1i2h - Revision history

OCA at 06:20, 9 August 2023

OCA — Wed, 09 Aug 2023 06:20:06 GMT

←Older revision		Revision as of 06:20, 9 August 2023
Line 3:		Line 3:
	<StructureSection load='1i2h' size='340' side='right'caption='[[1i2h]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1i2h' size='340' side='right'caption='[[1i2h]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1i2h]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2H OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1I2H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1i2h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I2H FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PSD~~-~~ZIP45 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1i2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i2h OCA], [~~http~~://pdbe.org/1i2h PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1i2h RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1i2h PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1i2h ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i2h OCA], [https://pdbe.org/1i2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i2h RCSB], [https://www.ebi.ac.uk/pdbsum/1i2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i2h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HOME1_RAT HOME1_RAT]] Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 3 counteracts the effects by competing for binding sites. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, and isoform 2 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.<ref>PMID:14528310</ref>	+	[https://www.uniprot.org/uniprot/HOME1_RAT HOME1_RAT] Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 3 counteracts the effects by competing for binding sites. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, and isoform 2 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.<ref>PMID:14528310</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fujiyoshi, Y]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Irie, K]]	+	[[Category: Fujiyoshi Y]]
-	[[Category: Kato, H]]	+	[[Category: Irie K]]
-	[[Category: Mitsuoka, K]]	+	[[Category: Kato H]]
-	[[Category: Nakatsu, T]]	+	[[Category: Mitsuoka K]]
-	~~[[Category: Enabled vasp homology 1 domain]]~~	+	[[Category: Nakatsu T]]
-	~~[[Category: Signaling protein~~]]	+

OCA at 10:35, 18 November 2020

OCA — Wed, 18 Nov 2020 10:35:30 GMT

←Older revision		Revision as of 10:35, 18 November 2020
Line 1:		Line 1:

	==CRYSTAL STRUCTURE ANALYSIS OF PSD-ZIP45(HOMER1C/VESL-1L)CONSERVED HOMER 1 DOMAIN==		==CRYSTAL STRUCTURE ANALYSIS OF PSD-ZIP45(HOMER1C/VESL-1L)CONSERVED HOMER 1 DOMAIN==
-	<StructureSection load='1i2h' size='340' side='right' caption='[[1i2h]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1i2h' size='340' side='right'caption='[[1i2h]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1i2h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2H OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1I2H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1i2h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2H OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1I2H FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PSD-ZIP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PSD-ZIP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1i2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i2h OCA], [http://pdbe.org/1i2h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i2h RCSB], [http://www.ebi.ac.uk/pdbsum/1i2h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1i2h ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1i2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i2h OCA], [http://pdbe.org/1i2h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i2h RCSB], [http://www.ebi.ac.uk/pdbsum/1i2h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1i2h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Fujiyoshi, Y]]		[[Category: Fujiyoshi, Y]]
	[[Category: Irie, K]]		[[Category: Irie, K]]

OCA at 09:34, 10 January 2018

OCA — Wed, 10 Jan 2018 09:34:26 GMT

←Older revision		Revision as of 09:34, 10 January 2018
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE ANALYSIS OF PSD-ZIP45(HOMER1C/VESL-1L)CONSERVED HOMER 1 DOMAIN==		==CRYSTAL STRUCTURE ANALYSIS OF PSD-ZIP45(HOMER1C/VESL-1L)CONSERVED HOMER 1 DOMAIN==
	<StructureSection load='1i2h' size='340' side='right' caption='[[1i2h]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1i2h' size='340' side='right' caption='[[1i2h]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1i2h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I2H FirstGlance]. <br>		<table><tr><td colspan='2'>[[1i2h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I2H FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PSD-ZIP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PSD-ZIP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i2h OCA], [http://pdbe.org/1i2h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i2h RCSB], [http://www.ebi.ac.uk/pdbsum/1i2h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i2h OCA], [http://pdbe.org/1i2h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i2h RCSB], [http://www.ebi.ac.uk/pdbsum/1i2h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1i2h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i2/1i2h_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i2/1i2h_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 05:16, 9 February 2016

OCA — Tue, 09 Feb 2016 05:16:35 GMT

←Older revision		Revision as of 05:16, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i2h ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:59, 10 September 2015

OCA — Thu, 10 Sep 2015 18:59:37 GMT

←Older revision		Revision as of 18:59, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1i2h' size='340' side='right' caption='[[1i2h]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1i2h' size='340' side='right' caption='[[1i2h]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1i2h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I2H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1i2h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I2H FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PSD-ZIP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PSD-ZIP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i2h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1i2h RCSB], [http://www.ebi.ac.uk/pdbsum/1i2h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i2h OCA], [http://pdbe.org/1i2h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i2h RCSB], [http://www.ebi.ac.uk/pdbsum/1i2h PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1i2h" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Fujiyoshi, Y]]		[[Category: Fujiyoshi, Y]]
	[[Category: Irie, K]]		[[Category: Irie, K]]

OCA at 04:41, 25 December 2014

OCA — Thu, 25 Dec 2014 04:41:32 GMT

←Older revision		Revision as of 04:41, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1i2h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I2H FirstGlance]. <br>		<table><tr><td colspan='2'>[[1i2h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I2H FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PSD-ZIP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PSD-ZIP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i2h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1i2h RCSB], [http://www.ebi.ac.uk/pdbsum/1i2h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i2h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1i2h RCSB], [http://www.ebi.ac.uk/pdbsum/1i2h PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HOME1_RAT HOME1_RAT]] Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 3 counteracts the effects by competing for binding sites. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, and isoform 2 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.<ref>PMID:14528310</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Fujiyoshi, Y.]]	+	[[Category: Fujiyoshi, Y]]
-	[[Category: Irie, K.]]	+	[[Category: Irie, K]]
-	[[Category: Kato, H.]]	+	[[Category: Kato, H]]
-	[[Category: Mitsuoka, K.]]	+	[[Category: Mitsuoka, K]]
-	[[Category: Nakatsu, T.]]	+	[[Category: Nakatsu, T]]
	[[Category: Enabled vasp homology 1 domain]]		[[Category: Enabled vasp homology 1 domain]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 11:31, 28 September 2014

OCA — Sun, 28 Sep 2014 11:31:21 GMT

←Older revision		Revision as of 11:31, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1i2h.~~png\|left~~\|200px]]	+	==CRYSTAL STRUCTURE ANALYSIS OF PSD-ZIP45(HOMER1C/VESL-1L)CONSERVED HOMER 1 DOMAIN==
		+	<StructureSection load='1i2h' size='340' side='right' caption='[[1i2h]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1i2h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I2H FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PSD-ZIP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i2h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1i2h RCSB], [http://www.ebi.ac.uk/pdbsum/1i2h PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i2/1i2h_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PSD-Zip45 (also named Homer 1c/Vesl-1L) is a synaptic scaffolding protein, which interacts with neurotransmitter receptors and other scaffolding proteins to target them into post-synaptic density (PSD), a specialized protein complex at the synaptic junction. Binding of the PSD-Zip45 to the receptors and scaffolding proteins results in colocalization and clustering of its binding partners in PSD. It has an Ena/VASP homology 1 (EVH1) domain in the N terminus for receptor binding, two leucine zipper motifs in the C terminus for clustering, and a linking region whose function is unclear despite the high level of conservation within the Homer 1 family. The X-ray crystallographic analysis of the largest fragment of residues 1-163, including an EVH1 domain reported here, demonstrates that the EVH1 domain contains an alpha-helix longer than that of the previous models, and that the linking part included in the conserved region of Homer 1 (CRH1) of the PSD-Zip45 interacts with the EVH1 domain of the neighbour CRH1 molecule in the crystal. The results suggest that the EVH1 domain recognizes the PPXXF motif found in the binding partners, and the SPLTP sequence (P-motif) in the linking region of the CRH1. The two types of binding are partly overlapped in the EVH1 domain, implying a mechanism to regulate multimerization of Homer 1 family proteins.

-	~~{{STRUCTURE_1i2h\| PDB=1i2h \| SCENE= }}~~	+	Crystal structure of the Homer 1 family conserved region reveals the interaction between the EVH1 domain and own proline-rich motif.,Irie K, Nakatsu T, Mitsuoka K, Miyazawa A, Sobue K, Hiroaki Y, Doi T, Fujiyoshi Y, Kato H J Mol Biol. 2002 May 10;318(4):1117-26. PMID:12054806<ref>PMID:12054806</ref>

-	~~===CRYSTAL STRUCTURE ANALYSIS OF PSD-ZIP45(HOMER1C~~/~~VESL-1L)CONSERVED HOMER 1 DOMAIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12054806}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1i2h]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1I2H OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012054806<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Fujiyoshi, Y.]]		[[Category: Fujiyoshi, Y.]]

OCA: Protected "1i2h" [edit=sysop:move=sysop]

OCA — Wed, 21 Nov 2012 16:22:38 GMT

Protected "1i2h" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:22, 21 November 2012

OCA at 16:22, 21 November 2012

OCA — Wed, 21 Nov 2012 16:22:34 GMT

←Older revision		Revision as of 16:22, 21 November 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1i2h.png\|left\|200px]]		[[Image:1i2h.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1i2h", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1i2h\| PDB=1i2h \| SCENE= }}		{{STRUCTURE_1i2h\| PDB=1i2h \| SCENE= }}

	===CRYSTAL STRUCTURE ANALYSIS OF PSD-ZIP45(HOMER1C/VESL-1L)CONSERVED HOMER 1 DOMAIN===		===CRYSTAL STRUCTURE ANALYSIS OF PSD-ZIP45(HOMER1C/VESL-1L)CONSERVED HOMER 1 DOMAIN===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12054806}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12054806 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12054806}}		{{ABSTRACT_PUBMED_12054806}}

	==About this Structure==		==About this Structure==
-	~~1I2H~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2H OCA].	+	[[1i2h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2H OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12054806~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012054806</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Fujiyoshi, Y.]]		[[Category: Fujiyoshi, Y.]]
Line 31:		Line 19:
	[[Category: Nakatsu, T.]]		[[Category: Nakatsu, T.]]
	[[Category: Enabled vasp homology 1 domain]]		[[Category: Enabled vasp homology 1 domain]]
-		+	[[Category: Signaling protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 06:46:11 2009''~~	+

OCA at 04:46, 17 February 2009

OCA — Tue, 17 Feb 2009 04:46:12 GMT

←Older revision		Revision as of 04:46, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1I2H is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2H OCA].	+	1I2H is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2H OCA].

	==Reference==		==Reference==
-	Crystal structure of the Homer 1 family conserved region reveals the interaction between the EVH1 domain and own proline-rich motif., Irie K, Nakatsu T, Mitsuoka K, Miyazawa A, Sobue K, Hiroaki Y, Doi T, Fujiyoshi Y, Kato H, J Mol Biol. 2002 May 10;318(4):1117-26. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/12054806 12054806]~~	+	<ref group="xtra">PMID:12054806</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Single protein]]
	[[Category: Fujiyoshi, Y.]]		[[Category: Fujiyoshi, Y.]]
	[[Category: Irie, K.]]		[[Category: Irie, K.]]
Line 33:		Line 32:
	[[Category: Enabled vasp homology 1 domain]]		[[Category: Enabled vasp homology 1 domain]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 1 10~~:18:~~55 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:46:11 2009''