1hzg - Revision history

OCA at 06:18, 9 August 2023

OCA — Wed, 09 Aug 2023 06:18:31 GMT

←Older revision		Revision as of 06:18, 9 August 2023
Line 3:		Line 3:
	<StructureSection load='1hzg' size='340' side='right'caption='[[1hzg]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='1hzg' size='340' side='right'caption='[[1hzg]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1hzg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HZG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1hzg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HZG FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.86Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1hq0\|1hq0]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzg OCA], [https://pdbe.org/1hzg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hzg RCSB], [https://www.ebi.ac.uk/pdbsum/1hzg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hzg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzg OCA], [https://pdbe.org/1hzg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hzg RCSB], [https://www.ebi.ac.uk/pdbsum/1hzg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hzg ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q47106_ECOLX Q47106_ECOLX]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Boquet, P]]	+	[[Category: Boquet P]]
-	[[Category: Buetow, L]]	+	[[Category: Buetow L]]
-	[[Category: Chiu, K]]	+	[[Category: Chiu K]]
-	[[Category: Flatau, G]]	+	[[Category: Flatau G]]
-	[[Category: Ghosh, P]]	+	[[Category: Ghosh P]]
-	~~[[Category: Beta sandwich]]~~	+
-	~~[[Category: Rho deamidase]]~~	+
-	~~[[Category: Rho transglutaminase]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 10:55, 4 August 2021

OCA — Wed, 04 Aug 2021 10:55:14 GMT

←Older revision		Revision as of 10:55, 4 August 2021
Line 3:		Line 3:
	<StructureSection load='1hzg' size='340' side='right'caption='[[1hzg]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='1hzg' size='340' side='right'caption='[[1hzg]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1hzg]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1HZG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1hzg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HZG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hq0\|1hq0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hq0\|1hq0]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1hzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzg OCA], [~~http~~://pdbe.org/1hzg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1hzg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1hzg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1hzg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzg OCA], [https://pdbe.org/1hzg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hzg RCSB], [https://www.ebi.ac.uk/pdbsum/1hzg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hzg ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:10, 30 October 2019

OCA — Wed, 30 Oct 2019 10:10:06 GMT

←Older revision		Revision as of 10:10, 30 October 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF THE INACTIVE C866S MUTANT OF THE CATALYTIC DOMAIN OF E. COLI CYTOTOXIC NECROTIZING FACTOR 1==		==CRYSTAL STRUCTURE OF THE INACTIVE C866S MUTANT OF THE CATALYTIC DOMAIN OF E. COLI CYTOTOXIC NECROTIZING FACTOR 1==
-	<StructureSection load='1hzg' size='340' side='right' caption='[[1hzg]], [[Resolution\|resolution]] 1.86Å' scene=''>	+	<StructureSection load='1hzg' size='340' side='right'caption='[[1hzg]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1hzg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HZG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1hzg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HZG FirstGlance]. <br>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Boquet, P]]		[[Category: Boquet, P]]
	[[Category: Buetow, L]]		[[Category: Buetow, L]]

OCA at 09:11, 10 January 2018

OCA — Wed, 10 Jan 2018 09:11:11 GMT

←Older revision		Revision as of 09:11, 10 January 2018
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE INACTIVE C866S MUTANT OF THE CATALYTIC DOMAIN OF E. COLI CYTOTOXIC NECROTIZING FACTOR 1==		==CRYSTAL STRUCTURE OF THE INACTIVE C866S MUTANT OF THE CATALYTIC DOMAIN OF E. COLI CYTOTOXIC NECROTIZING FACTOR 1==
	<StructureSection load='1hzg' size='340' side='right' caption='[[1hzg]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='1hzg' size='340' side='right' caption='[[1hzg]], [[Resolution\|resolution]] 1.86Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hq0\|1hq0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hq0\|1hq0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzg OCA], [http://pdbe.org/1hzg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hzg RCSB], [http://www.ebi.ac.uk/pdbsum/1hzg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzg OCA], [http://pdbe.org/1hzg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hzg RCSB], [http://www.ebi.ac.uk/pdbsum/1hzg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1hzg ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hz/1hzg_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hz/1hzg_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:48, 7 February 2016

OCA — Sun, 07 Feb 2016 20:48:26 GMT

←Older revision		Revision as of 20:48, 7 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hzg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:51, 10 September 2015

OCA — Thu, 10 Sep 2015 04:51:44 GMT

←Older revision		Revision as of 04:51, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1hzg' size='340' side='right' caption='[[1hzg]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='1hzg' size='340' side='right' caption='[[1hzg]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1hzg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HZG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1hzg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HZG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hq0\|1hq0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hq0\|1hq0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hzg RCSB], [http://www.ebi.ac.uk/pdbsum/1hzg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzg OCA], [http://pdbe.org/1hzg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hzg RCSB], [http://www.ebi.ac.uk/pdbsum/1hzg PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1hzg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Boquet, P]]		[[Category: Boquet, P]]
	[[Category: Buetow, L]]		[[Category: Buetow, L]]

OCA at 09:50, 2 January 2015

OCA — Fri, 02 Jan 2015 09:50:51 GMT

←Older revision		Revision as of 09:50, 2 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1hzg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HZG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1hzg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HZG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hq0\|1hq0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hq0\|1hq0]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hzg RCSB], [http://www.ebi.ac.uk/pdbsum/1hzg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hzg RCSB], [http://www.ebi.ac.uk/pdbsum/1hzg PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Boquet, P.]]	+	[[Category: Boquet, P]]
-	[[Category: Buetow, L.]]	+	[[Category: Buetow, L]]
-	[[Category: Chiu, K.]]	+	[[Category: Chiu, K]]
-	[[Category: Flatau, G.]]	+	[[Category: Flatau, G]]
-	[[Category: Ghosh, P.]]	+	[[Category: Ghosh, P]]
	[[Category: Beta sandwich]]		[[Category: Beta sandwich]]
	[[Category: Rho deamidase]]		[[Category: Rho deamidase]]
	[[Category: Rho transglutaminase]]		[[Category: Rho transglutaminase]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 09:23, 28 September 2014

OCA — Sun, 28 Sep 2014 09:23:48 GMT

←Older revision		Revision as of 09:23, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1hzg.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF THE INACTIVE C866S MUTANT OF THE CATALYTIC DOMAIN OF E. COLI CYTOTOXIC NECROTIZING FACTOR 1==
		+	<StructureSection load='1hzg' size='340' side='right' caption='[[1hzg]], [[Resolution\|resolution]] 1.86Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1hzg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HZG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hq0\|1hq0]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hzg RCSB], [http://www.ebi.ac.uk/pdbsum/1hzg PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hz/1hzg_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Certain uropathogenic and neonatal meningitis-causing strains of Escherichia coli express a 114 kDa protein toxin called cytotoxic necrotizing factor 1 (CNF1). The toxin causes alteration of the host cell actin cytoskeleton and promotes bacterial invasion of blood-brain barrier endothelial cells. CNF1 belongs to a unique group of large cytotoxins that cause constitutive activation of Rho guanosine triphosphatases (GTPases), which are key regulators of the actin cytoskeleton. This group also includes E. coli cytotoxic necrotizing factor 2 (CNF2, 114 kDa) and dermonecrotic toxins (DNT, 159 kDa) of Bordetella spp. with related sequences occurring in Yersinia spp. Here we show that the catalytic region of CNF1 exhibits a novel protein fold as determined by its 1.83 A resolution crystal structure. The structure reveals that CNF1 has a Cys-His-main chain oxygen catalytic triad reminiscent of enzymes belonging to the catalytic triad superfamily. The position of the catalytic Cys residue at the base of a deep pocket restricts access to potential substrates and helps explain the high specificity of this and related toxins.

-	~~{{STRUCTURE_1hzg\| PDB=1hzg \| SCENE= }}~~	+	Structure of the Rho-activating domain of Escherichia coli cytotoxic necrotizing factor 1.,Buetow L, Flatau G, Chiu K, Boquet P, Ghosh P Nat Struct Biol. 2001 Jul;8(7):584-8. PMID:11427886<ref>PMID:11427886</ref>

-	~~===CRYSTAL STRUCTURE OF THE INACTIVE C866S MUTANT OF THE CATALYTIC DOMAIN OF E. COLI CYTOTOXIC NECROTIZING FACTOR 1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11427886}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1hzg]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1HZG OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011427886<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Boquet, P.]]		[[Category: Boquet, P.]]

OCA: Protected "1hzg" [edit=sysop:move=sysop]

OCA — Wed, 21 Nov 2012 15:52:22 GMT

Protected "1hzg" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:52, 21 November 2012

OCA at 15:52, 21 November 2012

OCA — Wed, 21 Nov 2012 15:52:18 GMT

←Older revision		Revision as of 15:52, 21 November 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1hzg.png\|left\|200px]]		[[Image:1hzg.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1hzg", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1hzg\| PDB=1hzg \| SCENE= }}		{{STRUCTURE_1hzg\| PDB=1hzg \| SCENE= }}

	===CRYSTAL STRUCTURE OF THE INACTIVE C866S MUTANT OF THE CATALYTIC DOMAIN OF E. COLI CYTOTOXIC NECROTIZING FACTOR 1===		===CRYSTAL STRUCTURE OF THE INACTIVE C866S MUTANT OF THE CATALYTIC DOMAIN OF E. COLI CYTOTOXIC NECROTIZING FACTOR 1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11427886}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11427886 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11427886}}		{{ABSTRACT_PUBMED_11427886}}

	==About this Structure==		==About this Structure==
-	~~1HZG~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZG OCA].	+	[[1hzg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZG OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11427886~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011427886</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Boquet, P.]]		[[Category: Boquet, P.]]
Line 33:		Line 21:
	[[Category: Rho deamidase]]		[[Category: Rho deamidase]]
	[[Category: Rho transglutaminase]]		[[Category: Rho transglutaminase]]
-		+	[[Category: Toxin]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 16:24:41 2009''~~	+