1i5i - Revision history

OCA at 06:22, 9 August 2023

OCA — Wed, 09 Aug 2023 06:22:23 GMT

←Older revision		Revision as of 06:22, 9 August 2023
Line 3:		Line 3:
	<StructureSection load='1i5i' size='340' side='right'caption='[[1i5i]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1i5i' size='340' side='right'caption='[[1i5i]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1i5i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I5I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1i5i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I5I FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>~~[[~~4gcr~~\|~~4gcr~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i5i OCA], [https://pdbe.org/1i5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i5i RCSB], [https://www.ebi.ac.uk/pdbsum/1i5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i5i ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i5i OCA], [https://pdbe.org/1i5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i5i RCSB], [https://www.ebi.ac.uk/pdbsum/1i5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i5i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CRGB_BOVIN CRGB_BOVIN]] Crystallins are the dominant structural components of the vertebrate eye lens.	+	[https://www.uniprot.org/uniprot/CRGB_BOVIN CRGB_BOVIN] Crystallins are the dominant structural components of the vertebrate eye lens.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Asherie, N]]	+	[[Category: Asherie N]]
-	[[Category: Benedek~~, G B~~]]	+	[[Category: Benedek GB]]
-	[[Category: King~~, J A~~]]	+	[[Category: King JA]]
-	[[Category: Lomakin, A]]	+	[[Category: Lomakin A]]
-	[[Category: Lomakin, J]]	+	[[Category: Lomakin J]]
-	[[Category: Ogun, O]]	+	[[Category: Ogun O]]
-	[[Category: Pande, A]]	+	[[Category: Pande A]]
-	[[Category: Pande, J]]	+	[[Category: Pande J]]
-	[[Category: Stern~~, L J~~]]	+	[[Category: Stern LJ]]
-	[[Category: Zarutskie~~, J A]]~~	+	[[Category: Zarutskie JA]]
-	~~[[Category: Crystallin]]~~	+
-	~~[[Category: Eye lens protein]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 10:57, 4 August 2021

OCA — Wed, 04 Aug 2021 10:57:02 GMT

←Older revision		Revision as of 10:57, 4 August 2021
Line 3:		Line 3:
	<StructureSection load='1i5i' size='340' side='right'caption='[[1i5i]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1i5i' size='340' side='right'caption='[[1i5i]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1i5i]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I5I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1I5I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1i5i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I5I FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gcr\|4gcr]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4gcr\|4gcr]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1i5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i5i OCA], [~~http~~://pdbe.org/1i5i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1i5i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1i5i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1i5i ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i5i OCA], [https://pdbe.org/1i5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i5i RCSB], [https://www.ebi.ac.uk/pdbsum/1i5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i5i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CRGB_BOVIN CRGB_BOVIN]] Crystallins are the dominant structural components of the vertebrate eye lens.	+	[[https://www.uniprot.org/uniprot/CRGB_BOVIN CRGB_BOVIN]] Crystallins are the dominant structural components of the vertebrate eye lens.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:10, 30 October 2019

OCA — Wed, 30 Oct 2019 10:10:47 GMT

←Older revision		Revision as of 10:10, 30 October 2019
Line 1:		Line 1:

	==THE C18S MUTANT OF BOVINE (GAMMA-B)-CRYSTALLIN==		==THE C18S MUTANT OF BOVINE (GAMMA-B)-CRYSTALLIN==
-	<StructureSection load='1i5i' size='340' side='right' caption='[[1i5i]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='1i5i' size='340' side='right'caption='[[1i5i]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1i5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I5I FirstGlance]. <br>		<table><tr><td colspan='2'>[[1i5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I5I FirstGlance]. <br>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1i5i" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1i5i" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Crystallin 3D structures\|Crystallin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Bovin]]		[[Category: Bovin]]
		+	[[Category: Large Structures]]
	[[Category: Asherie, N]]		[[Category: Asherie, N]]
	[[Category: Benedek, G B]]		[[Category: Benedek, G B]]

OCA at 09:12, 10 January 2018

OCA — Wed, 10 Jan 2018 09:12:04 GMT

←Older revision		Revision as of 09:12, 10 January 2018
Line 1:		Line 1:
		+
	==THE C18S MUTANT OF BOVINE (GAMMA-B)-CRYSTALLIN==		==THE C18S MUTANT OF BOVINE (GAMMA-B)-CRYSTALLIN==
	<StructureSection load='1i5i' size='340' side='right' caption='[[1i5i]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1i5i' size='340' side='right' caption='[[1i5i]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1i5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I5I FirstGlance]. <br>		<table><tr><td colspan='2'>[[1i5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I5I FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gcr\|4gcr]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gcr\|4gcr]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i5i OCA], [http://pdbe.org/1i5i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i5i RCSB], [http://www.ebi.ac.uk/pdbsum/1i5i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i5i OCA], [http://pdbe.org/1i5i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i5i RCSB], [http://www.ebi.ac.uk/pdbsum/1i5i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1i5i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i5/1i5i_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i5/1i5i_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 18:26, 8 February 2016

OCA — Mon, 08 Feb 2016 18:26:14 GMT

←Older revision		Revision as of 18:26, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i5i ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:13, 10 September 2015

OCA — Thu, 10 Sep 2015 14:13:45 GMT

←Older revision		Revision as of 14:13, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1i5i' size='340' side='right' caption='[[1i5i]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1i5i' size='340' side='right' caption='[[1i5i]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1i5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I5I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1i5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I5I FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gcr\|4gcr]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gcr\|4gcr]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1i5i RCSB], [http://www.ebi.ac.uk/pdbsum/1i5i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i5i OCA], [http://pdbe.org/1i5i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i5i RCSB], [http://www.ebi.ac.uk/pdbsum/1i5i PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1i5i" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
	[[Category: Asherie, N]]		[[Category: Asherie, N]]
	[[Category: Benedek, G B]]		[[Category: Benedek, G B]]

OCA at 01:17, 25 December 2014

OCA — Thu, 25 Dec 2014 01:17:37 GMT

←Older revision		Revision as of 01:17, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1i5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I5I FirstGlance]. <br>		<table><tr><td colspan='2'>[[1i5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I5I FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gcr\|4gcr]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gcr\|4gcr]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1i5i RCSB], [http://www.ebi.ac.uk/pdbsum/1i5i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1i5i RCSB], [http://www.ebi.ac.uk/pdbsum/1i5i PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CRGB_BOVIN CRGB_BOVIN]] Crystallins are the dominant structural components of the vertebrate eye lens.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Asherie, N.]]	+	[[Category: Asherie, N]]
-	[[Category: Benedek, G B.]]	+	[[Category: Benedek, G B]]
-	[[Category: King, J A.]]	+	[[Category: King, J A]]
-	[[Category: Lomakin, A.]]	+	[[Category: Lomakin, A]]
-	[[Category: Lomakin, J.]]	+	[[Category: Lomakin, J]]
-	[[Category: Ogun, O.]]	+	[[Category: Ogun, O]]
-	[[Category: Pande, A.]]	+	[[Category: Pande, A]]
-	[[Category: Pande, J.]]	+	[[Category: Pande, J]]
-	[[Category: Stern, L J.]]	+	[[Category: Stern, L J]]
-	[[Category: Zarutskie, J A.]]	+	[[Category: Zarutskie, J A]]
	[[Category: Crystallin]]		[[Category: Crystallin]]
	[[Category: Eye lens protein]]		[[Category: Eye lens protein]]
	[[Category: Structural protein]]		[[Category: Structural protein]]

OCA at 12:38, 28 September 2014

OCA — Sun, 28 Sep 2014 12:38:55 GMT

←Older revision		Revision as of 12:38, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1i5i.~~png~~\|~~left~~\|200px]]	+	==THE C18S MUTANT OF BOVINE (GAMMA-B)-CRYSTALLIN==
		+	<StructureSection load='1i5i' size='340' side='right' caption='[[1i5i]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1i5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I5I FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gcr\|4gcr]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1i5i RCSB], [http://www.ebi.ac.uk/pdbsum/1i5i PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i5/1i5i_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The cysteine residues of the gamma crystallins, a family of ocular lens proteins, are involved in the aggregation and phase separation of these proteins. Both these phenomena are implicated in cataract formation. We have used bovine gammaB crystallin as a model system to study the role of the individual cysteine residues in the aggregation and phase separation of the gamma crystallins. Here, we compare the thermodynamic and kinetic behavior of the recombinant wild-type protein (WT) and the Cys18 to Ser (C18S) mutant. We find that the solubilities of the two proteins are similar. The kinetics of crystallization, however, are different. The WT crystallizes slowly enough for the metastable liquid-liquid coexistence to be easily observed. C18S, on the other hand, crystallizes rapidly; the metastable coexisting liquid phases of the pure mutant do not form. Nevertheless, the coexistence curve of C18S can be determined provided that crystallization is kinetically suppressed. In this way we found that the coexistence curve coincides with that of the WT. Despite the difference in the kinetics of crystallization, the two proteins were found to have the same crystal forms and almost identical X-ray structures. Our results demonstrate that even conservative point mutations can bring about dramatic changes in the kinetics of crystallization. The implications of our findings for cataract formation and protein crystallization are discussed.

-	~~{{STRUCTURE_1i5i\| PDB=1i5i \| SCENE= }}~~	+	Enhanced crystallization of the Cys18 to Ser mutant of bovine gammaB crystallin.,Asherie N, Pande J, Pande A, Zarutskie JA, Lomakin J, Lomakin A, Ogun O, Stern LJ, King J, Benedek GB J Mol Biol. 2001 Dec 7;314(4):663-9. PMID:11733987<ref>PMID:11733987</ref>

-	~~===THE C18S MUTANT OF BOVINE (GAMMA-B)-CRYSTALLIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11733987}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1i5i]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1I5I OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011733987<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Asherie, N.]]		[[Category: Asherie, N.]]

OCA: Protected "1i5i" [edit=sysop:move=sysop]

OCA — Wed, 21 Nov 2012 15:53:32 GMT

Protected "1i5i" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:53, 21 November 2012

OCA at 15:53, 21 November 2012

OCA — Wed, 21 Nov 2012 15:53:27 GMT

←Older revision		Revision as of 15:53, 21 November 2012
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-	{{Seed}}
	[[Image:1i5i.png\|left\|200px]]		[[Image:1i5i.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1i5i", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1i5i\| PDB=1i5i \| SCENE= }}		{{STRUCTURE_1i5i\| PDB=1i5i \| SCENE= }}

	===THE C18S MUTANT OF BOVINE (GAMMA-B)-CRYSTALLIN===		===THE C18S MUTANT OF BOVINE (GAMMA-B)-CRYSTALLIN===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11733987}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11733987 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11733987}}		{{ABSTRACT_PUBMED_11733987}}

	==About this Structure==		==About this Structure==
-	~~1I5I~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I5I OCA].	+	[[1i5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I5I OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11733987~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011733987</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Asherie, N.]]		[[Category: Asherie, N.]]
Line 38:		Line 26:
	[[Category: Eye lens protein]]		[[Category: Eye lens protein]]
	[[Category: Structural protein]]		[[Category: Structural protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 01:25:12 2009''