 2008

OCA — Sun, 30 Mar 2008 18:08:16 GMT

←Older revision		Revision as of 18:08, 30 March 2008
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	\|PDB= 1ho5 \|SIZE=350\|CAPTION= <scene name='initialview01'>1ho5</scene>, resolution 2.10Å		\|PDB= 1ho5 \|SIZE=350\|CAPTION= <scene name='initialview01'>1ho5</scene>, resolution 2.10Å
	\|SITE=		\|SITE=
-	\|LIGAND= <scene name='pdbligand=MN:~~MANGANESE+(II)+ION~~'>MN</scene>, <scene name='pdbligand=~~PO4~~:~~PHOSPHATE~~+ION'>~~PO4~~</scene> ~~and~~ <scene name='pdbligand=~~ADN~~:~~ADENOSINE~~'>~~ADN~~</scene>	+	\|LIGAND= <scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
	\|ACTIVITY=		\|ACTIVITY=
	\|GENE= USHA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])		\|GENE= USHA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
		+	\|DOMAIN=
		+	\|RELATEDENTRY=[[1ush\|1ush]], [[2ush\|2ush]], [[1hpu\|1HPU]], [[1hp1\|1HP1]]
		+	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ho5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ho5 OCA], [http://www.ebi.ac.uk/pdbsum/1ho5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ho5 RCSB]</span>
	}}		}}

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	[[Category: Knoefel, T.]]		[[Category: Knoefel, T.]]
	[[Category: Straeter, N.]]		[[Category: Straeter, N.]]
-	[[Category: ADN]]
-	[[Category: MN]]
-	[[Category: PO4]]
	[[Category: domain movement]]		[[Category: domain movement]]
	[[Category: metalloprotein]]		[[Category: metalloprotein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu~~ Mar ~~20 11~~:39:35 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:08:15 2008''