1hzt - Revision history

OCA at 13:24, 13 March 2024

OCA — Wed, 13 Mar 2024 13:24:07 GMT

←Older revision		Revision as of 13:24, 13 March 2024
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	<StructureSection load='1hzt' size='340' side='right'caption='[[1hzt]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='1hzt' size='340' side='right'caption='[[1hzt]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1hzt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1HZT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1hzt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HZT FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[1hx3\|1hx3]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">IDI ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzt OCA], [https://pdbe.org/1hzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hzt RCSB], [https://www.ebi.ac.uk/pdbsum/1hzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hzt ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isopentenyl-diphosphate_Delta-isomerase Isopentenyl-diphosphate Delta-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.3.2 5.3.3.2] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1hzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzt OCA], [~~http~~://pdbe.org/1hzt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1hzt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1hzt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1hzt ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/IDI_ECOLI IDI_ECOLI]] Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).<ref>PMID:10099534</ref> <ref>PMID:9603997</ref>	+	[https://www.uniprot.org/uniprot/IDI_ECOLI IDI_ECOLI] Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).<ref>PMID:10099534</ref> <ref>PMID:9603997</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hzt ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hzt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Isopentenyl diphosphate:dimethylallyl diphosphate (IPP:DMAPP) isomerase catalyses a crucial activation step in the isoprenoid biosynthesis pathway. This enzyme is responsible for the isomerization of the carbon-carbon double bond of IPP to create the potent electrophile DMAPP. DMAPP then alkylates other molecules, including IPP, to initiate the extraordinary variety of isoprenoid compounds found in nature. The crystal structures of free and metal-bound Escherichia coli IPP isomerase reveal critical active site features underlying its catalytic mechanism. The enzyme requires one Mn(2+) or Mg(2+) ion to fold in its active conformation, forming a distorted octahedral metal coordination site composed of three histidines and two glutamates and located in the active site. Two critical residues, C67 and E116, face each other within the active site, close to the metal-binding site. The structures are compatible with a mechanism in which the cysteine initiates the reaction by protonating the carbon-carbon double bond, with the antarafacial rearrangement ultimately achieved by one of the glutamates involved in the metal coordination sphere. W161 may stabilize the highly reactive carbocation generated during the reaction through quadrupole- charge interaction.
-
-	Crystal structure of isopentenyl diphosphate:dimethylallyl diphosphate isomerase.,Durbecq V, Sainz G, Oudjama Y, Clantin B, Bompard-Gilles C, Tricot C, Caillet J, Stalon V, Droogmans L, Villeret V EMBO J. 2001 Apr 2;20(7):1530-7. PMID:11285217<ref>PMID:11285217</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1hzt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895]]~~	+	[[Category: Escherichia coli]]
-	~~[[Category: Isopentenyl-diphosphate Delta-isomerase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bompard-Gilles, C]]	+	[[Category: Bompard-Gilles C]]
-	[[Category: Caillet, J]]	+	[[Category: Caillet J]]
-	[[Category: Clantin, B]]	+	[[Category: Clantin B]]
-	[[Category: Droogmans, L]]	+	[[Category: Droogmans L]]
-	[[Category: Durbecq, V]]	+	[[Category: Durbecq V]]
-	[[Category: Oudjama, Y]]	+	[[Category: Oudjama Y]]
-	[[Category: Sainz, G]]	+	[[Category: Sainz G]]
-	[[Category: Stalon, V]]	+	[[Category: Stalon V]]
-	[[Category: Tricot, C]]	+	[[Category: Tricot C]]
-	[[Category: Villeret, V]]	+	[[Category: Villeret V]]
-	~~[[Category: Dimethylallyl]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Isopentenyl]]~~	+
-	~~[[Category: Isoprenoid~~]]	+

OCA at 10:34, 18 November 2020

OCA — Wed, 18 Nov 2020 10:34:50 GMT

←Older revision		Revision as of 10:34, 18 November 2020
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF METAL-FREE ISOPENTENYL DIPHOSPHATE:DIMETHYLALLYL DIPHOSPHATE ISOMERASE==		==CRYSTAL STRUCTURE OF METAL-FREE ISOPENTENYL DIPHOSPHATE:DIMETHYLALLYL DIPHOSPHATE ISOMERASE==
-	<StructureSection load='1hzt' size='340' side='right' caption='[[1hzt]], [[Resolution\|resolution]] 1.45Å' scene=''>	+	<StructureSection load='1hzt' size='340' side='right'caption='[[1hzt]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1hzt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZT OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1HZT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1hzt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1HZT FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hx3\|1hx3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hx3\|1hx3]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IDI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IDI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isopentenyl-diphosphate_Delta-isomerase Isopentenyl-diphosphate Delta-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.3.2 5.3.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isopentenyl-diphosphate_Delta-isomerase Isopentenyl-diphosphate Delta-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.3.2 5.3.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1hzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzt OCA], [http://pdbe.org/1hzt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hzt RCSB], [http://www.ebi.ac.uk/pdbsum/1hzt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1hzt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1hzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzt OCA], [http://pdbe.org/1hzt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hzt RCSB], [http://www.ebi.ac.uk/pdbsum/1hzt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1hzt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1hzt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1hzt" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Isopentenyl-diphosphate delta-isomerase\|Isopentenyl-diphosphate delta-isomerase]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Isopentenyl-diphosphate Delta-isomerase]]		[[Category: Isopentenyl-diphosphate Delta-isomerase]]
		+	[[Category: Large Structures]]
	[[Category: Bompard-Gilles, C]]		[[Category: Bompard-Gilles, C]]
	[[Category: Caillet, J]]		[[Category: Caillet, J]]

OCA at 09:02, 10 January 2018

OCA — Wed, 10 Jan 2018 09:02:06 GMT

←Older revision		Revision as of 09:02, 10 January 2018
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF METAL-FREE ISOPENTENYL DIPHOSPHATE:DIMETHYLALLYL DIPHOSPHATE ISOMERASE==		==CRYSTAL STRUCTURE OF METAL-FREE ISOPENTENYL DIPHOSPHATE:DIMETHYLALLYL DIPHOSPHATE ISOMERASE==
	<StructureSection load='1hzt' size='340' side='right' caption='[[1hzt]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='1hzt' size='340' side='right' caption='[[1hzt]], [[Resolution\|resolution]] 1.45Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IDI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IDI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isopentenyl-diphosphate_Delta-isomerase Isopentenyl-diphosphate Delta-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.3.2 5.3.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isopentenyl-diphosphate_Delta-isomerase Isopentenyl-diphosphate Delta-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.3.2 5.3.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzt OCA], [http://pdbe.org/1hzt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hzt RCSB], [http://www.ebi.ac.uk/pdbsum/1hzt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzt OCA], [http://pdbe.org/1hzt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hzt RCSB], [http://www.ebi.ac.uk/pdbsum/1hzt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1hzt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hz/1hzt_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hz/1hzt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1hzt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1hzt" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Isopentenyl-diphosphate delta-isomerase\|Isopentenyl-diphosphate delta-isomerase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:07, 7 February 2016

OCA — Sun, 07 Feb 2016 02:07:33 GMT

←Older revision		Revision as of 02:07, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hzt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:39, 9 September 2015

OCA — Wed, 09 Sep 2015 20:39:50 GMT

←Older revision		Revision as of 20:39, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1hzt' size='340' side='right' caption='[[1hzt]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='1hzt' size='340' side='right' caption='[[1hzt]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1hzt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HZT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1hzt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HZT FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hx3\|1hx3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hx3\|1hx3]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IDI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IDI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isopentenyl-diphosphate_Delta-isomerase Isopentenyl-diphosphate Delta-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.3.2 5.3.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isopentenyl-diphosphate_Delta-isomerase Isopentenyl-diphosphate Delta-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.3.2 5.3.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hzt RCSB], [http://www.ebi.ac.uk/pdbsum/1hzt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzt OCA], [http://pdbe.org/1hzt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hzt RCSB], [http://www.ebi.ac.uk/pdbsum/1hzt PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1hzt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Isopentenyl-diphosphate Delta-isomerase]]		[[Category: Isopentenyl-diphosphate Delta-isomerase]]
	[[Category: Bompard-Gilles, C]]		[[Category: Bompard-Gilles, C]]

OCA at 06:56, 24 December 2014

OCA — Wed, 24 Dec 2014 06:56:41 GMT

←Older revision		Revision as of 06:56, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1hzt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HZT FirstGlance]. <br>		<table><tr><td colspan='2'>[[1hzt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HZT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hx3\|1hx3]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hx3\|1hx3]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IDI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IDI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isopentenyl-diphosphate_Delta-isomerase Isopentenyl-diphosphate Delta-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.3.2 5.3.3.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isopentenyl-diphosphate_Delta-isomerase Isopentenyl-diphosphate Delta-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.3.2 5.3.3.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hzt RCSB], [http://www.ebi.ac.uk/pdbsum/1hzt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hzt RCSB], [http://www.ebi.ac.uk/pdbsum/1hzt PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IDI_ECOLI IDI_ECOLI]] Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).<ref>PMID:10099534</ref> <ref>PMID:9603997</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Isopentenyl-diphosphate Delta-isomerase]]		[[Category: Isopentenyl-diphosphate Delta-isomerase]]
-	[[Category: Bompard-Gilles, C.]]	+	[[Category: Bompard-Gilles, C]]
-	[[Category: Caillet, J.]]	+	[[Category: Caillet, J]]
-	[[Category: Clantin, B.]]	+	[[Category: Clantin, B]]
-	[[Category: Droogmans, L.]]	+	[[Category: Droogmans, L]]
-	[[Category: Durbecq, V.]]	+	[[Category: Durbecq, V]]
-	[[Category: Oudjama, Y.]]	+	[[Category: Oudjama, Y]]
-	[[Category: Sainz, G.]]	+	[[Category: Sainz, G]]
-	[[Category: Stalon, V.]]	+	[[Category: Stalon, V]]
-	[[Category: Tricot, C.]]	+	[[Category: Tricot, C]]
-	[[Category: Villeret, V.]]	+	[[Category: Villeret, V]]
	[[Category: Dimethylallyl]]		[[Category: Dimethylallyl]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
	[[Category: Isopentenyl]]		[[Category: Isopentenyl]]
	[[Category: Isoprenoid]]		[[Category: Isoprenoid]]

OCA at 08:28, 28 September 2014

OCA — Sun, 28 Sep 2014 08:28:30 GMT

←Older revision		Revision as of 08:28, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1hzt.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF METAL-FREE ISOPENTENYL DIPHOSPHATE:DIMETHYLALLYL DIPHOSPHATE ISOMERASE==
		+	<StructureSection load='1hzt' size='340' side='right' caption='[[1hzt]], [[Resolution\|resolution]] 1.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1hzt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HZT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hx3\|1hx3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IDI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isopentenyl-diphosphate_Delta-isomerase Isopentenyl-diphosphate Delta-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.3.2 5.3.3.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hzt RCSB], [http://www.ebi.ac.uk/pdbsum/1hzt PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hz/1hzt_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Isopentenyl diphosphate:dimethylallyl diphosphate (IPP:DMAPP) isomerase catalyses a crucial activation step in the isoprenoid biosynthesis pathway. This enzyme is responsible for the isomerization of the carbon-carbon double bond of IPP to create the potent electrophile DMAPP. DMAPP then alkylates other molecules, including IPP, to initiate the extraordinary variety of isoprenoid compounds found in nature. The crystal structures of free and metal-bound Escherichia coli IPP isomerase reveal critical active site features underlying its catalytic mechanism. The enzyme requires one Mn(2+) or Mg(2+) ion to fold in its active conformation, forming a distorted octahedral metal coordination site composed of three histidines and two glutamates and located in the active site. Two critical residues, C67 and E116, face each other within the active site, close to the metal-binding site. The structures are compatible with a mechanism in which the cysteine initiates the reaction by protonating the carbon-carbon double bond, with the antarafacial rearrangement ultimately achieved by one of the glutamates involved in the metal coordination sphere. W161 may stabilize the highly reactive carbocation generated during the reaction through quadrupole- charge interaction.

-	~~{{STRUCTURE_1hzt\| PDB=1hzt \| SCENE= }}~~	+	Crystal structure of isopentenyl diphosphate:dimethylallyl diphosphate isomerase.,Durbecq V, Sainz G, Oudjama Y, Clantin B, Bompard-Gilles C, Tricot C, Caillet J, Stalon V, Droogmans L, Villeret V EMBO J. 2001 Apr 2;20(7):1530-7. PMID:11285217<ref>PMID:11285217</ref>

-	~~===CRYSTAL STRUCTURE OF METAL-FREE ISOPENTENYL DIPHOSPHATE:DIMETHYLALLYL DIPHOSPHATE ISOMERASE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_11285217}}~~	+	==See Also==
-		+	*[[Isopentenyl-diphosphate delta-isomerase\|Isopentenyl-diphosphate delta-isomerase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1hzt~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZT OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:011285217<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Isopentenyl-diphosphate Delta-isomerase]]		[[Category: Isopentenyl-diphosphate Delta-isomerase]]

OCA: Protected "1hzt" [edit=sysop:move=sysop]

OCA — Wed, 21 Nov 2012 15:41:27 GMT

Protected "1hzt" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:41, 21 November 2012

OCA at 15:41, 21 November 2012

OCA — Wed, 21 Nov 2012 15:41:25 GMT

←Older revision		Revision as of 15:41, 21 November 2012
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-	{{Seed}}
	[[Image:1hzt.png\|left\|200px]]		[[Image:1hzt.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1hzt", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1hzt\| PDB=1hzt \| SCENE= }}		{{STRUCTURE_1hzt\| PDB=1hzt \| SCENE= }}

	===CRYSTAL STRUCTURE OF METAL-FREE ISOPENTENYL DIPHOSPHATE:DIMETHYLALLYL DIPHOSPHATE ISOMERASE===		===CRYSTAL STRUCTURE OF METAL-FREE ISOPENTENYL DIPHOSPHATE:DIMETHYLALLYL DIPHOSPHATE ISOMERASE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11285217}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11285217 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11285217}}		{{ABSTRACT_PUBMED_11285217}}

	==About this Structure==		==About this Structure==
-	~~1HZT~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZT OCA].	+	[[1hzt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZT OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11285217~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011285217</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Isopentenyl-diphosphate Delta-isomerase]]		[[Category: Isopentenyl-diphosphate Delta-isomerase]]
Line 40:		Line 28:
	[[Category: Isopentenyl]]		[[Category: Isopentenyl]]
	[[Category: Isoprenoid]]		[[Category: Isoprenoid]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 10:09:28 2009''

OCA at 08:09, 16 February 2009

OCA — Mon, 16 Feb 2009 08:09:31 GMT

←Older revision		Revision as of 08:09, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1HZT is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZT OCA].	+	1HZT is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZT OCA].

	==Reference==		==Reference==
-	Crystal structure of isopentenyl diphosphate:dimethylallyl diphosphate isomerase., Durbecq V, Sainz G, Oudjama Y, Clantin B, Bompard-Gilles C, Tricot C, Caillet J, Stalon V, Droogmans L, Villeret V, EMBO J. 2001 Apr 2;20(7):1530-7. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/11285217 11285217]~~	+	<ref group="xtra">PMID:11285217</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Isopentenyl-diphosphate Delta-isomerase]]		[[Category: Isopentenyl-diphosphate Delta-isomerase]]
-	[[Category: Single protein]]
	[[Category: Bompard-Gilles, C.]]		[[Category: Bompard-Gilles, C.]]
	[[Category: Caillet, J.]]		[[Category: Caillet, J.]]
Line 42:		Line 41:
	[[Category: Isoprenoid]]		[[Category: Isoprenoid]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 1~~ 10:11:~~39 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 10:09:28 2009''