1i4g - Revision history

OCA at 06:21, 9 August 2023

OCA — Wed, 09 Aug 2023 06:21:11 GMT

←Older revision		Revision as of 06:21, 9 August 2023
Line 3:		Line 3:
	<StructureSection load='1i4g' size='340' side='right'caption='[[1i4g]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1i4g' size='340' side='right'caption='[[1i4g]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1i4g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I4G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I4G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1i4g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I4G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I4G FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1sxt\|1sxt]]~~, ~~[[1efs\|1efs]], [[1i4h\|1i4h]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i4g OCA], [https://pdbe.org/1i4g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i4g RCSB], [https://www.ebi.ac.uk/pdbsum/1i4g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i4g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i4g OCA], [https://pdbe.org/1i4g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i4g RCSB], [https://www.ebi.ac.uk/pdbsum/1i4g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i4g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ETXA_STAAU ETXA_STAAU]] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death.	+	[https://www.uniprot.org/uniprot/ETXA_STAAU ETXA_STAAU] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Antonsson, P~~]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: ~~Bjork,~~ P]]	+	[[Category: Antonsson P]]
-	[[Category: ~~Hakansson, M~~]]	+	[[Category: Bjork P]]
-	[[Category: ~~Svensson, L A~~]]	+	[[Category: Hakansson M]]
-	[[Category: ~~Beta-barrel]]~~	+	[[Category: Svensson LA]]
-	~~[[Category: Beta-grasp]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 14:23, 27 October 2021

OCA — Wed, 27 Oct 2021 14:23:03 GMT

←Older revision		Revision as of 14:23, 27 October 2021
Line 3:		Line 3:
	<StructureSection load='1i4g' size='340' side='right'caption='[[1i4g]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1i4g' size='340' side='right'caption='[[1i4g]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1i4g]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I4G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1I4G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1i4g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I4G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I4G FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sxt\|1sxt]], [[1efs\|1efs]], [[1i4h\|1i4h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1sxt\|1sxt]], [[1efs\|1efs]], [[1i4h\|1i4h]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1i4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i4g OCA], [~~http~~://pdbe.org/1i4g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1i4g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1i4g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1i4g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i4g OCA], [https://pdbe.org/1i4g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i4g RCSB], [https://www.ebi.ac.uk/pdbsum/1i4g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i4g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ETXA_STAAU ETXA_STAAU]] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death.	+	[[https://www.uniprot.org/uniprot/ETXA_STAAU ETXA_STAAU]] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:32, 14 October 2020

OCA — Wed, 14 Oct 2020 06:32:00 GMT

←Older revision		Revision as of 06:32, 14 October 2020
Line 1:		Line 1:

	==Crystal structure of Staphylococcal enterotoxin A mutant H187A with reduced Zn2+ affinity==		==Crystal structure of Staphylococcal enterotoxin A mutant H187A with reduced Zn2+ affinity==
-	<StructureSection load='1i4g' size='340' side='right' caption='[[1i4g]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1i4g' size='340' side='right'caption='[[1i4g]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1i4g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I4G OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1I4G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1i4g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I4G OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1I4G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sxt\|1sxt]], [[1efs\|1efs]], [[1i4h\|1i4h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sxt\|1sxt]], [[1efs\|1efs]], [[1i4h\|1i4h]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1i4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i4g OCA], [http://pdbe.org/1i4g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i4g RCSB], [http://www.ebi.ac.uk/pdbsum/1i4g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1i4g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1i4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i4g OCA], [http://pdbe.org/1i4g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i4g RCSB], [http://www.ebi.ac.uk/pdbsum/1i4g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1i4g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Antonsson, P]]		[[Category: Antonsson, P]]
	[[Category: Bjork, P]]		[[Category: Bjork, P]]

OCA at 06:56, 9 January 2019

OCA — Wed, 09 Jan 2019 06:56:27 GMT

←Older revision		Revision as of 06:56, 9 January 2019
Line 3:		Line 3:
	<StructureSection load='1i4g' size='340' side='right' caption='[[1i4g]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1i4g' size='340' side='right' caption='[[1i4g]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1i4g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I4G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1i4g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I4G FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sxt\|1sxt]], [[1efs\|1efs]], [[1i4h\|1i4h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sxt\|1sxt]], [[1efs\|1efs]], [[1i4h\|1i4h]]</td></tr>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i4/1i4g_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i4/1i4g_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:34, 5 April 2017

OCA — Wed, 05 Apr 2017 06:34:38 GMT

←Older revision		Revision as of 06:34, 5 April 2017
Line 1:		Line 1:
		+
	==Crystal structure of Staphylococcal enterotoxin A mutant H187A with reduced Zn2+ affinity==		==Crystal structure of Staphylococcal enterotoxin A mutant H187A with reduced Zn2+ affinity==
	<StructureSection load='1i4g' size='340' side='right' caption='[[1i4g]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1i4g' size='340' side='right' caption='[[1i4g]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1i4g]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I4G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1i4g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I4G FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sxt\|1sxt]], [[1efs\|1efs]], [[1i4h\|1i4h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sxt\|1sxt]], [[1efs\|1efs]], [[1i4h\|1i4h]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i4g OCA], [http://pdbe.org/1i4g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i4g RCSB], [http://www.ebi.ac.uk/pdbsum/1i4g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i4g OCA], [http://pdbe.org/1i4g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i4g RCSB], [http://www.ebi.ac.uk/pdbsum/1i4g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1i4g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i4g ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:32, 11 September 2015

OCA — Fri, 11 Sep 2015 21:32:26 GMT

←Older revision		Revision as of 21:32, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1i4g' size='340' side='right' caption='[[1i4g]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1i4g' size='340' side='right' caption='[[1i4g]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1i4g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus~~ aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I4G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1i4g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I4G FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sxt\|1sxt]], [[1efs\|1efs]], [[1i4h\|1i4h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sxt\|1sxt]], [[1efs\|1efs]], [[1i4h\|1i4h]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i4g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1i4g RCSB], [http://www.ebi.ac.uk/pdbsum/1i4g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i4g OCA], [http://pdbe.org/1i4g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i4g RCSB], [http://www.ebi.ac.uk/pdbsum/1i4g PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1i4g" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Staphylococcus aureus]]
	[[Category: Antonsson, P]]		[[Category: Antonsson, P]]
	[[Category: Bjork, P]]		[[Category: Bjork, P]]

OCA at 19:59, 25 December 2014

OCA — Thu, 25 Dec 2014 19:59:08 GMT

←Older revision		Revision as of 19:59, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1i4g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I4G FirstGlance]. <br>		<table><tr><td colspan='2'>[[1i4g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I4G FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sxt\|1sxt]], [[1efs\|1efs]], [[1i4h\|1i4h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sxt\|1sxt]], [[1efs\|1efs]], [[1i4h\|1i4h]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i4g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1i4g RCSB], [http://www.ebi.ac.uk/pdbsum/1i4g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i4g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1i4g RCSB], [http://www.ebi.ac.uk/pdbsum/1i4g PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ETXA_STAAU ETXA_STAAU]] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: Antonsson, P.]]	+	[[Category: Antonsson, P]]
-	[[Category: Bjork, P.]]	+	[[Category: Bjork, P]]
-	[[Category: Hakansson, M.]]	+	[[Category: Hakansson, M]]
-	[[Category: Svensson, L A.]]	+	[[Category: Svensson, L A]]
	[[Category: Beta-barrel]]		[[Category: Beta-barrel]]
	[[Category: Beta-grasp]]		[[Category: Beta-grasp]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 09:54, 28 September 2014

OCA — Sun, 28 Sep 2014 09:54:46 GMT

←Older revision		Revision as of 09:54, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1i4g.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of Staphylococcal enterotoxin A mutant H187A with reduced Zn2+ affinity==
		+	<StructureSection load='1i4g' size='340' side='right' caption='[[1i4g]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1i4g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I4G FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sxt\|1sxt]], [[1efs\|1efs]], [[1i4h\|1i4h]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i4g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1i4g RCSB], [http://www.ebi.ac.uk/pdbsum/1i4g PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i4/1i4g_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure of a mutant form of staphylococcal enterotoxin A (SEA) has been determined to 2.1 A resolution. The studied SEA substitution H187-->A187 (SEAH187A) leads to an almost 10-fold reduction of the binding to major histocompatibility complex (MHC) class II. H187 is important for this interaction since it coordinates Zn2+. The zinc ion is thought to hold MHC class II and SEA together in a complex. Interestingly, only one of two molecules in the asymmetric unit binds Zn2+. H225, D227, a water molecule, and H44 from a symmetry-related molecule ligate Zn2+. The symmetry-related histidine is necessary for this substituted Zn2+ site to bind to Zn2+ at low zinc concentration (no Zn2+ added). Since a water molecule replaces the missing H187, H44 binds Zn2+ at the position where betaH81 from MHC class II probably will bind. Dynamic light scattering analysis reveals that in solution as well as in the crystal lattice the SEA(H187A) mutant forms aggregates. The substitution per se does not cause aggregation since wild-type SEA also forms aggregates. Addition of EDTA reduces the size of the aggregates, indicating a cross-linking function of Zn2+. In agreement with the biological function, the aggregation is weak (i.e. not revealed by gel filtration) and non-specific.

-	~~{{STRUCTURE_1i4g\| PDB=1i4g \| SCENE= }}~~	+	Cooperative zinc binding in a staphylococcal enterotoxin A mutant mimics the SEA-MHC class II interaction.,Hakansson M, Antonsson P, Bjork P, Svensson LA J Biol Inorg Chem. 2001 Oct;6(8):757-62. PMID:11713682<ref>PMID:11713682</ref>

-	~~===Crystal structure~~ of ~~Staphylococcal enterotoxin A mutant H187A with reduced Zn2+ affinity===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11713682}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1i4g]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Staphylococcus_aureus Staphylococcus aureus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1I4G OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011713682<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Antonsson, P.]]		[[Category: Antonsson, P.]]

OCA: Protected "1i4g" [edit=sysop:move=sysop]

OCA — Wed, 21 Nov 2012 15:29:17 GMT

Protected "1i4g" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:29, 21 November 2012

OCA at 15:29, 21 November 2012

OCA — Wed, 21 Nov 2012 15:29:13 GMT

←Older revision		Revision as of 15:29, 21 November 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1i4g.png\|left\|200px]]		[[Image:1i4g.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1i4g", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1i4g\| PDB=1i4g \| SCENE= }}		{{STRUCTURE_1i4g\| PDB=1i4g \| SCENE= }}

	===Crystal structure of Staphylococcal enterotoxin A mutant H187A with reduced Zn2+ affinity===		===Crystal structure of Staphylococcal enterotoxin A mutant H187A with reduced Zn2+ affinity===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11713682}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11713682 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11713682}}		{{ABSTRACT_PUBMED_11713682}}

	==About this Structure==		==About this Structure==
-	~~1I4G~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I4G OCA].	+	[[1i4g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I4G OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11713682~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011713682</ref><references group="xtra"/>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Antonsson, P.]]		[[Category: Antonsson, P.]]
Line 31:		Line 19:
	[[Category: Beta-barrel]]		[[Category: Beta-barrel]]
	[[Category: Beta-grasp]]		[[Category: Beta-grasp]]
-		+	[[Category: Toxin]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 05:27:08 2009''~~	+