1hqz - Revision history

OCA at 06:15, 9 August 2023

OCA — Wed, 09 Aug 2023 06:15:26 GMT

←Older revision		Revision as of 06:15, 9 August 2023
Line 1:		Line 1:

	==Cofilin homology domain of a yeast actin-binding protein ABP1P==		==Cofilin homology domain of a yeast actin-binding protein ABP1P==
-	<StructureSection load='1hqz' size='340' side='right'caption='[[1hqz]]' scene=''>	+	<StructureSection load='1hqz' size='340' side='right'caption='[[1hqz]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1hqz]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HQZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hqz OCA], [https://pdbe.org/1hqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hqz RCSB], [https://www.ebi.ac.uk/pdbsum/1hqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hqz ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1hqz TOPSAN]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hqz OCA], [https://pdbe.org/1hqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hqz RCSB], [https://www.ebi.ac.uk/pdbsum/1hqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hqz ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1hqz TOPSAN]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ABP1_YEAST ABP1_YEAST] Regulates ARP2/3 complex-mediated actin assembly. Recruits ARP2/3 complex to sides of preexisting actin filaments, which may promote nucleation or stabilization of filament branches. Binds to actin filaments, but not actin monomers. Actin binding is required for ARP2/3 complex activation. May also have a role in linking the actin cytoskeleton to endocytosis. recruits components of the endocytotic machinery to cortical actin patches, known sites of endocytosis.<ref>PMID:11331312</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hqz ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hqz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A modified molecular-replacement method is described that makes use of six-dimensional searches and the phased translation function, providing a systematic examination of all possible search-model orientations in an experimental electron-density map. As an example, the structure solution of the cofilin-homology domain of the Saccharomyces cerevisiae actin-binding protein 1 (ABP1) is presented in detail. Additional examples are presented in which these tools have significantly aided structure solutions in a variety of contexts. These results suggest that this approach might be of widespread utility for challenging structures involving weak phase information, complex asymmetric units and search models with weak structural homology. Furthermore, this approach supports an exhaustive molecular-replacement strategy in cases where an appropriate search model cannot readily be identified on the basis of sequence homology. The fully automated web-based implementation of this phased translation function is described.
		+
		+	Phased translation function revisited: structure solution of the cofilin-homology domain from yeast actin-binding protein 1 using six-dimensional searches.,Strokopytov BV, Fedorov A, Mahoney NM, Kessels M, Drubin DG, Almo SC Acta Crystallogr D Biol Crystallogr. 2005 Mar;61(Pt 3):285-93. Epub 2005, Feb 24. PMID:15735338<ref>PMID:15735338</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 1hqz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Saccharomyces cerevisiae]]
	[[Category: Almo SC]]		[[Category: Almo SC]]
	[[Category: Burley SK]]		[[Category: Burley SK]]

OCA at 07:26, 7 April 2021

OCA — Wed, 07 Apr 2021 07:26:40 GMT

←Older revision		Revision as of 07:26, 7 April 2021
Line 1:		Line 1:

	==Cofilin homology domain of a yeast actin-binding protein ABP1P==		==Cofilin homology domain of a yeast actin-binding protein ABP1P==
-	<StructureSection load='1hqz' size='340' side='right'caption='[[1hqz]]~~, [[Resolution\|resolution]] 2.10Å~~' scene=''>	+	<StructureSection load='1hqz' size='340' side='right'caption='[[1hqz]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>~~[[1hqz]] is a 9 chain structure.~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1HQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HQZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1hqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hqz OCA], [~~http~~://pdbe.org/1hqz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1hqz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1hqz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1hqz ProSAT], [~~http~~://www.topsan.org/Proteins/NYSGXRC/1hqz TOPSAN]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hqz OCA], [https://pdbe.org/1hqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hqz RCSB], [https://www.ebi.ac.uk/pdbsum/1hqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hqz ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1hqz TOPSAN]</span></td></tr>
	</table>		</table>
-	== Function ==
-	[[http://www.uniprot.org/uniprot/ABP1_YEAST ABP1_YEAST]] Regulates ARP2/3 complex-mediated actin assembly. Recruits ARP2/3 complex to sides of preexisting actin filaments, which may promote nucleation or stabilization of filament branches. Binds to actin filaments, but not actin monomers. Actin binding is required for ARP2/3 complex activation. May also have a role in linking the actin cytoskeleton to endocytosis. recruits components of the endocytotic machinery to cortical actin patches, known sites of endocytosis.<ref>PMID:11331312</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 16:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hqz ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hqz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	A modified molecular-replacement method is described that makes use of six-dimensional searches and the phased translation function, providing a systematic examination of all possible search-model orientations in an experimental electron-density map. As an example, the structure solution of the cofilin-homology domain of the Saccharomyces cerevisiae actin-binding protein 1 (ABP1) is presented in detail. Additional examples are presented in which these tools have significantly aided structure solutions in a variety of contexts. These results suggest that this approach might be of widespread utility for challenging structures involving weak phase information, complex asymmetric units and search models with weak structural homology. Furthermore, this approach supports an exhaustive molecular-replacement strategy in cases where an appropriate search model cannot readily be identified on the basis of sequence homology. The fully automated web-based implementation of this phased translation function is described.
-
-	Phased translation function revisited: structure solution of the cofilin-homology domain from yeast actin-binding protein 1 using six-dimensional searches.,Strokopytov BV, Fedorov A, Mahoney NM, Kessels M, Drubin DG, Almo SC Acta Crystallogr D Biol Crystallogr. 2005 Mar;61(Pt 3):285-93. Epub 2005, Feb 24. PMID:15735338<ref>PMID:15735338</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1hqz" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Almo~~, S C~~]]	+	[[Category: Almo SC]]
-	[[Category: Burley~~, S K~~]]	+	[[Category: Burley SK]]
-	[[Category: Drubin~~, D G~~]]	+	[[Category: Drubin DG]]
-	[[Category: Fedorov~~, A A~~]]	+	[[Category: Fedorov AA]]
-	[[Category: Mahoney, N]]	+	[[Category: Mahoney N]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Strokopytov BV]]
-	[[Category: Strokopytov~~, B V]]~~	+
-	~~[[Category: Actin binding]]~~	+
-	~~[[Category: Cofilin homology domain]]~~	+
-	~~[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 07:37, 3 July 2019

OCA — Wed, 03 Jul 2019 07:37:56 GMT

←Older revision		Revision as of 07:37, 3 July 2019
Line 1:		Line 1:

	==Cofilin homology domain of a yeast actin-binding protein ABP1P==		==Cofilin homology domain of a yeast actin-binding protein ABP1P==
-	<StructureSection load='1hqz' size='340' side='right' caption='[[1hqz]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1hqz' size='340' side='right'caption='[[1hqz]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1hqz]] is a 9 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HQZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1hqz]] is a 9 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HQZ FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hq/1hqz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hq/1hqz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Almo, S C]]		[[Category: Almo, S C]]
	[[Category: Burley, S K]]		[[Category: Burley, S K]]

OCA at 10:40, 27 September 2017

OCA — Wed, 27 Sep 2017 10:40:40 GMT

←Older revision		Revision as of 10:40, 27 September 2017
Line 1:		Line 1:
		+
	==Cofilin homology domain of a yeast actin-binding protein ABP1P==		==Cofilin homology domain of a yeast actin-binding protein ABP1P==
	<StructureSection load='1hqz' size='340' side='right' caption='[[1hqz]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1hqz' size='340' side='right' caption='[[1hqz]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1hqz]] is a 9 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1hqz]] is a 9 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HQZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hqz OCA], [http://pdbe.org/1hqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hqz RCSB], [http://www.ebi.ac.uk/pdbsum/1hqz PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1hqz TOPSAN]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hqz OCA], [http://pdbe.org/1hqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hqz RCSB], [http://www.ebi.ac.uk/pdbsum/1hqz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1hqz ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/1hqz TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hqz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Almo, S C]]		[[Category: Almo, S C]]
	[[Category: Burley, S K]]		[[Category: Burley, S K]]

OCA at 10:49, 11 September 2015

OCA — Fri, 11 Sep 2015 10:49:51 GMT

←Older revision		Revision as of 10:49, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1hqz' size='340' side='right' caption='[[1hqz]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1hqz' size='340' side='right' caption='[[1hqz]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1hqz]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1hqz]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HQZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hqz RCSB], [http://www.ebi.ac.uk/pdbsum/1hqz PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1hqz TOPSAN]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hqz OCA], [http://pdbe.org/1hqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hqz RCSB], [http://www.ebi.ac.uk/pdbsum/1hqz PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1hqz TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1hqz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Almo, S C]]		[[Category: Almo, S C]]
	[[Category: Burley, S K]]		[[Category: Burley, S K]]

OCA at 15:26, 25 December 2014

OCA — Thu, 25 Dec 2014 15:26:48 GMT

←Older revision		Revision as of 15:26, 25 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hqz RCSB], [http://www.ebi.ac.uk/pdbsum/1hqz PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1hqz TOPSAN]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hqz RCSB], [http://www.ebi.ac.uk/pdbsum/1hqz PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1hqz TOPSAN]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ABP1_YEAST ABP1_YEAST]] Regulates ARP2/3 complex-mediated actin assembly. Recruits ARP2/3 complex to sides of preexisting actin filaments, which may promote nucleation or stabilization of filament branches. Binds to actin filaments, but not actin monomers. Actin binding is required for ARP2/3 complex activation. May also have a role in linking the actin cytoskeleton to endocytosis. recruits components of the endocytotic machinery to cortical actin patches, known sites of endocytosis.<ref>PMID:11331312</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:47, 6 November 2014

OCA — Thu, 06 Nov 2014 12:47:53 GMT

←Older revision		Revision as of 12:47, 6 November 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1hqz]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HQZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1hqz]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HQZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hqz RCSB], [http://www.ebi.ac.uk/pdbsum/1hqz PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1hqz TOPSAN]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hqz RCSB], [http://www.ebi.ac.uk/pdbsum/1hqz PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1hqz TOPSAN]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Almo, S C.]]	+	[[Category: Almo, S C]]
-	[[Category: Burley, S K.]]	+	[[Category: Burley, S K]]
-	[[Category: Drubin, D G.]]	+	[[Category: Drubin, D G]]
-	[[Category: Fedorov, A A.]]	+	[[Category: Fedorov, A A]]
-	[[Category: Mahoney, N.]]	+	[[Category: Mahoney, N]]
-	[[Category: ~~NYSGXRC, New York SGX Research Center for~~ Structural ~~Genomics.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Strokopytov, B V.]]	+	[[Category: Strokopytov, B V]]
	[[Category: Actin binding]]		[[Category: Actin binding]]
	[[Category: Cofilin homology domain]]		[[Category: Cofilin homology domain]]
-	[[Category: New ~~york sgx research center~~ for ~~structural genomic]]~~	+	[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
-	~~[[Category: Nysgxrc~~]]	+	[[Category: PSI, Protein structure initiative]]
-	[[Category: Protein structure initiative]]	+
-	~~[[Category: Psi]]~~	+
-	~~[[Category: Structural genomic~~]]	+
	[[Category: Structural protein]]		[[Category: Structural protein]]

OCA at 08:34, 3 October 2014

OCA — Fri, 03 Oct 2014 08:34:57 GMT

←Older revision		Revision as of 08:34, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1hqz\| PDB=1hqz \| SCENE= }}~~	+	==Cofilin homology domain of a yeast actin-binding protein ABP1P==
-	===Cofilin homology domain of a yeast actin-binding protein ABP1P===	+	<StructureSection load='1hqz' size='340' side='right' caption='[[1hqz]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_15735338}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1hqz]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HQZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hqz RCSB], [http://www.ebi.ac.uk/pdbsum/1hqz PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1hqz TOPSAN]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hq/1hqz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A modified molecular-replacement method is described that makes use of six-dimensional searches and the phased translation function, providing a systematic examination of all possible search-model orientations in an experimental electron-density map. As an example, the structure solution of the cofilin-homology domain of the Saccharomyces cerevisiae actin-binding protein 1 (ABP1) is presented in detail. Additional examples are presented in which these tools have significantly aided structure solutions in a variety of contexts. These results suggest that this approach might be of widespread utility for challenging structures involving weak phase information, complex asymmetric units and search models with weak structural homology. Furthermore, this approach supports an exhaustive molecular-replacement strategy in cases where an appropriate search model cannot readily be identified on the basis of sequence homology. The fully automated web-based implementation of this phased translation function is described.

-	~~==Function==~~	+	Phased translation function revisited: structure solution of the cofilin-homology domain from yeast actin-binding protein 1 using six-dimensional searches.,Strokopytov BV, Fedorov A, Mahoney NM, Kessels M, Drubin DG, Almo SC Acta Crystallogr D Biol Crystallogr. 2005 Mar;61(Pt 3):285-93. Epub 2005, Feb 24. PMID:15735338<ref>PMID:15735338</ref>
-	~~[[http~~:~~//www.uniprot.org/uniprot/ABP1_YEAST ABP1_YEAST]] Regulates ARP2/3 complex~~-~~mediated~~ actin ~~assembly~~. ~~Recruits ARP2/3 complex to sides of preexisting actin filaments~~, ~~which may promote nucleation or stabilization of filament branches. Binds to actin filaments~~, ~~but not actin monomers~~. ~~Actin binding is required for ARP2/~~3 ~~complex activation~~. ~~May also have a role in linking the actin cytoskeleton to endocytosis. recruits components of the endocytotic machinery to cortical actin patches~~, ~~known sites of endocytosis~~.<ref>PMID:~~11331312~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[1hqz]] is~~ a ~~9 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1HQZ OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:015735338</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Almo, S C.]]		[[Category: Almo, S C.]]

OCA at 10:35, 16 April 2014

OCA — Wed, 16 Apr 2014 10:35:51 GMT

←Older revision		Revision as of 10:35, 16 April 2014
Line 1:		Line 1:
-	[[Image:1hqz.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1hqz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1hqz\| PDB=1hqz \| SCENE= }}		{{STRUCTURE_1hqz\| PDB=1hqz \| SCENE= }}
-
	===Cofilin homology domain of a yeast actin-binding protein ABP1P===		===Cofilin homology domain of a yeast actin-binding protein ABP1P===
		+	{{ABSTRACT_PUBMED_15735338}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/ABP1_YEAST ABP1_YEAST]] Regulates ARP2/3 complex-mediated actin assembly. Recruits ARP2/3 complex to sides of preexisting actin filaments, which may promote nucleation or stabilization of filament branches. Binds to actin filaments, but not actin monomers. Actin binding is required for ARP2/3 complex activation. May also have a role in linking the actin cytoskeleton to endocytosis. recruits components of the endocytotic machinery to cortical actin patches, known sites of endocytosis.<ref>PMID:11331312</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_15735338}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 15735338~~ is the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_15735338}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:015735338</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015735338</ref><references group="xtra"/><references/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Almo, S C.]]		[[Category: Almo, S C.]]

OCA: Protected "1hqz" [edit=sysop:move=sysop]

OCA — Wed, 16 Nov 2011 10:46:34 GMT

Protected "1hqz" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:46, 16 November 2011